sws2

UniProt ID: O59772
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Review Status: COMPLETE
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Gene Description

Sws2 is the mitochondrial small-subunit ribosomal protein uS13m. Its conserved uS13 RNA-binding fold and mitochondrial localization support a structural role in the mitoribosome and mitochondrial protein synthesis.

Existing Annotations Review

GO Term Evidence Action Reason
GO:0003676 nucleic acid binding
IEA
GO_REF:0000002 		MODIFY
Summary: nucleic acid binding is reviewed in the context of sws2.
Reason: The broad nucleic acid binding annotation is compatible with the biology, but RNA binding captures the supported sws2 function more precisely.
Proposed replacements: RNA binding
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0003723 RNA binding
IEA
GO_REF:0000002 		ACCEPT
Summary: RNA binding is supported.
Reason: The target has the diagnostic uS13 family domain and a mitochondrial localization record. The S. cerevisiae structural supplementary table identifies Sws2/P53937 as uS13m and its contact with rRNA helix H62. This grounds transfer of the conserved RNA-associated mitoribosomal role while leaving exact S. pombe bridge geometry unresolved.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0003735 structural constituent of ribosome
IBA
GO_REF:0000033 		ACCEPT
Summary: structural constituent of ribosome is supported.
Reason: The target has the diagnostic uS13 family domain and a mitochondrial localization record. The S. cerevisiae structural supplementary table identifies Sws2/P53937 as uS13m and its contact with rRNA helix H62. This grounds transfer of the conserved RNA-associated mitoribosomal role while leaving exact S. pombe bridge geometry unresolved.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0003735 structural constituent of ribosome
IEA
GO_REF:0000002 		ACCEPT
Summary: structural constituent of ribosome is supported.
Reason: The target has the diagnostic uS13 family domain and a mitochondrial localization record. The S. cerevisiae structural supplementary table identifies Sws2/P53937 as uS13m and its contact with rRNA helix H62. This grounds transfer of the conserved RNA-associated mitoribosomal role while leaving exact S. pombe bridge geometry unresolved.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0005739 mitochondrion
HDA
PMID:16823372
ORFeome cloning and global analysis of protein localization ... 		ACCEPT
Summary: mitochondrion is supported.
Reason: Mitochondrial localization is concordant with the conserved mitochondrial ribosomal ortholog assignment. Retain the PomBase genome-scale localization annotation (PMID:16823372); the available abstract describes the screen but does not expose the target image. The source excerpt records the target HDA/IC annotation, not a reinspection of the individual microscopy image.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
GO:0005739 mitochondrion
IBA
GO_REF:0000033 		ACCEPT
Summary: mitochondrion is supported.
Reason: Mitochondrial localization is concordant with the conserved mitochondrial ribosomal ortholog assignment. Retain the PomBase genome-scale localization annotation (PMID:16823372); the available abstract describes the screen but does not expose the target image.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
GO:0005739 mitochondrion
IEA
GO_REF:0000044 		ACCEPT
Summary: mitochondrion is supported.
Reason: Mitochondrial localization is concordant with the conserved mitochondrial ribosomal ortholog assignment. Retain the PomBase genome-scale localization annotation (PMID:16823372); the available abstract describes the screen but does not expose the target image.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
GO:0005763 mitochondrial small ribosomal subunit
ISO
GO_REF:0000024 		ACCEPT
Summary: mitochondrial small ribosomal subunit is supported.
Reason: The target has the diagnostic uS13 family domain and a mitochondrial localization record. The S. cerevisiae structural supplementary table identifies Sws2/P53937 as uS13m and its contact with rRNA helix H62. This grounds transfer of the conserved RNA-associated mitoribosomal role while leaving exact S. pombe bridge geometry unresolved.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0005763 mitochondrial small ribosomal subunit
NAS
PMID:18245278
Bot1p is required for mitochondrial translation, respiratory... 		ACCEPT
Summary: mitochondrial small ribosomal subunit is supported.
Reason: The target has the diagnostic uS13 family domain and a mitochondrial localization record. The S. cerevisiae structural supplementary table identifies Sws2/P53937 as uS13m and its contact with rRNA helix H62. This grounds transfer of the conserved RNA-associated mitoribosomal role while leaving exact S. pombe bridge geometry unresolved.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0005840 ribosome
IEA
GO_REF:0000002 		MODIFY
Summary: ribosome is reviewed in the context of sws2.
Reason: The broad ribosome annotation is compatible with the biology, but mitochondrial small ribosomal subunit captures the supported sws2 function more precisely.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0006412 translation
IEA
GO_REF:0000002 		MODIFY
Summary: translation is reviewed in the context of sws2.
Reason: The broad translation annotation is compatible with the biology, but mitochondrial translation captures the supported sws2 function more precisely.
Proposed replacements: mitochondrial translation
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0015935 small ribosomal subunit
IBA
GO_REF:0000033 		MODIFY
Summary: small ribosomal subunit is reviewed in the context of sws2.
Reason: The broad small ribosomal subunit annotation is compatible with the biology, but mitochondrial small ribosomal subunit captures the supported sws2 function more precisely.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0032543 mitochondrial translation
ISO
GO_REF:0000024 		ACCEPT
Summary: mitochondrial translation is supported.
Reason: The target has the diagnostic uS13 family domain and a mitochondrial localization record. The S. cerevisiae structural supplementary table identifies Sws2/P53937 as uS13m and its contact with rRNA helix H62. This grounds transfer of the conserved RNA-associated mitoribosomal role while leaving exact S. pombe bridge geometry unresolved.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!
GO:0032543 mitochondrial translation
NAS
PMID:18245278
Bot1p is required for mitochondrial translation, respiratory... 		ACCEPT
Summary: mitochondrial translation is supported.
Reason: The target has the diagnostic uS13 family domain and a mitochondrial localization record. The S. cerevisiae structural supplementary table identifies Sws2/P53937 as uS13m and its contact with rRNA helix H62. This grounds transfer of the conserved RNA-associated mitoribosomal role while leaving exact S. pombe bridge geometry unresolved.
Supporting Evidence:
file:SCHPO/sws2/sws2-uniprot.txt
DR InterPro; IPR001892; Ribosomal_uS13.
file:SCHPO/sws2/sws2-28154081-supplement.txt
uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!

Core Functions

Provides the conserved uS13m small-subunit structural role in mitochondrial translation.

Molecular Function:
structural constituent of ribosome
Directly Involved In:
mitochondrial translation
Cellular Locations:
mitochondrion
In Complex:
mitochondrial small ribosomal subunit
Supporting Evidence:
  • file:SCHPO/sws2/sws2-uniprot.txt
    DR InterPro; IPR001892; Ribosomal_uS13.
  • file:SCHPO/sws2/sws2-28154081-supplement.txt
    uS13m! Sws2! P53937! MM! 14143! 16,089! 24121! ! ... mB13! uS13m:!34,!37B38,!41! H62:!1657B1658!

References

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External Prediction Reviews

These computational predictions are reviewed separately from the GOA annotation set used for this review. The assessments below are from this project and do not constitute official GO annotations or endorsement by GO/UniProt. They are not included in the existing annotation review above.

ProtNLM2 External predictions

View prediction review YAML · sws2-protnlm-predictions-review.yaml · Review status: COMPLETE

The broad GO predictions describe established biology; RNA binding is CNN and the remaining predictions are LSP.

Source documents: genes/SCHPO/sws2/sws2-protnlm-source.xml · genes/SCHPO/sws2/sws2-protnlm-source.json · genes/SCHPO/sws2/sws2-uniprot.txt · genes/SCHPO/sws2/sws2-28154081-supplement.txt

Review score: 2 = concordant with evidence; 1 = uncertain; 0 = discordant with evidence. This is an assessment score, not a model probability.

GO:0006412 translation GO_BP
LSP — Less precise than existing annotation Review score: 2/2
Prediction method: ProtNLM2 · Version: pre-release post-processed-2026_02_28k.xml · file:SCHPO/sws2/sws2-protnlm-source.xml
Review rationale: The target has the diagnostic uS13m family domain and mitochondrial localization. Characterized S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal role. Translation is therefore supported, and the existing mitochondrial translation annotation (GO:0032543) is more specific within the biological-process aspect. The generic prediction is LSP.
Supporting Evidence:
GO:0005840 ribosome GO_CC
LSP — Less precise than existing annotation Review score: 2/2
Prediction method: ProtNLM2 · Version: pre-release post-processed-2026_02_28k.xml · file:SCHPO/sws2/sws2-protnlm-source.xml
Review rationale: The target has the diagnostic uS13m family domain and mitochondrial localization. Characterized S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal role. Membership in the mitochondrial small ribosomal subunit is a supported cellular-component annotation and is more specific than ribosome. The predicted broad complex membership is LSP.
Supporting Evidence:
GO:0003723 RNA binding GO_MF
CNN — Correct but not novel Review score: 2/2
Prediction method: ProtNLM2 · Version: pre-release post-processed-2026_02_28k.xml · file:SCHPO/sws2/sws2-protnlm-source.xml
Review rationale: The target carries the diagnostic uS13 domain. In the experimentally determined S. cerevisiae mitoribosome, the homolog Sws2/P53937 is uS13m and contacts rRNA helix H62 (PMID:28154081, supplementary tables S2 and bridge table). This supports transfer of conserved RNA binding to fission-yeast Sws2, without asserting identical bridge geometry. The equivalent RNA-binding annotation already exists in target GOA, so CNN applies.
Supporting Evidence:
GO:1990904 ribonucleoprotein complex GO_CC
LSP — Less precise than existing annotation Review score: 2/2
Prediction method: ProtNLM2 · Version: pre-release post-processed-2026_02_28k.xml · file:SCHPO/sws2/sws2-protnlm-source.xml
Review rationale: The target has the diagnostic uS13m family domain and mitochondrial localization. Characterized S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal role. Membership in the mitochondrial small ribosomal subunit is a supported cellular-component annotation and is more specific than ribonucleoprotein complex. The predicted broad complex membership is LSP.
Supporting Evidence:

Deep Research

Falcon

(sws2-deep-research-falcon.md)

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📚 Additional Documentation

Notes

(sws2-notes.md)

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Protnlm Function Review

(sws2-protnlm-function-review.md)

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📄 View Raw YAML

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