| Substrate Name | Phosphorylation Site(s) | Biological Context/Cell Type | Functional Consequence | Supporting Citations |
|---|---|---|---|---|
| Lamin B1 | T575 | Dopaminergic neuronal cells under mitochondrial stress (tebufenpyrad model); organotypic midbrain slices; Parkinson disease-relevant context | PKCδ-dependent Lamin B1 phosphorylation promotes nuclear membrane damage/disassembly during stress-induced neuronal death; requires PKCδ activation and nuclear translocation | (pqac-00000011) |
| CD20 | Serine residues in the two cytosolic tails; three major serine phosphosites reported but not individually named in retrieved text | Human B cells (Ramos cells, peripheral blood B cells) | Constitutive PKCδ phosphorylation converts CD20 into a 14-3-3 binding platform linked to GEF-H1 and the microtubule network, supporting resting-state IgD-BCR nanocluster organization | (pqac-00000012) |
| p35 | Not specified in retrieved text | Developing neurons/cerebral cortex; BDNF-activated neuronal migration context | PKCδ phosphorylation stabilizes p35, maintaining CDK5/p35 activity and promoting radial migration and laminar positioning of newborn neurons | (pqac-00000006) |
| IRS-1 | Serine residues (specific site not given in retrieved text) | Metabolic signaling, especially insulin-responsive tissues | PKC signaling can phosphorylate IRS-1 on serine residues, inhibiting insulin signaling, reducing GLUT4 translocation and glucose uptake; this is cited in PKC family metabolic regulation summaries and is relevant to PKCδ-centered metabolic contexts | (pqac-00000002, pqac-00000007) |
| MARCKS | Not specified in retrieved text | B cells; insulin signaling/metabolic trafficking; general PKC substrate context | MARCKS phosphorylation promotes cytoskeletal remodeling and PIP2 release; in B cells, PKC family signaling modulates actin dynamics, and in metabolic settings MARCKS phosphorylation is linked to GLUT4 membrane trafficking | (pqac-00000002, pqac-00000006) |
| PFKL | S775 | Activated macrophages following pattern-recognition receptor signaling; PKCδ gain-of-function examined in pathway selection | PKCδ was selected as a candidate upstream kinase in macrophage metabolic reprogramming work; PFKL S775 phosphorylation increases catalytic activity and glycolysis, though the retrieved text does not establish PKCδ as the definitive direct kinase | (pqac-00000010) |
| Connexin 43 (Cx43) | S368 | Cardiac tissue/cardiomyocytes | PKC-mediated phosphorylation of Cx43 at S368 alters channel permeability, stability, and internalization; retrieved review notes PKCδ activation (T505) and Cx43 tail binding in this pathway, though isoform specificity can vary across studies | (pqac-00000010) |
| p47phox | Not specified in retrieved text | Neutrophils and eosinophils | PKCδ phosphorylation of p47phox promotes NADPH oxidase assembly and enhances the ROS burst for pathogen clearance | (pqac-00000006) |
| BCLAF1/Btf-associated transcriptional machinery | Direct binding/activation described; phosphosite not specified in retrieved text | Nuclear apoptotic signaling | Nuclear PKCδ directly binds and activates Btf/BCLAF1, increasing TP53 transcription and promoting cell-cycle arrest or apoptosis; retrieved text supports activation of this transcriptional axis even though the exact residue target is not given | (pqac-00000006) |
| ACSL4 pathway component | T328 on ACSL4 is described in the retrieved review for PKCβII rather than PKCδ | Lipid peroxidation/ferroptosis signaling | Included here as a cautionary comparator: this phosphosite is assigned to PKCβII, not PKCδ, underscoring the need to avoid over-attributing PKC family phosphosites across isoforms | (pqac-00000002) |


*Table: This table summarizes substrates and pathway targets linked to PKCδ, emphasizing experimentally supported phosphorylation events and clearly flagging cases where PKC-family rather than PKCδ-specific evidence is what is available. It is useful for functional annotation because it distinguishes direct validated targets from broader pathway-level inferences.*