id: Q9P6P2
gene_symbol: rrp36
locus_tag: SPAC823.04
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: Rrp36 is a conserved 90S preribosome factor supporting small-subunit rRNA maturation. Both
  predictions are supported but less precise than the established process and complex assignments.
source_documents:
- genes/SCHPO/rrp36/rrp36-protnlm-source.xml
- genes/SCHPO/rrp36/rrp36-uniprot.txt
- genes/SCHPO/rrp36/rrp36-ai-review.yaml
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  predicted_term:
    id: GO:0006364
    label: rRNA processing
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: The specific RRP36 domain and target nucleolar localization support the conserved preribosome
      role inferred by PAINT. Purification and depletion in budding yeast establish 90S/pre-40S association
      and early small-subunit rRNA maturation; human depletion supports conservation across eukaryotes.
      GOA already records maturation of SSU-rRNA from tricistronic rRNA transcript (GO:0000462). The broad
      rRNA-processing prediction is supported but loses small-subunit specificity; no intrinsic RNase
      chemistry is implied.
    supported_by:
    - &id001
      reference_id: PMID:20038530
      supporting_text: We show that the Rrp36p protein is nucleolar and interacts with 90S and pre-40S
        preribosomal particles. Its depletion affects early cleavages of the 35S pre-rRNA and results
        in a rapid decrease in mature 18S rRNA levels.
    - reference_id: file:SCHPO/rrp36/rrp36-uniprot.txt
      supporting_text: DR   InterPro; IPR009292; RRP36.
  source_reference_id: file:SCHPO/rrp36/rrp36-protnlm-source.xml
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  predicted_term:
    id: GO:1990904
    label: ribonucleoprotein complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: Rrp36 belongs to a specifically identified ribosome-biogenesis family; characterized ortholog
      copurification with RNA-containing 90S and pre-40S particles establishes the relevant complex type.
      Curated ancestral inference already places fission yeast Rrp36 in the 90S preribosome (GO:0030686),
      consistent with its nucleolar localization. A ribonucleoprotein complex is a broader description
      of that supported complex membership. The prediction is correct but less precise than the existing
      90S assignment.
    supported_by:
    - *id001
    - reference_id: file:SCHPO/rrp36/rrp36-uniprot.txt
      supporting_text: DR   InterPro; IPR009292; RRP36.
  source_reference_id: file:SCHPO/rrp36/rrp36-protnlm-source.xml
references:
- id: file:SCHPO/rrp36/rrp36-uniprot.txt
  title: 'UniProt record for rrp36: specific family/domain assignment'
- id: PMID:20038530
  title: Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production
    of the 40S ribosomal subunit.
- id: file:SCHPO/rrp36/rrp36-protnlm-source.xml
  title: Original pre-release ProtNLM2 XML entry for rrp36