GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0034982 mitochondrial protein processing biological_process ECO:0000318 IBA GO_REF:0000033 FB:FBgn0036702|MGI:MGI:1916847|MGI:MGI:1928277|PANTHER:PTN000554085|UniProtKB:Q9UQ90|UniProtKB:Q9Y4W6|WB:WBGene00004978 9606 Homo sapiens GO_Central Mitochondrial inner membrane m-AAA protease component AFG3L2 20251220 UniProtKB Q9Y4W6 AFG3L2 part_of GO:0005745 m-AAA complex cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0024992|FB:FBgn0036702|MGI:MGI:1916847|MGI:MGI:1928277|MGI:MGI:2385906|PANTHER:PTN000554085|SGD:S000000819|SGD:S000004695|UniProtKB:Q9UQ90|UniProtKB:Q9Y4W6 9606 Homo sapiens GO_Central Mitochondrial inner membrane m-AAA protease component AFG3L2 20240801 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN008683692|UniProtKB:Q9UQ90|UniProtKB:Q9Y4W6 9606 Homo sapiens GO_Central Mitochondrial inner membrane m-AAA protease component AFG3L2 20220623 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004176 ATP-dependent peptidase activity molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000642|InterPro:IPR005936|InterPro:IPR011546|InterPro:IPR037219 9606 Homo sapiens InterPro Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000642|InterPro:IPR005936|InterPro:IPR011546|InterPro:IPR037219 9606 Homo sapiens InterPro Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 enables GO:0005524 ATP binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000642|InterPro:IPR003959|InterPro:IPR003960|InterPro:IPR011546|InterPro:IPR037219 9606 Homo sapiens InterPro Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q8JZQ2|ensembl:ENSMUSP00000025408|UniProtKB-SubCell:SL-0168 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0006508 proteolysis biological_process ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00026291|InterPro:IPR000642|InterPro:IPR037219 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 enables GO:0008270 zinc ion binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR011546 9606 Homo sapiens InterPro Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0016020 membrane cellular_component ECO:0000256 IEA GO_REF:0000002 InterPro:IPR005936|InterPro:IPR011546 9606 Homo sapiens InterPro Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 enables GO:0016887 ATP hydrolysis activity molecular_function ECO:0000501 IEA GO_REF:0000120 InterPro:IPR003959|InterPro:IPR003960|RHEA:13065 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20260428 UniProtKB Q9Y4W6 AFG3L2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P42858 9606 Homo sapiens IntAct Mitochondrial inner membrane m-AAA protease component AFG3L2 20260425 UniProtKB Q9Y4W6 AFG3L2 part_of GO:0005745 m-AAA complex cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00088390|UniProtKB:Q8JZQ2|ensembl:ENSMUSP00000025408 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20260422 UniProtKB Q9Y4W6 AFG3L2 enables GO:0008237 metallopeptidase activity molecular_function ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q8JZQ2|ensembl:ENSMUSP00000025408 9606 Homo sapiens Ensembl Mitochondrial inner membrane m-AAA protease component AFG3L2 20260422 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0016485 protein processing biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q8JZQ2|ensembl:ENSMUSP00000025408 9606 Homo sapiens Ensembl Mitochondrial inner membrane m-AAA protease component AFG3L2 20260422 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0016540 protein autoprocessing biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q8JZQ2|ensembl:ENSMUSP00000025408 9606 Homo sapiens Ensembl Mitochondrial inner membrane m-AAA protease component AFG3L2 20260422 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0051604 protein maturation biological_process ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00026902|UniProtKB:Q8JZQ2|ensembl:ENSMUSP00000025408 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20260422 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0110097 regulation of calcium import into the mitochondrion biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q8JZQ2|ensembl:ENSMUSP00000025408 9606 Homo sapiens Ensembl Mitochondrial inner membrane m-AAA protease component AFG3L2 20260422 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005739 mitochondrion cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Mitochondrial inner membrane m-AAA protease component AFG3L2 20251115 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000315 IMP PMID:41075794 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20251031 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0034982 mitochondrial protein processing biological_process ECO:0000315 IMP PMID:41075794 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20251031 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000314 IDA PMID:31327635 9606 Homo sapiens ComplexPortal Mitochondrial inner membrane m-AAA protease component AFG3L2 20240918 UniProtKB Q9Y4W6 AFG3L2 part_of GO:0005745 m-AAA complex cellular_component ECO:0000353 IPI PMID:31327635 9606 Homo sapiens ComplexPortal Mitochondrial inner membrane m-AAA protease component AFG3L2 20240918 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0034982 mitochondrial protein processing biological_process ECO:0000314 IDA PMID:31327635 9606 Homo sapiens ComplexPortal Mitochondrial inner membrane m-AAA protease component AFG3L2 20240918 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005739 mitochondrion cellular_component ECO:0006056 HTP PMID:34800366 9606 Homo sapiens FlyBase Mitochondrial inner membrane m-AAA protease component AFG3L2 20240711 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0141164 mitochondrial protein quality control biological_process ECO:0000314 IDA PMID:26504172 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240318 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0141164 mitochondrial protein quality control biological_process ECO:0000314 IDA PMID:30683687 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240318 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0141164 mitochondrial protein quality control biological_process ECO:0000314 IDA PMID:34718584 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240318 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:29545505 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240216 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:27642048 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240215 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:28396416 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240215 UniProtKB Q9Y4W6 AFG3L2 is_active_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000314 IDA PMID:37917749 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240215 UniProtKB Q9Y4W6 AFG3L2 part_of GO:0005745 m-AAA complex cellular_component ECO:0000314 IDA PMID:28396416 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240215 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0110097 regulation of calcium import into the mitochondrion biological_process ECO:0000314 IDA PMID:27642048 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240215 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0110097 regulation of calcium import into the mitochondrion biological_process ECO:0000314 IDA PMID:28396416 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240215 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:37917749 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240214 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:38157846 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240214 UniProtKB Q9Y4W6 AFG3L2 is_active_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS PMID:31327635 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240214 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0030163 protein catabolic process biological_process ECO:0000314 IDA PMID:37917749 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240214 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0030163 protein catabolic process biological_process ECO:0000314 IDA PMID:38157846 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240214 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0072753 cellular response to glutathione biological_process ECO:0000314 IDA PMID:37917749 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240214 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0072753 cellular response to glutathione biological_process ECO:0000314 IDA PMID:38157846 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240214 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:19748354 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:29932645 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:31327635 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 part_of GO:0005745 m-AAA complex cellular_component ECO:0000314 IDA PMID:19748354 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 part_of GO:0005745 m-AAA complex cellular_component ECO:0000314 IDA PMID:31327635 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 enables GO:0016887 ATP hydrolysis activity molecular_function ECO:0000314 IDA PMID:19748354 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 enables GO:0016887 ATP hydrolysis activity molecular_function ECO:0000314 IDA PMID:31327635 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0051604 protein maturation biological_process ECO:0000314 IDA PMID:29932645 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20240213 UniProtKB Q9Y4W6 AFG3L2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:35912435 UniProtKB:Q9H3K2 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20230109 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0006508 proteolysis biological_process ECO:0000314 IDA PMID:35912435 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20230109 UniProtKB Q9Y4W6 AFG3L2 enables GO:0004222 metalloendopeptidase activity molecular_function ECO:0000314 IDA PMID:22354088 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20191003 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005739 mitochondrion cellular_component ECO:0000314 IDA PMID:22354088 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20191003 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0033619 membrane protein proteolysis biological_process ECO:0000314 IDA PMID:22354088 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20191003 UniProtKB Q9Y4W6 AFG3L2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:26387735 UniProtKB:Q9UQ90 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20170927 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q8JZQ2 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20170927 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0016485 protein processing biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q8JZQ2 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20170927 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0016540 protein autoprocessing biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q8JZQ2 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20170927 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8949649 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8949659 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8949661 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9838627 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9839053 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9839059 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9839105 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9839113 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005743 mitochondrial inner membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9839149 9606 Homo sapiens Reactome Mitochondrial inner membrane m-AAA protease component AFG3L2 20170122 UniProtKB Q9Y4W6 AFG3L2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:27642048 UniProtKB:Q8WWC4 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20160923 UniProtKB Q9Y4W6 AFG3L2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:27642048 UniProtKB:Q9H4I9 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20160923 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0006508 proteolysis biological_process ECO:0000315 IMP PMID:27642048 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20160923 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0007409 axonogenesis biological_process ECO:0000315 IMP PMID:27642048 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20160923 UniProtKB Q9Y4W6 AFG3L2 enables GO:0008237 metallopeptidase activity molecular_function ECO:0000315 IMP PMID:27642048 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20160923 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0036444 calcium import into the mitochondrion biological_process ECO:0000315 IMP PMID:27642048 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20160923 UniProtKB Q9Y4W6 AFG3L2 involved_in GO:0051560 mitochondrial calcium ion homeostasis biological_process ECO:0000315 IMP PMID:27642048 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20160923 UniProtKB Q9Y4W6 AFG3L2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:14623864 UniProtKB:Q9UQ90 9606 Homo sapiens UniProt Mitochondrial inner membrane m-AAA protease component AFG3L2 20120316 UniProtKB Q9Y4W6 AFG3L2 located_in GO:0005739 mitochondrion cellular_component ECO:0000304 TAS PMID:10395799 9606 Homo sapiens PINC Mitochondrial inner membrane m-AAA protease component AFG3L2 20030904