ID   A0A1S3Y076_TOBAC        Unreviewed;       540 AA.
AC   A0A1S3Y076;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   10-JUN-2026, entry version 40.
DE   RecName: Full=ribonuclease P {ECO:0000256|ARBA:ARBA00012179};
DE            EC=3.1.26.5 {ECO:0000256|ARBA:ARBA00012179};
GN   Name=LOC107770656 {ECO:0000313|RefSeq:XP_016445475.1};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097 {ECO:0000313|Proteomes:UP000790787, ECO:0000313|RefSeq:XP_016445475.1};
RN   [1] {ECO:0000313|Proteomes:UP000790787}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24807620; DOI=10.1038/ncomms4833;
RA   Sierro N., Battey J.N., Ouadi S., Bakaher N., Bovet L., Willig A.,
RA   Goepfert S., Peitsch M.C., Ivanov N.V.;
RT   "The tobacco genome sequence and its comparison with those of tomato and
RT   potato.";
RL   Nat. Commun. 5:3833-3833(2014).
RN   [2] {ECO:0000313|RefSeq:XP_016445475.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_016445475.1};
RG   RefSeq;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC         from tRNA precursor.; EC=3.1.26.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000928};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the PPR family. P subfamily.
CC       {ECO:0000256|ARBA:ARBA00007626}.
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DR   RefSeq; XP_016445475.1; XM_016589989.2.
DR   AlphaFoldDB; A0A1S3Y076; -.
DR   SMR; A0A1S3Y076; -.
DR   STRING; 4097.A0A1S3Y076; -.
DR   PaxDb; 4097-A0A1S3Y076; -.
DR   GeneID; 107770656; -.
DR   KEGG; nta:107770656; -.
DR   OMA; ACQRETR; -.
DR   OrthoDB; 46913at2759; -.
DR   Proteomes; UP000790787; Chromosome 22.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004526; F:ribonuclease P activity; IBA:GO_Central.
DR   GO; GO:0001682; P:tRNA 5'-leader removal; IBA:GO_Central.
DR   FunFam; 3.40.50.11980:FF:000002; Proteinaceous RNase P 2; 1.
DR   FunFam; 1.25.40.10:FF:003531; Uncharacterized protein; 1.
DR   Gene3D; 3.40.50.11980; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR002885; PPR_rpt.
DR   InterPro; IPR033443; PROP1-like_PPR_dom.
DR   InterPro; IPR031595; PRORP_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13547; -; 1.
DR   PANTHER; PTHR13547:SF13; PROTEINACEOUS RNASE P 2; 1.
DR   Pfam; PF17177; PPR_long; 1.
DR   Pfam; PF16953; PRORP; 1.
DR   PROSITE; PS51375; PPR; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000790787};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          4..208
FT                   /note="PROP1-like PPR"
FT                   /evidence="ECO:0000259|Pfam:PF17177"
FT   REPEAT          121..155
FT                   /note="PPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT   DOMAIN          251..476
FT                   /note="PRORP"
FT                   /evidence="ECO:0000259|Pfam:PF16953"
FT   REGION          521..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..540
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  60719 MW;  99E49BBE40F62C95 CRC64;
     MDKNKKKKNL TPEVQFRLSL DNCSKTKDLS TAISLYESAL STIRFSNNHF NSFLYICSNA
     VSDPSTKNPA IEFGFRIFDH MVSSNVTPNE ATVTAVARLA AATDDGDKAF ELAKGVGNCG
     KLRTYGPALF CYCKMGEADK AYQVEDHMRS IGLQLEEAEL VGLLKASVVK EREEKVYQYL
     HKLRMSVRSV SASAAEIIQS WFGGEMAAKL GLSDWDMGQV KEAILQNGGG WHGRGWLGKG
     KWIVQRSQIA PDGRCLTCQE RLVCVDIDKA ETERFAEAVA SLAMEREVHS NFKEFQDWLE
     KHSEYDAVVD AANVGLYQQN FAEGGFSIAQ LVTVVKELHS RSNKWPLVVL HKKRLRALLE
     NAYYRELLEE WINEKVLYGT PFGSNDDWYW LYAAVKRKCL LVTNDEMRDH IFELLGSSFF
     AIWKERHQVK YTFVKGEPKL LMPPTYSVVI QESENGSWHV PLAGEVAEES SRSWLCMSRH
     DKQHTSVEAA EVSELVCSDQ IEDSCHSDSF ASQNGLNTCS GLAGKRKERS PSPSHSSLQS
//