id: Q9KZ33
gene_symbol: Q9KZ33
taxon:
  id: NCBITaxon:100226
  label: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
status: COMPLETE
description: >-
  The ECF sigma-factor architecture supports a role in transcription initiation, adding a process annotation
  to the existing sigma-factor activity.
source_documents:
  - genes/STRCO/Q9KZ33/Q9KZ33-uniprot.txt
  - genes/STRCO/Q9KZ33/Q9KZ33-goa.tsv
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0006352
      label: DNA-templated transcription initiation
    predicted_term_type: GO_BP
    review:
      assessment: COR
      confidence_score: 2
      summary: >-
        The target has ECF sigma-70 domain assignments and a curated IBA for sigma factor activity. A
        sigma factor participates in promoter recognition and initiation by bacterial RNA polymerase,
        supporting the predicted biological process. The cached annotation regulation of DNA-templated
        transcription initiation is related but is not a more specific subtype of initiation itself. The
        exact initiation term is absent from the cached annotations; this is a supported process inference
        from the established molecular function.
      supported_by:
        - reference_id: file:STRCO/Q9KZ33/Q9KZ33-uniprot.txt
          supporting_text: >-
            ID   Q9KZ33_STRCO            Unreviewed;       300 AA. ... DR   GO; GO:0016987; F:sigma factor
            activity; IBA:GO_Central. ... DR   InterPro; IPR052704; ECF_Sigma-70_Domain. ... DR   PANTHER;
            PTHR30173:SF43; ECF RNA POLYMERASE SIGMA FACTOR SIGI-RELATED; 1.
references:
  - id: file:STRCO/Q9KZ33/Q9KZ33-uniprot.txt
    title: Q9KZ33-uniprot.txt