# AATF review notes

## 2026-06-03 PN batch re-review

- Falcon deep research was already present at `genes/human/AATF/AATF-deep-research-falcon.md`; no new provider run was needed.
- Publication caching was refreshed with `just fetch-gene-pmids human AATF`. `PMID:12450794` was newly cached as abstract-only.
- Core biology remains two-part: AATF is a nucleolar SSU processome component required for early small-subunit maturation [PMID:34516797 "The human small subunit processome mediates early maturation of the small ribosomal subunit by coupling RNA folding to subsequent RNA cleavage and processing steps"] and a nuclear RNA polymerase II transcriptional cofactor [PMID:10783144 "Here we describe Che-1, a novel human protein that interacts with hRPB11"; PMID:12847090 "Che-1 activates p21WAF1/Cip1 by displacing histone deacetylase (HDAC)1 from the Sp1 binding sites"].
- Proteostasis PN projection was evaluated conservatively. The PN candidate report projects `GO:0030687 preribosome, large subunit precursor` from `Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex`, but AATF's direct evidence and GOA rows support SSU processome / 40S maturation (`GO:0032040`, `GO:0030490`, `GO:0042274`) rather than pre-60S large-subunit precursor membership [PMID:34516797 "maturing human small subunit (SSU) processomes"]. Do not add the projected pre-60S term for AATF without gene-level evidence.
- The existing ER unfolded protein response annotation is supported but remains non-core. Ishigaki et al. show AATF is induced by PERK-eIF2alpha during ER stress and promotes AKT1-dependent survival [PMID:19911006 "AATF is induced by ER stress through the PERK-eIF2alpha pathway and transcriptionally activates the v-akt murine thymoma viral oncogene homolog 1 (AKT1) gene"], but this is a context-specific transcriptional regulatory output, not evidence that AATF is a chaperone, foldase, or direct protein-quality-control factor.
- Generic `protein binding` rows remain mostly non-core or modified to the more informative transcription coactivator term where the interaction directly supports AATF's Pol II/SP1/Rb transcriptional cofactor role. NGDN interactions are biologically coherent with SSU processome context but still do not make `protein binding` an informative core molecular-function annotation.