ABL1 (Tyrosine-protein kinase ABL1, EC 2.7.10.2) is a non-receptor tyrosine kinase with critical roles in cytoskeleton remodeling, DNA damage response, and cell signaling. The protein contains an N-terminal cap with myristoylation site, SH3 and SH2 domains that form an autoinhibitory clamp with the kinase domain, and a C-terminal F-actin binding region. ABL1 shuttles between nucleus and cytoplasm; nuclear ABL1 mediates DNA damage response and apoptosis, while cytoplasmic ABL1 regulates actin dynamics and receptor signaling. Key substrates include DNA repair proteins (RAD51, RAD52, WRN), cytoskeletal regulators (WAVE complex, cortactin), and transcriptional regulators (TP73, YAP1). BCR-ABL1 fusion resulting from t(9;22) translocation drives chronic myeloid leukemia.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004713 protein tyrosine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: ABL1 is definitively a protein tyrosine kinase (EC 2.7.10.2). This is its primary enzymatic function. Reason: Core molecular function of ABL1. Extensively validated by crystal structures, kinase assays, and identification of numerous substrates. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: ABL1 localizes to the plasma membrane through interactions with membrane-associated proteins and actin cytoskeleton. Reason: ABL1 localizes to membrane ruffles and the cell cortex where it regulates actin remodeling. The myristoylated isoform IB can associate with membranes. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 localizes to plasma membrane via interactions with membrane-associated proteins and actin cytoskeleton] |
| GO:0007229 integrin-mediated signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: ABL1 participates in integrin-mediated signaling, regulating cell adhesion and migration through phosphorylation of focal adhesion components. Reason: ABL1 is activated downstream of integrin engagement and phosphorylates key adhesion regulators including CRK, CRKL, and paxillin. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation |
| GO:0010595 positive regulation of endothelial cell migration | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: ABL1 promotes endothelial cell migration through its regulation of actin dynamics and integrin signaling. Reason: While ABL1 does regulate cell migration through actin remodeling, this is a cell-type-specific phenotypic outcome rather than a core evolved function. Supporting Evidence: PMID:24863063 Cell migration assay |
| GO:0007173 epidermal growth factor receptor signaling pathway | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: ABL1 modulates EGFR signaling by regulating receptor endocytosis through phosphorylation of CBL. Reason: ABL1 regulates EGFR endocytosis via CBL phosphorylation. However, this represents one of many RTK signaling pathways ABL1 can modulate, not a core evolved function. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 regulates EGFR endocytosis via CBL phosphorylation] |
| GO:0000166 nucleotide binding | IEA GO_REF:0000043 | MODIFY | Summary: As a kinase, ABL1 binds ATP. This is a necessary attribute of its kinase function but is too general. Reason: ABL1 binds ATP as part of its kinase catalytic mechanism. The more specific term GO:0005524 (ATP binding) is more informative. Proposed replacements: ATP binding |
| GO:0001784 phosphotyrosine residue binding | IEA GO_REF:0000117 | ACCEPT | Summary: The SH2 domain of ABL1 binds phosphotyrosine-containing sequences, enabling interactions with activated signaling proteins. Reason: The ABL1 SH2 domain binds phosphotyrosine motifs. This is a core regulatory function enabling ABL1 to respond to tyrosine kinase signaling. Supporting Evidence: PMID:12384576 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain |
| GO:0002252 immune effector process | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: ABL1 has roles in T cell signaling and immune cell function, but this term is very broad and non-specific. Reason: While ABL1 does function in T cell migration and differentiation, this extremely broad term provides little functional insight. |
| GO:0002429 immune response-activating cell surface receptor signaling pathway | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: ABL1 can be activated downstream of immune receptors but this is a secondary function. Reason: ABL1 functions downstream of BCR and other immune receptors but this is not a specific evolved function. The annotation is too broad. |
| GO:0003677 DNA binding | IEA GO_REF:0000043 | ACCEPT | Summary: ABL1 has a C-terminal DNA binding domain that preferentially binds distorted DNA structures including four-way junctions and bubble DNA. Reason: ABL1 has direct DNA binding activity through its C-terminal region. This is relevant to its nuclear DNA damage response functions. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 has a C-terminal DNA binding domain] |
| GO:0003785 actin monomer binding | IEA GO_REF:0000117 | ACCEPT | Summary: ABL1 contains an F-actin binding region in its C-terminus that enables direct interaction with actin. Reason: The C-terminal region of ABL1 contains an F-actin binding domain. This is a core structural feature enabling cytoskeletal regulatory functions. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 contains F-actin binding region in C-terminus] |
| GO:0004672 protein kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 is a protein kinase, but this term is less specific than the tyrosine kinase annotation. Reason: While ABL1 is primarily a tyrosine kinase, this general term is acceptable as a parent term. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: This is the core molecular function of ABL1 as a non-receptor tyrosine kinase. Reason: Core function supported by multiple evidence sources. ABL1 phosphorylates numerous substrates on tyrosine residues. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 is definitively a non-receptor (non-membrane spanning) tyrosine kinase. Reason: ABL1 belongs to the ABL subfamily of non-receptor tyrosine kinases. Unlike RTKs, it lacks a transmembrane domain. Supporting Evidence: PMID:20841568 Each ABL protein contains an SH3-SH2-TK (Src homology 3-Src homology 2-tyrosine kinase) domain cassette, which confers autoregulated kinase activity and is common among nonreceptor tyrosine kinases |
| GO:0005524 ATP binding | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 binds ATP in its kinase domain active site as required for phosphotransfer catalysis. Reason: ATP binding is essential for ABL1 kinase activity. Crystal structures show ATP analog binding in the kinase domain. Supporting Evidence: PMID:9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 localizes to the nucleus where it functions in DNA damage response and transcriptional regulation. Reason: ABL1 contains three NLS sequences enabling nuclear import. Nuclear localization is essential for its DNA damage response function. Supporting Evidence: PMID:9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation |
| GO:0005739 mitochondrion | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: ABL1 can translocate to mitochondria in response to oxidative stress where it mediates mitochondrial dysfunction. Reason: Mitochondrial localization occurs under oxidative stress. This is a stress-induced localization rather than constitutive. Supporting Evidence: PMID:24522549 Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease |
| GO:0005829 cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: ABL1 is predominantly cytosolic under basal conditions, regulated by 14-3-3 protein sequestration. Reason: Cytosolic localization is well-established. ABL1 is sequestered in cytoplasm through 14-3-3 protein interactions. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 is predominantly cytosolic, regulated by 14-3-3 protein sequestration] |
| GO:0005856 cytoskeleton | IEA GO_REF:0000044 | ACCEPT | Summary: ABL1 associates with the cytoskeleton through its F-actin binding domain and regulates cytoskeletal dynamics. Reason: ABL1 directly binds F-actin through its C-terminal actin binding domain. This is a core localization for cytoskeletal regulatory function. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 contains F-actin binding domain enabling cytoskeletal localization] |
| GO:0006281 DNA repair | IEA GO_REF:0000043 | ACCEPT | Summary: ABL1 participates in DNA repair by phosphorylating repair proteins RAD51, RAD52, and WRN in response to DNA damage. Reason: ABL1 phosphorylates multiple DNA repair proteins. This is a core nuclear function of ABL1 in the DNA damage response pathway. Supporting Evidence: PMID:9461559 Regulation of Rad51 function by c-Abl in response to DNA damage |
| GO:0006897 endocytosis | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: ABL1 regulates receptor endocytosis, particularly EGFR internalization, through phosphorylation of CBL. Reason: ABL1 regulates endocytosis of EGFR and other receptors. However, this is one of many downstream effects of ABL1 kinase activity. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 regulates receptor endocytosis through CBL phosphorylation] |
| GO:0006909 phagocytosis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 participates in Fc-gamma receptor signaling during phagocytosis. Reason: ABL1 is placed in Fc-gamma receptor-mediated phagocytosis pathway. This is a cell-type-specific function in immune cells, not a core evolved function. |
| GO:0006914 autophagy | IEA GO_REF:0000043 | MARK AS OVER ANNOTATED | Summary: ABL1 has been implicated in autophagy regulation, but the evidence for direct autophagy function is limited. Reason: While ABL1 regulates lysosomal trafficking, the annotation of ABL1 to the general autophagy process is over-annotation. ABL1's primary role is in lysosomal function, not autophagy per se. The deep research found no evidence that autophagy is a core evolved function of ABL1. |
| GO:0006915 apoptotic process | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 promotes apoptosis in response to DNA damage through phosphorylation of TP73 and CASP9. Reason: Nuclear ABL1 activates proapoptotic pathways following severe DNA damage. ABL1 phosphorylates TP73 and CASP9 on Tyr-153. Supporting Evidence: PMID:9037071 Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase |
| GO:0006974 DNA damage response | IEA GO_REF:0000043 | ACCEPT | Summary: ABL1 is a key mediator of the DNA damage response, activated by ATM following DNA double-strand breaks. Reason: DNA damage response is a core nuclear function of ABL1. ATM phosphorylates ABL1 following DNA damage, activating its nuclear functions. Supporting Evidence: PMID:9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation |
| GO:0007155 cell adhesion | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: ABL1 regulates cell adhesion through phosphorylation of adhesion signaling components including CRK, CRKL, and paxillin. Reason: ABL1 regulates cell adhesion through its cytoskeletal regulatory functions, but this is a phenotypic outcome rather than a core molecular function. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity |
| GO:0007204 positive regulation of cytosolic calcium ion concentration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 has been shown to positively regulate cytosolic calcium through effects on endothelial barrier function. Reason: ABL1 regulates calcium signaling in endothelial cells. This is a downstream effect in specific cell contexts, not a core evolved function. Supporting Evidence: PMID:24367707 Abl family kinases regulate endothelial barrier function in vitro and in mice |
| GO:0010468 regulation of gene expression | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 regulates gene expression through phosphorylation of transcriptional regulators and RNA polymerase II CTD. Reason: Nuclear ABL1 can phosphorylate RNAPII CTD and interact with transcriptional regulators. However, this is a very broad term. |
| GO:0010506 regulation of autophagy | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: ABL1 may indirectly regulate autophagy through effects on lysosomal function. Reason: Similar to GO:0006914, this is over-annotation. ABL1's primary role is in lysosomal trafficking and acidification, not autophagy regulation per se. |
| GO:0010557 positive regulation of macromolecule biosynthetic process | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: This is an extremely broad term with unclear relevance to ABL1 core function. Reason: This term is too general to provide meaningful functional information about ABL1. No specific evidence supports this as a core function. |
| GO:0010595 positive regulation of endothelial cell migration | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Duplicate of IBA annotation above. Reason: Same as IBA annotation - cell-type-specific outcome of cytoskeletal regulation. |
| GO:0016301 kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 has kinase activity, but this very general term is subsumed by more specific tyrosine kinase annotations. Reason: Correct but very general. The more specific protein tyrosine kinase activity annotations are more informative. |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | MODIFY | Summary: As a kinase, ABL1 has transferase activity (phosphotransfer), but this is extremely general. Reason: This term is too general. ABL1's specific transferase activity is protein tyrosine kinase activity. Proposed replacements: protein tyrosine kinase activity |
| GO:0030100 regulation of endocytosis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 regulates endocytosis of receptors through CBL and other mechanisms. Reason: ABL1 regulates EGFR and other receptor endocytosis. However, this is a downstream regulatory function, not core. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 regulates receptor endocytosis] |
| GO:0031965 nuclear membrane | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: The myristoylated isoform IB can associate with nuclear membrane. Reason: UniProt indicates isoform IB localizes to nuclear membrane via lipid anchor. This is isoform-specific. |
| GO:0032956 regulation of actin cytoskeleton organization | IEA GO_REF:0000117 | ACCEPT | Summary: ABL1 is a key regulator of actin cytoskeleton organization through phosphorylation of WAVE complex, cortactin, and other actin regulators. Reason: This is a core function of cytoplasmic ABL1. ABL1 phosphorylates WAVE proteins, cortactin, and other actin regulators. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 phosphorylates WAVE proteins, cortactin, and other actin regulators] |
| GO:0045595 regulation of cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 has roles in cell differentiation, particularly in hematopoietic and T cell differentiation. Reason: ABL1 regulates T cell differentiation in TBX21-dependent manner. This is a developmental/cell-type-specific function. |
| GO:0045785 positive regulation of cell adhesion | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 can positively regulate cell adhesion through focal adhesion signaling. Reason: ABL1 regulates adhesion signaling but the direction is context-dependent. This is a downstream phenotypic effect. |
| GO:0046872 metal ion binding | IEA GO_REF:0000043 | MODIFY | Summary: ABL1 binds magnesium and manganese ions as cofactors for kinase activity. Reason: ABL1 requires divalent cations for kinase activity. More specific terms GO:0000287 (magnesium ion binding) are preferable. Proposed replacements: magnesium ion binding |
| GO:0048008 platelet-derived growth factor receptor signaling pathway | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 is activated downstream of PDGFR and regulates PDGF-induced responses. Reason: ABL1 involvement in PDGFRB signaling is one of several RTK pathways ABL1 modulates, not a core function. Supporting Evidence: PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin |
| GO:0051726 regulation of cell cycle | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 is involved in cell cycle regulation through DNA damage checkpoint signaling. Reason: ABL1 participates in cell cycle regulation through DNA damage checkpoints. Not a core function. |
| GO:1901701 cellular response to oxygen-containing compound | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ABL1 responds to oxidative stress and reactive oxygen species. Reason: ABL1 is activated by oxidative stress and translocates to mitochondria. This is a stress response, not core evolved function. |
| GO:1902531 regulation of intracellular signal transduction | IEA GO_REF:0000117 | ACCEPT | Summary: ABL1 regulates multiple intracellular signaling cascades. Reason: This appropriately captures ABL1's role as a signaling hub integrating multiple pathways. |
| GO:0005515 protein binding | IPI PMID:10849448 Transformation of myeloid leukemia cells to cytokine indepen... | MARK AS OVER ANNOTATED | Summary: Generic protein binding annotation from interaction with HCK. Reason: Protein binding is uninformative per GO curation guidelines. Supporting Evidence: PMID:10849448 Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck. |
| GO:0005515 protein binding | IPI PMID:10970852 Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles a... | MARK AS OVER ANNOTATED | Summary: Interaction with WAVE/SCAR complex components. Reason: Protein binding is uninformative. WAVE-1 interaction is functionally important but generic binding term provides no insight. Supporting Evidence: PMID:10970852 Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. |
| GO:0005515 protein binding | IPI PMID:11374898 Cloning, mapping, and characterization of the human sorbin a... | MARK AS OVER ANNOTATED | Summary: Interaction with SORBS1 during insulin signaling. Reason: Generic protein binding is uninformative per GO curation guidelines. Supporting Evidence: PMID:11374898 Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B. |
| GO:0005515 protein binding | IPI PMID:11375976 Telomeric protein Pin2/TRF1 as an important ATM target in re... | MARK AS OVER ANNOTATED | Summary: Interaction with telomeric protein TRF1/Pin2. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:11375976 2001 May 25. Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. |
| GO:0005515 protein binding | IPI PMID:11418237 Isolation of hNap1BP which interacts with human Nap1 (NCKAP1... | MARK AS OVER ANNOTATED | Summary: Interaction with NAP1BP. Reason: Generic protein binding annotation is uninformative. Supporting Evidence: PMID:11418237 Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. |
| GO:0005515 protein binding | IPI PMID:11971963 c-Abl tyrosine kinase regulates the human Rad9 checkpoint pr... | MARK AS OVER ANNOTATED | Summary: Interaction with RAD9 checkpoint protein. Reason: Generic protein binding is uninformative per GO curation guidelines. The functional context (DNA damage checkpoint) is captured by other annotations. Supporting Evidence: PMID:11971963 c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:12384576 Structure of a regulatory complex involving the Abl SH3 doma... | MARK AS OVER ANNOTATED | Summary: Structural study of ABL SH3-CRK interaction. Reason: PMID:12384576 describes specific SH3-SH2 interactions with CRK. Generic protein binding is uninformative. Supporting Evidence: PMID:12384576 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. |
| GO:0005515 protein binding | IPI PMID:15448168 Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine... | MARK AS OVER ANNOTATED | Summary: Interaction with DNA topoisomerase I. Reason: ABL1 phosphorylates TOP1. Generic binding is uninformative. Supporting Evidence: PMID:15448168 2004 Sep 24. Phosphorylation of DNA topoisomerase I by the c-Abl tyrosine kinase confers camptothecin sensitivity. |
| GO:0005515 protein binding | IPI PMID:15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear tar... | MARK AS OVER ANNOTATED | Summary: Interaction with 14-3-3 proteins. Reason: ABL1 binds 14-3-3 proteins via phospho-Thr-735 for cytoplasmic sequestration. Generic binding is uninformative. Supporting Evidence: PMID:15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:15886098 RIN1 is an ABL tyrosine kinase activator and a regulator of ... | MARK AS OVER ANNOTATED | Summary: Interaction with RIN1. Reason: RIN1 is an ABL1 activator binding SH2 and SH3 domains. Generic protein binding is uninformative. Supporting Evidence: PMID:15886098 RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. |
| GO:0005515 protein binding | IPI PMID:16273093 A quantitative protein interaction network for the ErbB rece... | MARK AS OVER ANNOTATED | Summary: ErbB receptor interaction study. Reason: Protein microarray study. Generic binding uninformative. Supporting Evidence: PMID:16273093 A quantitative protein interaction network for the ErbB receptors using protein microarrays. |
| GO:0005515 protein binding | IPI PMID:16397227 Physical and functional interaction between hMSH5 and c-Abl. | MARK AS OVER ANNOTATED | Summary: Interaction with MSH5. Reason: ABL1-MSH5 interaction relates to DNA damage response. Generic binding is uninformative. Supporting Evidence: PMID:16397227 Physical and functional interaction between hMSH5 and c-Abl. |
| GO:0005515 protein binding | IPI PMID:16443220 Characterization of p87C3G, a novel, truncated C3G isoform t... | MARK AS OVER ANNOTATED | Summary: Interaction with C3G isoform. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:16443220 2006 Jan 27. Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl. |
| GO:0005515 protein binding | IPI PMID:16831423 Abl kinase interacts with and phosphorylates vinexin. | MARK AS OVER ANNOTATED | Summary: Interaction with vinexin. Reason: ABL1 phosphorylates vinexin. Generic binding is uninformative. Supporting Evidence: PMID:16831423 Epub 2006 Jul 5. Abl kinase interacts with and phosphorylates vinexin. |
| GO:0005515 protein binding | IPI PMID:16888623 MUC1 oncoprotein blocks nuclear targeting of c-Abl in the ap... | MARK AS OVER ANNOTATED | Summary: Interaction with MUC1. Reason: MUC1 blocks ABL1 nuclear targeting. Generic binding is uninformative. Supporting Evidence: PMID:16888623 Aug 3. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:17101133 NESH (Abi-3) is present in the Abi/WAVE complex but does not... | MARK AS OVER ANNOTATED | Summary: NESH/Abi-3 interaction study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:17101133 Epub 2006 Nov 7. NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. |
| GO:0005515 protein binding | IPI PMID:17112510 Consequences of Shb and c-Abl interactions for cell death in... | MARK AS OVER ANNOTATED | Summary: Interaction with Shb adapter protein. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:17112510 Epub 2006 Oct 24. Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli. |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | MARK AS OVER ANNOTATED | Summary: Beta-catenin interaction (BCR-ABL context). Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | MARK AS OVER ANNOTATED | Summary: SH3 domain interaction screen. Reason: Generic protein binding from high-throughput screen is uninformative. Supporting Evidence: PMID:17474147 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. |
| GO:0005515 protein binding | IPI PMID:17626041 Cockayne syndrome protein B interacts with and is phosphoryl... | MARK AS OVER ANNOTATED | Summary: Interaction with Cockayne syndrome protein B (ERCC6). Reason: ABL1 phosphorylates CSB/ERCC6. Generic binding is uninformative. Supporting Evidence: PMID:17626041 Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. |
| GO:0005515 protein binding | IPI PMID:18328268 Allosteric inhibition of the nonMyristoylated c-Abl tyrosine... | MARK AS OVER ANNOTATED | Summary: Abi1 phosphopeptide allosteric inhibition study. Reason: Describes specific allosteric regulation mechanism via Abi1 interaction. Generic binding is uninformative. Supporting Evidence: PMID:18328268 Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1. |
| GO:0005515 protein binding | IPI PMID:19234221 c-Abl kinase is required for beta 2 integrin-mediated neutro... | MARK AS OVER ANNOTATED | Summary: Beta2 integrin interaction in neutrophils. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:19234221 c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion. |
| GO:0005515 protein binding | IPI PMID:19442657 Evidence for a direct involvement of hMSH5 in promoting ioni... | MARK AS OVER ANNOTATED | Summary: MSH5 interaction promoting apoptosis. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:19442657 Epub 2009 May 12. Evidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosis. |
| GO:0005515 protein binding | IPI PMID:19470755 Cdo binds Abl to promote p38alpha/beta mitogen-activated pro... | MARK AS OVER ANNOTATED | Summary: CDO interaction promoting myogenic differentiation. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:19470755 May 26. Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation. |
| GO:0005515 protein binding | IPI PMID:19914245 c-Abl tyrosine kinase interacts with MAVS and regulates inna... | MARK AS OVER ANNOTATED | Summary: MAVS interaction regulating innate immunity. Reason: ABL1-MAVS interaction relevant to innate immune signaling. Generic binding is uninformative. Supporting Evidence: PMID:19914245 c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response. |
| GO:0005515 protein binding | IPI PMID:20598684 Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regula... | MARK AS OVER ANNOTATED | Summary: Abi1 phosphorylation study linking to PI3K. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:20598684 Epub 2010 Jun 23. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. |
| GO:0005515 protein binding | IPI PMID:20697350 The proximal signaling network of the BCR-ABL1 oncogene show... | MARK AS OVER ANNOTATED | Summary: BCR-ABL1 proximal signaling network study. Reason: Large-scale interactome study. Generic binding is uninformative. Supporting Evidence: PMID:20697350 The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. |
| GO:0005515 protein binding | IPI PMID:22286129 BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic ... | MARK AS OVER ANNOTATED | Summary: BCR-ABL JAK2-STAT5 uncoupling study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:22286129 BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. |
| GO:0005515 protein binding | IPI PMID:22401567 MutS homologue hMSH5 - role in cisplatin-induced DNA damage ... | MARK AS OVER ANNOTATED | Summary: MSH5 role in cisplatin response. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:22401567 MutS homologue hMSH5: role in cisplatin-induced DNA damage response. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | MARK AS OVER ANNOTATED | Summary: Membrane two-hybrid assay study. Reason: Generic protein binding from screening is uninformative. Supporting Evidence: PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | MARK AS OVER ANNOTATED | Summary: SH2 binding prediction study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:24728074 Epub 2014 Apr 12. Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. |
| GO:0005515 protein binding | IPI PMID:24947832 Differential protein-protein interactions of LRRK1 and LRRK2... | MARK AS OVER ANNOTATED | Summary: LRRK1/LRRK2 interaction study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:24947832 Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways. |
| GO:0005515 protein binding | IPI PMID:25036101 Identification of SH3 domain proteins interacting with the c... | MARK AS OVER ANNOTATED | Summary: ADAM10 SH3 domain interaction. Reason: SH3 domain-mediated interaction. Generic binding is uninformative. Supporting Evidence: PMID:25036101 eCollection 2014. Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10). |
| GO:0005515 protein binding | IPI PMID:25852190 Integrative analysis of kinase networks in TRAIL-induced apo... | MARK AS OVER ANNOTATED | Summary: TRAIL apoptosis kinase network. Reason: Generic protein binding from network analysis is uninformative. Supporting Evidence: PMID:25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. |
| GO:0005515 protein binding | IPI PMID:27348587 Activation of tyrosine kinase c-Abl contributes to Ξ±-synucle... | MARK AS OVER ANNOTATED | Summary: Alpha-synuclein interaction in neurodegeneration. Reason: ABL1 phosphorylates alpha-synuclein. Generic binding is uninformative. Supporting Evidence: PMID:27348587 Activation of tyrosine kinase c-Abl contributes to Ξ±-synuclein-induced neurodegeneration. |
| GO:0005515 protein binding | IPI PMID:28086240 ABL2 suppresses FLT3-ITD-induced cell proliferation through ... | MARK AS OVER ANNOTATED | Summary: ABL2 and FLT3-ITD study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:28086240 ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | MARK AS OVER ANNOTATED | Summary: Human interactome architecture study. Reason: Large-scale interactome. Generic binding is uninformative. Supporting Evidence: PMID:28514442 Architecture of the human interactome defines protein communities and disease networks. |
| GO:0005515 protein binding | IPI PMID:30021884 Histone Interaction Landscapes Visualized by Crosslinking Ma... | MARK AS OVER ANNOTATED | Summary: Histone crosslinking mass spec study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:30021884 Epub 2018 Jul 18. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. |
| GO:0005515 protein binding | IPI PMID:31175292 Structural and functional consequences of the STAT5B(N642H) ... | MARK AS OVER ANNOTATED | Summary: STAT5B driver mutation study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:31175292 Structural and functional consequences of the STAT5B(N642H) driver mutation. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | MARK AS OVER ANNOTATED | Summary: EGFR network in KRAS mutant cells. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D). |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MARK AS OVER ANNOTATED | Summary: Cell-specific interactome remodeling. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:33961781 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell - Endogenous tagging for the cartography of human c... | MARK AS OVER ANNOTATED | Summary: OpenCell endogenous tagging study. Reason: Large-scale study. Generic binding is uninformative. Supporting Evidence: PMID:35271311 2022 Mar 11. OpenCell: Endogenous tagging for the cartography of human cellular organization. |
| GO:0005515 protein binding | IPI PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human c... | MARK AS OVER ANNOTATED | Summary: 14-3-3 protein chaperone study. Reason: Relevant to ABL1 cytoplasmic sequestration by 14-3-3 proteins. Generic binding is uninformative. Supporting Evidence: PMID:36931259 A central chaperone-like role for 14-3-3 proteins in human cells. |
| GO:0005515 protein binding | IPI PMID:37219487 Large-scale phosphomimetic screening identifies phospho-modu... | MARK AS OVER ANNOTATED | Summary: Phosphomimetic motif interaction screen. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:37219487 2023 May 23. Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions. |
| GO:0005515 protein binding | IPI PMID:39009827 Proteome-scale characterisation of motif-based interactome r... | MARK AS OVER ANNOTATED | Summary: Disease mutation interactome rewiring. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:39009827 2024 Jul 15. Proteome-scale characterisation of motif-based interactome rewiring by disease mutations. |
| GO:0005515 protein binding | IPI PMID:39251607 Systematic identification of post-transcriptional regulatory... | MARK AS OVER ANNOTATED | Summary: Post-transcriptional regulatory module study. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:39251607 Systematic identification of post-transcriptional regulatory modules. |
| GO:0005515 protein binding | IPI PMID:9144171 Protein binding and signaling properties of RIN1 suggest a u... | MARK AS OVER ANNOTATED | Summary: RIN1 binding study demonstrating activator function. Reason: RIN1 is an ABL1 activator. Generic binding term is uninformative. Supporting Evidence: PMID:9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function. |
| GO:0005515 protein binding | IPI PMID:9168117 Interaction between ATM protein and c-Abl in response to DNA... | MARK AS OVER ANNOTATED | Summary: ATM interaction in DNA damage response. Reason: ATM-ABL1 interaction is functionally important for DNA damage response. Generic binding is uninformative. Supporting Evidence: PMID:9168117 Interaction between ATM protein and c-Abl in response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:9346925 SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste2... | MARK AS OVER ANNOTATED | Summary: HPK1 interaction via SH2/SH3 adapters. Reason: Generic protein binding is uninformative. Supporting Evidence: PMID:9346925 SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1. |
| GO:0005515 protein binding | IPI PMID:9593709 Identification of a candidate human spectrin Src homology 3 ... | MARK AS OVER ANNOTATED | Summary: Spectrin SH3 domain interaction. Reason: SH3-mediated interaction with cytoskeleton. Generic binding is uninformative. Supporting Evidence: PMID:9593709 Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. |
| GO:0000287 magnesium ion binding | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 requires magnesium as a cofactor for kinase activity. Reason: Divalent cation binding is essential for kinase catalysis. This is a core biochemical requirement. |
| GO:0001726 ruffle | IEA GO_REF:0000107 | ACCEPT | Summary: ABL1 localizes to membrane ruffles where it regulates actin dynamics. Reason: Localization to ruffles is consistent with ABL1's role in actin cytoskeleton remodeling. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 localizes to F-actin-rich membrane ruffles] |
| GO:0005737 cytoplasm | IEA GO_REF:0000107 | ACCEPT | Summary: ABL1 is predominantly cytoplasmic under basal conditions. Reason: Cytoplasmic localization is well-established. ABL1 shuttles between cytoplasm and nucleus. |
| GO:0007611 learning or memory | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 has been implicated in learning and memory through synaptic functions. Reason: Based on mouse orthologue data. This is a developmental/neurological phenotype, not a core molecular function. |
| GO:0008306 associative learning | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 has been implicated in associative learning. Reason: Based on mouse orthologue data. This is a behavioral phenotype, not a core molecular function. |
| GO:0009410 response to xenobiotic stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 responds to xenobiotic stimuli. Reason: This is a stress response phenotype, not a core evolved function. |
| GO:0014069 postsynaptic density | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 localizes to postsynaptic density in neurons. Reason: Cell-type-specific localization in neurons. Not a core function. |
| GO:0015629 actin cytoskeleton | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 localizes to and regulates the actin cytoskeleton. Reason: ABL1 directly binds F-actin and regulates actin dynamics. This is a core localization. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 directly binds F-actin through C-terminal region] |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: ABL1 binds other protein kinases. Reason: ABL1 interacts with multiple protein kinases including SRC family kinases and ATM. |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 binds proteins through its SH2 and SH3 domains. Reason: SH2 and SH3 domain-mediated interactions are core to ABL1 function and regulation. |
| GO:0030036 actin cytoskeleton organization | IEA GO_REF:0000107 | ACCEPT | Summary: ABL1 organizes the actin cytoskeleton. Reason: This is a core function of cytoplasmic ABL1 through phosphorylation of actin regulatory proteins. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 organizes actin cytoskeleton through phosphorylation of cortactin and other actin regulatory proteins] |
| GO:0030041 actin filament polymerization | IEA GO_REF:0000107 | ACCEPT | Summary: ABL1 regulates actin filament polymerization. Reason: ABL1 promotes actin polymerization through phosphorylation of WAVE complex and other regulators. |
| GO:0030145 manganese ion binding | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 can use manganese as an alternative divalent cation cofactor. Reason: Like many kinases, ABL1 can use Mn2+ in addition to Mg2+ for catalysis. |
| GO:0030425 dendrite | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 localizes to dendrites in neurons. Reason: Neuronal cell-type-specific localization. Not a core function. |
| GO:0030426 growth cone | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 localizes to growth cones where it regulates neurite extension. Reason: Neuronal cell-type-specific localization related to actin dynamics. Not a core function. |
| GO:0031252 cell leading edge | IEA GO_REF:0000107 | ACCEPT | Summary: ABL1 localizes to the cell leading edge during migration. Reason: Localization to the leading edge is consistent with ABL1's role in actin-based cell motility. |
| GO:0034599 cellular response to oxidative stress | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: ABL1 is activated by and responds to oxidative stress. Reason: Oxidative stress response including mitochondrial translocation. This is a stress response, not core function. |
| GO:0034976 response to endoplasmic reticulum stress | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 responds to ER stress. Reason: ER stress response is a secondary function, not a core evolved function. |
| GO:0035556 intracellular signal transduction | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 functions in intracellular signal transduction. Reason: ABL1 is a signaling kinase that transduces signals from multiple upstream inputs. |
| GO:0038191 neuropilin binding | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: ABL1 binds neuropilin. Reason: Neuropilin interaction relates to angiogenesis signaling. Not a core evolved function. |
| GO:0043025 neuronal cell body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 localizes to neuronal cell bodies. Reason: Neuronal cell-type-specific localization. Not a core function. |
| GO:0043065 positive regulation of apoptotic process | IEA GO_REF:0000120 | ACCEPT | Summary: ABL1 positively regulates apoptosis in response to DNA damage. Reason: Nuclear ABL1 promotes apoptosis following severe DNA damage via TP73 and CASP9 phosphorylation. Supporting Evidence: PMID:9037071 Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase |
| GO:0043525 positive regulation of neuron apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 can promote neuron apoptosis. Reason: Cell-type-specific apoptotic function in neurons. Related to Parkinson's disease pathology. |
| GO:0045580 regulation of T cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 regulates T cell differentiation. Reason: Cell-type-specific developmental function. Not a core evolved function. |
| GO:0045907 positive regulation of vasoconstriction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 positively regulates vasoconstriction. Reason: Physiological phenotype, not a core molecular function. |
| GO:0046875 ephrin receptor binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 binds ephrin receptors. Reason: Ephrin signaling is one of many pathways ABL1 participates in. Not a core function. |
| GO:0048013 ephrin receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 participates in ephrin receptor signaling. Reason: Ephrin signaling is one of many pathways ABL1 modulates. Not a core evolved function. |
| GO:0048146 positive regulation of fibroblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 promotes fibroblast proliferation. Reason: Cell-type-specific proliferative effect. Not a core function. |
| GO:0051015 actin filament binding | IEA GO_REF:0000107 | ACCEPT | Summary: ABL1 directly binds actin filaments through its C-terminal F-actin binding domain. Reason: Direct F-actin binding is a core structural feature of ABL1 enabling cytoskeletal regulation. Supporting Evidence: file:human/ABL1/ABL1-deep-research-falcon.md [ABL1 contains C-terminal F-actin binding domain for direct actin filament binding] |
| GO:0051450 myoblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 is involved in myoblast proliferation. Reason: Cell-type-specific developmental function. Not a core evolved function. |
| GO:0060038 cardiac muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 is involved in cardiac muscle cell proliferation. Reason: Cell-type-specific developmental function. Not a core evolved function. |
| GO:0070097 delta-catenin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 binds delta-catenin. Reason: Specific protein interaction. Not a core evolved function. |
| GO:0071560 cellular response to transforming growth factor beta stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 responds to TGF-beta stimulus. Reason: TGF-beta response is one of many signaling pathways ABL1 participates in. Not core. |
| GO:0071871 response to epinephrine | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 responds to epinephrine. Reason: Physiological response, not a core molecular function. |
| GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 promotes cell migration during angiogenesis. Reason: Developmental/physiological phenotype, not a core molecular function. |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 localizes to glutamatergic synapses. Reason: Neuronal cell-type-specific localization. Not a core function. |
| GO:0099150 regulation of postsynaptic specialization assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 regulates postsynaptic specialization assembly. Reason: Neuronal cell-type-specific function. Not a core evolved function. |
| GO:1900006 positive regulation of dendrite development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 promotes dendrite development. Reason: Neuronal developmental function. Not a core evolved function. |
| GO:1900272 negative regulation of long-term synaptic potentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 negatively regulates long-term synaptic potentiation. Reason: Neuronal physiological function. Not a core evolved function. |
| GO:1903055 positive regulation of extracellular matrix organization | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 promotes extracellular matrix organization. Reason: Downstream phenotypic effect. Not a core molecular function. |
| GO:1903210 podocyte apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 is involved in podocyte apoptosis. Reason: Cell-type-specific apoptotic function. Not a core evolved function. |
| GO:1903905 positive regulation of establishment of T cell polarity | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 promotes T cell polarity establishment. Reason: Cell-type-specific function in T cells. Not a core evolved function. |
| GO:1905244 regulation of modification of synaptic structure | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: ABL1 regulates synaptic structure modification. Reason: Neuronal function related to actin dynamics at synapses. Not a core evolved function. |
| GO:1905555 positive regulation of blood vessel branching | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 promotes blood vessel branching. Reason: Angiogenesis-related phenotype. Not a core molecular function. |
| GO:2000406 positive regulation of T cell migration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ABL1 promotes T cell migration. Reason: Cell-type-specific migration function. Not a core evolved function. |
| GO:0000287 magnesium ion binding | IDA PMID:9144171 Protein binding and signaling properties of RIN1 suggest a u... | ACCEPT | Summary: ABL1 binds magnesium ions as a cofactor for its kinase activity. Reason: Magnesium binding is required for ATP-dependent kinase activity. This is an intrinsic component of tyrosine kinase function. Supporting Evidence: PMID:9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function. |
| GO:0000400 four-way junction DNA binding | IDA PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase pr... | ACCEPT | Summary: ABL1 binds four-way junction DNA structures through its DNA binding domain. Reason: Direct experimental evidence demonstrates ABL1 binding to DNA junction structures. This contributes to DNA damage response functions. Supporting Evidence: PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. |
| GO:0000405 bubble DNA binding | IDA PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase pr... | ACCEPT | Summary: ABL1 binds bubble DNA structures. Reason: Direct experimental evidence for binding to DNA bubble structures. Relevant to DNA damage response function. Supporting Evidence: PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. |
| GO:0001784 phosphotyrosine residue binding | IPI PMID:20624904 Tarp regulates early Chlamydia-induced host cell survival th... | ACCEPT | Summary: ABL1 SH2 domain binds phosphotyrosine residues. Reason: SH2 domain-mediated phosphotyrosine binding is essential for ABL1 substrate recognition and signaling. Supporting Evidence: PMID:20624904 Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. |
| GO:0004672 protein kinase activity | IDA PMID:11120811 The c-Abl tyrosine kinase is regulated downstream of the B c... | ACCEPT | Summary: ABL1 possesses protein kinase activity. Reason: Core kinase function. ABL1 is a well-characterized protein kinase. Supporting Evidence: PMID:11120811 The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. |
| GO:0004672 protein kinase activity | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | ACCEPT | Summary: ABL1 kinase activity regulates neuropilin-dependent endothelial cell functions. Reason: Kinase activity is core function; this annotation documents its role in specific signaling context. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:24700464 The association of cortactin with profilin-1 is critical for... | ACCEPT | Summary: ABL1 phosphorylates serine/threonine residues in addition to tyrosine. Reason: Evidence supports dual-specificity kinase activity for ABL1 phosphorylating both tyrosine and serine/threonine residues. Supporting Evidence: PMID:24700464 2014 Apr 3. The association of cortactin with profilin-1 is critical for smooth muscle contraction. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyr... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity. Reason: Core molecular function of ABL1. Multiple lines of evidence support tyrosine kinase activity. Supporting Evidence: PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:11121037 Functional interaction between c-Abl and the p21-activated p... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity. Reason: Core molecular function. Additional experimental evidence for kinase activity. Supporting Evidence: PMID:11121037 Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:12944467 Werner syndrome protein phosphorylation by abl tyrosine kina... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity. Reason: Core molecular function with direct experimental evidence. Supporting Evidence: PMID:12944467 Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:15657060 c-Abl tyrosine kinase regulates caspase-9 autocleavage in th... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity in DNA damage response. Reason: Core molecular function demonstrated in DNA damage response context. Supporting Evidence: PMID:15657060 2005 Jan 18. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. |
| GO:0004713 protein tyrosine kinase activity | EXP PMID:15657136 Abelson-interactor-1 promotes WAVE2 membrane translocation a... | ACCEPT | Summary: Experimental evidence for ABL1 tyrosine kinase activity. Reason: Core molecular function with direct experimental validation. Supporting Evidence: PMID:15657136 Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:17888034 Fibroblast growth factor receptor 1 oncogene partner as a no... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity. Reason: Core molecular function. Additional IDA evidence. Supporting Evidence: PMID:17888034 Epub 2007 Sep 18. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:20823226 Phosphorylation by the c-Abl protein tyrosine kinase inhibit... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity. Reason: Core molecular function with direct experimental evidence. Supporting Evidence: PMID:20823226 Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:22810897 Abl family kinases modulate T cell-mediated inflammation and... | ACCEPT | Summary: Mutant phenotype evidence for ABL1 tyrosine kinase activity. Reason: IMP evidence supports core kinase function. Supporting Evidence: PMID:22810897 Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. |
| GO:0004713 protein tyrosine kinase activity | IMP PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association ... | ACCEPT | Summary: ABL1 kinase activity required for microtubule plus-end localization. Reason: Core kinase function demonstrated in cytoskeletal regulation context. Supporting Evidence: PMID:24520051 2014 Mar 12. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:7590236 Abi-2, a novel SH3-containing protein interacts with the c-A... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity. Reason: Early IDA evidence establishing ABL1 as a tyrosine kinase. Supporting Evidence: PMID:7590236 Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity. |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:9144171 Protein binding and signaling properties of RIN1 suggest a u... | ACCEPT | Summary: Direct demonstration of ABL1 tyrosine kinase activity with structural analysis. Reason: Core molecular function with structural characterization. Supporting Evidence: PMID:9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:10518561 Molecular cloning of a docking protein, BRDG1, that acts dow... | ACCEPT | Summary: ABL1 functions as a non-receptor tyrosine kinase. Reason: Core specific molecular function designation. Supporting Evidence: PMID:10518561 Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IMP PMID:28428613 Differential regulation of PKD isoforms in oxidative stress ... | ACCEPT | Summary: ABL1 non-receptor kinase activity demonstrated by mutant phenotypes. Reason: Core specific molecular function with IMP evidence. Supporting Evidence: PMID:28428613 Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop. |
| GO:0004715 non-membrane spanning protein tyrosine kinase activity | IDA PMID:9461559 Regulation of Rad51 function by c-Abl in response to DNA dam... | ACCEPT | Summary: ABL1 acts as non-receptor kinase phosphorylating Rad51. Reason: Core molecular function demonstrated through Rad51 phosphorylation. Supporting Evidence: PMID:9461559 Regulation of Rad51 function by c-Abl in response to DNA damage. |
| GO:0005080 protein kinase C binding | IPI PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyr... | ACCEPT | Summary: ABL1 physically interacts with protein kinase C. Reason: Documented physical interaction supporting ABL1's role in PKC signaling. Supporting Evidence: PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. |
| GO:0005515 protein binding | IPI PMID:15657060 c-Abl tyrosine kinase regulates caspase-9 autocleavage in th... | KEEP AS NON CORE | Summary: ABL1 binds to caspase-9. Reason: Generic protein binding term; the specific interaction partner (caspase-9) provides context for apoptosis function. Supporting Evidence: PMID:15657060 2005 Jan 18. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. |
| GO:0005515 protein binding | IPI PMID:17515907 Structural basis for the transforming activity of human canc... | KEEP AS NON CORE | Summary: ABL1 protein-protein interaction. Reason: Generic protein binding; specific partners provide functional context. Supporting Evidence: PMID:17515907 May 21. Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. |
| GO:0005515 protein binding | IPI PMID:17888034 Fibroblast growth factor receptor 1 oncogene partner as a no... | KEEP AS NON CORE | Summary: ABL1 protein-protein interaction. Reason: Generic protein binding term. Supporting Evidence: PMID:17888034 Epub 2007 Sep 18. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. |
| GO:0005515 protein binding | IPI PMID:22810897 Abl family kinases modulate T cell-mediated inflammation and... | KEEP AS NON CORE | Summary: ABL1 binds NEDD9. Reason: Generic protein binding; NEDD9 interaction relates to cell adhesion/migration. Supporting Evidence: PMID:22810897 Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. |
| GO:0005515 protein binding | IPI PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association ... | KEEP AS NON CORE | Summary: ABL1 binds CLASP2. Reason: Generic protein binding; CLASP2 interaction relates to microtubule regulation. Supporting Evidence: PMID:24520051 2014 Mar 12. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. |
| GO:0005515 protein binding | IPI PMID:9461559 Regulation of Rad51 function by c-Abl in response to DNA dam... | KEEP AS NON CORE | Summary: ABL1 binds RAD51. Reason: Generic protein binding; RAD51 interaction supports DNA damage response function. Supporting Evidence: PMID:9461559 Regulation of Rad51 function by c-Abl in response to DNA damage. |
| GO:0005524 ATP binding | IDA PMID:9144171 Protein binding and signaling properties of RIN1 suggest a u... | ACCEPT | Summary: ABL1 binds ATP as substrate for kinase activity. Reason: ATP binding is essential for kinase function. Core to molecular activity. Supporting Evidence: PMID:9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function. |
| GO:0005634 nucleus | IDA PMID:17626041 Cockayne syndrome protein B interacts with and is phosphoryl... | ACCEPT | Summary: ABL1 localizes to the nucleus. Reason: Consistent with nuclear DNA damage response function. Supporting Evidence: PMID:17626041 Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. |
| GO:0005634 nucleus | IDA PMID:17888034 Fibroblast growth factor receptor 1 oncogene partner as a no... | ACCEPT | Summary: ABL1 nuclear localization demonstrated. Reason: Core localization for DNA damage response function. Supporting Evidence: PMID:17888034 Epub 2007 Sep 18. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. |
| GO:0005634 nucleus | IDA PMID:9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosin... | ACCEPT | Summary: ABL1 accumulates in nucleus after DNA damage via ATM activation. Reason: Nuclear localization in response to DNA damage is a core function. Supporting Evidence: PMID:9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: ABL1 localizes to nucleoplasm. Reason: More specific nuclear localization supporting DNA damage response function. |
| GO:0005730 nucleolus | IDA PMID:12944467 Werner syndrome protein phosphorylation by abl tyrosine kina... | ACCEPT | Summary: ABL1 localizes to the nucleolus. Reason: Nucleolar localization supports role in transcription-related functions. Supporting Evidence: PMID:12944467 Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution. |
| GO:0005730 nucleolus | IDA PMID:17626041 Cockayne syndrome protein B interacts with and is phosphoryl... | ACCEPT | Summary: ABL1 localizes to the nucleolus during oxidative stress. Reason: Nucleolar localization in stress response. Supporting Evidence: PMID:17626041 Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. |
| GO:0005737 cytoplasm | IDA PMID:17515907 Structural basis for the transforming activity of human canc... | ACCEPT | Summary: ABL1 localizes to cytoplasm. Reason: Cytoplasmic localization is core, enabling cytoskeletal regulation functions. Supporting Evidence: PMID:17515907 May 21. Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. |
| GO:0005829 cytosol | IDA PMID:11120811 The c-Abl tyrosine kinase is regulated downstream of the B c... | ACCEPT | Summary: ABL1 localizes to cytosol. Reason: Cytosolic localization supporting signaling and cytoskeletal functions. Supporting Evidence: PMID:11120811 The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. |
| GO:0006974 DNA damage response | IDA PMID:15657060 c-Abl tyrosine kinase regulates caspase-9 autocleavage in th... | ACCEPT | Summary: ABL1 participates in DNA damage response. Reason: Core biological process function for ABL1. Supporting Evidence: PMID:15657060 2005 Jan 18. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. |
| GO:0006979 response to oxidative stress | IGI PMID:17626041 Cockayne syndrome protein B interacts with and is phosphoryl... | ACCEPT | Summary: ABL1 responds to oxidative stress, genetic interaction evidence. Reason: Part of ABL1's stress response functions. Supporting Evidence: PMID:17626041 Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase. |
| GO:0007204 positive regulation of cytosolic calcium ion concentration | IMP PMID:24367707 Abl family kinases regulate endothelial barrier function in ... | KEEP AS NON CORE | Summary: ABL1 regulates cytosolic calcium concentration. Reason: Downstream signaling effect rather than core function. Supporting Evidence: PMID:24367707 eCollection 2013. Abl family kinases regulate endothelial barrier function in vitro and in mice. |
| GO:0007229 integrin-mediated signaling pathway | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | ACCEPT | Summary: ABL1 regulates integrin-mediated signaling. Reason: Integrin signaling relates to core cytoskeletal regulatory function. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0008047 enzyme activator activity | IDA PMID:12893824 Glutathione peroxidase 1 is regulated by the c-Abl and Arg t... | KEEP AS NON CORE | Summary: ABL1 activates glutathione peroxidase 1. Reason: Enzyme activator is a more generic function; specific to oxidative stress response. Supporting Evidence: PMID:12893824 2003 Jul 31. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. |
| GO:0010595 positive regulation of endothelial cell migration | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | KEEP AS NON CORE | Summary: ABL1 promotes endothelial cell migration via neuropilin signaling. Reason: Cell-type-specific phenotype, not core function. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0016301 kinase activity | IMP PMID:28288113 Germline mutations in ABL1 cause an autosomal dominant syndr... | ACCEPT | Summary: ABL1 kinase activity demonstrated by mutant phenotype. Reason: General kinase activity is core to ABL1 function. Supporting Evidence: PMID:28288113 Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations. |
| GO:0016604 nuclear body | IDA GO_REF:0000052 | ACCEPT | Summary: ABL1 localizes to nuclear bodies. Reason: Nuclear body localization consistent with transcription/DNA damage functions. |
| GO:0019899 enzyme binding | IPI PMID:12893824 Glutathione peroxidase 1 is regulated by the c-Abl and Arg t... | KEEP AS NON CORE | Summary: ABL1 binds glutathione peroxidase 1. Reason: Generic enzyme binding; specific to oxidative stress context. Supporting Evidence: PMID:12893824 2003 Jul 31. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. |
| GO:0019905 syntaxin binding | IPI PMID:23006999 Tyrosine phosphorylation of a SNARE protein, syntaxin 17 - i... | KEEP AS NON CORE | Summary: ABL1 binds syntaxin. Reason: Specific binding interaction; not core function. Supporting Evidence: PMID:23006999 Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway. |
| GO:0030145 manganese ion binding | IDA PMID:9144171 Protein binding and signaling properties of RIN1 suggest a u... | ACCEPT | Summary: ABL1 binds manganese ions. Reason: Metal ion binding supports kinase activity (can substitute for magnesium). Supporting Evidence: PMID:9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function. |
| GO:0030516 regulation of axon extension | IMP PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association ... | KEEP AS NON CORE | Summary: ABL1 regulates axon extension through cytoskeletal effects. Reason: Cell-type-specific phenotype related to cytoskeletal regulation. Supporting Evidence: PMID:24520051 2014 Mar 12. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. |
| GO:0030845 phospholipase C-inhibiting G protein-coupled receptor signaling pathway | IMP PMID:24367707 Abl family kinases regulate endothelial barrier function in ... | KEEP AS NON CORE | Summary: ABL1 involved in PLC-inhibiting GPCR signaling. Reason: Specific signaling pathway involvement; not core function. Supporting Evidence: PMID:24367707 eCollection 2013. Abl family kinases regulate endothelial barrier function in vitro and in mice. |
| GO:0031113 regulation of microtubule polymerization | IMP PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association ... | ACCEPT | Summary: ABL1 regulates microtubule polymerization via CLASP2 phosphorylation. Reason: Part of core cytoskeletal regulatory function. Supporting Evidence: PMID:24520051 2014 Mar 12. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. |
| GO:0032489 regulation of Cdc42 protein signal transduction | IMP PMID:26051942 NRP1 Regulates CDC42 Activation to Promote Filopodia Formati... | ACCEPT | Summary: ABL1 regulates Cdc42 signaling. Reason: Cdc42 regulation relates to core cytoskeletal organization function. Supporting Evidence: PMID:26051942 2015 Jun 4. NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. |
| GO:0032956 regulation of actin cytoskeleton organization | IMP PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association ... | ACCEPT | Summary: ABL1 regulates actin cytoskeleton organization. Reason: Core biological process function of ABL1. Supporting Evidence: PMID:24520051 2014 Mar 12. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. |
| GO:0032956 regulation of actin cytoskeleton organization | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | ACCEPT | Summary: ABL1 regulates actin cytoskeleton organization in endothelial cells. Reason: Core cytoskeletal function; this is additional IMP evidence. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0034599 cellular response to oxidative stress | IDA PMID:12893824 Glutathione peroxidase 1 is regulated by the c-Abl and Arg t... | ACCEPT | Summary: ABL1 responds to oxidative stress by activating antioxidant enzymes. Reason: Part of ABL1's stress response function. Supporting Evidence: PMID:12893824 2003 Jul 31. Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases. |
| GO:0035556 intracellular signal transduction | IDA PMID:9144171 Protein binding and signaling properties of RIN1 suggest a u... | ACCEPT | Summary: ABL1 participates in intracellular signal transduction. Reason: Core function as a signaling kinase. Supporting Evidence: PMID:9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function. |
| GO:0035556 intracellular signal transduction | IDA PMID:11121037 Functional interaction between c-Abl and the p21-activated p... | ACCEPT | Summary: ABL1 participates in intracellular signal transduction. Reason: Core signaling function with additional IDA evidence. Supporting Evidence: PMID:11121037 Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. |
| GO:0035791 platelet-derived growth factor receptor-beta signaling pathway | IMP PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association ... | KEEP AS NON CORE | Summary: ABL1 involved in PDGFR-beta signaling. Reason: Specific growth factor signaling pathway; not core evolved function. Supporting Evidence: PMID:24520051 2014 Mar 12. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. |
| GO:0038189 neuropilin signaling pathway | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | KEEP AS NON CORE | Summary: ABL1 involved in neuropilin signaling pathway. Reason: Specific signaling pathway involvement. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0038191 neuropilin binding | IPI PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | KEEP AS NON CORE | Summary: ABL1 binds neuropilin. Reason: Specific binding interaction in angiogenesis context. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0042169 SH2 domain binding | IPI PMID:12384576 Structure of a regulatory complex involving the Abl SH3 doma... | ACCEPT | Summary: ABL1 engages in SH2 domain-mediated interactions. Reason: SH2 domain interactions are core to ABL1 signaling mechanisms. Supporting Evidence: PMID:12384576 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. |
| GO:0042770 signal transduction in response to DNA damage | IDA PMID:15657060 c-Abl tyrosine kinase regulates caspase-9 autocleavage in th... | ACCEPT | Summary: ABL1 signals in response to DNA damage. Reason: Core DNA damage response function. Supporting Evidence: PMID:15657060 2005 Jan 18. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. |
| GO:0042770 signal transduction in response to DNA damage | IDA PMID:18280240 Yap1 phosphorylation by c-Abl is a critical step in selectiv... | ACCEPT | Summary: ABL1 participates in DNA damage signaling. Reason: Core DNA damage response function with additional evidence. Supporting Evidence: PMID:18280240 Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. |
| GO:0042770 signal transduction in response to DNA damage | IDA PMID:9037071 Regulation of DNA damage-induced apoptosis by the c-Abl tyro... | ACCEPT | Summary: ABL1 signals in response to DNA damage to regulate apoptosis. Reason: Core DNA damage response function. Supporting Evidence: PMID:9037071 Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. |
| GO:0043065 positive regulation of apoptotic process | IDA PMID:9037071 Regulation of DNA damage-induced apoptosis by the c-Abl tyro... | ACCEPT | Summary: ABL1 promotes apoptosis in response to DNA damage. Reason: Pro-apoptotic function in response to irreparable DNA damage is a core function. Supporting Evidence: PMID:9037071 Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. |
| GO:0043539 protein serine/threonine kinase activator activity | IDA PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyr... | ACCEPT | Summary: ABL1 activates serine/threonine kinases including PKC. Reason: Kinase activator activity supports signaling function. Supporting Evidence: PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:17888034 Fibroblast growth factor receptor 1 oncogene partner as a no... | ACCEPT | Summary: ABL1 localizes to perinuclear region. Reason: Consistent with shuttling between cytoplasm and nucleus. Supporting Evidence: PMID:17888034 Epub 2007 Sep 18. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. |
| GO:0051019 mitogen-activated protein kinase binding | IPI PMID:11121037 Functional interaction between c-Abl and the p21-activated p... | ACCEPT | Summary: ABL1 binds MAPK/PAK2. Reason: MAPK binding supports signaling integration function. Supporting Evidence: PMID:11121037 Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK. |
| GO:0051444 negative regulation of ubiquitin-protein transferase activity | IDA PMID:20823226 Phosphorylation by the c-Abl protein tyrosine kinase inhibit... | KEEP AS NON CORE | Summary: ABL1 negatively regulates ubiquitin-protein transferase activity. Reason: Regulatory function but not core molecular function. Supporting Evidence: PMID:20823226 Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. |
| GO:0051496 positive regulation of stress fiber assembly | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | ACCEPT | Summary: ABL1 promotes stress fiber assembly. Reason: Part of core cytoskeletal regulatory function. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0051894 positive regulation of focal adhesion assembly | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | ACCEPT | Summary: ABL1 promotes focal adhesion assembly. Reason: Focal adhesion regulation is part of cytoskeletal function. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0070064 proline-rich region binding | IDA PMID:15657060 c-Abl tyrosine kinase regulates caspase-9 autocleavage in th... | ACCEPT | Summary: ABL1 binds proline-rich regions through its SH3 domain. Reason: SH3 domain-mediated binding is core to ABL1 protein interactions. Supporting Evidence: PMID:15657060 2005 Jan 18. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. |
| GO:0070301 cellular response to hydrogen peroxide | IDA PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyr... | ACCEPT | Summary: ABL1 responds to hydrogen peroxide (oxidative stress). Reason: Part of oxidative stress response function. Supporting Evidence: PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. |
| GO:0097100 supercoiled DNA binding | IDA NOT PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase pr... | ACCEPT | Summary: ABL1 does NOT bind supercoiled DNA (negative annotation with NOT qualifier). Reason: Negative annotation indicating specificity of DNA binding - binds junction/bubble structures but not supercoiled. Supporting Evidence: PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. |
| GO:0141214 positive regulation of phospholipase C/protein kinase C signal transduction | IDA PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyr... | KEEP AS NON CORE | Summary: ABL1 activates PLC/PKC signaling. Reason: Specific signaling pathway regulation; downstream of kinase activity. Supporting Evidence: PMID:10713049 Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. |
| GO:1904518 protein localization to cytoplasmic microtubule plus-end | IMP PMID:24520051 Abelson phosphorylation of CLASP2 modulates its association ... | ACCEPT | Summary: ABL1 promotes protein localization to microtubule plus-ends. Reason: Part of microtubule/cytoskeletal regulatory function. Supporting Evidence: PMID:24520051 2014 Mar 12. Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin. |
| GO:1900026 positive regulation of substrate adhesion-dependent cell spreading | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | KEEP AS NON CORE | Summary: ABL1 promotes cell spreading. Reason: Phenotypic outcome of cytoskeletal/adhesion regulation. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:1990837 sequence-specific double-stranded DNA binding | IDA PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase pr... | ACCEPT | Summary: ABL1 binds specific DNA sequences. Reason: Specific DNA binding supports DNA damage response function. Supporting Evidence: PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. |
| GO:2000042 negative regulation of double-strand break repair via homologous recombination | IDA PMID:9461559 Regulation of Rad51 function by c-Abl in response to DNA dam... | ACCEPT | Summary: ABL1 inhibits homologous recombination repair by phosphorylating RAD51. Reason: Important regulatory function in DNA damage response pathway. Supporting Evidence: PMID:9461559 Regulation of Rad51 function by c-Abl in response to DNA damage. |
| GO:0032991 protein-containing complex | IPI PMID:12384576 Structure of a regulatory complex involving the Abl SH3 doma... | KEEP AS NON CORE | Summary: ABL1 is part of protein complexes. Reason: Generic complex annotation; specific complexes are more informative. Supporting Evidence: PMID:12384576 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. |
| GO:0043542 endothelial cell migration | IMP PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting... | KEEP AS NON CORE | Summary: ABL1 involved in endothelial cell migration. Reason: Cell-type-specific phenotype. Supporting Evidence: PMID:24863063 Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. |
| GO:0000278 mitotic cell cycle | TAS PMID:24522549 Oxidative stress-induced signaling pathways implicated in th... | KEEP AS NON CORE | Summary: ABL1 involved in mitotic cell cycle regulation. Reason: Cell cycle involvement but not core molecular function. Supporting Evidence: PMID:24522549 Epub 2014 Feb 13. Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. |
| GO:0003677 DNA binding | NAS PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma pr... | ACCEPT | Summary: ABL1 binds DNA. Reason: DNA binding is a core molecular function of ABL1. Supporting Evidence: PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. |
| GO:0003713 transcription coactivator activity | TAS PMID:15865930 C-Abl as a modulator of p53. | ACCEPT | Summary: ABL1 acts as a transcription coactivator. Reason: Transcriptional regulation is part of nuclear ABL1 function. Supporting Evidence: PMID:15865930 C-Abl as a modulator of p53. |
| GO:0003785 actin monomer binding | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 binds G-actin monomers. Reason: G-actin binding is part of actin cytoskeleton regulatory function. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0004515 nicotinate-nucleotide adenylyltransferase activity | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | REMOVE | Summary: ABL1 has nicotinate-nucleotide adenylyltransferase activity. Reason: Demonstrably wrong. ABL1 is a non-receptor protein tyrosine kinase with no role in NAD biosynthesis; nicotinate-nucleotide adenylyltransferase (NMNAT) activity is unrelated. The cited reference (PMID:20841568) is a review of ABL kinase function/regulation and does not describe any NMNAT activity - the supporting_text is merely the paper title. This is a spurious GOA/curation artifact, not a genuine ambiguity, so REMOVE rather than UNDECIDED. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0004713 protein tyrosine kinase activity | TAS PMID:10391249 The tyrosine kinase c-Abl regulates p73 in apoptotic respons... | ACCEPT | Summary: ABL1 is a protein tyrosine kinase. Reason: Core molecular function. Supporting Evidence: PMID:10391249 The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-428888 | ACCEPT | Summary: ABL1 tyrosine kinase activity in Reactome pathway. Reason: Core molecular function documented in pathway context. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-5686587 | ACCEPT | Summary: ABL1 tyrosine kinase activity in Reactome pathway. Reason: Core molecular function in pathway context. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-8956659 | ACCEPT | Summary: ABL1 tyrosine kinase activity in Reactome pathway. Reason: Core molecular function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9841924 | ACCEPT | Summary: ABL1 tyrosine kinase activity. Reason: Core molecular function. |
| GO:0004713 protein tyrosine kinase activity | TAS Reactome:R-HSA-9865196 | ACCEPT | Summary: ABL1 tyrosine kinase activity. Reason: Core molecular function. |
| GO:0005634 nucleus | NAS PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma pr... | ACCEPT | Summary: ABL1 localizes to nucleus. Reason: Core localization. Supporting Evidence: PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. |
| GO:0005634 nucleus | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 localizes to nucleus. Reason: Core localization. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5686578 | ACCEPT | Summary: ABL1 localizes to nucleoplasm. Reason: Core nuclear localization. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5686587 | ACCEPT | Summary: ABL1 localizes to nucleoplasm. Reason: Core nuclear localization. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8956659 | ACCEPT | Summary: ABL1 localizes to nucleoplasm. Reason: Core nuclear localization. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9841924 | ACCEPT | Summary: ABL1 localizes to nucleoplasm. Reason: Core nuclear localization. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9842028 | ACCEPT | Summary: ABL1 localizes to nucleoplasm. Reason: Core nuclear localization. |
| GO:0005737 cytoplasm | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 localizes to cytoplasm. Reason: Core localization. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0005739 mitochondrion | NAS PMID:24522549 Oxidative stress-induced signaling pathways implicated in th... | ACCEPT | Summary: ABL1 localizes to mitochondria. Reason: Mitochondrial localization documented, relevant to apoptosis and oxidative stress functions. Supporting Evidence: PMID:24522549 Epub 2014 Feb 13. Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130194 | ACCEPT | Summary: ABL1 localizes to cytosol. Reason: Core cytosolic localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-376141 | ACCEPT | Summary: ABL1 in cytosol (Reactome pathway). Reason: Core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-428888 | ACCEPT | Summary: ABL1 in cytosol. Reason: Core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448958 | ACCEPT | Summary: ABL1 in cytosol. Reason: Core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9865184 | ACCEPT | Summary: ABL1 in cytosol. Reason: Core localization. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9865196 | ACCEPT | Summary: ABL1 in cytosol. Reason: Core localization. |
| GO:0006298 mismatch repair | TAS PMID:10391249 The tyrosine kinase c-Abl regulates p73 in apoptotic respons... | ACCEPT | Summary: ABL1 involved in mismatch repair. Reason: Part of DNA damage response function. Supporting Evidence: PMID:10391249 The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. |
| GO:0006355 regulation of DNA-templated transcription | TAS PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma pr... | ACCEPT | Summary: ABL1 regulates transcription. Reason: Part of nuclear ABL1 function. Supporting Evidence: PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. |
| GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage | TAS PMID:10391249 The tyrosine kinase c-Abl regulates p73 in apoptotic respons... | ACCEPT | Summary: ABL1 promotes intrinsic apoptosis after DNA damage. Reason: Core DNA damage response function. Supporting Evidence: PMID:10391249 The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. |
| GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 involved in DNA damage-induced apoptosis. Reason: Core function. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0010506 regulation of autophagy | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | MARK AS OVER ANNOTATED | Summary: ABL1 regulates autophagy. Reason: Per previous guidance, autophagy-related annotations should be marked as over-annotated for ABL1. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0015629 actin cytoskeleton | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 localizes to actin cytoskeleton. Reason: Core localization for cytoskeletal function. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0030100 regulation of endocytosis | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | KEEP AS NON CORE | Summary: ABL1 regulates endocytosis. Reason: Endocytosis regulation is a downstream effect of cytoskeletal function. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0030155 regulation of cell adhesion | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 regulates cell adhesion. Reason: Cell adhesion regulation is part of core cytoskeletal/integrin functions. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0032956 regulation of actin cytoskeleton organization | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 regulates actin cytoskeleton organization. Reason: Core biological process function. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0034599 cellular response to oxidative stress | TAS PMID:24522549 Oxidative stress-induced signaling pathways implicated in th... | ACCEPT | Summary: ABL1 responds to oxidative stress. Reason: Part of stress response function. Supporting Evidence: PMID:24522549 Epub 2014 Feb 13. Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. |
| GO:0036211 protein modification process | NAS PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma pr... | ACCEPT | Summary: ABL1 modifies proteins (phosphorylation). Reason: General annotation for kinase function. Supporting Evidence: PMID:8242749 A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-2029480 | KEEP AS NON CORE | Summary: ABL1 involved in Fc-gamma receptor signaling. Reason: Specific signaling pathway; not core function. |
| GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis | TAS Reactome:R-HSA-9664422 | KEEP AS NON CORE | Summary: ABL1 in Fc-gamma receptor signaling. Reason: Specific pathway annotation. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | TAS PMID:15865930 C-Abl as a modulator of p53. | ACCEPT | Summary: ABL1 promotes RNA Pol II transcription. Reason: Part of transcriptional coactivator function. Supporting Evidence: PMID:15865930 C-Abl as a modulator of p53. |
| GO:0051726 regulation of cell cycle | TAS PMID:24522549 Oxidative stress-induced signaling pathways implicated in th... | KEEP AS NON CORE | Summary: ABL1 regulates cell cycle. Reason: Cell cycle regulation is downstream of core signaling functions. Supporting Evidence: PMID:24522549 Epub 2014 Feb 13. Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. |
| GO:0051882 mitochondrial depolarization | TAS PMID:24522549 Oxidative stress-induced signaling pathways implicated in th... | KEEP AS NON CORE | Summary: ABL1 involved in mitochondrial depolarization. Reason: Related to apoptosis but specific mitochondrial effect. Supporting Evidence: PMID:24522549 Epub 2014 Feb 13. Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. |
| GO:0071103 DNA conformation change | IDA PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase pr... | ACCEPT | Summary: ABL1 induces DNA conformation changes. Reason: Part of DNA binding/DNA damage response function. Supporting Evidence: PMID:9558345 The DNA binding domain of the human c-Abl tyrosine kinase preferentially binds to DNA sequences containing an AAC motif and to distorted DNA structures. |
| GO:0097706 vascular endothelial cell response to oscillatory fluid shear stress | TAS Reactome:R-HSA-9860927 | KEEP AS NON CORE | Summary: ABL1 involved in endothelial shear stress response. Reason: Cell-type-specific response. |
| GO:0098794 postsynapse | TAS PMID:24658113 EphA4 activation of c-Abl mediates synaptic loss and LTP blo... | KEEP AS NON CORE | Summary: ABL1 localizes to postsynapse. Reason: Cell-type-specific localization in neurons. Supporting Evidence: PMID:24658113 eCollection 2014. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-Ξ² oligomers. |
| GO:1902036 regulation of hematopoietic stem cell differentiation | TAS Reactome:R-HSA-8939236 | KEEP AS NON CORE | Summary: ABL1 regulates hematopoietic stem cell differentiation. Reason: Cell-type-specific developmental function. |
| GO:1903351 cellular response to dopamine | TAS PMID:24522549 Oxidative stress-induced signaling pathways implicated in th... | KEEP AS NON CORE | Summary: ABL1 responds to dopamine. Reason: Specific stimulus response; relevant to Parkinson's disease context. Supporting Evidence: PMID:24522549 Epub 2014 Feb 13. Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease. |
| GO:2000145 regulation of cell motility | TAS PMID:20841568 ABL tyrosine kinases - evolution of function, regulation, an... | ACCEPT | Summary: ABL1 regulates cell motility. Reason: Motility regulation through cytoskeletal effects is a core function. Supporting Evidence: PMID:20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity. |
| GO:0005634 nucleus | ISS GO_REF:0000024 | ACCEPT | Summary: ABL1 nuclear localization inferred from sequence similarity. Reason: Consistent with experimentally validated nuclear localization. |
| GO:0030036 actin cytoskeleton organization | ISS GO_REF:0000024 | ACCEPT | Summary: ABL1 role in actin organization inferred from mouse ortholog. Reason: Core function consistent with experimental evidence. |
| GO:0030425 dendrite | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ABL1 dendrite localization from ortholog inference. Reason: Cell-type-specific neuronal localization. |
| GO:0043025 neuronal cell body | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ABL1 neuronal cell body localization inferred. Reason: Cell-type-specific localization. |
| GO:0045580 regulation of T cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ABL1 regulates T cell differentiation (ortholog inference). Reason: Cell-type-specific developmental function. |
| GO:0046875 ephrin receptor binding | ISS GO_REF:0000024 | ACCEPT | Summary: ABL1 binds ephrin receptors (ortholog inference). Reason: Ephrin receptor interaction documented, relevant to cytoskeletal signaling. |
| GO:1900272 negative regulation of long-term synaptic potentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ABL1 negatively regulates LTP (ortholog inference). Reason: Cell-type-specific neuronal function. |
| GO:1903905 positive regulation of establishment of T cell polarity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ABL1 promotes T cell polarity (ortholog inference). Reason: Cell-type-specific function. |
| GO:1905244 regulation of modification of synaptic structure | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ABL1 regulates synaptic structure (ortholog inference). Reason: Cell-type-specific neuronal function. |
| GO:2000406 positive regulation of T cell migration | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ABL1 promotes T cell migration (ortholog inference). Reason: Cell-type-specific function. |
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