id: A0A8J0SCI2
gene_symbol: A0A8J0SCI2
taxon:
  id: NCBITaxon:8364
  label: Xenopus tropicalis
status: COMPLETE
description: >-
  The C2H2 zinc-finger architecture supports the existing curated transcription-factor and nuclear annotations.
  Whether this factor specifically activates transcription is unresolved.
source_documents:
  - genes/XENTR/A0A8J0SCI2/A0A8J0SCI2-uniprot.txt
  - genes/XENTR/A0A8J0SCI2/A0A8J0SCI2-goa.tsv
  - genes/XENTR/A0A8J0SCI2/A0A8J0SCI2-hypotheses/prediction-tf-activator/openscientist.md
predictions:
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0000978
      label: RNA polymerase II cis-regulatory region sequence-specific DNA binding
    predicted_term_type: GO_MF
    review:
      assessment: CNN
      confidence_score: 2
      summary: >-
        The target contains eight tandem C2H2 zinc-finger domains, consistent with sequence-specific DNA
        recognition. The cached GOA record has an exact curated IBA for RNA polymerase II cis-regulatory
        region sequence-specific DNA binding, alongside the corresponding transcription-factor activity.
        This is a curator-assessed phylogenetic inference consistent with the target architecture, not
        an ARBA assertion. The available evidence supports the function without identifying a particular
        DNA motif or target gene.
      supported_by:
        - reference_id: file:XENTR/A0A8J0SCI2/A0A8J0SCI2-uniprot.txt
          supporting_text: >-
            ID   A0A8J0SCI2_XENTR        Unreviewed;       265 AA. ... DR   GO; GO:0005634; C:nucleus;
            IBA:GO_Central. ... DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA
            polymerase II-specific; IBA:GO_Central. ... DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory
            region sequence-specific DNA binding; IBA:GO_Central. ... DR   GO; GO:0006357; P:regulation
            of transcription by RNA polymerase II; IBA:GO_Central. ... DR   InterPro; IPR013087; Znf_C2H2_type.
            ... DR   PANTHER; PTHR24381:SF440; OOCYTE ZINC FINGER PROTEIN XLCOF7.1-LIKE; 1. ... FT   DOMAIN          37..64
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          65..92 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          93..120 ... FT                   /note="C2H2-type" ... FT   DOMAIN          121..148
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          149..176 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          177..204 ... FT                   /note="C2H2-type" ... FT   DOMAIN          205..232
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          233..260 ... FT                   /note="C2H2-type"
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0006357
      label: regulation of transcription by RNA polymerase II
    predicted_term_type: GO_BP
    review:
      assessment: CNN
      confidence_score: 2
      summary: >-
        The target has the tandem C2H2 zinc-finger architecture of a sequence-specific DNA-binding factor.
        The exact regulation of transcription by RNA polymerase II annotation is present as a curated
        IBA in the cached GOA record, together with compatible DNA-binding transcription-factor activity.
        These phylogenetic annotations and the target architecture support the broad regulatory process.
        They do not specify whether the factor activates or represses its targets.
      supported_by:
        - reference_id: file:XENTR/A0A8J0SCI2/A0A8J0SCI2-uniprot.txt
          supporting_text: >-
            ID   A0A8J0SCI2_XENTR        Unreviewed;       265 AA. ... DR   GO; GO:0005634; C:nucleus;
            IBA:GO_Central. ... DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA
            polymerase II-specific; IBA:GO_Central. ... DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory
            region sequence-specific DNA binding; IBA:GO_Central. ... DR   GO; GO:0006357; P:regulation
            of transcription by RNA polymerase II; IBA:GO_Central. ... DR   InterPro; IPR013087; Znf_C2H2_type.
            ... DR   PANTHER; PTHR24381:SF440; OOCYTE ZINC FINGER PROTEIN XLCOF7.1-LIKE; 1. ... FT   DOMAIN          37..64
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          65..92 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          93..120 ... FT                   /note="C2H2-type" ... FT   DOMAIN          121..148
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          149..176 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          177..204 ... FT                   /note="C2H2-type" ... FT   DOMAIN          205..232
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          233..260 ... FT                   /note="C2H2-type"
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0005634
      label: nucleus
    predicted_term_type: GO_CC
    review:
      assessment: CNN
      confidence_score: 2
      summary: >-
        The target zinc-finger architecture is compatible with its curated DNA-binding transcription-factor
        assignment. Nucleus is already present as a curated IBA in the cached GOA record, supporting this
        localization through a phylogenetic judgment consistent with the molecular function. No target
        localization experiment is asserted. The exact overlap makes this a supported, non-novel annotation.
      supported_by:
        - reference_id: file:XENTR/A0A8J0SCI2/A0A8J0SCI2-uniprot.txt
          supporting_text: >-
            ID   A0A8J0SCI2_XENTR        Unreviewed;       265 AA. ... DR   GO; GO:0005634; C:nucleus;
            IBA:GO_Central. ... DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA
            polymerase II-specific; IBA:GO_Central. ... DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory
            region sequence-specific DNA binding; IBA:GO_Central. ... DR   GO; GO:0006357; P:regulation
            of transcription by RNA polymerase II; IBA:GO_Central. ... DR   InterPro; IPR013087; Znf_C2H2_type.
            ... DR   PANTHER; PTHR24381:SF440; OOCYTE ZINC FINGER PROTEIN XLCOF7.1-LIKE; 1. ... FT   DOMAIN          37..64
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          65..92 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          93..120 ... FT                   /note="C2H2-type" ... FT   DOMAIN          121..148
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          149..176 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          177..204 ... FT                   /note="C2H2-type" ... FT   DOMAIN          205..232
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          233..260 ... FT                   /note="C2H2-type"
  - source_method: ProtNLM2
    source_version: UniProt 2024_06 pilot
    predicted_term:
      id: GO:0001228
      label: DNA-binding transcription activator activity, RNA polymerase II-specific
    predicted_term_type: GO_MF
    review:
      assessment: UNC
      confidence_score: 1
      summary: >-
        The zinc-finger array and existing curated IBA support a DNA-binding RNA polymerase II transcription
        factor. They do not determine whether its effect on transcription is activating, repressing, or
        context-dependent. Absence of a recognizable activation domain is not decisive because activation
        can depend on partners or short interaction regions. The activator-specific term is absent from
        the cached annotations, and evidence for regulatory direction is needed.
      supported_by:
        - reference_id: file:XENTR/A0A8J0SCI2/A0A8J0SCI2-uniprot.txt
          supporting_text: >-
            ID   A0A8J0SCI2_XENTR        Unreviewed;       265 AA. ... DR   GO; GO:0005634; C:nucleus;
            IBA:GO_Central. ... DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA
            polymerase II-specific; IBA:GO_Central. ... DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory
            region sequence-specific DNA binding; IBA:GO_Central. ... DR   GO; GO:0006357; P:regulation
            of transcription by RNA polymerase II; IBA:GO_Central. ... DR   InterPro; IPR013087; Znf_C2H2_type.
            ... DR   PANTHER; PTHR24381:SF440; OOCYTE ZINC FINGER PROTEIN XLCOF7.1-LIKE; 1. ... FT   DOMAIN          37..64
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          65..92 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          93..120 ... FT                   /note="C2H2-type" ... FT   DOMAIN          121..148
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          149..176 ... FT                   /note="C2H2-type"
            ... FT   DOMAIN          177..204 ... FT                   /note="C2H2-type" ... FT   DOMAIN          205..232
            ... FT                   /note="C2H2-type" ... FT   DOMAIN          233..260 ... FT                   /note="C2H2-type"
        - reference_id: file:XENTR/A0A8J0SCI2/A0A8J0SCI2-hypotheses/prediction-tf-activator/openscientist.md
          supporting_text: >-
            it is simply not demonstrably an *activator*
references:
  - id: file:XENTR/A0A8J0SCI2/A0A8J0SCI2-uniprot.txt
    title: A0A8J0SCI2-uniprot.txt
  - id: file:XENTR/A0A8J0SCI2/A0A8J0SCI2-hypotheses/prediction-tf-activator/openscientist.md
    title: 'OpenScientist focused report: A0A8J0SCI2 activator-specific ProtNLM term'