apmA

UniProt ID: A0A1D0AST6
Organism: Staphylococcus aureus
Review Status: DRAFT
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Gene Description

apmA encodes an aminoglycoside N-acetyltransferase in Staphylococcus aureus. UniProt/CARD identify this entry as an aminoglycoside-modifying resistance enzyme that inactivates aminoglycosides by acetyl transfer. UniProt names the protein 'Aminocyclitol acetyltransferase ApmA' (accession A0A1D0AST6).

Existing Annotations Review

GO Term Evidence Action Reason
GO:0034069 aminoglycoside N-acetyltransferase activity
RCA
file:projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml 		NEW
Summary: NEW candidate annotation from the curated ARO->GO mapping: aminoglycoside N-acetyltransferase activity.
Reason: The UniProt record cross-references a CARD/ARO AMR determinant, and the curated ARO->GO mapping projects the family-specific molecular function aminoglycoside N-acetyltransferase activity. This focused draft accepts the candidate as a curator lead for this AMR determinant.
Supporting Evidence:
file:projects/ANTIMICROBIAL_RESISTANCE/data/candidate_new_annotations.tsv
A0A1D0AST6 ARO:3003918 ARO:3000121 narrower RO:0002327 GO:0034069 aminoglycoside N-acetyltransferase activity
file:genes/STAAU/apmA/apmA-uniprot.txt
DR CARD; ARO:3003918; apmA; ARO:0001004; antibiotic inactivation.
GO:0046677 response to antibiotic
RCA
file:projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml 		NEW
Summary: NEW process annotation: apmA is an AMR determinant involved in antibiotic response/resistance.
Reason: CARD/ARO identity places this gene in an antimicrobial-resistance determinant family; response to antibiotic is the appropriate high-level GO biological process for the resistance role.
Supporting Evidence:
file:genes/STAAU/apmA/apmA-uniprot.txt
DR CARD; ARO:3003918; apmA; ARO:0001004; antibiotic inactivation.

Core Functions

apmA acetylates aminoglycoside antibiotics, reducing drug activity and contributing to antibiotic resistance.

Molecular Function:
aminoglycoside N-acetyltransferase activity
Directly Involved In:
response to antibiotic
Supporting Evidence:
  • file:genes/STAAU/apmA/apmA-uniprot.txt
    DR CARD; ARO:3003918; apmA; ARO:0001004; antibiotic inactivation.

References

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Suggested Questions for Experts

Q: Is the ARO-derived aminoglycoside N-acetyltransferase activity annotation sufficiently specific for apmA, or is a narrower substrate/site-specific GO term warranted?

Suggested Experiments

Experiment: Biochemically assay purified apmA against representative antibiotic substrates for the inferred AMR family and measure loss of drug activity or target modification.

Type: in vitro enzyme assay

📚 Additional Documentation

Notes

(apmA-notes.md)

Notes: apmA

Focused AMR batch review. UniProt accession: A0A1D0AST6. Source organism: Staphylococcus aureus.

  • UniProt/CARD provenance: DR CARD; ARO:3003918; apmA; ARO:0001004; antibiotic inactivation.
  • ARO-to-GO candidate: GO:0034069 (aminoglycoside N-acetyltransferase activity) from projects/ANTIMICROBIAL_RESISTANCE/data/candidate_new_annotations.tsv and projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml.
  • This is a DRAFT focused review intended to cover the AMR annotation gap; it has not had a gene-specific deep-research pass.

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