id: O59772
gene_symbol: sws2
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: The broad GO predictions describe established biology; RNA binding is CNN and the remaining
  predictions are LSP.
source_documents:
- genes/SCHPO/sws2/sws2-protnlm-source.xml
- genes/SCHPO/sws2/sws2-protnlm-source.json
- genes/SCHPO/sws2/sws2-uniprot.txt
- genes/SCHPO/sws2/sws2-28154081-supplement.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/sws2/sws2-protnlm-source.xml
  predicted_term:
    id: GO:0006412
    label: translation
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target has the diagnostic uS13m family domain and mitochondrial localization. Characterized
      S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal
      role. Translation is therefore supported, and the existing mitochondrial translation annotation
      (GO:0032543) is more specific within the biological-process aspect. The generic prediction is LSP.
    supported_by:
    - reference_id: file:SCHPO/sws2/sws2-uniprot.txt
      supporting_text: DR   InterPro; IPR001892; Ribosomal_uS13.
    - &id001
      reference_id: file:SCHPO/sws2/sws2-28154081-supplement.txt
      supporting_text: uS13m!     Sws2!         P53937!     MM!      14143!       16,089! 24121!               !
        ... mB13!      uS13m:!34,!37B38,!41!                       H62:!1657B1658!
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/sws2/sws2-protnlm-source.xml
  predicted_term:
    id: GO:0005840
    label: ribosome
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target has the diagnostic uS13m family domain and mitochondrial localization. Characterized
      S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal
      role. Membership in the mitochondrial small ribosomal subunit is a supported cellular-component
      annotation and is more specific than ribosome. The predicted broad complex membership is LSP.
    supported_by:
    - reference_id: file:SCHPO/sws2/sws2-uniprot.txt
      supporting_text: DR   InterPro; IPR001892; Ribosomal_uS13.
    - *id001
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/sws2/sws2-protnlm-source.xml
  predicted_term:
    id: GO:0003723
    label: RNA binding
  predicted_term_type: GO_MF
  review:
    assessment: CNN
    confidence_score: 2
    summary: The target carries the diagnostic uS13 domain. In the experimentally determined S. cerevisiae
      mitoribosome, the homolog Sws2/P53937 is uS13m and contacts rRNA helix H62 (PMID:28154081, supplementary
      tables S2 and bridge table). This supports transfer of conserved RNA binding to fission-yeast Sws2,
      without asserting identical bridge geometry. The equivalent RNA-binding annotation already exists
      in target GOA, so CNN applies.
    supported_by:
    - reference_id: file:SCHPO/sws2/sws2-uniprot.txt
      supporting_text: DR   InterPro; IPR001892; Ribosomal_uS13.
    - *id001
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/sws2/sws2-protnlm-source.xml
  predicted_term:
    id: GO:1990904
    label: ribonucleoprotein complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target has the diagnostic uS13m family domain and mitochondrial localization. Characterized
      S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal
      role. Membership in the mitochondrial small ribosomal subunit is a supported cellular-component
      annotation and is more specific than ribonucleoprotein complex. The predicted broad complex membership
      is LSP.
    supported_by:
    - reference_id: file:SCHPO/sws2/sws2-uniprot.txt
      supporting_text: DR   InterPro; IPR001892; Ribosomal_uS13.
    - *id001
references:
- id: file:SCHPO/sws2/sws2-uniprot.txt
  title: sws2 UniProt sequence/domain and annotation record
  findings: []
- id: file:SCHPO/sws2/sws2-28154081-supplement.txt
  title: Supplementary tables of the S. cerevisiae mitoribosome structure (PMID:28154081)
  findings: []