id: Q8P365
gene_symbol: btuE
taxon:
  id: NCBITaxon:190485
  label: Xanthomonas campestris pv. campestris
status: COMPLETE
description: >-
  The BtuE glutathione-peroxidase family supports oxidative-stress protection. The predicted response
  is broader than the existing cellular-response annotation.
source_documents:
  - genes/XANCP/Q8P365/Q8P365-uniprot.txt
  - genes/XANCP/Q8P365/Q8P365-goa.tsv
  - publications/PMID_20621065.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0006979
      label: response to oxidative stress
    predicted_term_type: GO_BP
    review:
      assessment: LSP
      confidence_score: 2
      summary: >-
        The target has the BtuE subfamily assignment, glutathione-peroxidase domain, and peroxidase active-site
        signature. Purified E. coli BtuE reduces peroxides and its expression responds to oxidative stress
        (PMID:20621065), supporting transfer of the broad protective role. The target already has a curated
        IBA for cellular response to oxidative stress, which is more specific than response to oxidative
        stress. The prediction is supported but less precise; annotation overlap does not establish training-data
        contamination.
      supported_by:
        - reference_id: file:XANCP/Q8P365/Q8P365-uniprot.txt
          supporting_text: >-
            ID   Q8P365_XANCP            Unreviewed;       181 AA. ... DR   GO; GO:0034599; P:cellular
            response to oxidative stress; IBA:GO_Central. ... DR   InterPro; IPR000889; Glutathione_peroxidase.
            ... DR   InterPro; IPR029759; GPX_AS. ... DR   PANTHER; PTHR11592:SF40; THIOREDOXIN_GLUTATHIONE
            PEROXIDASE BTUE; 1. ... FT   ACT_SITE        37
        - reference_id: PMID:20621065
          supporting_text: >-
            Purified BtuE decomposes in vitro hydrogen peroxide in a glutathione-dependent manner
references:
  - id: file:XANCP/Q8P365/Q8P365-uniprot.txt
    title: Q8P365-uniprot.txt
  - id: PMID:20621065
    title: The Escherichia coli btuE gene, encodes a glutathione peroxidase that is induced under
      oxidative stress conditions.