id: A0A1S3Y076
gene_symbol: A0A1S3Y076
taxon:
  id: NCBITaxon:4097
  label: Nicotiana tabacum
status: COMPLETE
description: >-
  The PRORP architecture supports tRNA maturation, already represented by the more specific tRNA 5-prime-leader-removal
  annotation.
source_documents:
  - genes/TOBAC/A0A1S3Y076/A0A1S3Y076-uniprot.txt
  - genes/TOBAC/A0A1S3Y076/A0A1S3Y076-goa.tsv
  - publications/PMID_22549728.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0008033
      label: tRNA processing
    predicted_term_type: GO_BP
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The target combines PPR repeats with the PRORP catalytic region and has curated IBAs for RNase
        P activity and tRNA 5-prime-leader removal. Experiments on Arabidopsis PRORPs establish this cleavage
        step in plant tRNA maturation (PMID:22549728), supporting transfer to the tobacco homolog. The
        predicted tRNA processing term is broader than the existing leader-removal process. It is biologically
        supported but less precise.
      supported_by:
        - reference_id: file:TOBAC/A0A1S3Y076/A0A1S3Y076-uniprot.txt
          supporting_text: >-
            ID   A0A1S3Y076_TOBAC        Unreviewed;       540 AA. ... DR   GO; GO:0004526; F:ribonuclease
            P activity; IBA:GO_Central. ... DR   GO; GO:0001682; P:tRNA 5'-leader removal; IBA:GO_Central.
            ... DR   InterPro; IPR031595; PRORP_C. ... DR   PANTHER; PTHR13547:SF13; PROTEINACEOUS RNASE
            P 2; 1. ... FT   DOMAIN          4..208 ... FT                   /note="PROP1-like PPR" ...
            FT   DOMAIN          251..476 ... FT                   /note="PRORP"
        - reference_id: PMID:22549728
          supporting_text: >-
            cleaves the 5' leader sequence of tRNA precursors
references:
  - id: file:TOBAC/A0A1S3Y076/A0A1S3Y076-uniprot.txt
    title: A0A1S3Y076-uniprot.txt
  - id: PMID:22549728
    title: PRORP proteins support RNase P activity in both organelles and the nucleus in
      Arabidopsis.