ID   A0A8J1IYX6_XENTR        Unreviewed;       424 AA.
AC   A0A8J1IYX6;
DT   25-MAY-2022, integrated into UniProtKB/TrEMBL.
DT   25-MAY-2022, sequence version 1.
DT   10-JUN-2026, entry version 20.
DE   SubName: Full=Protein kinase C delta type {ECO:0000313|RefSeq:XP_031749696.1};
GN   Name=LOC101732819 {ECO:0000313|RefSeq:XP_031749696.1,
GN   ECO:0000313|Xenbase:XB-GENE-29086459};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Proteomes:UP000008143, ECO:0000313|RefSeq:XP_031749696.1};
RN   [1] {ECO:0000313|RefSeq:XP_031749696.1}
RP   IDENTIFICATION.
RC   STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031749696.1};
RC   TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031749696.1};
RG   RefSeq;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   RefSeq; XP_031749696.1; XM_031893836.1.
DR   AlphaFoldDB; A0A8J1IYX6; -.
DR   GeneID; 101732819; -.
DR   KEGG; xtr:101732819; -.
DR   AGR; Xenbase:XB-GENE-29086459; -.
DR   Xenbase; XB-GENE-29086459; LOC101732819.
DR   OrthoDB; 10047816at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   FunFam; 1.10.510.10:FF:000048; Protein kinase C; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000961; AGC-kinase_C.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_031749696.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW   ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          113..366
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          367..424
FT                   /note="AGC-kinase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51285"
FT   REGION          1..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..98
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         142
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   424 AA;  48569 MW;  22B27C8C5FE0D10B CRC64;
     MSPCGEKPPE DGTIKRKRTE EPTEKIKDSQ EEERKSLSDE TSKPESKKRK KDEEEKNKKK
     SSSEEFLQSS SYGRSKEQED NKEKKRSRED LLEGKEEIPC GSEKATPLDI QSYTFHRKLG
     EGTGGKVMLA SFAPKKQLVA IKIVQKKPNR CNYPWIMMEA QLLKFARECP FLCHSHATFQ
     SKAQAFFVLE YAGGGTLYRM ISRQKTLPTK SIQFYSAEMV VALQFLHYNG IIHRDLKPDN
     ILVDNDGHIK ICDFGIAAVG MFAGWKIRGL AGTPGYRAPE MLSLEAYDAA VDWWSLGVIM
     YEMATGRLPF VPSLDPAREF VDMKQTKVDY PSHMSQEMLD LLPKLLEMDN NNRLGLNGNI
     REHQFYAGIN WSEVERRTTR TPFKPKIPPA DKLKEIKPGF CTETSEENKL EDFSNVDSNW
     NWQE
//