id: A0A3B6RKV1 gene_symbol: A0A3B6RKV1 taxon: id: NCBITaxon:4565 label: Triticum aestivum status: COMPLETE description: >- Sequence similarity to experimentally characterized Arabidopsis JMJ22 and matching F-box/JmjC architecture support inferred epigenetic regulation. Conservation of specific light, hormone, and germination roles remains unresolved. source_documents: - genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt - genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-goa.tsv - publications/PMID_22483719.md - genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/protnlm.json - genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/Q67XX3-uniprot.txt - genes/WHEAT/A0A3B6RKV1/A0A3B6RKV1-hypotheses/prediction-jmj22-developmental-roles/openscientist.md predictions: - source_method: ProtNLM2 source_version: UniProt 2024_06 pilot predicted_term: id: GO:0010099 label: regulation of photomorphogenesis predicted_term_type: GO_BP review: assessment: UNC confidence_score: 1 summary: >- The target shares F-box/JmjC architecture with Arabidopsis JMJ22, and the raw ProtNLM evidence record reports a phmmer match to reviewed JMJ22 Q67XX3 with score 689.2. Primary JMJ20/22 experiments establish a role in light-controlled germination (PMID:22483719), making a related developmental function plausible. This similarity does not resolve conservation of the broader photomorphogenic program in wheat. The exact process is absent from the cached target annotations and remains uncertain pending pathway-level evidence. supported_by: - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt supporting_text: >- ID A0A3B6RKV1_WHEAT Unreviewed; 511 AA. ... DR GO; GO:0005634; C:nucleus; IBA:GO_Central. ... DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. ... DR InterPro; IPR003347; JmjC_dom. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 89..135 ... FT /note="F-box" ... FT DOMAIN 285..445 ... FT /note="JmjC" - reference_id: PMID:22483719 supporting_text: >- histone arginine demethylases, JMJ20 and JMJ22 - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/protnlm.json supporting_text: >- "key": "phmmer_accession", "value": "Q67XX3" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/Q67XX3-uniprot.txt supporting_text: >- ID JMJ22_ARATH Reviewed; 502 AA. ... GN Name=JMJ22 {ECO:0000303|PubMed:18713399}; ... DR GO; GO:0010099; P:regulation of photomorphogenesis; IMP:UniProtKB. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 80..126 ... FT /note="F-box" ... FT DOMAIN 279..439 ... FT /note="JmjC" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-hypotheses/prediction-jmj22-developmental-roles/openscientist.md supporting_text: >- No wheat functional study exists - source_method: ProtNLM2 source_version: UniProt 2024_06 pilot predicted_term: id: GO:0010476 label: gibberellin mediated signaling pathway predicted_term_type: GO_BP review: assessment: UNC confidence_score: 1 summary: >- The target has matching F-box/JmjC architecture and a strong reported phmmer match to characterized Arabidopsis JMJ22. JMJ20/22 affect gibberellin levels by modifying chromatin at biosynthetic genes (PMID:22483719), while gibberellin-mediated signaling is a distinct claim. Sequence similarity supports a related chromatin enzyme but does not establish the target's place in a hormone-signaling pathway. The exact process is absent from the cached target annotations and remains uncertain. supported_by: - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt supporting_text: >- ID A0A3B6RKV1_WHEAT Unreviewed; 511 AA. ... DR GO; GO:0005634; C:nucleus; IBA:GO_Central. ... DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. ... DR InterPro; IPR003347; JmjC_dom. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 89..135 ... FT /note="F-box" ... FT DOMAIN 285..445 ... FT /note="JmjC" - reference_id: PMID:22483719 supporting_text: >- histone arginine demethylases, JMJ20 and JMJ22 - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/protnlm.json supporting_text: >- "key": "phmmer_accession", "value": "Q67XX3" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/Q67XX3-uniprot.txt supporting_text: >- ID JMJ22_ARATH Reviewed; 502 AA. ... GN Name=JMJ22 {ECO:0000303|PubMed:18713399}; ... DR GO; GO:0010476; P:gibberellin mediated signaling pathway; IMP:UniProtKB. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 80..126 ... FT /note="F-box" ... FT DOMAIN 279..439 ... FT /note="JmjC" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-hypotheses/prediction-jmj22-developmental-roles/openscientist.md supporting_text: >- No wheat functional study exists - source_method: ProtNLM2 source_version: UniProt 2024_06 pilot predicted_term: id: GO:0040029 label: epigenetic regulation of gene expression predicted_term_type: GO_BP review: assessment: COR confidence_score: 2 summary: >- The target shares F-box/JmjC architecture with reviewed Arabidopsis JMJ22 Q67XX3, the phmmer match reported in the raw prediction evidence with score 689.2. Primary experiments establish histone arginine demethylation by JMJ20/22 and regulation of chromatin at gibberellin-biosynthetic genes (PMID:22483719). Together, the sequence relationship, domain architecture, and characterized relative support transfer of broad epigenetic regulation; this is a family-based inference, not an assay on wheat or a claim of H3K4 lysine demethylation. The process is absent from the cached target annotations. supported_by: - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt supporting_text: >- ID A0A3B6RKV1_WHEAT Unreviewed; 511 AA. ... DR GO; GO:0005634; C:nucleus; IBA:GO_Central. ... DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. ... DR InterPro; IPR003347; JmjC_dom. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 89..135 ... FT /note="F-box" ... FT DOMAIN 285..445 ... FT /note="JmjC" - reference_id: PMID:22483719 supporting_text: >- histone arginine demethylases, JMJ20 and JMJ22 - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/protnlm.json supporting_text: >- "key": "phmmer_accession", "value": "Q67XX3" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/Q67XX3-uniprot.txt supporting_text: >- ID JMJ22_ARATH Reviewed; 502 AA. ... GN Name=JMJ22 {ECO:0000303|PubMed:18713399}; ... DR GO; GO:0040029; P:epigenetic regulation of gene expression; IDA:UniProtKB. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 80..126 ... FT /note="F-box" ... FT DOMAIN 279..439 ... FT /note="JmjC" - source_method: ProtNLM2 source_version: UniProt 2024_06 pilot predicted_term: id: GO:0010114 label: response to red light predicted_term_type: GO_BP review: assessment: UNC confidence_score: 1 summary: >- The target has a strong reported sequence match to Arabidopsis JMJ22 and matching F-box/JmjC architecture. JMJ20/22 are derepressed following phytochrome B activation (PMID:22483719), establishing a red-light-related regulatory context in Arabidopsis. The target's catalytic-family relationship does not establish conservation of that light-dependent regulation in wheat. The response term is absent from the cached target annotations and remains uncertain pending regulatory or expression evidence. supported_by: - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt supporting_text: >- ID A0A3B6RKV1_WHEAT Unreviewed; 511 AA. ... DR GO; GO:0005634; C:nucleus; IBA:GO_Central. ... DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. ... DR InterPro; IPR003347; JmjC_dom. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 89..135 ... FT /note="F-box" ... FT DOMAIN 285..445 ... FT /note="JmjC" - reference_id: PMID:22483719 supporting_text: >- histone arginine demethylases, JMJ20 and JMJ22 - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/protnlm.json supporting_text: >- "key": "phmmer_accession", "value": "Q67XX3" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/Q67XX3-uniprot.txt supporting_text: >- ID JMJ22_ARATH Reviewed; 502 AA. ... GN Name=JMJ22 {ECO:0000303|PubMed:18713399}; ... DR GO; GO:0010114; P:response to red light; IMP:UniProtKB. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 80..126 ... FT /note="F-box" ... FT DOMAIN 279..439 ... FT /note="JmjC" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-hypotheses/prediction-jmj22-developmental-roles/openscientist.md supporting_text: >- No wheat functional study exists - source_method: ProtNLM2 source_version: UniProt 2024_06 pilot predicted_term: id: GO:0010030 label: positive regulation of seed germination predicted_term_type: GO_BP review: assessment: UNC confidence_score: 1 summary: >- The target shares domain architecture and a strong reported sequence match with Arabidopsis JMJ22. JMJ20/22 redundantly promote germination by affecting chromatin at gibberellin-biosynthetic genes (PMID:22483719), supporting a relevant developmental hypothesis. The wheat protein's expression context, target loci, and regulatory direction during germination are not established by this sequence relationship. The exact process is absent from the cached target annotations and remains uncertain. supported_by: - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt supporting_text: >- ID A0A3B6RKV1_WHEAT Unreviewed; 511 AA. ... DR GO; GO:0005634; C:nucleus; IBA:GO_Central. ... DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. ... DR InterPro; IPR003347; JmjC_dom. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 89..135 ... FT /note="F-box" ... FT DOMAIN 285..445 ... FT /note="JmjC" - reference_id: PMID:22483719 supporting_text: >- histone arginine demethylases, JMJ20 and JMJ22 - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/protnlm.json supporting_text: >- "key": "phmmer_accession", "value": "Q67XX3" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/Q67XX3-uniprot.txt supporting_text: >- ID JMJ22_ARATH Reviewed; 502 AA. ... GN Name=JMJ22 {ECO:0000303|PubMed:18713399}; ... DR GO; GO:0010030; P:positive regulation of seed germination; IMP:UniProtKB. ... DR InterPro; IPR050910; JMJD6_ArgDemeth/LysHydrox. ... DR PANTHER; PTHR12480:SF21; JMJC DOMAIN-CONTAINING PROTEIN 8; 1. ... FT DOMAIN 80..126 ... FT /note="F-box" ... FT DOMAIN 279..439 ... FT /note="JmjC" - reference_id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-hypotheses/prediction-jmj22-developmental-roles/openscientist.md supporting_text: >- No wheat functional study exists references: - id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-uniprot.txt title: A0A3B6RKV1-uniprot.txt - id: PMID:22483719 title: Control of seed germination by light-induced histone arginine demethylation activity. - id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/protnlm.json title: protnlm.json - id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-prediction-evidence/Q67XX3-uniprot.txt title: Q67XX3-uniprot.txt - id: file:WHEAT/A0A3B6RKV1/A0A3B6RKV1-hypotheses/prediction-jmj22-developmental-roles/openscientist.md title: 'OpenScientist focused report: A0A3B6RKV1 JMJ22 developmental ProtNLM terms'