ID   RPA49_SCHPO             Reviewed;         425 AA.
AC   O14086;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   02-SEP-2026, entry version 143.
DE   RecName: Full=DNA-directed RNA polymerase I subunit rpa49;
DE            Short=RNA polymerase I subunit A49;
DE   AltName: Full=DNA-directed RNA polymerase I 49 kDa polypeptide;
GN   Name=rpa49; ORFNames=SPAC2F3.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=972 / ATCC 24843;
RA   Shematorova E.K., Shpakovski G.V.;
RT   "Molecular cloning and complementation studies of the fission yeast genes
RT   encoding subunits Rpa12 and Rpa49 specific for nuclear RNA polymerase I.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC       DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC       Component of RNA polymerase I which synthesizes ribosomal RNA
CC       precursors.
CC   -!- SUBUNIT: Component of the RNA polymerase I (Pol I) complex consisting
CC       of 14 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AJ278613; CAC20964.1; -; mRNA.
DR   EMBL; CU329670; CAB16261.1; -; Genomic_DNA.
DR   PIR; T38536; T38536.
DR   RefSeq; NP_594382.1; NM_001019803.3.
DR   AlphaFoldDB; O14086; -.
DR   SMR; O14086; -.
DR   BioGRID; 278404; 11.
DR   FunCoup; O14086; 219.
DR   STRING; 284812.O14086; -.
DR   iPTMnet; O14086; -.
DR   PaxDb; 284812-O14086; -.
DR   GeneID; 2541914; -.
DR   KEGG; spo:2541914; -.
DR   PomBase; SPAC2F3.03c; rpa49.
DR   VEuPathDB; FungiDB:SPAC2F3.03c; -.
DR   eggNOG; KOG4183; Eukaryota.
DR   HOGENOM; CLU_034953_2_1_1; -.
DR   InParanoid; O14086; -.
DR   OMA; DVYPFDE; -.
DR   PhylomeDB; O14086; -.
DR   Reactome; R-SPO-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-SPO-73772; RNA Polymerase I Promoter Escape.
DR   PRO; PR:O14086; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005736; C:RNA polymerase I complex; IDA:PomBase.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0001188; P:RNA polymerase I preinitiation complex assembly; IBA:GO_Central.
DR   GO; GO:0006362; P:transcription elongation by RNA polymerase I; IDA:PomBase.
DR   InterPro; IPR009668; RNA_pol-assoc_fac_A49-like.
DR   PANTHER; PTHR14440; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49; 1.
DR   Pfam; PF06870; RNA_pol_I_A49; 1.
PE   2: Evidence at transcript level;
KW   DNA-directed RNA polymerase; Nucleus; Reference proteome; Transcription.
FT   CHAIN           1..425
FT                   /note="DNA-directed RNA polymerase I subunit rpa49"
FT                   /id="PRO_0000073954"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   425 AA;  48066 MW;  1191EC48E6A75A76 CRC64;
     MAGDELKGKK RKYRDSHSGD EKSVKILPLS ESSLPPLVTT ISGFYPPENT RFQLLKKSNQ
     SNRDASLIGR TERVQFEAKN QSTATVEANY CLAVADKTGR VKKIVPAKYL NTFERNILAL
     QEKDKFLKKK HGTVSGTVME QRANLGLAFG TRKSQKAIME ESANRVKAET LGDVKDQLVS
     NVQKATEALP TQEDIAAAQA QDRPIPPVNV GAESIEDAYK LEDIIPKEEF SAIYIKPLLE
     NPDERNWAKL LPYRHSLFIN ERFQRLLSIE EVDQKRARIL YYISLLQAFL FSRRSVGNRE
     TLRKKLADPP EILIDGLIKR FTQTTGIGSV QVSSREVDKI ICYILVLCLI VDNYSTDVLT
     LANDLNVKTM KANELFRTVG CRIMAYTETQ RMALGLNKTD AKNHKRAVLK IPLEFPKPRR
     GRARN
//