htd2

Summary: PAINT inference of mitochondrial location.

Reason: Mitochondrion is a root organelle term; UniProt assigns mitochondrial location by similarity and the protein belongs to the HTD2 family of mitochondrial type II fatty acid synthesis dehydratases, so the organelle claim holds. There is no S. pombe experimental data; the evidence is curated by-similarity text in UniProt (to the characterized HTD2 family member, S. cerevisiae Htd2) plus family classification.

Summary: UniProt subcellular location mapping; consistent.

Reason: Same claim as the IBA row: UniProt assigns mitochondrial location by similarity, consistent with HTD2 family membership. There is no S. pombe experimental data; the evidence is curated by-similarity text in UniProt (to the characterized HTD2 family member, S. cerevisiae Htd2) plus family classification.

Summary: Similarity: mitochondrial type II fatty acid synthesis.

Reason: UniProt describes Htd2 as a mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, by similarity, and the protein belongs to the HTD2 family. There is no S. pombe experimental data; the evidence is curated by-similarity text in UniProt (to the characterized HTD2 family member, S. cerevisiae Htd2) plus family classification.

Summary: PAINT inference: (3R)-hydroxyacyl-ACP dehydratase (S. cerevisiae Htd2 node).

Reason: Family membership (HTD2 family; PANTHER HTD2 subfamily) and the by-similarity UniProt function statement (3-hydroxyacyl-thioester dehydratase in fatty acid biosynthesis) support the dehydratase step of mitochondrial FAS. There is no S. pombe experimental data; the evidence is curated by-similarity text in UniProt (to the characterized HTD2 family member, S. cerevisiae Htd2) plus family classification.