id: Q16186
gene_symbol: ADRM1
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: ADRM1 encodes the human proteasomal ubiquitin receptor Rpn13, a 19S regulatory-particle subunit/cofactor
  of the 26S proteasome. Its N-terminal Pru domain binds ubiquitin signals and the Rpn2/PSMD1 proteasome
  scaffold, while its C-terminal DEUBAD region binds the UCHL5/UCH37 deubiquitinase. Through these interactions
  ADRM1 helps recruit ubiquitinated substrates and coordinate deubiquitinase activity during proteasome-mediated
  protein degradation in cytosolic and nuclear proteostasis.
existing_annotations:
- term:
    id: GO:0008541
    label: proteasome regulatory particle, lid subcomplex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: part_of
  review:
    summary: The evidence supports ADRM1/Rpn13 as a 19S regulatory-particle ubiquitin receptor, but the
      lid-subcomplex placement is less accurate for ADRM1 than the base-subcomplex placement used by the
      PN projection.
    action: MODIFY
    reason: Modify to proteasome regulatory particle, base subcomplex. Primary and structural literature
      describe Rpn13/ADRM1 as a 19S regulatory-particle subunit and as one of the base ubiquitin receptors;
      this supports the PN base-subcomplex projection and argues against retaining the lid-subcomplex
      term for ADRM1.
    proposed_replacement_terms:
    - id: GO:0008540
      label: proteasome regulatory particle, base subcomplex
    - id: GO:0005838
      label: proteasome regulatory particle
    additional_reference_ids:
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
    - reference_id: file:human/ADRM1/ADRM1-deep-research-manual.md
      supporting_text: The Proteostasis PN projection is conservative for ADRM1; proteasome complex
        and regulatory-particle terms are safe, and literature supports modifying the lid-subcomplex
        annotation to the base subcomplex.
- term:
    id: GO:0061133
    label: endopeptidase activator activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: ADRM1 activates the proteasome-associated deubiquitinase UCHL5/UCH37, so the current endopeptidase
      activator term is too generic and mechanistically imprecise.
    action: MODIFY
    reason: Modify to deubiquitinase activator activity. The cited evidence is about recruiting/activating
      UCH37/UCHL5 deubiquitinating activity at 26S proteasomes, not a broad endopeptidase activator role.
    proposed_replacement_terms:
    - id: GO:0035800
      label: deubiquitinase activator activity
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:16990800
      supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0070628
    label: proteasome binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: ADRM1 binds/incorporates into the 26S proteasome regulatory particle through its Rpn13/Rpn2-associated
      receptor role.
    action: ACCEPT
    reason: Accept as a direct molecular function. ADRM1 is a proteasome-associated ubiquitin receptor
      and interacts with the proteasome scaffolding protein Rpn2/PSMD1; this is also consistent with the
      PN regulatory-particle projection.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16713569
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16990800
  qualifier: enables
  review:
    summary: This protein-binding evidence is real but should be represented by more specific proteasome
      binding and UCHL5/UCH37 binding terms.
    action: MODIFY
    reason: Modify away from generic protein binding. The original evidence supports ADRM1 association
      with proteasome subunits and the UCHL5/UCH37 deubiquitinase, which are better captured by proteasome
      binding and ubiquitin-specific protease binding/deubiquitinase-regulator annotations.
    proposed_replacement_terms:
    - id: GO:0070628
      label: proteasome binding
    - id: GO:1990381
      label: ubiquitin-specific protease binding
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17139257
  qualifier: enables
  review:
    summary: This protein-binding evidence is real but should be represented by more specific proteasome
      binding and UCHL5/UCH37 binding terms.
    action: MODIFY
    reason: Modify away from generic protein binding. The original evidence supports ADRM1 association
      with proteasome subunits and the UCHL5/UCH37 deubiquitinase, which are better captured by proteasome
      binding and ubiquitin-specific protease binding/deubiquitinase-regulator annotations.
    proposed_replacement_terms:
    - id: GO:0070628
      label: proteasome binding
    - id: GO:1990381
      label: ubiquitin-specific protease binding
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18497817
  qualifier: enables
  review:
    summary: This protein-binding row captures direct ubiquitin/UBL-substrate receptor evidence and should
      be replaced by ubiquitin binding.
    action: MODIFY
    reason: Modify to ubiquitin binding. Husnjak et al. identify Rpn13/ADRM1 as a proteasomal ubiquitin
      receptor and map ubiquitin binding to the Pru domain; generic protein binding hides the informative
      molecular function.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: Rpn13 functions as a ubiquitin receptor for the proteasome
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18922472
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19490896
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19615732
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20059542
  qualifier: enables
  review:
    summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit
      interactions, but those should be represented with more specific terms.
    action: MODIFY
    reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly
      recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is
      too broad for curation.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    - id: GO:0070628
      label: proteasome binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21516116
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24811749
  qualifier: enables
  review:
    summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit
      interactions, but those should be represented with more specific terms.
    action: MODIFY
    reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly
      recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is
      too broad for curation.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    - id: GO:0070628
      label: proteasome binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25416956
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27107012
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28514442
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31064842
  qualifier: enables
  review:
    summary: This generic protein-binding annotation reflects ADRM1 receptor/shuttle-factor or proteasome-subunit
      interactions, but those should be represented with more specific terms.
    action: MODIFY
    reason: Modify to more informative binding terms where the evidence supports them. ADRM1 directly
      recognizes ubiquitin and associates with the proteasome/Rpn2 context; generic protein binding is
      too broad for curation.
    proposed_replacement_terms:
    - id: GO:0043130
      label: ubiquitin binding
    - id: GO:0070628
      label: proteasome binding
    additional_reference_ids:
    - PMID:18497817
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31515488
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:40205054
  qualifier: enables
  review:
    summary: This generic protein-binding annotation comes from interaction evidence, but generic protein
      binding is uninformative for ADRM1.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. ADRM1 has specific, better-supported binding functions as a proteasomal
      ubiquitin receptor, a proteasome/Rpn2-associated protein, and a UCHL5-binding deubiquitinase regulator.
      Screen-derived or duplicate protein-binding rows should not be retained as core molecular functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: NAS
  original_reference_id: PMID:29636472
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: NAS
  original_reference_id: PMID:33729481
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: NAS
  original_reference_id: PMID:37228199
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: NAS
  original_reference_id: PMID:12032076
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0006979
    label: response to oxidative stress
  evidence_type: NAS
  original_reference_id: PMID:35858375
  qualifier: involved_in
  review:
    summary: The cited PA28-20S structural work does not provide ADRM1-specific oxidative-stress function.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. Proteasome capacity and ADRM1/Rpn13 autoubiquitination can respond
      to proteotoxic stress, but the GOA-cited PA28-20S paper does not make ADRM1 a direct response-to-oxidative-stress
      gene product.
    additional_reference_ids:
    - PMID:24811749
    supported_by:
    - reference_id: PMID:24811749
      supporting_text: Rpn13 becomes extensively and selectively poly-ubiquitinated by the proteasome-associated
        ubiquitin ligase, Ube3c/Hul5
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0008021
    label: synaptic vesicle
  evidence_type: NAS
  original_reference_id: PMID:37228199
  qualifier: located_in
  review:
    summary: The cited work supports free 19S regulatory particles near synapses, but not ADRM1 as a synaptic-vesicle
      component.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. A 19S regulatory-particle pool at synapses is relevant proteasome
      biology, but synaptic vesicle is too specific for ADRM1 without direct ADRM1-resolved localization
      evidence.
    additional_reference_ids:
    - PMID:37228199
    supported_by:
    - reference_id: PMID:37228199
      supporting_text: unexpected abundance of free 19S particles near synapses
- term:
    id: GO:0010498
    label: proteasomal protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:33729481
  qualifier: involved_in
  review:
    summary: ADRM1 contributes to proteasomal protein catabolism by recognizing ubiquitinated substrates
      as Rpn13 and supporting proteasome-associated UCHL5 activity.
    action: ACCEPT
    reason: Accept as a direct proteostasis process at an appropriate broad level. ADRM1 is not the protease
      catalytic subunit, but its ubiquitin-receptor and UCHL5-regulatory roles are part of proteasomal
      substrate processing.
    additional_reference_ids:
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:33729481
      supporting_text: Proteasomes are also vital for maintaining intracellular protein quality control
        by removing misfolded or aggregate-prone damaged proteins
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:19489727
  qualifier: involved_in
  review:
    summary: ADRM1/Rpn13 functions in ubiquitin-dependent proteasomal degradation by binding ubiquitin
      signals and supporting 26S proteasome substrate processing.
    action: ACCEPT
    reason: Accept as a core biological process. Multiple primary studies and reviews support ADRM1 as
      a 26S proteasome ubiquitin receptor required for efficient degradation of ubiquitin conjugates.
    additional_reference_ids:
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:33729481
  qualifier: involved_in
  review:
    summary: ADRM1/Rpn13 functions in ubiquitin-dependent proteasomal degradation by binding ubiquitin
      signals and supporting 26S proteasome substrate processing.
    action: ACCEPT
    reason: Accept as a core biological process. Multiple primary studies and reviews support ADRM1 as
      a 26S proteasome ubiquitin receptor required for efficient degradation of ubiquitin conjugates.
    additional_reference_ids:
    - PMID:17139257
    - PMID:18497817
    - PMID:20471946
    - PMID:33729481
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:18497817
      supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
        receptor for ubiquitin (Pru) domain
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0061136
    label: regulation of proteasomal protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:12032076
  qualifier: involved_in
  review:
    summary: ADRM1 regulates proteasomal protein catabolism through substrate-recognition and UCHL5-recruitment
      mechanisms.
    action: ACCEPT
    reason: Accept. The term is broad, but it fits ADRM1/Rpn13 as a ubiquitin receptor and UCHL5 recruiter
      whose loss or modification changes degradation of ubiquitin conjugates.
    additional_reference_ids:
    - PMID:17139257
    - PMID:20471946
    - PMID:24811749
    supported_by:
    - reference_id: PMID:17139257
      supporting_text: Knockdown of hRpn13 in 293T cells increases the cellular levels of ubiquitin conjugates
        and decreases the degradation of short-lived proteins
    - reference_id: PMID:20471946
      supporting_text: When wild-type hRpn13 was added to these proteasomes, the degradation of ubiquitinated
        cyclin B was strongly stimulated
    - reference_id: PMID:24811749
      supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
        ubiquitin-conjugated proteins
- term:
    id: GO:0071357
    label: cellular response to type I interferon
  evidence_type: NAS
  original_reference_id: PMID:31380390
  qualifier: involved_in
  review:
    summary: The cited review discusses proteasome regulation in broad cellular contexts and does not
      establish ADRM1 as a direct type-I-interferon response effector.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. Type-I-interferon biology can regulate proteasome composition/activity,
      but ADRM1 should not receive a gene-level cellular response to type I interferon annotation from
      this broad proteasome-regulation review.
    additional_reference_ids:
    - PMID:31380390
    supported_by:
    - reference_id: PMID:31380390
      supporting_text: altered transcription of proteasomal subunits and activators
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: EXP
  original_reference_id: PMID:16990800
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: EXP
  original_reference_id: PMID:16990800
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174058
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-187574
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-188191
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5635854
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-68825
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-69600
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8939801
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952408
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9762096
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9604648
  qualifier: located_in
  review:
    summary: ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome
      distribution.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. Reactome nucleoplasm rows represent proteasome-catalyzed
      degradation events in nuclear pathways rather than independent ADRM1 pathway functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1168640
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234159
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1236970
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1504193
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174105
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174202
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174203
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-174255
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-180573
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-180603
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-209061
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2130282
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-264458
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-353125
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3640874
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-450466
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4608855
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4641256
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4641260
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5362448
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5387392
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5607724
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5607731
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610754
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610758
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610760
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5635868
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5658430
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5665854
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5665871
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5668481
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5668520
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5687112
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5689539
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-68948
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-69016
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-75825
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8850992
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8852354
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8854044
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8854071
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8866553
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8866858
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8932355
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956140
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956184
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8957265
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9755303
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9755306
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9766223
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-983150
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9907980
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9908026
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9908178
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929352
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929486
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9931314
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9934893
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9954728
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-212917
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-5610751
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9011324
  qualifier: located_in
  review:
    summary: ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization
      annotations also support cytosol/cytoplasm.
    action: ACCEPT
    reason: Accept as a broad supported cellular location. The many Reactome cytosol rows reflect placement
      of the proteasome catalyst in substrate-degradation events; they should not be read as separate
      substrate-specific ADRM1 functions.
    additional_reference_ids:
    - PMID:16990800
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:33729481
      supporting_text: The 26S proteasome is the major proteasome species in eukaryotes, responsible for
        proteolysis in the cytoplasm, in the nucleus
- term:
    id: GO:0140678
    label: molecular function inhibitor activity
  evidence_type: EXP
  original_reference_id: PMID:20471946
  qualifier: enables
  review:
    summary: The evidence describes intramolecular/autoregulatory inhibition of free hRpn13 ubiquitin-receptor
      activity by its C-terminal domain, not ADRM1 acting primarily as a standalone inhibitor.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. The autoinhibitory structural state is real, but the core function
      of ADRM1 is proteasomal ubiquitin receptor/deubiquitinase regulator; proteasome docking activates
      ubiquitin binding, so a broad inhibitor-activity annotation overstates the gene product role.
    additional_reference_ids:
    - PMID:20471946
    supported_by:
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
    - reference_id: PMID:20471946
      supporting_text: hRpn13's Uch37-binding domain can inhibit its activity as a ubiquitin receptor
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: IDA
  original_reference_id: PMID:17323924
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0061133
    label: endopeptidase activator activity
  evidence_type: IDA
  original_reference_id: PMID:16990800
  qualifier: enables
  review:
    summary: ADRM1 activates the proteasome-associated deubiquitinase UCHL5/UCH37, so the current endopeptidase
      activator term is too generic and mechanistically imprecise.
    action: MODIFY
    reason: Modify to deubiquitinase activator activity. The cited evidence is about recruiting/activating
      UCH37/UCHL5 deubiquitinating activity at 26S proteasomes, not a broad endopeptidase activator role.
    proposed_replacement_terms:
    - id: GO:0035800
      label: deubiquitinase activator activity
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:16990800
      supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
- term:
    id: GO:0002020
    label: protease binding
  evidence_type: IPI
  original_reference_id: PMID:18922472
  qualifier: enables
  review:
    summary: The original protease-binding row is specifically UCHL5/UCH37 binding and should use the
      more informative ubiquitin-specific protease binding term.
    action: MODIFY
    reason: Modify to ubiquitin-specific protease binding. UCHL5/UCH37 is a proteasome-associated deubiquitinating
      enzyme, and ADRM1 binds/recruits it through the C-terminal DEUBAD region.
    proposed_replacement_terms:
    - id: GO:1990381
      label: ubiquitin-specific protease binding
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:18922472
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
        enzyme, UCH37, and enhances its isopeptidase activity
    - reference_id: PMID:18922472
      supporting_text: The conserved DUB Uch37 is found on proteasomes
    - reference_id: PMID:20471946
      supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
        and Uch37
- term:
    id: GO:0070628
    label: proteasome binding
  evidence_type: IDA
  original_reference_id: PMID:18162577
  qualifier: enables
  review:
    summary: ADRM1 binds/incorporates into the 26S proteasome regulatory particle through its Rpn13/Rpn2-associated
      receptor role.
    action: ACCEPT
    reason: Accept as a direct molecular function. ADRM1 is a proteasome-associated ubiquitin receptor
      and interacts with the proteasome scaffolding protein Rpn2/PSMD1; this is also consistent with the
      PN regulatory-particle projection.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:20471946
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:20471946
      supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
        interactions, thus activating hRpn13 for ubiquitin binding
- term:
    id: GO:0000502
    label: proteasome complex
  evidence_type: IDA
  original_reference_id: PMID:16990800
  qualifier: part_of
  review:
    summary: ADRM1 is a component of the 26S proteasome/regulatory-particle complex and is repeatedly
      recovered in proteasome structural and biochemical studies.
    action: ACCEPT
    reason: Accept. Although the more precise PN-supported complex placement is the regulatory-particle
      base subcomplex, proteasome complex is a true broader cellular-component annotation for ADRM1.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    - PMID:29636472
    - PMID:33729481
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    - reference_id: PMID:29636472
      supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
        Rpn10 and Rpn13, the base subunits within the holoenzyme
    - reference_id: PMID:33729481
      supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated
        ubiquitin tag on the substrate
- term:
    id: GO:0006368
    label: transcription elongation by RNA polymerase II
  evidence_type: IMP
  original_reference_id: PMID:11818576
  qualifier: involved_in
  review:
    summary: The cached abstract for the cited Elongator paper does not connect ADRM1 to RNA polymerase
      II transcription elongation.
    action: REMOVE
    reason: Remove this annotation. The cited paper describes the human Elongator complex and RNA polymerase
      II transcription through chromatin, but the cached text provides no ADRM1/Rpn13-specific connection;
      ADRM1's supported role is proteasomal ubiquitin recognition and UCHL5/UCH37 regulation, not transcription
      elongation.
    additional_reference_ids:
    - PMID:11818576
    supported_by:
    - reference_id: PMID:11818576
      supporting_text: human Elongator facilitates transcription by RNA polymerase II
- term:
    id: GO:0043248
    label: proteasome assembly
  evidence_type: IDA
  original_reference_id: PMID:16990800
  qualifier: involved_in
  review:
    summary: ADRM1 is recruited to 26S proteasomes and recruits UCHL5, but the cited evidence does not
      clearly show a proteasome assembly process role.
    action: MARK_AS_OVER_ANNOTATED
    reason: Mark as over-annotated. The evidence supports proteasome binding/base-subcomplex membership
      and UCHL5 recruitment. It does not show ADRM1 catalyzing or directing proteasome assembly as a core
      biological process.
    additional_reference_ids:
    - PMID:16990800
    - PMID:17139257
    supported_by:
    - reference_id: PMID:16990800
      supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
        in mammalian cells
    - reference_id: PMID:16990800
      supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    - reference_id: PMID:17139257
      supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
references:
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:11818576
  title: Human Elongator facilitates RNA polymerase II transcription through chromatin.
  findings:
  - statement: The paper supports human Elongator in RNA polymerase II transcription through chromatin,
      not an ADRM1/Rpn13 role.
    supporting_text: human Elongator facilitates transcription by RNA polymerase II in a chromatin- and
      acetyl-CoA-dependent manner
    reference_section_type: ABSTRACT
- id: PMID:12032076
  title: Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.
  findings: []
- id: PMID:16713569
  title: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell
    degeneration.
  findings: []
- id: PMID:16990800
  title: A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.
  findings:
  - statement: ADRM1/Rpn13 is a mammalian proteasome-interacting protein that recruits UCH37 to 26S
      proteasomes.
    supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
    reference_section_type: ABSTRACT
  - statement: ADRM1/Rpn13 depletion reduces proteasome-associated UCH37 and deubiquitinating activity.
    supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
    reference_section_type: ABSTRACT
- id: PMID:17139257
  title: hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.
  findings:
  - statement: ADRM1/Rpn13 is a 407-residue subunit of the human 19S regulatory complex.
    supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
    reference_section_type: ABSTRACT
  - statement: ADRM1/Rpn13 binds UCH37 and enhances its isopeptidase activity.
    supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
      enzyme, UCH37, and enhances its isopeptidase activity
    reference_section_type: ABSTRACT
- id: PMID:17323924
  title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
  findings: []
- id: PMID:18162577
  title: Relative structural and functional roles of multiple deubiquitylating proteins associated with
    mammalian 26S proteasome.
  findings: []
- id: PMID:18497817
  title: Proteasome subunit Rpn13 is a novel ubiquitin receptor.
  findings:
  - statement: ADRM1/Rpn13 is a proteasomal ubiquitin receptor whose Pru domain binds ubiquitin.
    supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
      receptor for ubiquitin (Pru) domain
    reference_section_type: ABSTRACT
- id: PMID:18922472
  title: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the
    Ino80 chromatin-remodeling complex.
  findings: []
- id: PMID:19489727
  title: Recognition and processing of ubiquitin-protein conjugates by the proteasome.
  findings: []
- id: PMID:19490896
  title: Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific
    chaperones.
  findings: []
- id: PMID:19615732
  title: Defining the human deubiquitinating enzyme interaction landscape.
  findings: []
- id: PMID:20059542
  title: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S
    proteasome-mediated proteolysis.
  findings: []
- id: PMID:20471946
  title: Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein
    hRpn2.
  findings:
  - statement: Human Rpn13 serves as a receptor for both ubiquitin and Uch37.
    supporting_text: Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin
      and Uch37
    reference_section_type: ABSTRACT
  - statement: hRpn2/S1 binding activates hRpn13 for ubiquitin binding.
    supporting_text: hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain
      interactions, thus activating hRpn13 for ubiquitin binding
    reference_section_type: ABSTRACT
- id: PMID:21516116
  title: Next-generation sequencing to generate interactome datasets.
  findings: []
- id: PMID:24811749
  title: Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
  findings:
  - statement: Rpn13 ubiquitination reduces the proteasome's ability to bind and degrade ubiquitin-conjugated
      proteins.
    supporting_text: Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade
      ubiquitin-conjugated proteins
    reference_section_type: ABSTRACT
- id: PMID:25416956
  title: A proteome-scale map of the human interactome network.
  findings: []
- id: PMID:27107012
  title: Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
  findings: []
- id: PMID:28514442
  title: Architecture of the human interactome defines protein communities and disease networks.
  findings: []
- id: PMID:29636472
  title: Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated
    human 26S proteasome.
  findings: []
- id: PMID:31064842
  title: Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction
    with the ubiquitin receptor RPN13.
  findings: []
- id: PMID:31380390
  title: Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms.
  findings: []
- id: PMID:31515488
  title: Extensive disruption of protein interactions by genetic variants across the allele frequency
    spectrum in human populations.
  findings: []
- id: PMID:33729481
  title: 'Proteasome in action: substrate degradation by the 26S proteasome.'
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
  findings: []
- id: PMID:35858375
  title: Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification
    of endogenous proteins.
  findings: []
- id: PMID:37228199
  title: An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses.
  findings: []
- id: PMID:40205054
  title: Multimodal cell maps as a foundation for structural and functional genomics.
  findings: []
- id: Reactome:R-HSA-1168640
  title: Ubiquitinated IkB is degraded
  findings: []
- id: Reactome:R-HSA-1234159
  title: Proteasome proteolyzes ub-HIF-alpha
  findings: []
- id: Reactome:R-HSA-1236970
  title: Proteasomal clevage of exogenous antigen (26S proteasome catalyst)
  findings: []
- id: Reactome:R-HSA-1504193
  title: Ubiquitinated DVL is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-174058
  title: Degradation of multiubiquitinated Cdh1
  findings: []
- id: Reactome:R-HSA-174105
  title: Degradation of multiubiquitinated cell cycle proteins
  findings: []
- id: Reactome:R-HSA-174202
  title: Degradation of multiubiquitinated Securin
  findings: []
- id: Reactome:R-HSA-174203
  title: SCF-mediated degradation of Emi1
  findings: []
- id: Reactome:R-HSA-174255
  title: Degradation multiubiquitinated Cyclin A
  findings: []
- id: Reactome:R-HSA-180573
  title: Degradation of ubiquitinated CD4
  findings: []
- id: Reactome:R-HSA-180603
  title: Proteosome-mediated degradation of APOBEC3G
  findings: []
- id: Reactome:R-HSA-187574
  title: Degradation of ubiquitinated p27/p21 by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-188191
  title: APC/C:Cdh1-mediated degradation of Skp2
  findings: []
- id: Reactome:R-HSA-209061
  title: Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
  findings: []
- id: Reactome:R-HSA-2130282
  title: Degradation of ubiquitinated beta catenin by the proteasome
  findings: []
- id: Reactome:R-HSA-264458
  title: Proteasome mediated degradation of COP1
  findings: []
- id: Reactome:R-HSA-353125
  title: 26S proteosome degrades ODC holoenzyme complex
  findings: []
- id: Reactome:R-HSA-3640874
  title: Ub-RibC-AXIN is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-450466
  title: AUF1:mRNA complex is degraded
  findings: []
- id: Reactome:R-HSA-4608855
  title: PRICKLE1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-4641256
  title: Ubiquitinated AXIN is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-4641260
  title: Ubiquitinated DVL1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5362448
  title: Hh C-terminal fragments are degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5387392
  title: processing defective Hh variants are degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5607724
  title: 26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
  findings: []
- id: Reactome:R-HSA-5607731
  title: 26S proteasome processes p-7S-p100:RELB to form p52:RELB
  findings: []
- id: Reactome:R-HSA-5610754
  title: GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
  findings: []
- id: Reactome:R-HSA-5610758
  title: GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
  findings: []
- id: Reactome:R-HSA-5610760
  title: GLI1 is degraded by the proteasome after ubiquitination by ITCH
  findings: []
- id: Reactome:R-HSA-5635854
  title: GLI2,3 are degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5635868
  title: ub-GLI is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5658430
  title: NF1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5665854
  title: ADRM1:26S proteaseome binds UCHL5
  findings: []
- id: Reactome:R-HSA-5665871
  title: ADRM1 binds 26S proteasome
  findings: []
- id: Reactome:R-HSA-5668481
  title: Protesomal degradation of K48polyUb-TRAF3
  findings: []
- id: Reactome:R-HSA-5668520
  title: 26Sproteasome degrades K48polyUb-NIK
  findings: []
- id: Reactome:R-HSA-5687112
  title: MAPK6 is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-5689539
  title: ADRM1:26S proteaseome binds USP14
  findings: []
- id: Reactome:R-HSA-68825
  title: Ubiquitinated geminin is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-68948
  title: Ubiquitinated Orc1 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-69016
  title: Ubiquitinated Cdc6 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-69600
  title: Proteolytic degradation of ubiquitinated-Cdc25A
  findings: []
- id: Reactome:R-HSA-75825
  title: Proteasome mediated degradation of Cyclin D1
  findings: []
- id: Reactome:R-HSA-8850992
  title: Proteasome degrades polyubiquitinated PTEN
  findings: []
- id: Reactome:R-HSA-8852354
  title: GTSE1 facilitates proteasome-mediated degradation of TP53
  findings: []
- id: Reactome:R-HSA-8854044
  title: Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
  findings: []
- id: Reactome:R-HSA-8854071
  title: Proteasome-mediated degradation of PolyUb-FBXL7
  findings: []
- id: Reactome:R-HSA-8866553
  title: misfolded CFTR is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-8866858
  title: CFTR F508del is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-8932355
  title: 26S proteasome degrades Ub-NFE2L2
  findings: []
- id: Reactome:R-HSA-8939801
  title: 26S proteasome degrades PolyUb-RUNX2
  findings: []
- id: Reactome:R-HSA-8952408
  title: Polyubiquitinated RUNX3 is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-8956140
  title: NEDD8 and UBD bind NUB1 and the 26S proteasome
  findings: []
- id: Reactome:R-HSA-8956184
  title: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
  findings: []
- id: Reactome:R-HSA-8957265
  title: 26S proteasome degrades TP73 polyubiquitinated by ITCH
  findings: []
- id: Reactome:R-HSA-9755303
  title: 26S proteasome degrades HIFalpha
  findings: []
- id: Reactome:R-HSA-9755306
  title: ub UBXN7 is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-9762096
  title: Ub,pS335,S338,T NFE2L2 is degraded
  findings: []
- id: Reactome:R-HSA-9766223
  title: Proteasome-dependent degradation of ubiquitinated CDH1
  findings: []
- id: Reactome:R-HSA-983150
  title: Proteasomal cleavage of substrate
  findings: []
- id: Reactome:R-HSA-9907980
  title: Formation of the 19S regulatory particle base precursor
  findings: []
- id: Reactome:R-HSA-9908026
  title: Formation of the 19S regulatory particle precursor
  findings: []
- id: Reactome:R-HSA-9908178
  title: Formation of the 26S proteasome
  findings: []
- id: Reactome:R-HSA-9929352
  title: Ubiquitinated CD274 is degraded by the 26S proteasome
  findings: []
- id: Reactome:R-HSA-9929486
  title: SPOP-mediated degradation of CD274 by 26S Proteosome
  findings: []
- id: Reactome:R-HSA-9931314
  title: Proteasomal degradation of polyUb-p-S195-CD274
  findings: []
- id: Reactome:R-HSA-9934893
  title: Proteolysis of K48polyUb-K,p-S-PER1,2,3
  findings: []
- id: Reactome:R-HSA-9954728
  title: The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide
  findings: []
- id: Reactome:R-NUL-212917
  title: Proteasome mediated degradation of PAK-2p34
  findings: []
- id: Reactome:R-NUL-5610751
  title: Gli2is degraded by the proteasome
  findings: []
- id: Reactome:R-NUL-9011324
  title: Proteasome degrades SAX-3 ubiquitinated by EBAX-1
  findings: []
- id: Reactome:R-NUL-9604648
  title: Proteasome degrades ubiquitinated mouse NICD4
  findings: []
- id: file:human/ADRM1/ADRM1-notes.md
  title: ADRM1 PN review notes
  findings: []
- id: file:human/ADRM1/ADRM1-deep-research-manual.md
  title: ADRM1 manual deep research
  findings: []
- id: file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_annotations.tsv
  title: Proteostasis PN projected annotations
  findings: []
core_functions:
- description: Proteasomal ubiquitin receptor activity within the 19S regulatory particle, linking ubiquitin-tagged
    substrates to the 26S proteasome for degradation.
  molecular_function:
    id: GO:0043130
    label: ubiquitin binding
  directly_involved_in:
  - id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  - id: GO:0010498
    label: proteasomal protein catabolic process
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005654
    label: nucleoplasm
  in_complex:
    id: GO:0008540
    label: proteasome regulatory particle, base subcomplex
  supported_by:
  - reference_id: PMID:18497817
    supporting_text: Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like
      receptor for ubiquitin (Pru) domain
  - reference_id: PMID:20471946
    supporting_text: Rpn13 functions as a ubiquitin receptor for the proteasome
  - reference_id: PMID:33729481
    supporting_text: Three of these integral subunits (Rpn1, Rpn10 and Rpn13) bind to the conjugated ubiquitin
      tag on the substrate
- description: Recruitment and activation of the UCHL5/UCH37 deubiquitinase at the 26S proteasome regulatory
    particle.
  molecular_function:
    id: GO:0035800
    label: deubiquitinase activator activity
  directly_involved_in:
  - id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005654
    label: nucleoplasm
  in_complex:
    id: GO:0008540
    label: proteasome regulatory particle, base subcomplex
  supported_by:
  - reference_id: PMID:16990800
    supporting_text: hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes
  - reference_id: PMID:16990800
    supporting_text: loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes
  - reference_id: PMID:17139257
    supporting_text: The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating
      enzyme, UCH37, and enhances its isopeptidase activity
- description: Stable association with the 19S regulatory-particle/base proteasome subcomplex through
    Rpn2/PSMD1 and related regulatory-particle contacts.
  molecular_function:
    id: GO:0070628
    label: proteasome binding
  directly_involved_in:
  - id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005654
    label: nucleoplasm
  in_complex:
    id: GO:0008540
    label: proteasome regulatory particle, base subcomplex
  supported_by:
  - reference_id: PMID:16990800
    supporting_text: we describe the identification of Adrm1 as a novel proteasome interacting protein
      in mammalian cells
  - reference_id: PMID:17139257
    supporting_text: we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex
  - reference_id: PMID:29636472
    supporting_text: Recognition of a ubiquitylated substrate is mediated principally by ubiquitin receptors
      Rpn10 and Rpn13, the base subunits within the holoenzyme
proposed_new_terms: []
suggested_questions:
- question: Should the current ADRM1/Rpn13 GO annotation to proteasome regulatory particle, lid subcomplex
    be replaced by proteasome regulatory particle, base subcomplex in GOA/PAINT?
  experts:
  - Youdong Mao
  - Michael H. Glickman
  - Keiji Tanaka
- question: Should ADRM1 receive direct ubiquitin binding and deubiquitinase activator activity annotations
    in GOA to replace generic protein binding and endopeptidase activator activity?
  experts:
  - Kylie J. Walters
  - Alfred L. Goldberg
  - Keiji Tanaka
suggested_experiments:
- experiment_type: endogenous proteasome structural proteomics
  hypothesis: Endogenous ADRM1 is a base/regulatory-particle ubiquitin receptor rather than a lid-subcomplex
    subunit.
  description: Map endogenous ADRM1 contacts and cryo-EM density in substrate-engaged human 26S proteasomes,
    comparing wild-type ADRM1 with Pru-domain and DEUBAD-domain mutants for Rpn2, ubiquitin-chain, and
    UCHL5 association.
- experiment_type: catalytic-rescue degradation assay
  hypothesis: ADRM1 supports ubiquitin-dependent substrate degradation through both Pru-domain ubiquitin
    recognition and DEUBAD-dependent UCHL5 activation.
  description: Rescue ADRM1-deficient cells with wild-type, ubiquitin-binding-defective, Rpn2-binding-defective,
    and UCHL5-binding-defective ADRM1 alleles, then quantify degradation of defined K48-ubiquitinated
    substrates and proteasome-associated UCHL5 activity.