AGO2

UniProt ID: Q9UKV8
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for AGO2

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005634 nucleus
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004521 RNA endonuclease activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036464 cytoplasmic ribonucleoprotein granule
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003727 single-stranded RNA binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000340 RNA 7-methylguanosine cap binding
IEA
GO_REF:0000104 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000932 P-body
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003676 nucleic acid binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003723 RNA binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003725 double-stranded RNA binding
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003727 single-stranded RNA binding
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006355 regulation of DNA-templated transcription
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006413 translational initiation
IEA
GO_REF:0000108 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016891 RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
IEA
GO_REF:0000104 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031047 regulatory ncRNA-mediated gene silencing
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035197 siRNA binding
IEA
GO_REF:0000104 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036464 cytoplasmic ribonucleoprotein granule
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045947 negative regulation of translational initiation
IEA
GO_REF:0000104 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070922 RISC complex assembly
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098808 mRNA cap binding
IEA
GO_REF:0000104 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:14749716
Characterization of the interactions between mammalian PAZ P... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16424907
The role of PACT in the RNA silencing pathway. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16756390
Translation repression in human cells by microRNA-induced ge... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17400507
Identification of potential protein interactors of Lrrk2. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17891150
A conserved motif in Argonaute-interacting proteins mediates... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17932509
Proteomic and functional analysis of Argonaute-containing mR... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18178619
In vitro reconstitution of the human RISC-loading complex. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19167051
Importin 8 is a gene silencing factor that targets argonaute... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19324964
The C-terminal half of human Ago2 binds to multiple GW-rich ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19383768
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C s... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19716330
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-d... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19820710
Structural insights into RNA processing by the human RISC-lo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19838187
Ago-TNRC6 triggers microRNA-mediated decay by promoting two ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19955415
CRM1 mediates nuclear-cytoplasmic shuttling of mature microR... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20671708
Pathogenic LRRK2 negatively regulates microRNA-mediated tran... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21525958
The ribosomal protein RACK1 is required for microRNA functio... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21840310
Ago2/miRISC-mediated inhibition of CBP80/20-dependent transl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21858095
Nuclear pore complex protein mediated nuclear localization o... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21903422
Mapping a dynamic innate immunity protein interaction networ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21981923
GW182 proteins directly recruit cytoplasmic deadenylase comp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22366686
Senescence is an endogenous trigger for microRNA-directed tr... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22484317
Human prion protein binds Argonaute and promotes accumulatio... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23085987
Wig1 prevents cellular senescence by regulating p21 mRNA dec... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23090477
Defining a new role of GW182 in maintaining miRNA stability. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23622242
ADAR1 forms a complex with Dicer to promote microRNA process... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23636329
EGFR modulates microRNA maturation in response to hypoxia th... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23661684
Differential roles of human Dicer-binding proteins TRBP and ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23741051
Hsp90 cochaperones p23 and FKBP4 physically interact with hA... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24043833
Structural features of Argonaute-GW182 protein interactions. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24550003
Involvement of telomerase reverse transcriptase in heterochr... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24981741
MTDH-SND1 interaction is crucial for expansion and activity ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25446899
Cancer exosomes perform cell-independent microRNA biogenesis... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26496610
A human interactome in three quantitative dimensions organiz... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:28683311
Argonaute Utilization for miRNA Silencing Is Determined by P... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:28877994
Cadherin complexes recruit mRNAs and RISC to regulate epithe... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human ce... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:39251607
Systematic identification of post-transcriptional regulatory... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003729 mRNA binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004521 RNA endonuclease activity
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030425 dendrite
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990904 ribonucleoprotein complex
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035196 miRNA processing
NAS
PMID:28781232
Multivalent Recruitment of Human Argonaute by GW182. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
TAS
Reactome:R-HSA-426496 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036464 cytoplasmic ribonucleoprotein granule
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004521 RNA endonuclease activity
TAS
Reactome:R-HSA-426520 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090128 regulation of synapse maturation
IDA
PMID:29735530
NMDA receptor-dependent dephosphorylation of serine 387 in A... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090128 regulation of synapse maturation
IMP
PMID:29735530
NMDA receptor-dependent dephosphorylation of serine 387 in A... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098794 postsynapse
IDA
PMID:29735530
NMDA receptor-dependent dephosphorylation of serine 387 in A... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098794 postsynapse
IMP
PMID:29735530
NMDA receptor-dependent dephosphorylation of serine 387 in A... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098978 glutamatergic synapse
IDA
PMID:29735530
NMDA receptor-dependent dephosphorylation of serine 387 in A... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098978 glutamatergic synapse
IMP
PMID:29735530
NMDA receptor-dependent dephosphorylation of serine 387 in A... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098808 mRNA cap binding
IDA
PMID:17524464
An mRNA m7G cap binding-like motif within human Ago2 repress... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:17932509
Proteomic and functional analysis of Argonaute-containing mR... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0033962 P-body assembly
IDA
PMID:31400113
KSHV RNA-binding protein ORF57 inhibits P-body formation to ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035925 mRNA 3'-UTR AU-rich region binding
IDA
PMID:17382880
AU-rich-element-mediated upregulation of translation by FXR1... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045727 positive regulation of translation
IDA
PMID:17382880
AU-rich-element-mediated upregulation of translation by FXR1... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5578742 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5578744 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5578966 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
IDA
PMID:23409027
eIF4GI facilitates the MicroRNA-mediated gene silencing. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:19701182
An RNA-dependent RNA polymerase formed by TERT and the RMRP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070922 RISC complex assembly
IDA
PMID:19701182
An RNA-dependent RNA polymerase formed by TERT and the RMRP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:29395067
High-Density Proximity Mapping Reveals the Subcellular Organ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IGI
PMID:31507089
Reciprocal regulation of miR-206 and IL-6/STAT3 pathway medi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IPI
PMID:31507089
Reciprocal regulation of miR-206 and IL-6/STAT3 pathway medi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IGI
PMID:31012336
MicroRNA-31 Negatively Regulates Interleukin-34 Expression I... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IPI
PMID:31012336
MicroRNA-31 Negatively Regulates Interleukin-34 Expression I... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26009488
Clnk plays a role in TNF-alpha-induced cell death in murine ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IPI
PMID:19826008
An integrated approach for experimental target identificatio... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IDA
PMID:23985560
microRNA-9 targets the long non-coding RNA MALAT1 for degrad... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24726324
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA t... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1606561 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1606682 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912362 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912363 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912364 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912366 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912367 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912368 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912406 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-203862 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-2106614 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-2106615 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-2106625 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-210805 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-2318752 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-426464 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-426489 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-426520 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-4518575 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5578712 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5578744 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5578965 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5578966 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5687103 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8935864 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8935930 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8936058 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8936068 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8939129 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944483 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944522 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944538 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944569 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944599 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944632 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944684 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8945709 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948524 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948536 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948569 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948582 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948583 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948594 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948602 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948612 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948621 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948623 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948641 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8948651 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9011958 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9012203 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9012208 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9023909 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9023912 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9038545 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9618392 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9618486 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9624925 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9657791 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9759950 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9768616 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9768643 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9768788 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9860139 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9860160 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9860168 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9924908 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9924921 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9924968 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925087 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925095 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925159 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925246 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925270 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925289 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925320 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925324 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:28546213
Tudor-SN-mediated endonucleolytic decay of human cell microR... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25697406
Roquin binds microRNA-146a and Argonaute2 to regulate microR... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045766 positive regulation of angiogenesis
IDA
PMID:27208409
miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and... 		PENDING
Summary: TODO: Review this GOA annotation
GO:1901165 positive regulation of trophoblast cell migration
IMP
PMID:27208409
miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000932 P-body
IDA
PMID:23125361
The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23125361
The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:17531811
RNA helicase A interacts with RISC in human cells and functi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IDA
PMID:17531811
RNA helicase A interacts with RISC in human cells and functi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17531811
RNA helicase A interacts with RISC in human cells and functi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23361462
Structural insights into RISC assembly facilitated by dsRNA-... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070062 extracellular exosome
IDA
PMID:28159509
Human Pericardial Fluid Contains Exosomes Enriched with Card... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IDA
PMID:16424907
The role of PACT in the RNA silencing pathway. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IDA
PMID:23661684
Differential roles of human Dicer-binding proteins TRBP and ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24862572
Mammalian microtubule P-body dynamics are mediated by nespri... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:27157137
Post-transcriptional gene silencing activity of human GIGYF2... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23409027
eIF4GI facilitates the MicroRNA-mediated gene silencing. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098808 mRNA cap binding
IPI
PMID:23409027
eIF4GI facilitates the MicroRNA-mediated gene silencing. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:15766526
Involvement of microRNA in AU-rich element-mediated mRNA ins... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17507929
MicroRNA silencing through RISC recruitment of eIF6. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045944 positive regulation of transcription by RNA polymerase II
IMP
PMID:25336585
Cellular microRNAs up-regulate transcription via interaction... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
TAS
PMID:19820710
Structural insights into RNA processing by the human RISC-lo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IDA
PMID:19820710
Structural insights into RNA processing by the human RISC-lo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IDA
PMID:15973356
TRBP recruits the Dicer complex to Ago2 for microRNA process... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001046 core promoter sequence-specific DNA binding
IMP
PMID:25336585
Cellular microRNAs up-regulate transcription via interaction... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IC
PMID:25336585
Cellular microRNAs up-regulate transcription via interaction... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000993 RNA polymerase II complex binding
IDA
PMID:25336585
Cellular microRNAs up-regulate transcription via interaction... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25336585
Cellular microRNAs up-regulate transcription via interaction... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA
IMP
PMID:22795694
Slicing-independent RISC activation requires the argonaute P... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
IMP
PMID:22795694
Slicing-independent RISC activation requires the argonaute P... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035196 miRNA processing
IDA
PMID:23661684
Differential roles of human Dicer-binding proteins TRBP and ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035196 miRNA processing
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003725 double-stranded RNA binding
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003727 single-stranded RNA binding
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070922 RISC complex assembly
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004521 RNA endonuclease activity
IDA
PMID:18178619
In vitro reconstitution of the human RISC-loading complex. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IDA
PMID:18178619
In vitro reconstitution of the human RISC-loading complex. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IDA
PMID:18178619
In vitro reconstitution of the human RISC-loading complex. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035197 siRNA binding
IDA
PMID:19701182
An RNA-dependent RNA polymerase formed by TERT and the RMRP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
HDA
PMID:19946888
Defining the membrane proteome of NK cells. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003723 RNA binding
HDA
PMID:22658674
Insights into RNA biology from an atlas of mammalian mRNA-bi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003723 RNA binding
HDA
PMID:22681889
The mRNA-bound proteome and its global occupancy profile on ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031047 regulatory ncRNA-mediated gene silencing
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000932 P-body
IDA
PMID:22915799
HIV-1 replication and APOBEC3 antiviral activity are not reg... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16699599
Human retroviral host restriction factors APOBEC3G and APOBE... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22915799
HIV-1 replication and APOBEC3 antiviral activity are not reg... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16289642
Identification of novel argonaute-associated proteins. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20616046
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:20014101
Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19801630
RNA-binding motif protein 4 translocates to cytoplasmic gran... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
IDA
PMID:19801630
RNA-binding motif protein 4 translocates to cytoplasmic gran... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045947 negative regulation of translational initiation
IDA
PMID:19801630
RNA-binding motif protein 4 translocates to cytoplasmic gran... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:17932509
Proteomic and functional analysis of Argonaute-containing mR... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000932 P-body
IDA
PMID:20616046
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:20616046
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
IDA
PMID:17524464
An mRNA m7G cap binding-like motif within human Ago2 repress... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000340 RNA 7-methylguanosine cap binding
IDA
PMID:17524464
An mRNA m7G cap binding-like motif within human Ago2 repress... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035197 siRNA binding
IDA
PMID:15973356
TRBP recruits the Dicer complex to Ago2 for microRNA process... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:17671087
Let-7 microRNA-mediated mRNA deadenylation and translational... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IDA
PMID:17671087
Let-7 microRNA-mediated mRNA deadenylation and translational... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035197 siRNA binding
IDA
PMID:17495927
The human RNA kinase hClp1 is active on 3' transfer RNA exon... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
IDA
PMID:17671087
Let-7 microRNA-mediated mRNA deadenylation and translational... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
IMP
PMID:18771919
Importance of translation and nonnucleolytic ago proteins fo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
IDA
PMID:17524464
An mRNA m7G cap binding-like motif within human Ago2 repress... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
IMP
PMID:18771919
Importance of translation and nonnucleolytic ago proteins fo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045947 negative regulation of translational initiation
IDA
PMID:17524464
An mRNA m7G cap binding-like motif within human Ago2 repress... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003743 translation initiation factor activity
NAS
PMID:10534406
Human eukaryotic initiation factor EIF2C1 gene: cDNA sequenc... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006412 translation
NAS
PMID:10534406
Human eukaryotic initiation factor EIF2C1 gene: cDNA sequenc... 		PENDING
Summary: TODO: Review this GOA annotation

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000104
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10534406
Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression.
PMID:14749716
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer.
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
PMID:15766526
Involvement of microRNA in AU-rich element-mediated mRNA instability.
PMID:15973356
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.
PMID:16289642
Identification of novel argonaute-associated proteins.
PMID:16424907
The role of PACT in the RNA silencing pathway.
PMID:16699599
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.
PMID:16756390
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.
PMID:17382880
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.
PMID:17400507
Identification of potential protein interactors of Lrrk2.
PMID:17495927
The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.
PMID:17507929
MicroRNA silencing through RISC recruitment of eIF6.
PMID:17524464
An mRNA m7G cap binding-like motif within human Ago2 represses translation.
PMID:17531811
RNA helicase A interacts with RISC in human cells and functions in RISC loading.
PMID:17671087
Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system.
PMID:17891150
A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain.
PMID:17932509
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
PMID:18178619
In vitro reconstitution of the human RISC-loading complex.
PMID:18771919
Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.
PMID:19167051
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.
PMID:19324964
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.
PMID:19383768
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.
PMID:19701182
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
PMID:19716330
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
PMID:19801630
RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.
PMID:19820710
Structural insights into RNA processing by the human RISC-loading complex.
PMID:19826008
An integrated approach for experimental target identification of hypoxia-induced miR-210.
PMID:19838187
Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.
PMID:19946888
Defining the membrane proteome of NK cells.
PMID:19955415
CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.
PMID:19966796
ATP-dependent human RISC assembly pathways.
PMID:20014101
Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.
PMID:20616046
LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.
PMID:20671708
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.
PMID:21525958
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans.
PMID:21840310
Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2.
PMID:21858095
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.
PMID:21903422
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
PMID:21981923
GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.
PMID:22366686
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.
PMID:22484317
Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes.
PMID:22658674
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
PMID:22681889
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
PMID:22795694
Slicing-independent RISC activation requires the argonaute PAZ domain.
PMID:22915799
HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.
PMID:23085987
Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.
PMID:23090477
Defining a new role of GW182 in maintaining miRNA stability.
PMID:23125361
The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.
PMID:23361462
Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).
PMID:23409027
eIF4GI facilitates the MicroRNA-mediated gene silencing.
PMID:23622242
ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.
PMID:23636329
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
PMID:23661684
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.
PMID:23741051
Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells.
PMID:23985560
microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus.
PMID:24043833
Structural features of Argonaute-GW182 protein interactions.
PMID:24550003
Involvement of telomerase reverse transcriptase in heterochromatin maintenance.
PMID:24726324
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
PMID:24862572
Mammalian microtubule P-body dynamics are mediated by nesprin-1.
PMID:24981741
MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.
PMID:25336585
Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs.
PMID:25446899
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis.
PMID:25697406
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
PMID:26009488
Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.
PMID:26496610
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
PMID:27157137
Post-transcriptional gene silencing activity of human GIGYF2.
PMID:27208409
miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and in a model of angiogenesis defects related to inflammation.
PMID:28159509
Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.
PMID:28546213
Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G(1)/S phase transition.
PMID:28683311
Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.
PMID:28781232
Multivalent Recruitment of Human Argonaute by GW182.
PMID:28877994
Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.
PMID:29395067
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
PMID:29735530
NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases its degradation and affects dendritic spine density and maturation.
PMID:31012336
MicroRNA-31 Negatively Regulates Interleukin-34 Expression In Vitro.
PMID:31400113
KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.
PMID:31507089
Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human cellular organization.
PMID:39251607
Systematic identification of post-transcriptional regulatory modules.
Reactome:R-HSA-1606561
MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
Reactome:R-HSA-1606682
MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
Reactome:R-HSA-1912362
MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
Reactome:R-HSA-1912363
MIR200B/C microRNAs bind NOTCH1 mRNA
Reactome:R-HSA-1912364
MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
Reactome:R-HSA-1912366
MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
Reactome:R-HSA-1912367
MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
Reactome:R-HSA-1912368
MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
Reactome:R-HSA-1912406
p53 positively regulates transcription of MIR34 microRNAs
Reactome:R-HSA-203862
TODO: Fetch title
Reactome:R-HSA-2106614
Duplex miRNA is loaded into Argonaute
Reactome:R-HSA-2106615
Removal of siRNA passenger strand
Reactome:R-HSA-2106625
Duplex siRNA is loaded into Argonaute
Reactome:R-HSA-210805
Removal of miRNA passenger strand
Reactome:R-HSA-2318752
miR-26A microRNAs bind PTEN mRNA
Reactome:R-HSA-426464
Dicer cleaves double-stranded RNA to yield double-stranded siRNA
Reactome:R-HSA-426489
RISC binds inexactly matching target RNAs
Reactome:R-HSA-426496
Post-transcriptional silencing by small RNAs
Reactome:R-HSA-426520
Endonucleolytic RISC hydrolyzes target RNAs
Reactome:R-HSA-4518575
miR-92b binds 3'UTR of NLK mRNA
Reactome:R-HSA-5578712
Importin-8 binds AGO2:miRNA
Reactome:R-HSA-5578742
AGO1,2:small RNA complexes interact with chromatin
Reactome:R-HSA-5578744
Importin-8 imports AGO2:miRNA into the nucleus
Reactome:R-HSA-5578965
TNRC6A binds AGO2:miRNA
Reactome:R-HSA-5578966
TNRC6A:AGO2:miRNA is transported into the nucleus
Reactome:R-HSA-5687103
FOXO3 regulates MIR34B,C expression
Reactome:R-HSA-8935864
miR-302b binds RUNX1 mRNA
Reactome:R-HSA-8935930
miR-18a binds RUNX1 mRNA
Reactome:R-HSA-8936058
miR-675 binds RUNX1 mRNA
Reactome:R-HSA-8936068
H19 is cleaved to produce miR-675
Reactome:R-HSA-8939129
miR-215 binds RUNX1 mRNA
Reactome:R-HSA-8944483
miR-17 microRNA binds PTEN mRNA
Reactome:R-HSA-8944522
miR-19a microRNA binds PTEN mRNA
Reactome:R-HSA-8944538
miR-22 microRNA binds PTEN mRNA
Reactome:R-HSA-8944569
miR-25 microRNA binds PTEN mRNA
Reactome:R-HSA-8944599
miR-93 microRNA binds PTEN mRNA
Reactome:R-HSA-8944632
miR-106 microRNAs bind PTEN mRNA
Reactome:R-HSA-8944684
miR-205 microRNA binds PTEN mRNA
Reactome:R-HSA-8945709
miR-20 microRNAs bind PTEN mRNA
Reactome:R-HSA-8948524
PTENP1 mRNA binds miR-19b RISC
Reactome:R-HSA-8948536
PTENP1 mRNA binds miR-20 RISC
Reactome:R-HSA-8948569
miR-19b microRNA binds PTEN mRNA
Reactome:R-HSA-8948582
miR-17 microRNA binds VAPA mRNA
Reactome:R-HSA-8948583
miR-17 microRNA binds CNOT6L mRNA
Reactome:R-HSA-8948594
miR-19a microRNA binds VAPA mRNA
Reactome:R-HSA-8948602
miR-19a microRNA binds CNOT6L mRNA
Reactome:R-HSA-8948612
miR-19b microRNA binds CNOT6L mRNA
Reactome:R-HSA-8948621
miR-20 microRNAs bind VAPA mRNA
Reactome:R-HSA-8948623
miR-20 microRNAs bind CNOT6L mRNA
Reactome:R-HSA-8948641
miR-106 microRNAs bind VAPA mRNA
Reactome:R-HSA-8948651
miR-106a,(miR106b) microRNA binds CNOT6L mRNA
Reactome:R-HSA-9011958
miR-26A and B bind to the 3'UTR of the GREB1 mRNA
Reactome:R-HSA-9012203
miR-26A and B bind to the 3'UTR of the CHD11 mRNA
Reactome:R-HSA-9012208
miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
Reactome:R-HSA-9023909
C3PO hydrolyzes cleaved passenger strand
Reactome:R-HSA-9023912
AGO2 cleaves passenger strand of duplex siRNA
Reactome:R-HSA-9038545
miR-613 binds to the 3'UTR of the NR1H3 mRNA
Reactome:R-HSA-9618392
miR-26 binds to the 3'UTR of the ARL4C mRNA
Reactome:R-HSA-9618486
miR-26 binds to the 3'UTR of the ABCA1 mRNA
Reactome:R-HSA-9624925
miR-33 binds to the 3'UTR of the ABCA1 mRNA
Reactome:R-HSA-9657791
miR-144 binds to the 3'UTR of the ABCA1 mRNA
Reactome:R-HSA-9759950
miR-200c-3p binds CDH11 mRNA
Reactome:R-HSA-9768616
miR-9 binds CDH1 mRNA
Reactome:R-HSA-9768643
miR-10b binds CDH1 mRNA
Reactome:R-HSA-9768788
miR-224 binds NPAS4 mRNA
Reactome:R-HSA-9860139
MIR27B microRNA binds 3'UTR of TGFBR3 mRNA
Reactome:R-HSA-9860160
MIR-Let7-a1 microRNA binds 3'UTR of TGFBR3 mRNA
Reactome:R-HSA-9860168
MIR23B microRNA binds 3'UTR of TGFBR3 mRNA
Reactome:R-HSA-9924908
CD274 mRNA binds miR-93 RISC
Reactome:R-HSA-9924921
CD274 mRNA binds miR-34 RISC
Reactome:R-HSA-9924968
CD274 mRNA binds miR-429 RISC
Reactome:R-HSA-9925087
CD274 mRNA binds miR-138-5p RISC
Reactome:R-HSA-9925095
CD274 mRNA binds miR-340 RISC
Reactome:R-HSA-9925158
CD274 mRNA binds miR-152 RISC
Reactome:R-HSA-9925159
CD274 mRNA binds miR-140 RISC
Reactome:R-HSA-9925246
CD274 mRNA binds miR-Let7-a1 RISC
Reactome:R-HSA-9925270
CD274 mRNA binds miR-148a-3p RISC
Reactome:R-HSA-9925289
CD274 mRNA binds miR-424 RISC
Reactome:R-HSA-9925320
CD274 mRNA binds miR-142-5p RISC
Reactome:R-HSA-9925324
CD274 mRNA binds miR-200B/C RISC

📄 View Raw YAML

 
id: Q9UKV8
gene_symbol: AGO2
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for AGO2'
alternative_products:
- name: '1'
  id: Q9UKV8-1
- name: '2'
  id: Q9UKV8-2
  sequence_note: VSP_037001
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004521
    label: RNA endonuclease activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035194
    label: regulatory ncRNA-mediated post-transcriptional gene silencing
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036464
    label: cytoplasmic ribonucleoprotein granule
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003727
    label: single-stranded RNA binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000340
    label: RNA 7-methylguanosine cap binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000104
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000932
    label: P-body
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003676
    label: nucleic acid binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003725
    label: double-stranded RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003727
    label: single-stranded RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006355
    label: regulation of DNA-templated transcription
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006413
    label: translational initiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016891
    label: RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism
  evidence_type: IEA
  original_reference_id: GO_REF:0000104
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031047
    label: regulatory ncRNA-mediated gene silencing
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035197
    label: siRNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000104
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035278
    label: miRNA-mediated gene silencing by inhibition of translation
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035279
    label: miRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036464
    label: cytoplasmic ribonucleoprotein granule
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045947
    label: negative regulation of translational initiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000104
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070551
    label: endoribonuclease activity, cleaving siRNA-paired mRNA
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070922
    label: RISC complex assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098808
    label: mRNA cap binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000104
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14749716
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16424907
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16756390
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17400507
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17891150
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17932509
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18178619
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19167051
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19324964
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19383768
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19716330
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19820710
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19838187
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19955415
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20671708
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21525958
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21840310
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21858095
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21903422
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21981923
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22366686
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22484317
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23085987
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23090477
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23622242
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23636329
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23661684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23741051
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24043833
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24550003
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24981741
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25446899
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26496610
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28683311
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28877994
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32814053
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35271311
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:39251607
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003729
    label: mRNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004521
    label: RNA endonuclease activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060213
    label: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1900153
    label: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent
      decay
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1990904
    label: ribonucleoprotein complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035196
    label: miRNA processing
  evidence_type: NAS
  original_reference_id: PMID:28781232
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035194
    label: regulatory ncRNA-mediated post-transcriptional gene silencing
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-426496
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036464
    label: cytoplasmic ribonucleoprotein granule
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004521
    label: RNA endonuclease activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-426520
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090128
    label: regulation of synapse maturation
  evidence_type: IDA
  original_reference_id: PMID:29735530
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090128
    label: regulation of synapse maturation
  evidence_type: IMP
  original_reference_id: PMID:29735530
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098794
    label: postsynapse
  evidence_type: IDA
  original_reference_id: PMID:29735530
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098794
    label: postsynapse
  evidence_type: IMP
  original_reference_id: PMID:29735530
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IDA
  original_reference_id: PMID:29735530
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IMP
  original_reference_id: PMID:29735530
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098808
    label: mRNA cap binding
  evidence_type: IDA
  original_reference_id: PMID:17524464
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:17932509
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0033962
    label: P-body assembly
  evidence_type: IDA
  original_reference_id: PMID:31400113
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035925
    label: mRNA 3'-UTR AU-rich region binding
  evidence_type: IDA
  original_reference_id: PMID:17382880
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045727
    label: positive regulation of translation
  evidence_type: IDA
  original_reference_id: PMID:17382880
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5578742
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5578744
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5578966
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035278
    label: miRNA-mediated gene silencing by inhibition of translation
  evidence_type: IDA
  original_reference_id: PMID:23409027
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:19701182
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070922
    label: RISC complex assembly
  evidence_type: IDA
  original_reference_id: PMID:19701182
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:29395067
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IGI
  original_reference_id: PMID:31507089
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IPI
  original_reference_id: PMID:31507089
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IGI
  original_reference_id: PMID:31012336
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IPI
  original_reference_id: PMID:31012336
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26009488
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IPI
  original_reference_id: PMID:19826008
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:23985560
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042985
    label: negative regulation of amyloid precursor protein biosynthetic process
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24726324
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1606561
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1606682
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912362
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912363
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912364
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912366
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912367
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912368
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912406
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-203862
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2106614
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2106615
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2106625
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-210805
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2318752
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-426464
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-426489
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-426520
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4518575
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5578712
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5578744
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5578965
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5578966
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5687103
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8935864
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8935930
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8936058
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8936068
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8939129
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944483
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944522
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944538
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944569
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944599
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944632
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8945709
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948524
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948536
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948569
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948582
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948583
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948594
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948602
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948612
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948621
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948623
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948641
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8948651
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9011958
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9012203
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9012208
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9023909
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9023912
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9038545
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9618392
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9618486
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9624925
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9657791
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9759950
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9768616
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9768643
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9768788
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9860139
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9860160
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9860168
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9924908
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9924921
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9924968
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925087
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925095
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925158
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925246
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925270
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925289
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925320
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925324
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28546213
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25697406
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045766
    label: positive regulation of angiogenesis
  evidence_type: IDA
  original_reference_id: PMID:27208409
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1901165
    label: positive regulation of trophoblast cell migration
  evidence_type: IMP
  original_reference_id: PMID:27208409
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000932
    label: P-body
  evidence_type: IDA
  original_reference_id: PMID:23125361
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23125361
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:17531811
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IDA
  original_reference_id: PMID:17531811
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17531811
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23361462
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: IDA
  original_reference_id: PMID:28159509
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IDA
  original_reference_id: PMID:16424907
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IDA
  original_reference_id: PMID:23661684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24862572
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27157137
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23409027
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098808
    label: mRNA cap binding
  evidence_type: IPI
  original_reference_id: PMID:23409027
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15766526
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17507929
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045944
    label: positive regulation of transcription by RNA polymerase II
  evidence_type: IMP
  original_reference_id: PMID:25336585
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: TAS
  original_reference_id: PMID:19820710
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IDA
  original_reference_id: PMID:19820710
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IDA
  original_reference_id: PMID:15973356
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001046
    label: core promoter sequence-specific DNA binding
  evidence_type: IMP
  original_reference_id: PMID:25336585
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IC
  original_reference_id: PMID:25336585
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000993
    label: RNA polymerase II complex binding
  evidence_type: IDA
  original_reference_id: PMID:25336585
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25336585
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090624
    label: endoribonuclease activity, cleaving miRNA-paired mRNA
  evidence_type: IMP
  original_reference_id: PMID:22795694
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090625
    label: siRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IMP
  original_reference_id: PMID:22795694
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035196
    label: miRNA processing
  evidence_type: IDA
  original_reference_id: PMID:23661684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035196
    label: miRNA processing
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003725
    label: double-stranded RNA binding
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003727
    label: single-stranded RNA binding
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070922
    label: RISC complex assembly
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090624
    label: endoribonuclease activity, cleaving miRNA-paired mRNA
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090625
    label: siRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035279
    label: miRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070551
    label: endoribonuclease activity, cleaving siRNA-paired mRNA
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004521
    label: RNA endonuclease activity
  evidence_type: IDA
  original_reference_id: PMID:18178619
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IDA
  original_reference_id: PMID:18178619
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IDA
  original_reference_id: PMID:18178619
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035197
    label: siRNA binding
  evidence_type: IDA
  original_reference_id: PMID:19701182
  qualifier: contributes_to
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016020
    label: membrane
  evidence_type: HDA
  original_reference_id: PMID:19946888
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: HDA
  original_reference_id: PMID:22658674
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: HDA
  original_reference_id: PMID:22681889
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031047
    label: regulatory ncRNA-mediated gene silencing
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0060213
    label: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1900153
    label: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent
      decay
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000932
    label: P-body
  evidence_type: IDA
  original_reference_id: PMID:22915799
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16699599
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22915799
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16289642
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20616046
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:20014101
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19801630
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035278
    label: miRNA-mediated gene silencing by inhibition of translation
  evidence_type: IDA
  original_reference_id: PMID:19801630
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045947
    label: negative regulation of translational initiation
  evidence_type: IDA
  original_reference_id: PMID:19801630
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:17932509
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000932
    label: P-body
  evidence_type: IDA
  original_reference_id: PMID:20616046
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:20616046
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070551
    label: endoribonuclease activity, cleaving siRNA-paired mRNA
  evidence_type: IDA
  original_reference_id: PMID:17524464
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000340
    label: RNA 7-methylguanosine cap binding
  evidence_type: IDA
  original_reference_id: PMID:17524464
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035197
    label: siRNA binding
  evidence_type: IDA
  original_reference_id: PMID:15973356
  qualifier: contributes_to
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:17671087
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IDA
  original_reference_id: PMID:17671087
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035197
    label: siRNA binding
  evidence_type: IDA
  original_reference_id: PMID:17495927
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035278
    label: miRNA-mediated gene silencing by inhibition of translation
  evidence_type: IDA
  original_reference_id: PMID:17671087
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035278
    label: miRNA-mediated gene silencing by inhibition of translation
  evidence_type: IMP
  original_reference_id: PMID:18771919
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035279
    label: miRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IDA
  original_reference_id: PMID:17524464
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035279
    label: miRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IMP
  original_reference_id: PMID:18771919
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045947
    label: negative regulation of translational initiation
  evidence_type: IDA
  original_reference_id: PMID:17524464
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003743
    label: translation initiation factor activity
  evidence_type: NAS
  original_reference_id: PMID:10534406
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006412
    label: translation
  evidence_type: NAS
  original_reference_id: PMID:10534406
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000104
  title: Electronic Gene Ontology annotations created by transferring manual GO annotations
    between related proteins based on shared sequence features
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on inter-ontology
    links
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10534406
  title: 'Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization,
    localization to chromosomal bands 1p34-p35, and expression.'
  findings: []
- id: PMID:14749716
  title: Characterization of the interactions between mammalian PAZ PIWI domain proteins
    and Dicer.
  findings: []
- id: PMID:15260970
  title: Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
  findings: []
- id: PMID:15766526
  title: Involvement of microRNA in AU-rich element-mediated mRNA instability.
  findings: []
- id: PMID:15973356
  title: TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene
    silencing.
  findings: []
- id: PMID:16289642
  title: Identification of novel argonaute-associated proteins.
  findings: []
- id: PMID:16424907
  title: The role of PACT in the RNA silencing pathway.
  findings: []
- id: PMID:16699599
  title: Human retroviral host restriction factors APOBEC3G and APOBEC3F localize
    to mRNA processing bodies.
  findings: []
- id: PMID:16756390
  title: Translation repression in human cells by microRNA-induced gene silencing
    requires RCK/p54.
  findings: []
- id: PMID:17382880
  title: AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute
    2.
  findings: []
- id: PMID:17400507
  title: Identification of potential protein interactors of Lrrk2.
  findings: []
- id: PMID:17495927
  title: The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering
    RNAs.
  findings: []
- id: PMID:17507929
  title: MicroRNA silencing through RISC recruitment of eIF6.
  findings: []
- id: PMID:17524464
  title: An mRNA m7G cap binding-like motif within human Ago2 represses translation.
  findings: []
- id: PMID:17531811
  title: RNA helicase A interacts with RISC in human cells and functions in RISC loading.
  findings: []
- id: PMID:17671087
  title: Let-7 microRNA-mediated mRNA deadenylation and translational repression in
    a mammalian cell-free system.
  findings: []
- id: PMID:17891150
  title: A conserved motif in Argonaute-interacting proteins mediates functional interactions
    through the Argonaute PIWI domain.
  findings: []
- id: PMID:17932509
  title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes
    in human cells.
  findings: []
- id: PMID:18178619
  title: In vitro reconstitution of the human RISC-loading complex.
  findings: []
- id: PMID:18771919
  title: Importance of translation and nonnucleolytic ago proteins for on-target RNA
    interference.
  findings: []
- id: PMID:19167051
  title: Importin 8 is a gene silencing factor that targets argonaute proteins to
    distinct mRNAs.
  findings: []
- id: PMID:19324964
  title: The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182
    and requires GW182 to mediate silencing.
  findings: []
- id: PMID:19383768
  title: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound
    transcripts independently of Argonaute proteins.
  findings: []
- id: PMID:19701182
  title: An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
  findings: []
- id: PMID:19716330
  title: Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
  findings: []
- id: PMID:19801630
  title: RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses
    translation via argonaute2 during muscle cell differentiation.
  findings: []
- id: PMID:19820710
  title: Structural insights into RNA processing by the human RISC-loading complex.
  findings: []
- id: PMID:19826008
  title: An integrated approach for experimental target identification of hypoxia-induced
    miR-210.
  findings: []
- id: PMID:19838187
  title: Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation
    steps.
  findings: []
- id: PMID:19946888
  title: Defining the membrane proteome of NK cells.
  findings: []
- id: PMID:19955415
  title: CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs.
  findings: []
- id: PMID:19966796
  title: ATP-dependent human RISC assembly pathways.
  findings: []
- id: PMID:20014101
  title: Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and
    its dominant-negative mutant caused two-cell-stage embryonic arrest.
  findings: []
- id: PMID:20616046
  title: LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated
    gene silencing.
  findings: []
- id: PMID:20671708
  title: Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.
  findings: []
- id: PMID:21525958
  title: The ribosomal protein RACK1 is required for microRNA function in both C.
    elegans and humans.
  findings: []
- id: PMID:21840310
  title: Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby
    abrogation of nonsense-mediated mRNA decay require the cap-associating activity
    of Ago2.
  findings: []
- id: PMID:21858095
  title: Nuclear pore complex protein mediated nuclear localization of dicer protein
    in human cells.
  findings: []
- id: PMID:21903422
  title: Mapping a dynamic innate immunity protein interaction network regulating
    type I interferon production.
  findings: []
- id: PMID:21981923
  title: GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA
    targets.
  findings: []
- id: PMID:22366686
  title: Senescence is an endogenous trigger for microRNA-directed transcriptional
    gene silencing in human cells.
  findings: []
- id: PMID:22484317
  title: Human prion protein binds Argonaute and promotes accumulation of microRNA
    effector complexes.
  findings: []
- id: PMID:22658674
  title: Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
  findings: []
- id: PMID:22681889
  title: The mRNA-bound proteome and its global occupancy profile on protein-coding
    transcripts.
  findings: []
- id: PMID:22795694
  title: Slicing-independent RISC activation requires the argonaute PAZ domain.
  findings: []
- id: PMID:22915799
  title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.
  findings: []
- id: PMID:23085987
  title: Wig1 prevents cellular senescence by regulating p21 mRNA decay through control
    of RISC recruitment.
  findings: []
- id: PMID:23090477
  title: Defining a new role of GW182 in maintaining miRNA stability.
  findings: []
- id: PMID:23125361
  title: The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.
  findings: []
- id: PMID:23361462
  title: Structural insights into RISC assembly facilitated by dsRNA-binding domains
    of human RNA helicase A (DHX9).
  findings: []
- id: PMID:23409027
  title: eIF4GI facilitates the MicroRNA-mediated gene silencing.
  findings: []
- id: PMID:23622242
  title: ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced
    gene silencing.
  findings: []
- id: PMID:23636329
  title: EGFR modulates microRNA maturation in response to hypoxia through phosphorylation
    of AGO2.
  findings: []
- id: PMID:23661684
  title: Differential roles of human Dicer-binding proteins TRBP and PACT in small
    RNA processing.
  findings: []
- id: PMID:23741051
  title: Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate
    RNA interference-mediated silencing in mammalian cells.
  findings: []
- id: PMID:23985560
  title: microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the
    nucleus.
  findings: []
- id: PMID:24043833
  title: Structural features of Argonaute-GW182 protein interactions.
  findings: []
- id: PMID:24550003
  title: Involvement of telomerase reverse transcriptase in heterochromatin maintenance.
  findings: []
- id: PMID:24726324
  title: MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation
    by translocation along 3' UTRs.
  findings: []
- id: PMID:24862572
  title: Mammalian microtubule P-body dynamics are mediated by nesprin-1.
  findings: []
- id: PMID:24981741
  title: MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating
    cells in diverse oncogene- and carcinogen-induced mammary tumors.
  findings: []
- id: PMID:25336585
  title: Cellular microRNAs up-regulate transcription via interaction with promoter
    TATA-box motifs.
  findings: []
- id: PMID:25446899
  title: Cancer exosomes perform cell-independent microRNA biogenesis and promote
    tumorigenesis.
  findings: []
- id: PMID:25697406
  title: Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
  findings: []
- id: PMID:26009488
  title: Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma
    cell line L929.
  findings: []
- id: PMID:26496610
  title: A human interactome in three quantitative dimensions organized by stoichiometries
    and abundances.
  findings: []
- id: PMID:27157137
  title: Post-transcriptional gene silencing activity of human GIGYF2.
  findings: []
- id: PMID:27208409
  title: miR-15b-AGO2 play a critical role in HTR8/SVneo invasion and in a model of
    angiogenesis defects related to inflammation.
  findings: []
- id: PMID:28159509
  title: Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed
    MicroRNAs and Promotes Therapeutic Angiogenesis.
  findings: []
- id: PMID:28546213
  title: Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes
    G(1)/S phase transition.
  findings: []
- id: PMID:28683311
  title: Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent
    Recruitment of LIM-Domain-Containing Proteins.
  findings: []
- id: PMID:28781232
  title: Multivalent Recruitment of Human Argonaute by GW182.
  findings: []
- id: PMID:28877994
  title: Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling.
  findings: []
- id: PMID:29395067
  title: High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated
    Granules and Bodies.
  findings: []
- id: PMID:29735530
  title: NMDA receptor-dependent dephosphorylation of serine 387 in Argonaute 2 increases
    its degradation and affects dendritic spine density and maturation.
  findings: []
- id: PMID:31012336
  title: MicroRNA-31 Negatively Regulates Interleukin-34 Expression In Vitro.
  findings: []
- id: PMID:31400113
  title: KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral
    multiplication by interaction with Ago2 and GW182.
  findings: []
- id: PMID:31507089
  title: Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced
    gefitinib resistance in EGFR-mutant lung cancer cells.
  findings: []
- id: PMID:32814053
  title: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins
    and Uncovers Widespread Protein Aggregation in Affected Brains.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human
    interactome.
  findings: []
- id: PMID:35271311
  title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
  findings: []
- id: PMID:39251607
  title: Systematic identification of post-transcriptional regulatory modules.
  findings: []
- id: Reactome:R-HSA-1606561
  title: MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
  findings: []
- id: Reactome:R-HSA-1606682
  title: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
  findings: []
- id: Reactome:R-HSA-1912362
  title: MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
  findings: []
- id: Reactome:R-HSA-1912363
  title: MIR200B/C microRNAs bind NOTCH1 mRNA
  findings: []
- id: Reactome:R-HSA-1912364
  title: MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
  findings: []
- id: Reactome:R-HSA-1912366
  title: MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
  findings: []
- id: Reactome:R-HSA-1912367
  title: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
  findings: []
- id: Reactome:R-HSA-1912368
  title: MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
  findings: []
- id: Reactome:R-HSA-1912406
  title: p53 positively regulates transcription of MIR34 microRNAs
  findings: []
- id: Reactome:R-HSA-203862
  title: 'TODO: Fetch title'
  findings: []
- id: Reactome:R-HSA-2106614
  title: Duplex miRNA is loaded into Argonaute
  findings: []
- id: Reactome:R-HSA-2106615
  title: Removal of siRNA passenger strand
  findings: []
- id: Reactome:R-HSA-2106625
  title: Duplex siRNA is loaded into Argonaute
  findings: []
- id: Reactome:R-HSA-210805
  title: Removal of miRNA passenger strand
  findings: []
- id: Reactome:R-HSA-2318752
  title: miR-26A microRNAs bind PTEN mRNA
  findings: []
- id: Reactome:R-HSA-426464
  title: Dicer cleaves double-stranded RNA to yield double-stranded siRNA
  findings: []
- id: Reactome:R-HSA-426489
  title: RISC binds inexactly matching target RNAs
  findings: []
- id: Reactome:R-HSA-426496
  title: Post-transcriptional silencing by small RNAs
  findings: []
- id: Reactome:R-HSA-426520
  title: Endonucleolytic RISC hydrolyzes target RNAs
  findings: []
- id: Reactome:R-HSA-4518575
  title: miR-92b binds 3'UTR of NLK mRNA
  findings: []
- id: Reactome:R-HSA-5578712
  title: Importin-8 binds AGO2:miRNA
  findings: []
- id: Reactome:R-HSA-5578742
  title: AGO1,2:small RNA complexes interact with chromatin
  findings: []
- id: Reactome:R-HSA-5578744
  title: Importin-8 imports AGO2:miRNA into the nucleus
  findings: []
- id: Reactome:R-HSA-5578965
  title: TNRC6A binds AGO2:miRNA
  findings: []
- id: Reactome:R-HSA-5578966
  title: TNRC6A:AGO2:miRNA is transported into the nucleus
  findings: []
- id: Reactome:R-HSA-5687103
  title: FOXO3 regulates MIR34B,C expression
  findings: []
- id: Reactome:R-HSA-8935864
  title: miR-302b binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8935930
  title: miR-18a binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8936058
  title: miR-675 binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8936068
  title: H19 is cleaved to produce miR-675
  findings: []
- id: Reactome:R-HSA-8939129
  title: miR-215 binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8944483
  title: miR-17 microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944522
  title: miR-19a microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944538
  title: miR-22 microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944569
  title: miR-25 microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944599
  title: miR-93 microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944632
  title: miR-106 microRNAs bind PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944684
  title: miR-205 microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8945709
  title: miR-20 microRNAs bind PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8948524
  title: PTENP1 mRNA binds miR-19b RISC
  findings: []
- id: Reactome:R-HSA-8948536
  title: PTENP1 mRNA binds miR-20 RISC
  findings: []
- id: Reactome:R-HSA-8948569
  title: miR-19b microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8948582
  title: miR-17 microRNA binds VAPA mRNA
  findings: []
- id: Reactome:R-HSA-8948583
  title: miR-17 microRNA binds CNOT6L mRNA
  findings: []
- id: Reactome:R-HSA-8948594
  title: miR-19a microRNA binds VAPA mRNA
  findings: []
- id: Reactome:R-HSA-8948602
  title: miR-19a microRNA binds CNOT6L mRNA
  findings: []
- id: Reactome:R-HSA-8948612
  title: miR-19b microRNA binds CNOT6L mRNA
  findings: []
- id: Reactome:R-HSA-8948621
  title: miR-20 microRNAs bind VAPA mRNA
  findings: []
- id: Reactome:R-HSA-8948623
  title: miR-20 microRNAs bind CNOT6L mRNA
  findings: []
- id: Reactome:R-HSA-8948641
  title: miR-106 microRNAs bind VAPA mRNA
  findings: []
- id: Reactome:R-HSA-8948651
  title: miR-106a,(miR106b) microRNA binds CNOT6L mRNA
  findings: []
- id: Reactome:R-HSA-9011958
  title: miR-26A and B bind to the 3'UTR of the GREB1 mRNA
  findings: []
- id: Reactome:R-HSA-9012203
  title: miR-26A and B bind to the 3'UTR of the CHD11 mRNA
  findings: []
- id: Reactome:R-HSA-9012208
  title: miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
  findings: []
- id: Reactome:R-HSA-9023909
  title: C3PO hydrolyzes cleaved passenger strand
  findings: []
- id: Reactome:R-HSA-9023912
  title: AGO2 cleaves passenger strand of duplex siRNA
  findings: []
- id: Reactome:R-HSA-9038545
  title: miR-613 binds to the 3'UTR of the NR1H3 mRNA
  findings: []
- id: Reactome:R-HSA-9618392
  title: miR-26 binds to the 3'UTR of the ARL4C mRNA
  findings: []
- id: Reactome:R-HSA-9618486
  title: miR-26 binds to the 3'UTR of the ABCA1 mRNA
  findings: []
- id: Reactome:R-HSA-9624925
  title: miR-33 binds to the 3'UTR of the ABCA1 mRNA
  findings: []
- id: Reactome:R-HSA-9657791
  title: miR-144 binds to the 3'UTR of the ABCA1 mRNA
  findings: []
- id: Reactome:R-HSA-9759950
  title: miR-200c-3p binds CDH11 mRNA
  findings: []
- id: Reactome:R-HSA-9768616
  title: miR-9 binds CDH1 mRNA
  findings: []
- id: Reactome:R-HSA-9768643
  title: miR-10b binds CDH1 mRNA
  findings: []
- id: Reactome:R-HSA-9768788
  title: miR-224 binds NPAS4 mRNA
  findings: []
- id: Reactome:R-HSA-9860139
  title: MIR27B microRNA binds 3'UTR of TGFBR3 mRNA
  findings: []
- id: Reactome:R-HSA-9860160
  title: MIR-Let7-a1 microRNA binds 3'UTR of TGFBR3 mRNA
  findings: []
- id: Reactome:R-HSA-9860168
  title: MIR23B microRNA binds 3'UTR of TGFBR3 mRNA
  findings: []
- id: Reactome:R-HSA-9924908
  title: CD274 mRNA binds miR-93 RISC
  findings: []
- id: Reactome:R-HSA-9924921
  title: CD274 mRNA binds miR-34 RISC
  findings: []
- id: Reactome:R-HSA-9924968
  title: CD274 mRNA binds miR-429 RISC
  findings: []
- id: Reactome:R-HSA-9925087
  title: CD274 mRNA binds miR-138-5p RISC
  findings: []
- id: Reactome:R-HSA-9925095
  title: CD274 mRNA binds miR-340 RISC
  findings: []
- id: Reactome:R-HSA-9925158
  title: CD274 mRNA binds miR-152 RISC
  findings: []
- id: Reactome:R-HSA-9925159
  title: CD274 mRNA binds miR-140 RISC
  findings: []
- id: Reactome:R-HSA-9925246
  title: CD274 mRNA binds miR-Let7-a1 RISC
  findings: []
- id: Reactome:R-HSA-9925270
  title: CD274 mRNA binds miR-148a-3p RISC
  findings: []
- id: Reactome:R-HSA-9925289
  title: CD274 mRNA binds miR-424 RISC
  findings: []
- id: Reactome:R-HSA-9925320
  title: CD274 mRNA binds miR-142-5p RISC
  findings: []
- id: Reactome:R-HSA-9925324
  title: CD274 mRNA binds miR-200B/C RISC
  findings: []