ID   ABTB2_HUMAN             Reviewed;        1025 AA.
AC   Q8N961; A8K6S9; E9PRW7; Q52LD6; Q6MZW4; Q8NB44;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 2.
DT   28-JAN-2026, entry version 178.
DE   RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein 2;
GN   Name=ABTB2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   GLN-250.
RC   TISSUE=Fetal brain, and Placenta;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 626-1025 (ISOFORM 1/2).
RC   TISSUE=Rectum tumor;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- FUNCTION: May be involved in the initiation of hepatocyte growth.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N961; P62258: YWHAE; NbExp=2; IntAct=EBI-11603395, EBI-356498;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N961-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N961-2; Sequence=VSP_046439;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH93968.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC03697.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAF84433.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAF84433.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK091560; BAC03697.1; ALT_INIT; mRNA.
DR   EMBL; AK095632; BAC04595.1; -; mRNA.
DR   EMBL; AK291744; BAF84433.1; ALT_SEQ; mRNA.
DR   EMBL; AC090469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL035079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL133294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL139174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC093968; AAH93968.1; ALT_INIT; mRNA.
DR   EMBL; BX640841; CAE45913.3; -; mRNA.
DR   CCDS; CCDS7890.2; -. [Q8N961-1]
DR   RefSeq; NP_665803.2; NM_145804.3. [Q8N961-1]
DR   AlphaFoldDB; Q8N961; -.
DR   SMR; Q8N961; -.
DR   BioGRID; 117367; 130.
DR   FunCoup; Q8N961; 135.
DR   IntAct; Q8N961; 88.
DR   STRING; 9606.ENSP00000410157; -.
DR   GlyGen; Q8N961; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N961; -.
DR   PhosphoSitePlus; Q8N961; -.
DR   BioMuta; ABTB2; -.
DR   DMDM; 485955977; -.
DR   jPOST; Q8N961; -.
DR   MassIVE; Q8N961; -.
DR   PaxDb; 9606-ENSP00000410157; -.
DR   PeptideAtlas; Q8N961; -.
DR   ProteomicsDB; 23438; -.
DR   ProteomicsDB; 72494; -. [Q8N961-1]
DR   Pumba; Q8N961; -.
DR   Antibodypedia; 12992; 67 antibodies from 16 providers.
DR   DNASU; 25841; -.
DR   Ensembl; ENST00000435224.3; ENSP00000410157.2; ENSG00000166016.7. [Q8N961-1]
DR   GeneID; 25841; -.
DR   KEGG; hsa:25841; -.
DR   MANE-Select; ENST00000435224.3; ENSP00000410157.2; NM_145804.3; NP_665803.2.
DR   UCSC; uc001mvl.3; human. [Q8N961-1]
DR   AGR; HGNC:23842; -.
DR   ClinPGx; PA134937734; -.
DR   CTD; 25841; -.
DR   DisGeNET; 25841; -.
DR   GeneCards; ABTB2; -.
DR   HGNC; HGNC:23842; ABTB2.
DR   HPA; ENSG00000166016; Tissue enhanced (brain).
DR   MIM; 621014; gene.
DR   OpenTargets; ENSG00000166016; -.
DR   VEuPathDB; HostDB:ENSG00000166016; -.
DR   eggNOG; ENOG502QSQY; Eukaryota.
DR   GeneTree; ENSGT00940000157661; -.
DR   HOGENOM; CLU_001918_0_0_1; -.
DR   InParanoid; Q8N961; -.
DR   OMA; LQCNGST; -.
DR   OrthoDB; 2316821at2759; -.
DR   PAN-GO; Q8N961; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; Q8N961; -.
DR   PathwayCommons; Q8N961; -.
DR   SignaLink; Q8N961; -.
DR   Agora; ENSG00000166016; -.
DR   BioGRID-ORCS; 25841; 19 hits in 1192 CRISPR screens.
DR   ChiTaRS; ABTB2; human.
DR   GenomeRNAi; 25841; -.
DR   Pharos; Q8N961; Tdark.
DR   PRO; PR:Q8N961; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8N961; protein.
DR   Bgee; ENSG00000166016; Expressed in secondary oocyte and 165 other cell types or tissues.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0097237; P:cellular response to toxic substance; IEA:Ensembl.
DR   CDD; cd18526; BACK_ABTB2; 1.
DR   CDD; cd18350; BTB_POZ_ABTB2_BPOZ2; 1.
DR   CDD; cd22913; HFD_ABTB2-like; 1.
DR   FunFam; 1.25.40.20:FF:000045; Ankyrin repeat and BTB/POZ domain-containing protein 2; 1.
DR   FunFam; 1.10.20.10:FF:000057; ankyrin repeat and BTB/POZ domain-containing protein 2; 1.
DR   FunFam; 3.30.710.10:FF:000030; Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   Gene3D; 3.30.710.10; Potassium Channel Kv1.1, Chain A; 1.
DR   InterPro; IPR059008; ABTB2/3_histone.
DR   InterPro; IPR048063; ABTB2_BTB_POZ.
DR   InterPro; IPR052089; Ankyrin-BTB/POZ_domain.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46071; ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR46071:SF3; ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF26281; Histone_ABTB; 1.
DR   SMART; SM00248; ANK; 5.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF47113; Histone-fold; 2.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
DR   PROSITE; PS50097; BTB; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; ANK repeat; Proteomics identification;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1025
FT                   /note="Ankyrin repeat and BTB/POZ domain-containing protein
FT                   2"
FT                   /id="PRO_0000066887"
FT   REPEAT          521..550
FT                   /note="ANK 1"
FT   REPEAT          567..596
FT                   /note="ANK 2"
FT   REPEAT          606..635
FT                   /note="ANK 3"
FT   REPEAT          649..678
FT                   /note="ANK 4"
FT   DOMAIN          845..914
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   VAR_SEQ         1..186
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_046439"
FT   VARIANT         250
FT                   /note="H -> Q (in dbSNP:rs1925368)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_022087"
FT   VARIANT         918
FT                   /note="T -> A (in dbSNP:rs2473928)"
FT                   /id="VAR_024171"
FT   CONFLICT        189
FT                   /note="A -> D (in Ref. 1; BAF84433)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1025 AA;  113656 MW;  E0DBA1B9BC0AFB82 CRC64;
     MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS
     MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF
     SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
     ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
     EIRARVMASH SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
     AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
     CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
     PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR
     AATEKFNQDL GFRMLNCGRT DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM
     LIDAGANLDI QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
     GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED MNCFSHSAAH
     GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG SGSEGPVRLS RTRTKALQEA
     MYYSAEHGYV DITMELRALG VPWKLHIWIE SLRTSFSQSR YSVVQSLLRD FSSIREEEYN
     EELVTEGLQL MFDILKTSKN DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN
     NKEMSDVTFL VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM
     MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME SAVNTYKYAK
     IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ GLDPLQDLQN TLAERVHSVY
     ITSRV
//