id: A0A674PKV4
gene_symbol: gas7a
taxon:
  id: NCBITaxon:31033
  label: Takifugu rubripes
status: COMPLETE
description: >-
  The GAS7-family architecture supports cytoplasmic membrane association, consistent with an existing
  cytoplasmic annotation.
source_documents:
  - genes/TAKRU/A0A674PKV4/A0A674PKV4-uniprot.txt
  - genes/TAKRU/A0A674PKV4/A0A674PKV4-goa.tsv
  - publications/PMID_31628328.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005737
      label: cytoplasm
    predicted_term_type: GO_CC
    review:
      assessment: CNN
      confidence_score: 2
      summary: >-
        The target contains the GAS7-specific F-BAR domain, supporting a peripheral membrane-associated
        cytoplasmic protein. Experiments on GAS7 show assembly on membranes during phagocytic-cup formation
        (PMID:31628328), providing biological grounding for broad cytoplasmic localization. The exact
        cytoplasm term is already in the cached GOA record. Membrane or vesicle association supplies additional
        context, but does not by itself establish a more specific cytoplasmic compartment for this target.
      supported_by:
        - reference_id: file:TAKRU/A0A674PKV4/A0A674PKV4-uniprot.txt
          supporting_text: >-
            ID   A0A674PKV4_TAKRU        Unreviewed;       401 AA. ... DR   InterPro; IPR037957; GAS7_F-BAR.
            ... DR   PANTHER; PTHR23065:SF57; GROWTH ARREST-SPECIFIC PROTEIN 7; 1. ... FT   DOMAIN          121..381
            ... FT                   /note="F-BAR"
        - reference_id: PMID:31628328
          supporting_text: >-
            sheet formation on flat membranes
references:
  - id: file:TAKRU/A0A674PKV4/A0A674PKV4-uniprot.txt
    title: A0A674PKV4-uniprot.txt
  - id: PMID:31628328
    title: Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.