id: O14003
gene_symbol: rfc3
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: The broad GO predictions describe established biology; all are less specific than supported
  curated annotations (LSP).
source_documents:
- genes/SCHPO/rfc3/rfc3-protnlm-source.xml
- genes/SCHPO/rfc3/rfc3-protnlm-source.json
- genes/SCHPO/rfc3/rfc3-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/rfc3/rfc3-protnlm-source.xml
  predicted_term:
    id: GO:0006260
    label: DNA replication
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target-specific rfc3 conditional-mutant study establishes DNA replication defects (PMID:10588638),
      and purified fission-yeast RFC supports processive DNA synthesis (PMID:10748208). Replication is
      an established function of this clamp-loader subunit. The existing DNA-templated DNA replication
      and strand-elongation annotations are more specific, making the generic prediction LSP.
    supported_by:
    - reference_id: PMID:10588638
      supporting_text: 'From these results, we conclude that rfc3(+) is

        required not only for DNA replication but also for replication and damage

        checkpoint controls, probably functioning as a checkpoint sensor.'
references:
- id: PMID:10588638
  title: Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex,
    plays a role in both replication and damage checkpoints.
  findings: []