id: Q9UUB6
gene_symbol: uch2
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: Ubiquitin-dependent protein catabolism is supported but less precise than the established
  proteasomal process.
source_documents:
- genes/SCHPO/uch2/uch2-protnlm-source.xml
- genes/SCHPO/uch2/uch2-uniprot-source.json
- genes/SCHPO/uch2/uch2-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/uch2/uch2-protnlm-source.xml
  predicted_term:
    id: GO:0006511
    label: ubiquitin-dependent protein catabolic process
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: Fission-yeast Uch2 is directly characterized as the major deubiquitinating enzyme associated
      with the 26S proteasome, and proteomic work recovers its association with the proteasome. Processing
      ubiquitin conjugates at this complex is a function in ubiquitin-dependent protein turnover even
      though the DUB removes ubiquitin rather than degrading the substrate polypeptide itself. The supported,
      more precise proteasomal protein catabolic process annotation GO:0010498 is already present. Thus
      the general catabolic-process prediction is correct but less precise; weak deletion phenotypes reflect
      redundancy and do not negate pathway participation.
    supported_by:
    - reference_id: PMID:15533439
      supporting_text: 'We report that the subunit Uch2/Uch37 is the major

        deubiquitinating enzyme associated with the fission yeast 26S proteasome.'
    - reference_id: PMID:20838651
      supporting_text: Rpn11 and Uch2 co-purified all of the 26S proteasome subunits (19S regulatory particle
        and 20S core particle) in quantities similar to those of the bait (Table S1)
references:
- id: PMID:15533439
  title: Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission
    yeast.
  findings: []
  full_text_unavailable: true
- id: PMID:20838651
  title: A global census of fission yeast deubiquitinating enzyme localization and interaction networks
    reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.
  findings: []
  full_text_unavailable: false