id: O14086
gene_symbol: rpa49
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: The broad GO predictions describe established biology; all are less specific than supported
  curated annotations (LSP).
source_documents:
- genes/SCHPO/rpa49/rpa49-protnlm-source.xml
- genes/SCHPO/rpa49/rpa49-protnlm-source.json
- genes/SCHPO/rpa49/rpa49-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/rpa49/rpa49-protnlm-source.xml
  predicted_term:
    id: GO:0000428
    label: DNA-directed RNA polymerase complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: S. pombe RPA51/Rpa49 is an experimentally established Pol I subunit required for efficient
      rDNA transcription (PMID:12893961). The predicted DNA-directed RNA polymerase complex is biologically
      supported. The existing RNA polymerase I complex annotation is more specific within the same GO
      aspect, so the prediction is LSP. This is a process/complex assignment to an accessory subunit,
      not independent polymerase catalysis.
    supported_by: &id001
    - reference_id: PMID:12893961
      supporting_text: 'Transcripts analysis in vivo and in vitro shows that RPA51 plays a

        general role for maximizing transcription of rDNA whereas it is dispensable for

        non-specific transcription.'
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/rpa49/rpa49-protnlm-source.xml
  predicted_term:
    id: GO:0006351
    label: DNA-templated transcription
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: S. pombe RPA51/Rpa49 is an experimentally established Pol I subunit required for efficient
      rDNA transcription (PMID:12893961). The predicted DNA-templated transcription is biologically supported.
      The existing transcription elongation by RNA polymerase I annotation is more specific within the
      same GO aspect, so the prediction is LSP. This is a process/complex assignment to an accessory subunit,
      not independent polymerase catalysis.
    supported_by: *id001
references:
- id: PMID:12893961
  title: The fission yeast RPA51 is a functional homolog of the budding yeast A49 subunit of RNA polymerase
    I and required for maximizing transcription of ribosomal DNA.
  findings: []