id: O13993
gene_symbol: rpo41
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: The broad GO predictions describe established biology; all are less specific than supported
  curated annotations (LSP).
source_documents:
- genes/SCHPO/rpo41/rpo41-protnlm-source.xml
- genes/SCHPO/rpo41/rpo41-protnlm-source.json
- genes/SCHPO/rpo41/rpo41-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/rpo41/rpo41-protnlm-source.xml
  predicted_term:
    id: GO:0003677
    label: DNA binding
  predicted_term_type: GO_MF
  review:
    assessment: LSP
    confidence_score: 2
    summary: Purified S. pombe Rpo41 binds mitochondrial promoters and supports transcription together
      with Mtf1 (PMID:21357609). The predicted DNA binding is biologically supported. The existing mitochondrial
      promoter sequence-specific DNA binding annotation is more specific within the same GO aspect, so
      the prediction is LSP.
    supported_by: &id001
    - reference_id: PMID:21357609
      supporting_text: We show biochemically, that purified Mtf1 and Rpo41 together can bind to the S.
        pombe mitochondrial promoters and can support transcription from the S. pombe mitochondrial promoters
        in vitro.
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/rpo41/rpo41-protnlm-source.xml
  predicted_term:
    id: GO:0006351
    label: DNA-templated transcription
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Purified S. pombe Rpo41 binds mitochondrial promoters and supports transcription together
      with Mtf1 (PMID:21357609). The predicted DNA-templated transcription is biologically supported.
      The existing mitochondrial transcription annotation is more specific within the same GO aspect,
      so the prediction is LSP.
    supported_by: *id001
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/rpo41/rpo41-protnlm-source.xml
  predicted_term:
    id: GO:0000428
    label: DNA-directed RNA polymerase complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Purified S. pombe Rpo41 binds mitochondrial promoters and supports transcription together
      with Mtf1 (PMID:21357609). The predicted DNA-directed RNA polymerase complex is biologically supported.
      The existing mitochondrial DNA-directed RNA polymerase complex annotation is more specific within
      the same GO aspect, so the prediction is LSP.
    supported_by: *id001
references:
- id: PMID:21357609
  title: Identification and characterization of the mitochondrial RNA polymerase and transcription factor
    in the fission yeast Schizosaccharomyces pombe.
  findings: []