id: C6T1A2
gene_symbol: C6T1A2
taxon:
  id: NCBITaxon:3847
  label: Glycine max
status: COMPLETE
description: >-
  The plant ZFP-family protein plausibly acts in the nucleus. A negative role in ABA signaling is supported
  in related Arabidopsis factors but remains unresolved for this soybean member.
source_documents:
  - genes/SOYBN/C6T1A2/C6T1A2-uniprot.txt
  - genes/SOYBN/C6T1A2/C6T1A2-goa.tsv
  - publications/PMID_24808098.md
  - genes/SOYBN/C6T1A2/C6T1A2-hypotheses/prediction-negative-regulation-aba-signaling/openscientist.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0009788
      label: negative regulation of abscisic acid-activated signaling pathway
    predicted_term_type: GO_BP
    review:
      assessment: UNC
      confidence_score: 1
      summary: >-
        The target is a plant C2H2 zinc-finger protein assigned to the ZFP7-like subfamily. Arabidopsis
        ZFP3 and overexpressed relatives including ZFP7 affect ABA sensitivity during germination (PMID:24808098),
        providing a relevant family-based hypothesis. However, the experiments do not establish the endogenous
        regulatory direction of this soybean paralog, and zinc-finger architecture alone cannot do so.
        The exact process is absent from the cached annotations and remains uncertain pending more resolved
        orthology or functional evidence.
      supported_by:
        - reference_id: file:SOYBN/C6T1A2/C6T1A2-uniprot.txt
          supporting_text: >-
            ID   C6T1A2_SOYBN            Unreviewed;       210 AA. ... DR   InterPro; IPR053266; Zinc_finger_protein_7.
            ... DR   InterPro; IPR013087; Znf_C2H2_type. ... FT   DOMAIN          79..106 ... FT                   /note="C2H2-type"
        - reference_id: PMID:24808098
          supporting_text: >-
            ZFP3, a nuclear C2H2 zinc finger protein
        - reference_id: file:SOYBN/C6T1A2/C6T1A2-hypotheses/prediction-negative-regulation-aba-signaling/openscientist.md
          supporting_text: exact GO:0009788 role cannot be established from sequence, orthology, or
            domain evidence alone
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005634
      label: nucleus
    predicted_term_type: GO_CC
    review:
      assessment: COR
      confidence_score: 2
      summary: >-
        The target has the plant ZFP-family C2H2 DNA-binding architecture and a ZFP7-like subfamily assignment.
        Primary work identifies the related Arabidopsis ZFP3 as a nuclear protein (PMID:24808098), supporting
        broad nuclear localization by transfer within this transcription-factor group. This is a family-based
        inference rather than a localization experiment on soybean C6T1A2. Nucleus is absent from the
        cached GOA/UniProt annotations, so it is supported as an additional localization rather than an
        existing annotation match.
      supported_by:
        - reference_id: file:SOYBN/C6T1A2/C6T1A2-uniprot.txt
          supporting_text: >-
            ID   C6T1A2_SOYBN            Unreviewed;       210 AA. ... DR   InterPro; IPR053266; Zinc_finger_protein_7.
            ... DR   InterPro; IPR013087; Znf_C2H2_type. ... FT   DOMAIN          79..106 ... FT                   /note="C2H2-type"
        - reference_id: PMID:24808098
          supporting_text: >-
            ZFP3, a nuclear C2H2 zinc finger protein
references:
  - id: file:SOYBN/C6T1A2/C6T1A2-uniprot.txt
    title: C6T1A2-uniprot.txt
  - id: PMID:24808098
    title: The Arabidopsis ZINC FINGER PROTEIN3 Interferes with Abscisic Acid and Light Signaling in
      Seed Germination and Plant Development.
  - id: file:SOYBN/C6T1A2/C6T1A2-hypotheses/prediction-negative-regulation-aba-signaling/openscientist.md
    title: Focused OpenScientist report on C6T1A2 ABA signaling prediction
    reference_review:
      relevance: HIGH
      review_notes: >-
        Substantive computational synthesis directly addressing the ABA-signaling prediction. The cached
        UniProt InterPro records independently support the C2H2 zinc-finger/ZFP-family architecture,
        and PMID:24808098 supports nuclear localization and ABA phenotypes for related Arabidopsis ZFPs.
        The report appropriately treats the precise negative regulation of ABA signaling as unresolved
        for soybean C6T1A2, because ZFP-family domain evidence does not identify the endogenous direction
        or process role of this paralog.