| Claim/Item | Key result/data (include any numbers) | Evidence type | Citation ID(s) | Publication date | URL |
|---|---|---|---|---|---|
| UniProt A0A1D1W3Y1 / gene RvY_17310-1 in *Ramazzottius varieornatus* | Direct literature linkage is limited: the retrieved *R. varieornatus* SOD literature did **not** explicitly mention locus **RvY_17310-1 / RvY_17310**. UniProt annotation identifies it as a **Cu/Zn superoxide dismutase** family protein, so function is currently inferred mainly from family/domain annotation rather than a locus-specific paper. | Database annotation plus negative literature-mapping result | (pqac-00000000, pqac-00000001, pqac-00000004) | No direct locus paper found in retrieved literature (search through 2025) | https://www.uniprot.org/uniprotkb/A0A1D1W3Y1 |
| RvSOD15 structural study in *R. varieornatus* | Crystal structures of **RvSOD15** solved at **2.2 Å** (WT; PDB **7ypp**) and **2.10 Å** (V87H; PDB **7ypr**). A canonical Cu-liganding His is replaced by **Val87**; copper site shows only **3 histidine ligands** plus waters in WT. Authors infer some tardigrade SOD paralogs may have **low or lost canonical SOD activity**. RvSOD15 is predicted to have an **N-terminal signal peptide** (secreted). | Primary structural biology study | (pqac-00000001, pqac-00000002, pqac-00000003, pqac-00000004) | Jun 2023 | https://doi.org/10.1107/S2053230X2300523X |
| Genome-wide SOD expansion in *R. varieornatus* | Genome study reported **16 SOD genes** in *R. varieornatus*, versus **fewer than 10** in most metazoans; interpreted as expansion of stress-response gene families potentially relevant to oxidative stress during desiccation. | Primary genome analysis | (pqac-00000008) | Sep 2016 | https://doi.org/10.1038/ncomms12808 |
| 2024 review synthesis on tardigrade antioxidant defense | Review summarizes that *R. varieornatus* has an expanded/diversified SOD repertoire, citing **16–17 SODs** in the species and noting CuZn-SODs are highly expressed in tardigrades. It also highlights that some *R. varieornatus* paralogs appear atypical and may not retain full canonical SOD function, so gene-copy expansion alone may not explain stress tolerance. | Recent expert review/synthesis | (pqac-00000005, pqac-00000006, pqac-00000007) | Aug 2024 | https://doi.org/10.3390/ijms25158393 |
| Transcriptomic cross-tolerance: UVC and anhydrobiosis in *R. varieornatus* | Time-series transcriptomics found **3,324 DEGs** after UVC exposure and **141 genes** upregulated in both UVC and desiccation entry; shared-response genes were enriched for antioxidative functions including **superoxide dismutase activity**, supporting ROS-defense overlap between radiation and anhydrobiosis. No SOD-locus-specific fold change for RvY_17310-1 was provided in the retrieved excerpt. | Primary transcriptomic study | (pqac-00000010, pqac-00000011) | May 2022 | https://doi.org/10.1186/s12864-022-08642-1 |


*Table: This table summarizes the strongest retrieved evidence relevant to Cu/Zn superoxide dismutases in Ramazzottius varieornatus, including the locus-specific evidence gap for UniProt A0A1D1W3Y1. It is useful for separating direct evidence from family-level inference and for highlighting the most relevant genome, structure, review, and transcriptome sources.*