id: Q9P7B5
gene_symbol: wss1
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: 'Membrane residence remains unresolved: the source hydrates it from the Nucleus keyword,
  which does not establish membrane association.'
source_documents:
- genes/SCHPO/wss1/wss1-protnlm-source.xml
- genes/SCHPO/wss1/wss1-uniprot-source.json
- genes/SCHPO/wss1/wss1-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/wss1/wss1-protnlm-source.xml
  predicted_term:
    id: GO:0016020
    label: membrane
  predicted_term_type: GO_CC
  review:
    assessment: UNC
    confidence_score: 1
    summary: The reviewed target record places Wss1 in the nucleus and identifies a soluble WLM metalloprotease
      domain; it does not establish membrane residence. The original XML hydrates the membrane claim from
      KW-0539, which is the UniProt keyword Nucleus, not a membrane-specific observation. Nuclear residence
      alone does not entail association with the nuclear envelope, and the family DNA-protein-crosslink
      repair mechanism does not require a membrane. Nevertheless, lack of a transmembrane helix would
      not exclude peripheral membrane association, so the broad claim cannot be conclusively refuted solely
      from these data. Direct membrane fractionation, colocalization or an established membrane-associated
      complex is missing.
    supported_by:
    - reference_id: file:SCHPO/wss1/wss1-uniprot.txt
      supporting_text: 'CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.'
    - reference_id: file:SCHPO/wss1/wss1-keyword-KW-0539.json
      supporting_text: "\"name\": \"Nucleus\",\n    \"id\": \"KW-0539\""
references:
- id: file:SCHPO/wss1/wss1-uniprot.txt
  title: Frozen source record used for prediction assessment
  findings: []
- id: file:SCHPO/wss1/wss1-keyword-KW-0539.json
  title: Frozen source record used for prediction assessment
  findings: []