ID   RL4P_SCHPO              Reviewed;         261 AA.
AC   O74801;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   02-SEP-2026, entry version 127.
DE   RecName: Full=Large ribosomal subunit protein uL4m {ECO:0000305};
DE   AltName: Full=54S ribosomal protein yml6, mitochondrial;
DE   Flags: Precursor;
GN   Name=yml6; ORFNames=SPBC2D10.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAA21166.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Component of the mitochondrial ribosome (mitoribosome), a
CC       dedicated translation machinery responsible for the synthesis of
CC       mitochondrial genome-encoded proteins, including at least some of the
CC       essential transmembrane subunits of the mitochondrial respiratory
CC       chain. The mitoribosomes are attached to the mitochondrial inner
CC       membrane and translation products are cotranslationally integrated into
CC       the membrane. {ECO:0000250|UniProtKB:P51998}.
CC   -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt-
CC       LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S)
CC       and a large (54S) subunit. The 37S small subunit contains a 15S
CC       ribosomal RNA (15S mt-rRNA) and at least 32 different proteins. The 54S
CC       large subunit contains a 21S rRNA (21S mt-rRNA) and at least 45
CC       different proteins. {ECO:0000250|UniProtKB:P51998}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC       {ECO:0000255}.
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DR   EMBL; CU329671; CAA21166.1; -; Genomic_DNA.
DR   PIR; T40111; T40111.
DR   RefSeq; NP_596227.1; NM_001022147.2.
DR   AlphaFoldDB; O74801; -.
DR   SMR; O74801; -.
DR   BioGRID; 276977; 1.
DR   ComplexPortal; CPX-10323; 54S mitochondrial large ribosomal subunit.
DR   FunCoup; O74801; 242.
DR   STRING; 284812.O74801; -.
DR   PaxDb; 284812-O74801; -.
DR   GeneID; 2540449; -.
DR   KEGG; spo:2540449; -.
DR   PomBase; SPBC2D10.08c; yml6.
DR   VEuPathDB; FungiDB:SPBC2D10.08c; -.
DR   eggNOG; KOG1624; Eukaryota.
DR   HOGENOM; CLU_041575_4_2_1; -.
DR   InParanoid; O74801; -.
DR   OMA; KTFGPHP; -.
DR   PhylomeDB; O74801; -.
DR   PRO; PR:O74801; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0032543; P:mitochondrial translation; ISS:PomBase.
DR   GO; GO:0006417; P:regulation of translation; IBA:GO_Central.
DR   Gene3D; 3.40.1370.10; -; 1.
DR   InterPro; IPR002136; Ribosomal_uL4.
DR   InterPro; IPR013005; Ribosomal_uL4-like.
DR   InterPro; IPR023574; Ribosomal_uL4_dom_sf.
DR   NCBIfam; TIGR03953; rplD_bact; 1.
DR   PANTHER; PTHR10746; 50S RIBOSOMAL PROTEIN L4; 1.
DR   PANTHER; PTHR10746:SF6; LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M; 1.
DR   Pfam; PF00573; Ribosomal_L4; 1.
DR   SUPFAM; SSF52166; Ribosomal protein L4; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   Transit peptide.
FT   TRANSIT         1..35
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..261
FT                   /note="Large ribosomal subunit protein uL4m"
FT                   /id="PRO_0000314628"
FT   REGION          72..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29550 MW;  DB7B51A6FA59A914 CRC64;
     MTAKMLHLVR YKFPSLEPAS LFLIPGSFLQ ERFRRDILHR AVIYEADNDR QGTASSKRRN
     EITCSGRKLY RQKGTGHARV GDASSPIRRG GAKSHGPKPR DFSTKLQTQV YNLAMRIALS
     TRFINNELTI LENPINLSQP KTRILLEVLK QHKLGHEYGK ALFVLNDNYF EDESLKNNNL
     LLASRQLGYH CSFIPVGEFQ VRDALKFGKL FIDSEAMSLI VEKFAQRNTL SDMDQPASLT
     AYVDANSSSF TKSKPEPSLS L
//