id: G1TUN6
gene_symbol: UBE2L6
taxon:
  id: NCBITaxon:9986
  label: Oryctolagus cuniculus
status: COMPLETE
description: >-
  The UBC enzyme architecture supports transferase activity, which is less specific than the existing
  ubiquitin-like-protein transfer annotations.
source_documents:
  - genes/RABIT/G1TUN6/G1TUN6-uniprot.txt
  - genes/RABIT/G1TUN6/G1TUN6-goa.tsv
  - publications/PMID_15131269.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0016740
      label: transferase activity
    predicted_term_type: GO_MF
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The target has a UBC conjugating-enzyme domain and the active-site cysteine annotation, consistent
        with its UBE2L6-family assignment. Experiments on UbcH8/UBE2L6 establish E2-mediated ubiquitin
        and ISG15 conjugation (PMID:15131269), supporting transfer of the broad catalytic class. Cached
        target annotations already include ISG15 transferase and ubiquitin-like protein transferase activities.
        Generic transferase activity is supported but less precise than those functions.
      supported_by:
        - reference_id: file:RABIT/G1TUN6/G1TUN6-uniprot.txt
          supporting_text: >-
            ID   G1TUN6_RABIT            Unreviewed;       153 AA. ... DR   InterPro; IPR000608; UBC.
            ... DR   InterPro; IPR023313; UBQ-conjugating_AS. ... FT   DOMAIN          2..149 ... FT                   /note="UBC
            core" ... FT   ACT_SITE        86
        - reference_id: PMID:15131269
          supporting_text: >-
            UbcH8 is a major E2 enzyme for ISG15 conjugation
references:
  - id: file:RABIT/G1TUN6/G1TUN6-uniprot.txt
    title: G1TUN6-uniprot.txt
  - id: PMID:15131269
    title: The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced
      ubiquitin-like protein.