AGO4

UniProt ID: Q9HCK5
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for AGO4

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005634 nucleus
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004521 RNA endonuclease activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036464 cytoplasmic ribonucleoprotein granule
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003727 single-stranded RNA binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000932 P-body
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003676 nucleic acid binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003723 RNA binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003725 double-stranded RNA binding
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003727 single-stranded RNA binding
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036464 cytoplasmic ribonucleoprotein granule
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070922 RISC complex assembly
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19167051
Importin 8 is a gene silencing factor that targets argonaute... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19324964
The C-terminal half of human Ago2 binds to multiple GW-rich ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19383768
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C s... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035196 miRNA processing
NAS
PMID:28781232
Multivalent Recruitment of Human Argonaute by GW182. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036464 cytoplasmic ribonucleoprotein granule
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:15766526
Involvement of microRNA in AU-rich element-mediated mRNA ins... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035196 miRNA processing
IMP
PMID:22795694
Slicing-independent RISC activation requires the argonaute P... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031054 pre-miRNA processing
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003725 double-stranded RNA binding
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003727 single-stranded RNA binding
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070578 RISC-loading complex
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070922 RISC complex assembly
IDA
PMID:19966796
ATP-dependent human RISC assembly pathways. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
IDA NOT
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016442 RISC complex
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035198 miRNA binding
IDA
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
IDA NOT
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
HDA
PMID:19946888
Defining the membrane proteome of NK cells. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1606561 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1606682 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912362 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912363 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912364 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912366 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912367 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912368 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1912406 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-2318752 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-3209151 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-426489 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-426522 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-4518575 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5687103 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8935766 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8937097 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8937134 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8938440 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8938487 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8938507 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944650 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944684 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8944706 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9011958 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9012203 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9012208 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9038545 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9618392 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9618486 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9624925 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9657791 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9858289 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9858309 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9924921 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925095 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925158 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925159 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9925324 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006402 mRNA catabolic process
IDA
PMID:18771919
Importance of translation and nonnucleolytic ago proteins fo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
IDA
PMID:18771919
Importance of translation and nonnucleolytic ago proteins fo... 		PENDING
Summary: TODO: Review this GOA annotation

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:15260970
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
PMID:15766526
Involvement of microRNA in AU-rich element-mediated mRNA instability.
PMID:18771919
Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.
PMID:19167051
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs.
PMID:19324964
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.
PMID:19383768
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.
PMID:19946888
Defining the membrane proteome of NK cells.
PMID:19966796
ATP-dependent human RISC assembly pathways.
PMID:22795694
Slicing-independent RISC activation requires the argonaute PAZ domain.
PMID:28781232
Multivalent Recruitment of Human Argonaute by GW182.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Reactome:R-HSA-1606561
MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
Reactome:R-HSA-1606682
MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
Reactome:R-HSA-1912362
MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
Reactome:R-HSA-1912363
MIR200B/C microRNAs bind NOTCH1 mRNA
Reactome:R-HSA-1912364
MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
Reactome:R-HSA-1912366
MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
Reactome:R-HSA-1912367
MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
Reactome:R-HSA-1912368
MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
Reactome:R-HSA-1912406
p53 positively regulates transcription of MIR34 microRNAs
Reactome:R-HSA-2318752
miR-26A microRNAs bind PTEN mRNA
Reactome:R-HSA-3209151
miR-24 binds p16INK4A and p14ARF mRNAs
Reactome:R-HSA-426489
RISC binds inexactly matching target RNAs
Reactome:R-HSA-426522
Nonendonucleolytic RISC binds exactly matching target RNAs
Reactome:R-HSA-4518575
miR-92b binds 3'UTR of NLK mRNA
Reactome:R-HSA-5687103
FOXO3 regulates MIR34B,C expression
Reactome:R-HSA-8935766
miR-378 binds RUNX1 mRNA
Reactome:R-HSA-8937097
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
Reactome:R-HSA-8937134
miR-27a binds RUNX1 mRNA
Reactome:R-HSA-8938440
miR-17 binds RUNX1 mRNA
Reactome:R-HSA-8938487
miR-20a binds RUNX1 mRNA
Reactome:R-HSA-8938507
miR-106a binds RUNX1 mRNA
Reactome:R-HSA-8944650
miR-214 microRNA binds PTEN mRNA
Reactome:R-HSA-8944684
miR-205 microRNA binds PTEN mRNA
Reactome:R-HSA-8944706
miR-21 nonendonucleolytic RISC binds PTEN mRNA
Reactome:R-HSA-9011958
miR-26A and B bind to the 3'UTR of the GREB1 mRNA
Reactome:R-HSA-9012203
miR-26A and B bind to the 3'UTR of the CHD11 mRNA
Reactome:R-HSA-9012208
miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
Reactome:R-HSA-9038545
miR-613 binds to the 3'UTR of the NR1H3 mRNA
Reactome:R-HSA-9618392
miR-26 binds to the 3'UTR of the ARL4C mRNA
Reactome:R-HSA-9618486
miR-26 binds to the 3'UTR of the ABCA1 mRNA
Reactome:R-HSA-9624925
miR-33 binds to the 3'UTR of the ABCA1 mRNA
Reactome:R-HSA-9657791
miR-144 binds to the 3'UTR of the ABCA1 mRNA
Reactome:R-HSA-9858289
MITF-M-dependent miR-211 expression
Reactome:R-HSA-9858309
miR-211 RISC binds POU3F2 mRNA
Reactome:R-HSA-9924921
CD274 mRNA binds miR-34 RISC
Reactome:R-HSA-9925095
CD274 mRNA binds miR-340 RISC
Reactome:R-HSA-9925158
CD274 mRNA binds miR-152 RISC
Reactome:R-HSA-9925159
CD274 mRNA binds miR-140 RISC
Reactome:R-HSA-9925324
CD274 mRNA binds miR-200B/C RISC

📄 View Raw YAML

 
id: Q9HCK5
gene_symbol: AGO4
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for AGO4'
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004521
    label: RNA endonuclease activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035194
    label: regulatory ncRNA-mediated post-transcriptional gene silencing
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036464
    label: cytoplasmic ribonucleoprotein granule
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003727
    label: single-stranded RNA binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000932
    label: P-body
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003676
    label: nucleic acid binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003723
    label: RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003725
    label: double-stranded RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003727
    label: single-stranded RNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035278
    label: miRNA-mediated gene silencing by inhibition of translation
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036464
    label: cytoplasmic ribonucleoprotein granule
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070922
    label: RISC complex assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19167051
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19324964
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19383768
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035196
    label: miRNA processing
  evidence_type: NAS
  original_reference_id: PMID:28781232
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036464
    label: cytoplasmic ribonucleoprotein granule
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15766526
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035196
    label: miRNA processing
  evidence_type: IMP
  original_reference_id: PMID:22795694
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031054
    label: pre-miRNA processing
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003725
    label: double-stranded RNA binding
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0003727
    label: single-stranded RNA binding
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070578
    label: RISC-loading complex
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070922
    label: RISC complex assembly
  evidence_type: IDA
  original_reference_id: PMID:19966796
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0090625
    label: siRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IDA
  original_reference_id: PMID:15260970
  negated: true
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016442
    label: RISC complex
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035198
    label: miRNA binding
  evidence_type: IDA
  original_reference_id: PMID:15260970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035279
    label: miRNA-mediated gene silencing by mRNA destabilization
  evidence_type: IDA
  original_reference_id: PMID:15260970
  negated: true
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016020
    label: membrane
  evidence_type: HDA
  original_reference_id: PMID:19946888
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1606561
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1606682
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912362
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912363
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912364
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912366
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912367
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912368
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1912406
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2318752
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3209151
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-426489
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-426522
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4518575
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5687103
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8935766
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8937097
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8937134
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8938440
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8938487
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8938507
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944650
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944684
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8944706
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9011958
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9012203
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9012208
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9038545
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9618392
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9618486
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9624925
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9657791
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9858289
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9858309
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9924921
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925095
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925158
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9925324
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006402
    label: mRNA catabolic process
  evidence_type: IDA
  original_reference_id: PMID:18771919
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035278
    label: miRNA-mediated gene silencing by inhibition of translation
  evidence_type: IDA
  original_reference_id: PMID:18771919
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:15260970
  title: Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
  findings: []
- id: PMID:15766526
  title: Involvement of microRNA in AU-rich element-mediated mRNA instability.
  findings: []
- id: PMID:18771919
  title: Importance of translation and nonnucleolytic ago proteins for on-target RNA
    interference.
  findings: []
- id: PMID:19167051
  title: Importin 8 is a gene silencing factor that targets argonaute proteins to
    distinct mRNAs.
  findings: []
- id: PMID:19324964
  title: The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182
    and requires GW182 to mediate silencing.
  findings: []
- id: PMID:19383768
  title: The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound
    transcripts independently of Argonaute proteins.
  findings: []
- id: PMID:19946888
  title: Defining the membrane proteome of NK cells.
  findings: []
- id: PMID:19966796
  title: ATP-dependent human RISC assembly pathways.
  findings: []
- id: PMID:22795694
  title: Slicing-independent RISC activation requires the argonaute PAZ domain.
  findings: []
- id: PMID:28781232
  title: Multivalent Recruitment of Human Argonaute by GW182.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human
    interactome.
  findings: []
- id: Reactome:R-HSA-1606561
  title: MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
  findings: []
- id: Reactome:R-HSA-1606682
  title: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
  findings: []
- id: Reactome:R-HSA-1912362
  title: MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
  findings: []
- id: Reactome:R-HSA-1912363
  title: MIR200B/C microRNAs bind NOTCH1 mRNA
  findings: []
- id: Reactome:R-HSA-1912364
  title: MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
  findings: []
- id: Reactome:R-HSA-1912366
  title: MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
  findings: []
- id: Reactome:R-HSA-1912367
  title: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
  findings: []
- id: Reactome:R-HSA-1912368
  title: MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
  findings: []
- id: Reactome:R-HSA-1912406
  title: p53 positively regulates transcription of MIR34 microRNAs
  findings: []
- id: Reactome:R-HSA-2318752
  title: miR-26A microRNAs bind PTEN mRNA
  findings: []
- id: Reactome:R-HSA-3209151
  title: miR-24 binds p16INK4A and p14ARF mRNAs
  findings: []
- id: Reactome:R-HSA-426489
  title: RISC binds inexactly matching target RNAs
  findings: []
- id: Reactome:R-HSA-426522
  title: Nonendonucleolytic RISC binds exactly matching target RNAs
  findings: []
- id: Reactome:R-HSA-4518575
  title: miR-92b binds 3'UTR of NLK mRNA
  findings: []
- id: Reactome:R-HSA-5687103
  title: FOXO3 regulates MIR34B,C expression
  findings: []
- id: Reactome:R-HSA-8935766
  title: miR-378 binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8937097
  title: MIR27A gene transcription is stimulated by the complex containing RUNX1,
    PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
  findings: []
- id: Reactome:R-HSA-8937134
  title: miR-27a binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8938440
  title: miR-17 binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8938487
  title: miR-20a binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8938507
  title: miR-106a binds RUNX1 mRNA
  findings: []
- id: Reactome:R-HSA-8944650
  title: miR-214 microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944684
  title: miR-205 microRNA binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-8944706
  title: miR-21 nonendonucleolytic RISC binds PTEN mRNA
  findings: []
- id: Reactome:R-HSA-9011958
  title: miR-26A and B bind to the 3'UTR of the GREB1 mRNA
  findings: []
- id: Reactome:R-HSA-9012203
  title: miR-26A and B bind to the 3'UTR of the CHD11 mRNA
  findings: []
- id: Reactome:R-HSA-9012208
  title: miR-26A and B bind to the 3'UTR of the KPNA2 mRNA
  findings: []
- id: Reactome:R-HSA-9038545
  title: miR-613 binds to the 3'UTR of the NR1H3 mRNA
  findings: []
- id: Reactome:R-HSA-9618392
  title: miR-26 binds to the 3'UTR of the ARL4C mRNA
  findings: []
- id: Reactome:R-HSA-9618486
  title: miR-26 binds to the 3'UTR of the ABCA1 mRNA
  findings: []
- id: Reactome:R-HSA-9624925
  title: miR-33 binds to the 3'UTR of the ABCA1 mRNA
  findings: []
- id: Reactome:R-HSA-9657791
  title: miR-144 binds to the 3'UTR of the ABCA1 mRNA
  findings: []
- id: Reactome:R-HSA-9858289
  title: MITF-M-dependent miR-211 expression
  findings: []
- id: Reactome:R-HSA-9858309
  title: miR-211 RISC binds POU3F2 mRNA
  findings: []
- id: Reactome:R-HSA-9924921
  title: CD274 mRNA binds miR-34 RISC
  findings: []
- id: Reactome:R-HSA-9925095
  title: CD274 mRNA binds miR-340 RISC
  findings: []
- id: Reactome:R-HSA-9925158
  title: CD274 mRNA binds miR-152 RISC
  findings: []
- id: Reactome:R-HSA-9925159
  title: CD274 mRNA binds miR-140 RISC
  findings: []
- id: Reactome:R-HSA-9925324
  title: CD274 mRNA binds miR-200B/C RISC
  findings: []