ID   CBH1_SCHPO              Reviewed;         514 AA.
AC   O14423; O14294;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 2.
DT   02-SEP-2026, entry version 164.
DE   RecName: Full=CENP-B homolog protein 1;
DE            Short=CBHP-1;
GN   Name=cbh1; Synonyms=cbh; ORFNames=SPAC9E9.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND FUNCTION.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=9237993; DOI=10.1073/pnas.94.16.8427;
RA   Lee J.-K., Huberman J.A., Hurwitz J.;
RT   "Purification and characterization of a CENP-B homologue protein that binds
RT   to the centromeric K-type repeat DNA of Schizosaccharomyces pombe.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:8427-8432(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Binds to centromeric K-type repeat DNA and ARS3002 DNA. The
CC       CBH-binding consensus sequence is Py-Pu-A-T-A-T-Py-Pu-T-A.
CC       {ECO:0000269|PubMed:9237993}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere.
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DR   EMBL; U86754; AAB80698.1; -; mRNA.
DR   EMBL; CU329670; CAB16408.1; -; Genomic_DNA.
DR   PIR; T39217; T39217.
DR   RefSeq; NP_594583.1; NM_001020012.3.
DR   AlphaFoldDB; O14423; -.
DR   SMR; O14423; -.
DR   BioGRID; 279715; 81.
DR   FunCoup; O14423; 288.
DR   IntAct; O14423; 3.
DR   STRING; 284812.O14423; -.
DR   iPTMnet; O14423; -.
DR   PaxDb; 284812-O14423; -.
DR   GeneID; 2543290; -.
DR   KEGG; spo:2543290; -.
DR   PomBase; SPAC9E9.10c; cbh1.
DR   VEuPathDB; FungiDB:SPAC9E9.10c; -.
DR   eggNOG; KOG3105; Eukaryota.
DR   HOGENOM; CLU_018294_0_3_1; -.
DR   InParanoid; O14423; -.
DR   OMA; WIKTEWP; -.
DR   PhylomeDB; O14423; -.
DR   PRO; PR:O14423; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; NAS:PomBase.
DR   GO; GO:0000779; C:condensed chromosome, centromeric region; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0019237; F:centromeric DNA binding; IDA:PomBase.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   FunFam; 1.10.10.60:FF:000313; major centromere autoantigen B; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR   InterPro; IPR050863; CenT-Element_Derived.
DR   InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR   InterPro; IPR009057; Homeodomain-like_sf.
DR   InterPro; IPR041188; HTH_ABP1_N.
DR   InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR   PANTHER; PTHR19303:SF73; PROTEIN PDC2; 1.
DR   PANTHER; PTHR19303; TRANSPOSON; 1.
DR   Pfam; PF03184; DDE_1; 1.
DR   Pfam; PF18107; HTH_ABP1_N; 1.
DR   Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR   SMART; SM00674; CENPB; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 2.
DR   PROSITE; PS51253; HTH_CENPB; 1.
PE   1: Evidence at protein level;
KW   Centromere; Chromosome; Direct protein sequencing; DNA-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..514
FT                   /note="CENP-B homolog protein 1"
FT                   /id="PRO_0000126134"
FT   DOMAIN          69..144
FT                   /note="HTH CENPB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT   CONFLICT        168
FT                   /note="I -> M (in Ref. 1; AAB80698)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   514 AA;  59865 MW;  A48102EBAD0BB1E3 CRC64;
     MPPIRQAVSL AEKKAIRDYY NQSAHRIPQK EVTEWFRKTY NKDLSQSTIS EILSPKYSYL
     DDGSVRLGDI KKIRAPKFPL LDNAVYEWLQ QREVEGLPIS GDMIKQAATR FWSKIPAYAS
     LPLPDFSNGW LDKFRRRHYI QQSAVNQALE SIKFEVFREY PVHIQEFIRP YAQKDIFCVG
     GTSLFWKLTP NKQNLDYQEI QGMKRGKAKV SLIMCCNADG SERLPLWIVG YAQNPRSFEQ
     CGIFPKSMNF EWKWNGRASI SPIIMEEWLR WFDTRMQGRK VLLMLESNDT YQFGVESVRR
     FKGGFQNTSV FRIPEKTLDI KSPFEQGIVD TFKANYRRYW LQYSLNQINI LRDPLKAVNV
     LKAIRWMLWS WNFGVSEKTI QASFLRSGLL GPHSEAEGQG MESYQKAIME IGNLISSKGS
     EAVKQINEYI RPSEEDETKL HQDAVDTVAA EFLEERRFES DEEEDVEPQI SNVEAAMAFE
     VLIKYFEQHE NGDPSFVLDL YRRQRVIAPN NLIA
//