id: O74801
gene_symbol: yml6
taxon:
  id: NCBITaxon:284812
  label: Schizosaccharomyces pombe (strain 972 / ATCC 24843)
status: COMPLETE
description: The broad GO predictions describe established biology; all are less specific than supported
  curated annotations (LSP).
source_documents:
- genes/SCHPO/yml6/yml6-protnlm-source.xml
- genes/SCHPO/yml6/yml6-protnlm-source.json
- genes/SCHPO/yml6/yml6-uniprot.txt
predictions:
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/yml6/yml6-protnlm-source.xml
  predicted_term:
    id: GO:0006412
    label: translation
  predicted_term_type: GO_BP
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target has the diagnostic uL4m family domain and mitochondrial localization. Target Yml6
      also co-purifies at low levels with Ppr10 among mitoribosomal proteins (PMID:34119521). Characterized
      S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal
      role. Translation is therefore supported, and the existing mitochondrial translation annotation
      (GO:0032543) is more specific within the biological-process aspect. The generic prediction is LSP.
    supported_by: &id002
    - reference_id: file:SCHPO/yml6/yml6-uniprot.txt
      supporting_text: DR   InterPro; IPR002136; Ribosomal_uL4.
    - reference_id: PMID:24675956
      supporting_text: Beyond the entrance, the tunnel is lined by conserved elements (Fig. 6C), including
        the constriction site formed by uL22 and uL4.
    - &id001
      reference_id: PMID:34119521
      supporting_text: Mass spectrometry (MS) analysis of Ppr10-copurified proteins revealed that some
        proteins were specifically detected in the Ppr10-TAP preparation, albeit at low levels. These
        proteins included mt-SSU proteins (Nam9, Mrps28, Mrp4, and Mrps9), mt-LSU proteins (Aco2-Mrpl49,
        Mrpl7, and Yml6), SPAC750.08c (a putative NAD-dependent malic enzyme), SPBP4H10.18c (a Schizosaccharomyces
        specific protein of unknown function), and Anc1 (a mitochondrial ADP/ATP carrier)
    - *id001
    - *id001
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/yml6/yml6-protnlm-source.xml
  predicted_term:
    id: GO:1990904
    label: ribonucleoprotein complex
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target has the diagnostic uL4m family domain and mitochondrial localization. Target Yml6
      also co-purifies at low levels with Ppr10 among mitoribosomal proteins (PMID:34119521). Characterized
      S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal
      role. Membership in the mitochondrial large ribosomal subunit is a supported cellular-component
      annotation and is more specific than ribonucleoprotein complex. The predicted broad complex membership
      is LSP.
    supported_by: *id002
- source_method: ProtNLM2
  source_version: pre-release post-processed-2026_02_28k.xml
  source_reference_id: file:SCHPO/yml6/yml6-protnlm-source.xml
  predicted_term:
    id: GO:0005840
    label: ribosome
  predicted_term_type: GO_CC
  review:
    assessment: LSP
    confidence_score: 2
    summary: The target has the diagnostic uL4m family domain and mitochondrial localization. Target Yml6
      also co-purifies at low levels with Ppr10 among mitoribosomal proteins (PMID:34119521). Characterized
      S. cerevisiae mitoribosome structures support transfer of the conserved mitochondrial ribosomal
      role. Membership in the mitochondrial large ribosomal subunit is a supported cellular-component
      annotation and is more specific than ribosome. The predicted broad complex membership is LSP.
    supported_by: *id002
references:
- id: PMID:24675956
  title: Structure of the yeast mitochondrial large ribosomal subunit.
  findings: []
- id: file:SCHPO/yml6/yml6-uniprot.txt
  title: yml6 UniProt sequence/domain record
  findings: []
- id: PMID:34119521
  title: Schizosaccharomyces pombe Ppr10 and Mpa1 together mediate mitochondrial translational initiation.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: The inspected primary full text reports low-level recovery of Yml6 with Ppr10 by mass
      spectrometry (Figure 4A/Table S2), supporting target association with the mitochondrial translation
      machinery. The linked 2022 correction changes a funding grant number only; it does not alter the
      reported association.