> SlrP is a *Salmonella enterica* serovar Typhimurium leucine-rich repeat (LRR/LPX)–NEL family type III secretion effector and E3 ubiquitin ligase that is delivered into host cells by both SPI-1/T3SS1 and SPI-2/T3SS2, with translocation varying by host cell type and infection stage. After translocation, it acts mainly in the host cytosol and partly at the endoplasmic reticulum, where it catalyzes ubiquitin transfer to selected host proteins, including thioredoxin-1, the ER chaperone ERdj3-associated pathway, and the spliceosomal protein SNRPD2; these activities are linked to reduced thioredoxin function, interference with ERdj3 folding activity, and likely non-proteolytic modulation of host RNA-processing machinery through SNRPD2 ubiquitination at K85/K92. (pqac-00000009, pqac-00000013, pqac-00000018, pqac-00000019)


*Blockquote: This blockquote summarizes the most evidence-supported functional annotation for SlrP: its identity, secretion route, enzymatic activity, major host substrates, and intracellular site of action. It is useful as a concise evidence-based statement for gene/protein annotation.*