id: Q9UUI1
gene_symbol: lsm6
locus_tag: SPAC2F3.17c
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: Lsm6 participates in experimentally established Lsm RNA-binding rings. The broad Sm-like
  family-complex prediction is supported but less precise than the named Lsm2-8 and Lsm1-7-Pat1 complexes.
source_documents:
- genes/SCHPO/lsm6/lsm6-protnlm-source.xml
- genes/SCHPO/lsm6/lsm6-uniprot.txt
- genes/SCHPO/lsm6/lsm6-ai-review.yaml
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  predicted_term:
    id: GO:0120114
    label: Sm-like protein family complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Fission yeast crystallography and biochemical reconstitution establish Lsm6 within Sm-fold
      RNA-binding rings. These primary results validate the broad Sm-like family-complex assertion independently
      of its ARBA overlap. GOA already contains the more specific Lsm2-8 and Lsm1-7-Pat1 complex annotations.
      The prediction is therefore correct but less informative than the established complex assignments.
    supported_by:
    - reference_id: PMID:22615807
      supporting_text: RNA binding assays show that Lsm2/3 and Lsm5/6/7 bind to oligo(U) whereas no RNA
        binding is observed for Lsm3 and Lsm4. Analysis of the inter-subunit interactions in Lsm5/6/7
        reveals the organization order among Lsm5, Lsm6 and Lsm7.
    - reference_id: PMID:32518066
      supporting_text: The multi-ORF expression system was assembled into a single plasmid through ligation
        independent cloning as described for Lsm2–8, with the ORFs assembled in order Lsm6, Lsm3, Lsm2,
        Lsm1, Lsm4, Lsm7, and Lsm5.
  source_reference_id: file:SCHPO/lsm6/lsm6-protnlm-source.xml
references:
- id: PMID:22615807
  title: Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.
- id: PMID:32518066
  title: Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes.
- id: file:SCHPO/lsm6/lsm6-protnlm-source.xml
  title: Original pre-release ProtNLM2 XML entry for lsm6