id: O14423
gene_symbol: cbh1
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: Generic nucleic acid binding is directly supported and less precise than established centromeric
  DNA binding.
source_documents:
- genes/SCHPO/cbh1/cbh1-protnlm-source.xml
- genes/SCHPO/cbh1/cbh1-uniprot-source.json
- genes/SCHPO/cbh1/cbh1-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/cbh1/cbh1-protnlm-source.xml
  predicted_term:
    id: GO:0003676
    label: nucleic acid binding
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: Purified fission-yeast Cbh1 directly binds centromeric K-type repeat DNA and was characterized
      by DNA-binding and footprinting assays. Its in vivo centromeric-chromatin association was independently
      examined. These target observations directly establish nucleic acid binding. The target already
      has the more precise experimental centromeric DNA-binding annotation GO:0019237, so the broad prediction
      is correct but less precise.
    supported_by:
    - reference_id: PMID:9237993
      supporting_text: 'Cbh protein specifically interacts in vitro with the K-type repeat

        DNA, which is essential for centromere function.'
    - reference_id: PMID:10733588
      supporting_text: 'In vivo, epitope-tagged Cbhp associated with centromeric K repeat chromatin, as

        well as with noncentromeric regions.'
references:
- id: PMID:9237993
  title: Purification and characterization of a CENP-B homologue protein that binds to the centromeric
    K-type repeat DNA of Schizosaccharomyces pombe.
  findings: []
  full_text_unavailable: true
- id: PMID:10733588
  title: Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome
    segregation.
  findings: []
  full_text_unavailable: true