TODO: Add description for AGO3
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
|
GO:0005634
nucleus
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005737
cytoplasm
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0004521
RNA endonuclease activity
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035194
regulatory ncRNA-mediated post-transcriptional gene silencing
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0016442
RISC complex
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0036464
cytoplasmic ribonucleoprotein granule
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031054
pre-miRNA processing
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035198
miRNA binding
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003727
single-stranded RNA binding
|
IBA
GO_REF:0000033 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000932
P-body
|
IEA
GO_REF:0000044 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003676
nucleic acid binding
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003723
RNA binding
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003725
double-stranded RNA binding
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003727
single-stranded RNA binding
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0016442
RISC complex
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031047
regulatory ncRNA-mediated gene silencing
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031054
pre-miRNA processing
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035198
miRNA binding
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035278
miRNA-mediated gene silencing by inhibition of translation
|
IEA
GO_REF:0000120 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035279
miRNA-mediated gene silencing by mRNA destabilization
|
IEA
GO_REF:0000108 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0036464
cytoplasmic ribonucleoprotein granule
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070578
RISC-loading complex
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070922
RISC complex assembly
|
IEA
GO_REF:0000117 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072091
regulation of stem cell proliferation
|
IEA
GO_REF:0000002 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:19167051 Importin 8 is a gene silencing factor that targets argonaute... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:19324964 The C-terminal half of human Ago2 binds to multiple GW-rich ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:19383768 The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C s... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:23064648 DICER- and AGO3-dependent generation of retinoic acid-induce... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:28330616 Systematic Analysis of Human Protein Phosphatase Interaction... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:28683311 Argonaute Utilization for miRNA Silencing Is Determined by P... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0000794
condensed nuclear chromosome
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0010628
positive regulation of gene expression
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:1901224
positive regulation of non-canonical NF-kappaB signal transduction
|
IEA
GO_REF:0000107 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035196
miRNA processing
|
NAS
PMID:28781232 Multivalent Recruitment of Human Argonaute by GW182. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0036464
cytoplasmic ribonucleoprotein granule
|
IDA
GO_REF:0000052 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0004521
RNA endonuclease activity
|
IMP
PMID:29040713 Human Argonaute3 has slicer activity. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0090624
endoribonuclease activity, cleaving miRNA-paired mRNA
|
IMP
PMID:29040713 Human Argonaute3 has slicer activity. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035196
miRNA processing
|
IMP
PMID:22795694 Slicing-independent RISC activation requires the argonaute P... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0031054
pre-miRNA processing
|
IDA
PMID:19966796 ATP-dependent human RISC assembly pathways. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003725
double-stranded RNA binding
|
IDA
PMID:19966796 ATP-dependent human RISC assembly pathways. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003727
single-stranded RNA binding
|
IDA
PMID:19966796 ATP-dependent human RISC assembly pathways. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0016442
RISC complex
|
IDA
PMID:19966796 ATP-dependent human RISC assembly pathways. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070578
RISC-loading complex
|
IDA
PMID:19966796 ATP-dependent human RISC assembly pathways. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0070922
RISC complex assembly
|
IDA
PMID:19966796 ATP-dependent human RISC assembly pathways. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0090625
siRNA-mediated gene silencing by mRNA destabilization
|
IDA
NOT
PMID:15260970 Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005737
cytoplasm
|
IDA
PMID:15260970 Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0016442
RISC complex
|
IDA
PMID:15260970 Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035198
miRNA binding
|
IDA
PMID:15260970 Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035279
miRNA-mediated gene silencing by mRNA destabilization
|
IDA
NOT
PMID:15260970 Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0016020
membrane
|
HDA
PMID:19946888 Defining the membrane proteome of NK cells. |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003723
RNA binding
|
HDA
PMID:22658674 Insights into RNA biology from an atlas of mammalian mRNA-bi... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0003723
RNA binding
|
HDA
PMID:22681889 The mRNA-bound proteome and its global occupancy profile on ... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1606561 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1606682 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1912362 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1912363 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1912364 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1912366 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1912367 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1912368 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-1912406 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-2318752 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-3209151 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-426489 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-426522 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-4518575 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-5687103 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8935766 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8937097 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8937134 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8938440 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8938487 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8938507 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8944650 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8944684 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-8944706 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9011958 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9012203 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9012208 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9038545 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9618392 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9618486 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9624925 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9657791 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9858289 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9858309 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9924921 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9925095 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9925158 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9925159 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005829
cytosol
|
TAS
Reactome:R-HSA-9925324 |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0072091
regulation of stem cell proliferation
|
IMP
PMID:23064648 DICER- and AGO3-dependent generation of retinoic acid-induce... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0005515
protein binding
|
IPI
PMID:22915799 HIV-1 replication and APOBEC3 antiviral activity are not reg... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0006402
mRNA catabolic process
|
IDA
PMID:18771919 Importance of translation and nonnucleolytic ago proteins fo... |
PENDING |
Summary: TODO: Review this GOA annotation
|
|
GO:0035278
miRNA-mediated gene silencing by inhibition of translation
|
IDA
PMID:18771919 Importance of translation and nonnucleolytic ago proteins fo... |
PENDING |
Summary: TODO: Review this GOA annotation
|
id: Q9H9G7
gene_symbol: AGO3
product_type: PROTEIN
status: INITIALIZED
taxon:
id: NCBITaxon:9606
label: Homo sapiens
description: 'TODO: Add description for AGO3'
alternative_products:
- name: '1'
id: Q9H9G7-1
- name: '2'
id: Q9H9G7-2
sequence_note: VSP_041084
existing_annotations:
- term:
id: GO:0005634
label: nucleus
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0004521
label: RNA endonuclease activity
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035194
label: regulatory ncRNA-mediated post-transcriptional gene silencing
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0016442
label: RISC complex
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0036464
label: cytoplasmic ribonucleoprotein granule
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031054
label: pre-miRNA processing
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035198
label: miRNA binding
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003727
label: single-stranded RNA binding
evidence_type: IBA
original_reference_id: GO_REF:0000033
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000932
label: P-body
evidence_type: IEA
original_reference_id: GO_REF:0000044
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003676
label: nucleic acid binding
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003723
label: RNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003725
label: double-stranded RNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003727
label: single-stranded RNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0016442
label: RISC complex
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031047
label: regulatory ncRNA-mediated gene silencing
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031054
label: pre-miRNA processing
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035198
label: miRNA binding
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035278
label: miRNA-mediated gene silencing by inhibition of translation
evidence_type: IEA
original_reference_id: GO_REF:0000120
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035279
label: miRNA-mediated gene silencing by mRNA destabilization
evidence_type: IEA
original_reference_id: GO_REF:0000108
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0036464
label: cytoplasmic ribonucleoprotein granule
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070578
label: RISC-loading complex
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070922
label: RISC complex assembly
evidence_type: IEA
original_reference_id: GO_REF:0000117
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072091
label: regulation of stem cell proliferation
evidence_type: IEA
original_reference_id: GO_REF:0000002
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19167051
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19324964
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:19383768
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:23064648
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28330616
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:28683311
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0000794
label: condensed nuclear chromosome
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0010628
label: positive regulation of gene expression
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:1901224
label: positive regulation of non-canonical NF-kappaB signal transduction
evidence_type: IEA
original_reference_id: GO_REF:0000107
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035196
label: miRNA processing
evidence_type: NAS
original_reference_id: PMID:28781232
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0036464
label: cytoplasmic ribonucleoprotein granule
evidence_type: IDA
original_reference_id: GO_REF:0000052
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0004521
label: RNA endonuclease activity
evidence_type: IMP
original_reference_id: PMID:29040713
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0090624
label: endoribonuclease activity, cleaving miRNA-paired mRNA
evidence_type: IMP
original_reference_id: PMID:29040713
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035196
label: miRNA processing
evidence_type: IMP
original_reference_id: PMID:22795694
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0031054
label: pre-miRNA processing
evidence_type: IDA
original_reference_id: PMID:19966796
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003725
label: double-stranded RNA binding
evidence_type: IDA
original_reference_id: PMID:19966796
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003727
label: single-stranded RNA binding
evidence_type: IDA
original_reference_id: PMID:19966796
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0016442
label: RISC complex
evidence_type: IDA
original_reference_id: PMID:19966796
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070578
label: RISC-loading complex
evidence_type: IDA
original_reference_id: PMID:19966796
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0070922
label: RISC complex assembly
evidence_type: IDA
original_reference_id: PMID:19966796
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0090625
label: siRNA-mediated gene silencing by mRNA destabilization
evidence_type: IDA
original_reference_id: PMID:15260970
negated: true
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005737
label: cytoplasm
evidence_type: IDA
original_reference_id: PMID:15260970
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0016442
label: RISC complex
evidence_type: IDA
original_reference_id: PMID:15260970
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035198
label: miRNA binding
evidence_type: IDA
original_reference_id: PMID:15260970
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035279
label: miRNA-mediated gene silencing by mRNA destabilization
evidence_type: IDA
original_reference_id: PMID:15260970
negated: true
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0016020
label: membrane
evidence_type: HDA
original_reference_id: PMID:19946888
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003723
label: RNA binding
evidence_type: HDA
original_reference_id: PMID:22658674
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0003723
label: RNA binding
evidence_type: HDA
original_reference_id: PMID:22681889
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1606561
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1606682
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1912362
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1912363
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1912364
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1912366
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1912367
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1912368
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-1912406
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-2318752
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-3209151
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-426489
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-426522
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-4518575
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-5687103
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8935766
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8937097
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8937134
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8938440
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8938487
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8938507
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8944650
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8944684
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-8944706
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9011958
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9012203
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9012208
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9038545
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9618392
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9618486
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9624925
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9657791
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9858289
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9858309
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9924921
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9925095
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9925158
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9925159
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005829
label: cytosol
evidence_type: TAS
original_reference_id: Reactome:R-HSA-9925324
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0072091
label: regulation of stem cell proliferation
evidence_type: IMP
original_reference_id: PMID:23064648
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0005515
label: protein binding
evidence_type: IPI
original_reference_id: PMID:22915799
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0006402
label: mRNA catabolic process
evidence_type: IDA
original_reference_id: PMID:18771919
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
- term:
id: GO:0035278
label: miRNA-mediated gene silencing by inhibition of translation
evidence_type: IDA
original_reference_id: PMID:18771919
review:
summary: 'TODO: Review this GOA annotation'
action: PENDING
references:
- id: GO_REF:0000002
title: Gene Ontology annotation through association of InterPro records with GO
terms
findings: []
- id: GO_REF:0000033
title: Annotation inferences using phylogenetic trees
findings: []
- id: GO_REF:0000044
title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
vocabulary mapping, accompanied by conservative changes to GO terms applied by
UniProt
findings: []
- id: GO_REF:0000052
title: Gene Ontology annotation based on curation of immunofluorescence data
findings: []
- id: GO_REF:0000107
title: Automatic transfer of experimentally verified manual GO annotation data to
orthologs using Ensembl Compara
findings: []
- id: GO_REF:0000108
title: Automatic assignment of GO terms using logical inference, based on on inter-ontology
links
findings: []
- id: GO_REF:0000117
title: Electronic Gene Ontology annotations created by ARBA machine learning models
findings: []
- id: GO_REF:0000120
title: Combined Automated Annotation using Multiple IEA Methods
findings: []
- id: PMID:15260970
title: Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
findings: []
- id: PMID:18771919
title: Importance of translation and nonnucleolytic ago proteins for on-target RNA
interference.
findings: []
- id: PMID:19167051
title: Importin 8 is a gene silencing factor that targets argonaute proteins to
distinct mRNAs.
findings: []
- id: PMID:19324964
title: The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182
and requires GW182 to mediate silencing.
findings: []
- id: PMID:19383768
title: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound
transcripts independently of Argonaute proteins.
findings: []
- id: PMID:19946888
title: Defining the membrane proteome of NK cells.
findings: []
- id: PMID:19966796
title: ATP-dependent human RISC assembly pathways.
findings: []
- id: PMID:22658674
title: Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
findings: []
- id: PMID:22681889
title: The mRNA-bound proteome and its global occupancy profile on protein-coding
transcripts.
findings: []
- id: PMID:22795694
title: Slicing-independent RISC activation requires the argonaute PAZ domain.
findings: []
- id: PMID:22915799
title: HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.
findings: []
- id: PMID:23064648
title: DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs
regulates human stem cell proliferation.
findings: []
- id: PMID:28330616
title: Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
findings: []
- id: PMID:28683311
title: Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent
Recruitment of LIM-Domain-Containing Proteins.
findings: []
- id: PMID:28781232
title: Multivalent Recruitment of Human Argonaute by GW182.
findings: []
- id: PMID:29040713
title: Human Argonaute3 has slicer activity.
findings: []
- id: Reactome:R-HSA-1606561
title: MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
findings: []
- id: Reactome:R-HSA-1606682
title: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
findings: []
- id: Reactome:R-HSA-1912362
title: MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
findings: []
- id: Reactome:R-HSA-1912363
title: MIR200B/C microRNAs bind NOTCH1 mRNA
findings: []
- id: Reactome:R-HSA-1912364
title: MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
findings: []
- id: Reactome:R-HSA-1912366
title: MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
findings: []
- id: Reactome:R-HSA-1912367
title: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
findings: []
- id: Reactome:R-HSA-1912368
title: MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
findings: []
- id: Reactome:R-HSA-1912406
title: p53 positively regulates transcription of MIR34 microRNAs
findings: []
- id: Reactome:R-HSA-2318752
title: miR-26A microRNAs bind PTEN mRNA
findings: []
- id: Reactome:R-HSA-3209151
title: miR-24 binds p16INK4A and p14ARF mRNAs
findings: []
- id: Reactome:R-HSA-426489
title: RISC binds inexactly matching target RNAs
findings: []
- id: Reactome:R-HSA-426522
title: Nonendonucleolytic RISC binds exactly matching target RNAs
findings: []
- id: Reactome:R-HSA-4518575
title: miR-92b binds 3'UTR of NLK mRNA
findings: []
- id: Reactome:R-HSA-5687103
title: FOXO3 regulates MIR34B,C expression
findings: []
- id: Reactome:R-HSA-8935766
title: miR-378 binds RUNX1 mRNA
findings: []
- id: Reactome:R-HSA-8937097
title: MIR27A gene transcription is stimulated by the complex containing RUNX1,
PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
findings: []
- id: Reactome:R-HSA-8937134
title: miR-27a binds RUNX1 mRNA
findings: []
- id: Reactome:R-HSA-8938440
title: miR-17 binds RUNX1 mRNA
findings: []
- id: Reactome:R-HSA-8938487
title: miR-20a binds RUNX1 mRNA
findings: []
- id: Reactome:R-HSA-8938507
title: miR-106a binds RUNX1 mRNA
findings: []
- id: Reactome:R-HSA-8944650
title: miR-214 microRNA binds PTEN mRNA
findings: []
- id: Reactome:R-HSA-8944684
title: miR-205 microRNA binds PTEN mRNA
findings: []
- id: Reactome:R-HSA-8944706
title: miR-21 nonendonucleolytic RISC binds PTEN mRNA
findings: []
- id: Reactome:R-HSA-9011958
title: miR-26A and B bind to the 3'UTR of the GREB1 mRNA
findings: []
- id: Reactome:R-HSA-9012203
title: miR-26A and B bind to the 3'UTR of the CHD11 mRNA
findings: []
- id: Reactome:R-HSA-9012208
title: miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
findings: []
- id: Reactome:R-HSA-9038545
title: miR-613 binds to the 3'UTR of the NR1H3 mRNA
findings: []
- id: Reactome:R-HSA-9618392
title: miR-26 binds to the 3'UTR of the ARL4C mRNA
findings: []
- id: Reactome:R-HSA-9618486
title: miR-26 binds to the 3'UTR of the ABCA1 mRNA
findings: []
- id: Reactome:R-HSA-9624925
title: miR-33 binds to the 3'UTR of the ABCA1 mRNA
findings: []
- id: Reactome:R-HSA-9657791
title: miR-144 binds to the 3'UTR of the ABCA1 mRNA
findings: []
- id: Reactome:R-HSA-9858289
title: MITF-M-dependent miR-211 expression
findings: []
- id: Reactome:R-HSA-9858309
title: miR-211 RISC binds POU3F2 mRNA
findings: []
- id: Reactome:R-HSA-9924921
title: CD274 mRNA binds miR-34 RISC
findings: []
- id: Reactome:R-HSA-9925095
title: CD274 mRNA binds miR-340 RISC
findings: []
- id: Reactome:R-HSA-9925158
title: CD274 mRNA binds miR-152 RISC
findings: []
- id: Reactome:R-HSA-9925159
title: CD274 mRNA binds miR-140 RISC
findings: []
- id: Reactome:R-HSA-9925324
title: CD274 mRNA binds miR-200B/C RISC
findings: []