GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB O43918 AIRE is_active_in GO:0005634 nucleus cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338803|PANTHER:PTN005329562 9606 Homo sapiens GO_Central Autoimmune regulator 20250904 UniProtKB O43918 AIRE involved_in GO:0045944 positive regulation of transcription by RNA polymerase II biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338803|PANTHER:PTN005329562|UniProtKB:O43918 9606 Homo sapiens GO_Central Autoimmune regulator 20201002 UniProtKB O43918 AIRE enables GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN005329562|UniProtKB:O43918 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE involved_in GO:0002458 peripheral T cell tolerance induction biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338803|PANTHER:PTN002931439 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE involved_in GO:0002509 central tolerance induction to self antigen biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN002931439|UniProtKB:O43918 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE enables GO:0003682 chromatin binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN005329562|UniProtKB:O43918 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE involved_in GO:0006959 humoral immune response biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338803|PANTHER:PTN002931439 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE enables GO:0042393 histone binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN005329562|UniProtKB:O43918 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE involved_in GO:0045060 negative thymic T cell selection biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338803|PANTHER:PTN002931439 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE involved_in GO:0097536 thymus epithelium morphogenesis biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338803|PANTHER:PTN002931439 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE involved_in GO:2000410 regulation of thymocyte migration biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1338803|PANTHER:PTN002931439 9606 Homo sapiens GO_Central Autoimmune regulator 20180816 UniProtKB O43918 AIRE involved_in GO:0002507 tolerance induction biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00088939 9606 Homo sapiens UniProt Autoimmune regulator 20260428 UniProtKB O43918 AIRE enables GO:0003677 DNA binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000770|InterPro:IPR008087 9606 Homo sapiens InterPro Autoimmune regulator 20260428 UniProtKB O43918 AIRE located_in GO:0005634 nucleus cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904|InterPro:IPR004865|InterPro:IPR008087|UniProtKB-SubCell:SL-0191 9606 Homo sapiens UniProt Autoimmune regulator 20260428 UniProtKB O43918 AIRE located_in GO:0005737 cytoplasm cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904|InterPro:IPR008087|UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt Autoimmune regulator 20260428 UniProtKB O43918 AIRE involved_in GO:0006417 regulation of translation biological_process ECO:0000366 IEA GO_REF:0000108 GO:0045182 9606 Homo sapiens GOC Autoimmune regulator 20260428 UniProtKB O43918 AIRE involved_in GO:0006955 immune response biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026313 9606 Homo sapiens UniProt Autoimmune regulator 20260428 UniProtKB O43918 AIRE involved_in GO:0006959 humoral immune response biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR008087 9606 Homo sapiens InterPro Autoimmune regulator 20260428 UniProtKB O43918 AIRE enables GO:0045182 translation regulator activity molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR008087 9606 Homo sapiens InterPro Autoimmune regulator 20260428 UniProtKB O43918 AIRE involved_in GO:0045944 positive regulation of transcription by RNA polymerase II biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00027996 9606 Homo sapiens UniProt Autoimmune regulator 20260428 UniProtKB O43918 AIRE enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:17474147 UniProtKB:P16333 9606 Homo sapiens IntAct Autoimmune regulator 20260425 UniProtKB O43918 AIRE enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:18292755 UniProtKB:P68431 9606 Homo sapiens IntAct Autoimmune regulator 20260425 UniProtKB O43918 AIRE enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20085707 UniProtKB:P78527 9606 Homo sapiens IntAct Autoimmune regulator 20260425 UniProtKB O43918 AIRE enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20185822 UniProtKB:Q9UER7 9606 Homo sapiens IntAct Autoimmune regulator 20260425 UniProtKB O43918 AIRE enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:15712268 UniProtKB:O43918 9606 Homo sapiens IntAct Autoimmune regulator 20260425 UniProtKB O43918 AIRE enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:20185822 UniProtKB:O43918 9606 Homo sapiens IntAct Autoimmune regulator 20260425 UniProtKB O43918 AIRE enables GO:0042802 identical protein binding molecular_function ECO:0000353 IPI PMID:28540407 UniProtKB:O43918 9606 Homo sapiens IntAct Autoimmune regulator 20260425 UniProtKB O43918 AIRE involved_in GO:0002458 peripheral T cell tolerance induction biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904 9606 Homo sapiens Ensembl Autoimmune regulator 20260422 UniProtKB O43918 AIRE located_in GO:0016604 nuclear body cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904 9606 Homo sapiens Ensembl Autoimmune regulator 20260422 UniProtKB O43918 AIRE involved_in GO:0032722 positive regulation of chemokine production biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904 9606 Homo sapiens Ensembl Autoimmune regulator 20260422 UniProtKB O43918 AIRE enables GO:0042802 identical protein binding molecular_function ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00027930|UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904 9606 Homo sapiens UniProt Autoimmune regulator 20260422 UniProtKB O43918 AIRE involved_in GO:0097536 thymus epithelium morphogenesis biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904 9606 Homo sapiens Ensembl Autoimmune regulator 20260422 UniProtKB O43918 AIRE involved_in GO:2000410 regulation of thymocyte migration biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9Z0E3|ensembl:ENSMUSP00000114904 9606 Homo sapiens Ensembl Autoimmune regulator 20260422 UniProtKB O43918 AIRE located_in GO:0005634 nucleus cellular_component ECO:0000269 EXP PMID:14974083 9606 Homo sapiens UniProt Autoimmune regulator 20240508 UniProtKB O43918 AIRE located_in GO:0005634 nucleus cellular_component ECO:0000269 EXP PMID:26084028 9606 Homo sapiens UniProt Autoimmune regulator 20240508 UniProtKB O43918 AIRE located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:11274163 9606 Homo sapiens UniProt Autoimmune regulator 20240508 UniProtKB O43918 AIRE located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:14974083 9606 Homo sapiens UniProt Autoimmune regulator 20240508 UniProtKB O43918 AIRE located_in GO:0016604 nuclear body cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9Z0E3 9606 Homo sapiens UniProt Autoimmune regulator 20161003 UniProtKB O43918 AIRE involved_in GO:0032722 positive regulation of chemokine production biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9Z0E3 9606 Homo sapiens UniProt Autoimmune regulator 20161003 UniProtKB O43918 AIRE involved_in GO:0097536 thymus epithelium morphogenesis biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9Z0E3 9606 Homo sapiens UniProt Autoimmune regulator 20161003 UniProtKB O43918 AIRE involved_in GO:2000410 regulation of thymocyte migration biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9Z0E3 9606 Homo sapiens UniProt Autoimmune regulator 20161003 UniProtKB O43918 AIRE involved_in GO:0002458 peripheral T cell tolerance induction biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9Z0E3 9606 Homo sapiens UniProt Autoimmune regulator 20160930 UniProtKB O43918 AIRE involved_in GO:0002509 central tolerance induction to self antigen biological_process ECO:0000315 IMP PMID:26084028 9606 Homo sapiens UniProt Autoimmune regulator 20160928 UniProtKB O43918 AIRE involved_in GO:0045893 positive regulation of DNA-templated transcription biological_process ECO:0000315 IMP PMID:26084028 9606 Homo sapiens UniProt Autoimmune regulator 20160928 UniProtKB O43918 AIRE enables GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function ECO:0000314 IDA PMID:11533054 9606 Homo sapiens NTNU_SB Autoimmune regulator 20141117 UniProtKB O43918 AIRE involved_in GO:0045944 positive regulation of transcription by RNA polymerase II biological_process ECO:0000315 IMP PMID:11274163 9606 Homo sapiens NTNU_SB Autoimmune regulator 20141117 UniProtKB O43918 AIRE enables GO:0003682 chromatin binding molecular_function ECO:0000314 IDA PMID:18292755 9606 Homo sapiens UniProt Autoimmune regulator 20090716 UniProtKB O43918 AIRE involved_in GO:0006355 regulation of DNA-templated transcription biological_process ECO:0000314 IDA PMID:18292755 9606 Homo sapiens UniProt Autoimmune regulator 20090716 UniProtKB O43918 AIRE enables GO:0008270 zinc ion binding molecular_function ECO:0000314 IDA PMID:19446523 9606 Homo sapiens UniProt Autoimmune regulator 20090716 UniProtKB O43918 AIRE enables GO:0042393 histone binding molecular_function ECO:0000314 IDA PMID:18292755 9606 Homo sapiens UniProt Autoimmune regulator 20090716 UniProtKB O43918 AIRE enables GO:0042393 histone binding molecular_function ECO:0000314 IDA PMID:19446523 9606 Homo sapiens UniProt Autoimmune regulator 20090716 UniProtKB O43918 AIRE involved_in GO:0045893 positive regulation of DNA-templated transcription biological_process ECO:0000314 IDA PMID:18292755 9606 Homo sapiens UniProt Autoimmune regulator 20090716 UniProtKB O43918 AIRE located_in GO:0005634 nucleus cellular_component ECO:0000304 TAS PMID:9398839 9606 Homo sapiens PINC Autoimmune regulator 20030904 UniProtKB O43918 AIRE involved_in GO:0006955 immune response biological_process ECO:0000304 TAS PMID:9398840 9606 Homo sapiens PINC Autoimmune regulator 20030904 UniProtKB O43918 AIRE located_in GO:0005634 nucleus cellular_component ECO:0000303 NAS PMID:9398840 9606 Homo sapiens UniProt Autoimmune regulator 20021105