ID   F6WPT1_XENTR            Unreviewed;       179 AA.
AC   F6WPT1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 3.
DT   10-JUN-2026, entry version 79.
DE   SubName: Full=ADP-ribosylation factor-like protein 5A {ECO:0000313|RefSeq:XP_002936704.1};
GN   Name=arl5a {ECO:0000313|RefSeq:XP_002936704.1,
GN   ECO:0000313|Xenbase:XB-GENE-1004384};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Proteomes:UP000008143, ECO:0000313|RefSeq:XP_002936704.1};
RN   [1] {ECO:0000313|RefSeq:XP_002936704.1}
RP   IDENTIFICATION.
RC   STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002936704.1};
RC   TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002936704.1};
RG   RefSeq;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000256|ARBA:ARBA00010290, ECO:0000256|RuleBase:RU003925}.
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DR   RefSeq; XP_002936704.1; XM_002936658.5.
DR   GeneID; 100490823; -.
DR   KEGG; xtr:100490823; -.
DR   AGR; Xenbase:XB-GENE-1004384; -.
DR   CTD; 26225; -.
DR   Xenbase; XB-GENE-1004384; arl5a.
DR   eggNOG; KOG0070; Eukaryota.
DR   GeneTree; ENSGT00940000154714; -.
DR   OMA; ILFARIW; -.
DR   OrthoDB; 2011769at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Bgee; ENSXETG00000021692; Expressed in testis and 12 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:1903292; P:protein localization to Golgi membrane; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd04153; Arl5_Arl8; 1.
DR   FunFam; 3.40.50.300:FF:000294; ADP-ribosylation factor-like protein 5A; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR11711; ADP RIBOSYLATION FACTOR-RELATED; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00177; ARF; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR606689-
KW   1}; Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR606689-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR606689-2};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRSR:PIRSR606689-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT   BINDING         23..30
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-1"
FT   BINDING         30
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-2"
FT   BINDING         47
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-2"
FT   BINDING         69
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-1"
FT   BINDING         125..128
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606689-1"
SQ   SEQUENCE   179 AA;  20558 MW;  971669064BF1D9F2 CRC64;
     MGILFAKIWR LFSHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS NVEEIVVNNT
     RFLMWDIGGQ ESLRSSWNTY YTNTEFVIIV VDSTDRERIA VTREELYKML SHEDLKKAGL
     LVFANKQDVK ECMTVAEISQ YLKLTSVKDH PWHIQACCAL TGEGLCQGLE WMMSRLKVR
//