id: A2FPI7
gene_symbol: A2FPI7
taxon:
  id: NCBITaxon:412133
  label: Trichomonas vaginalis
status: COMPLETE
description: >-
  The nearly complete KilA-N DNA-binding domain supports a broad DNA-binding inference without specifying
  a regulatory target.
source_documents:
  - genes/TRIV3/A2FPI7/A2FPI7-uniprot.txt
  - genes/TRIV3/A2FPI7/A2FPI7-goa.tsv
  - publications/PMID_11897024.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0003677
      label: DNA binding
    predicted_term_type: GO_MF
    review:
      assessment: COR
      confidence_score: 2
      summary: >-
        The 129-residue target contains a KilA-N domain spanning residues 19–124 and a KilA/APSES helix-turn-helix
        assignment. The primary comparative analysis defining KilA-N identifies a conserved DNA-binding
        module in viral and cellular regulatory proteins (PMID:11897024). This provides a domain-based
        inference for broad DNA binding, not an experimental binding measurement on Trichomonas A2FPI7
        or evidence for a specific DNA sequence. The molecular function is absent from the cached annotations.
      supported_by:
        - reference_id: file:TRIV3/A2FPI7/A2FPI7-uniprot.txt
          supporting_text: >-
            ID   A2FPI7_TRIV3            Unreviewed;       129 AA. ... DR   InterPro; IPR018004; KilA/APSES_HTH.
            ... DR   InterPro; IPR017880; KilA_N. ... FT   DOMAIN          19..124 ... FT                   /note="KilA-N"
        - reference_id: PMID:11897024
          supporting_text: >-
            a novel, conserved DNA-binding domain (the KilA-N domain)
references:
  - id: file:TRIV3/A2FPI7/A2FPI7-uniprot.txt
    title: A2FPI7-uniprot.txt
  - id: PMID:11897024
    title: Extensive domain shuffling in transcription regulators of DNA viruses and implications
      for the origin of fungal APSES transcription factors.