AIRIM (AFG2-interacting ribosome maturation factor, formerly C1orf109) is a small nuclear and cytoplasmic protein that functions as a structural subunit of the 55LCC complex, a eumetazoan AAA+ ATPase assembly of 4:2:2:2 stoichiometry, which it forms together with the ATPase subunits AFG2A/SPATA5 and AFG2B/SPATA5L1 and the partner protein CINP. Within the assembly, AIRIM and CINP sit above the cylindrical ATPase motor and build a funnel-like entry structure, so AIRIM contributes the architecture through which substrates reach the motor rather than any catalytic activity of its own. The complex acts in two distinct settings. In the cytoplasm it drives a late step of pre-60S ribosomal large subunit maturation, and loss of AIRIM reduces the supply of mature ribosomes and depresses global protein synthesis. In the nucleus the same complex is chromatin-associated and performs replisome proteostasis: its ATPase activity is stimulated by replication fork DNA and is coupled to protease-dependent clearance of replisome proteins after fork damage, a route that is independent of the ubiquitin-VCP/p97 pathway that terminates replication. Losing the complex therefore produces both translational deficits and replication stress with chromosome instability. Because ribosome supply is limiting during neural development, hypomorphic AIRIM variants cause a neurodevelopmental disorder, paralleling the disorders caused by recessive AFG2A/SPATA5 mutations; these developmental defects are suppressed by enhancing mTOR activity. A separate, isoform-specific activity has been reported for the long isoform C1orf109L, which binds DHX9 and promotes R-loop-dependent DNA damage; that is not currently covered by any GO annotation on this gene and should not be assumed to hold for the canonical product.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein binding with ZBED1, from a high-throughput Y2H pilot, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZBED1 in a high-throughput Y2H pilot, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:21516116 test the strategy in a high-throughput yeast two-hybrid (Y2H) system |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein binding with ZNF398, from a high-throughput Y2H pilot, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZNF398 in a high-throughput Y2H pilot, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:21516116 test the strategy in a high-throughput yeast two-hybrid (Y2H) system |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein binding with KIFC3, from a high-throughput Y2H pilot, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KIFC3 in a high-throughput Y2H pilot, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:21516116 test the strategy in a high-throughput yeast two-hybrid (Y2H) system |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with KRT13, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT13 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with PLK4, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PLK4 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with SDCBP, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SDCBP in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with CRX, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CRX in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TADA2A, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TADA2A in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with STX11, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with STX11 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with LDOC1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with LDOC1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with ZBED1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZBED1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with KRT19, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT19 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TCF4, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TCF4 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with MEOX2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MEOX2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with REL, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with REL in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TLE5, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TLE5 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with GOLGA2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with GOLGA2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TRAF1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TRAF1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with IKZF1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with IKZF1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with KRT31, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT31 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with CEP55, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CEP55 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with MTUS2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MTUS2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with PDE4DIP, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PDE4DIP in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with KRT40, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT40 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with RINT1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with RINT1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with C1orf94, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with C1orf94 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with NECAB2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with NECAB2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TRIM42, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TRIM42 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with PHC2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PHC2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with IHO1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with IHO1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with VPS52, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with VPS52 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with USHBP1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with USHBP1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with CBY2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CBY2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with ZNF398, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZNF398 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with SPAG5, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SPAG5 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TCF12, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TCF12 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with LZTS2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with LZTS2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with KIFC3, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KIFC3 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with KATNAL1, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KATNAL1 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | MODIFY | Summary: Interaction with CINP, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: CINP is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TRIM54, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TRIM54 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with PPP1R12C, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PPP1R12C in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with MKRN2, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MKRN2 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with RNF41, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with RNF41 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with TFIP11, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TFIP11 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding with IKZF3, from HI-II-14, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with IKZF3 in HI-II-14, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:25416956 Here, we describe a systematic map of ~14,000 high-quality human binary protein-protein interactions. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | MODIFY | Summary: Interaction with CINP, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: CINP is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CCDC88B, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CCDC88B in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with GOLGA6L9, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with GOLGA6L9 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with OOEP, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with OOEP in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with MEI4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MEI4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZBTB42, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZBTB42 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with FAM22F, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with FAM22F in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with NME4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with NME4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SOCS6, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SOCS6 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PRMT5, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PRMT5 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with MDM4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MDM4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZSCAN9, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZSCAN9 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SORBS3, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SORBS3 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with GIGYF1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with GIGYF1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TADA2A, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TADA2A in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with STX11, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with STX11 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT75, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT75 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZBED1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZBED1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with POMC, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with POMC in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT18, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT18 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT19, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT19 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT16, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT16 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZNF688, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZNF688 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZNF17, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZNF17 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZNF20, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZNF20 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with NDUFB7, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with NDUFB7 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PAX7, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PAX7 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with LMO2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with LMO2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PAX6, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PAX6 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PSMB4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PSMB4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with HOXC8, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with HOXC8 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TNNI2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TNNI2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with MEOX1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MEOX1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with VBP1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with VBP1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CTAG1A; CTAG1B, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CTAG1A; CTAG1B in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with POU6F2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with POU6F2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT76, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT76 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PAX5, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PAX5 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with REL, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with REL in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TLE5, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TLE5 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PUDP, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PUDP in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TRAF1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TRAF1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with IKZF1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with IKZF1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SERTAD2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SERTAD2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT31, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT31 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ECM1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ECM1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KIAA0753, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KIAA0753 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT24, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT24 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TSGA10IP, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TSGA10IP in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRTAP13-3, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRTAP13-3 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with USH1G, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with USH1G in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CEP55, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CEP55 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with AVPI1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with AVPI1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with RNF20, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with RNF20 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PDE4DIP, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PDE4DIP in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TASOR2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TASOR2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TTC23, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TTC23 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with MEOX2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MEOX2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT80, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT80 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with RINT1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with RINT1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TTC23L, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TTC23L in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with GET4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with GET4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with NUP54, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with NUP54 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with NECAB2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with NECAB2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SAPCD2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SAPCD2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CCDC125, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CCDC125 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with IHO1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with IHO1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with VPS52, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with VPS52 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CBY2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CBY2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SPMIP6, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SPMIP6 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SLAIN1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SLAIN1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PNMA1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PNMA1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with NFKBID, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with NFKBID in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZNF420, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZNF420 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with UHMK1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with UHMK1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with MIPOL1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MIPOL1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CCHCR1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CCHCR1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CT55, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CT55 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TEKT4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TEKT4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with MBD3L1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MBD3L1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KRT35, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KRT35 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ADD1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ADD1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with HOOK2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with HOOK2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with INKA1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with INKA1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SMARCD1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SMARCD1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with BORCS6, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with BORCS6 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CCDC120, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CCDC120 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TEPSIN, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TEPSIN in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with VGLL1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with VGLL1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ECSIT, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ECSIT in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ANTKMT, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ANTKMT in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with LZTS2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with LZTS2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KIFC3, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KIFC3 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with RUSC1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with RUSC1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KATNAL1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KATNAL1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MODIFY | Summary: Interaction with CINP, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: CINP is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with C1QTNF2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with C1QTNF2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with CDCA4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with CDCA4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PBX4, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PBX4 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TRIM54, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TRIM54 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PPP1R12C, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PPP1R12C in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with FTO, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with FTO in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with MTFR1L, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with MTFR1L in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZMYND12, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZMYND12 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with RNF41, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with RNF41 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with STN1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with STN1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TTC12, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TTC12 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with PRDM6, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with PRDM6 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with DISC1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with DISC1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with FAM217B, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with FAM217B in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with FAM86C1P, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with FAM86C1P in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with GOLGA6A, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with GOLGA6A in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ABI2, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ABI2 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with STMN3, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with STMN3 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with TFIP11, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with TFIP11 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with HESX1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with HESX1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ZMAT5, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ZMAT5 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with SERTAD1, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with SERTAD1 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with KLF15, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with KLF15 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with IKZF3, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with IKZF3 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with RPH3AL, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with RPH3AL in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding with ATP23, from HuRI, a systematic binary interactome screen. Uninformative as a function statement. Reason: This row records that AIRIM scored an interaction with ATP23 in HuRI, a proteome-scale binary interaction dataset rather than a study of AIRIM. Such datasets are valuable and the interaction is not being disputed here; the objection is to the GO term. GO:0005515 says only that two proteins touch, which for a gene carrying 174 such rows conveys nothing about what AIRIM does, and none of these partners is a 55LCC subunit or otherwise supports a more specific molecular function that could be proposed instead. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:32296183 Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. PMID:32296183 With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: Interaction with CINP, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: CINP is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005515 protein binding | IPI PMID:35354024 Labeling of heterochronic ribosomes reveals C1ORF109 and SPA... | MODIFY | Summary: Interaction with AFG2A, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: AFG2A is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005515 protein binding | IPI PMID:35354024 Labeling of heterochronic ribosomes reveals C1ORF109 and SPA... | MODIFY | Summary: Interaction with AFG2B, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: AFG2B is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005515 protein binding | IPI PMID:35354024 Labeling of heterochronic ribosomes reveals C1ORF109 and SPA... | MODIFY | Summary: Interaction with CINP, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: CINP is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005515 protein binding | IPI PMID:38554706 The SPATA5-SPATA5L1 ATPase complex directs replisome proteos... | REMOVE | Summary: Generic protein binding with TASOR2. No more informative molecular function is supported by this evidence. Reason: The interaction with TASOR2 is recorded only as generic protein binding. It is not one of the 55LCC subunits (AFG2A, AFG2B, CINP), so unlike those rows there is no complex-membership term to modify it into, and the evidence does not support inventing a specific molecular function from an interaction alone. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). |
| GO:0005515 protein binding | IPI PMID:38554706 The SPATA5-SPATA5L1 ATPase complex directs replisome proteos... | MODIFY | Summary: Interaction with CINP, a genuine subunit of the 55LCC complex. The interaction is real and important, but 'protein binding' is the wrong way to record it - complex membership is. Reason: CINP is not an incidental interactor: it is one of the four subunits of the 55LCC ATPase assembly (4:2:2:2 SPATA5:SPATA5L1:C1orf109:CINP), alongside AIRIM/C1orf109 itself [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."]. The architecture is resolved, with AIRIM and CINP forming a funnel above the ATPase motor [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. A generic protein-binding term discards all of that. The informative statement is that AIRIM is a constituent of this complex, which the gene already carries as GO:1904949 ATPase complex from the same study. MODIFY rather than REMOVE because a more informative, evidence-backed term exists. Per the project's curation policy, GO:0005515 protein binding is removed as uninformative rather than marked over-annotated: the problem is that it conveys no functional information, not that it claims more than the evidence supports. Removing it does not assert that the interaction is false. Proposed replacements: ATPase complex Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: Nucleus inherited through the PANTHER node. AIRIM appears in its own WITH/FROM, which correctly marks that the node has experimental grounding on this very gene. Reason: Sound. The target appearing among the sources of its own IBA is expected rather than circular: AIRIM's experimental nuclear annotation is one of the descendant evidences the PAINT curator used to place the node. The underlying observation is direct [PMID:22548824 "The protein C1ORF109 was mainly located in the nucleus and cytoplasm."]. Supporting Evidence: PMID:22548824 The protein C1ORF109 was mainly located in the nucleus and cytoplasm. |
| GO:0005634 nucleus | IDA PMID:22548824 Identification and characterization of a novel gene, c1orf10... | ACCEPT | Summary: Nucleus, directly observed by immunofluorescence and immunogold. Consistent with the chromatin-associated replisome role. Reason: Directly demonstrated [PMID:22548824 "The protein C1ORF109 was mainly located in the nucleus and cytoplasm."] and independently expected from the replisome function, since the 55LCC complex is chromatin-associated and acts at replication forks [PMID:38554706 "55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage."]. AIRIM is genuinely dual-compartment, which is not a contradiction: the pre-60S step it controls is cytoplasmic while the replisome role is nuclear. Supporting Evidence: PMID:22548824 The protein C1ORF109 was mainly located in the nucleus and cytoplasm. PMID:38554706 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: Nucleus from the UniProt subcellular-location vocabulary; agrees with the direct observation. Reason: The SL-0191 mapping reflects UniProt's curated nuclear location, which rests on the same direct imaging [PMID:22548824 "The protein C1ORF109 was mainly located in the nucleus and cytoplasm."]. Correct and redundant with the IDA row, which is fine. Supporting Evidence: PMID:22548824 The protein C1ORF109 was mainly located in the nucleus and cytoplasm. |
| GO:0005634 nucleus | IPI PMID:38554706 The SPATA5-SPATA5L1 ATPase complex directs replisome proteos... | ACCEPT | Summary: Nucleus recorded with interaction evidence from the 55LCC study; consistent with the chromatin-associated complex. Reason: Colocalisation with the replisome-associated complex supports the nuclear placement [PMID:38554706 "55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage."], and the location is independently established by direct imaging [PMID:22548824 "The protein C1ORF109 was mainly located in the nucleus and cytoplasm."]. Supporting Evidence: PMID:38554706 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. PMID:22548824 The protein C1ORF109 was mainly located in the nucleus and cytoplasm. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: Nucleoplasm. Consistent with the chromatin-associated 55LCC role at replication forks. Reason: The more precise nuclear term, and the one that matches the replisome function: 55LCC acts on replisome substrates at damaged forks [PMID:38554706 "55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage."], with loss causing replication stress and chromosome instability [PMID:38554706 "Deficiency in the 55LCC complex elicited ubiquitin-independent proteotoxicity, replication stress, and severe chromosome instability."]. Supporting Evidence: PMID:38554706 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. PMID:38554706 Deficiency in the 55LCC complex elicited ubiquitin-independent proteotoxicity, replication stress, and severe chromosome instability. |
| GO:0005730 nucleolus | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: Nucleolus. Plausible for a ribosome biogenesis factor, but the demonstrated AIRIM step is cytoplasmic, so this is the least well-anchored location row. Reason: Retained but demoted. A nucleolar pool is unsurprising for a ribosome assembly factor and the HPA-derived IDA is a real observation, but the function that has actually been demonstrated for AIRIM is a LATE and explicitly CYTOPLASMIC step [PMID:35354024 "We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm."], not an early nucleolar one, and the replisome role is nucleoplasmic and chromatin-associated [PMID:38554706 "55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage."]. So nucleolar residence is not where either characterised activity takes place. Marked non-core rather than removed, since the observation stands on its own. Supporting Evidence: PMID:35354024 We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm. PMID:38554706 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: Cytoplasm inherited through the PANTHER node, with AIRIM's own experimental annotation among the sources - a marker of grounding, not circularity. Reason: The node placement is consistent with a conserved cytoplasmic ribosome-maturation role [PMID:35354024 "We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm."], and AIRIM's own direct evidence [PMID:22548824 "The protein C1ORF109 was mainly located in the nucleus and cytoplasm."] is one of the descendant evidences behind it, which is why the accession legitimately appears in its own WITH/FROM. Supporting Evidence: PMID:35354024 We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm. PMID:22548824 The protein C1ORF109 was mainly located in the nucleus and cytoplasm. |
| GO:0005737 cytoplasm | IDA PMID:22548824 Identification and characterization of a novel gene, c1orf10... | ACCEPT | Summary: Cytoplasm, directly observed, and required by the cytoplasmic pre-60S maturation step. Reason: Directly shown [PMID:22548824 "The protein C1ORF109 was mainly located in the nucleus and cytoplasm."], and the ribosome function is explicitly cytoplasmic [PMID:35354024 "We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm."]. The cytosol row (GO:0005829) is the more precise form. Supporting Evidence: PMID:22548824 The protein C1ORF109 was mainly located in the nucleus and cytoplasm. PMID:35354024 We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: Cytoplasm from the UniProt subcellular-location vocabulary; agrees with the direct evidence. Reason: SL-0086 reflects UniProt's curated cytoplasmic location, itself grounded in direct imaging [PMID:22548824 "The protein C1ORF109 was mainly located in the nucleus and cytoplasm."] and consistent with the cytoplasmic pre-60S step [PMID:35354024 "We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm."]. Supporting Evidence: PMID:22548824 The protein C1ORF109 was mainly located in the nucleus and cytoplasm. PMID:35354024 We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: Cytosol. The most precise cytoplasmic term, and the compartment where the pre-60S step occurs. Reason: Preferred over the bare cytoplasm rows. The maturation step AIRIM controls is explicitly cytoplasmic and post-nuclear-export [PMID:35354024 "We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm."], and loss of AIRIM reduces bulk translation [PMID:35354024 "Loss of either C1orf109 or SPATA5 impairs global protein synthesis."], which is a cytosolic readout. Supporting Evidence: PMID:35354024 We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm. PMID:35354024 Loss of either C1orf109 or SPATA5 impairs global protein synthesis. |
| GO:0006260 DNA replication | IDA PMID:38554706 The SPATA5-SPATA5L1 ATPase complex directs replisome proteos... | ACCEPT | Summary: DNA replication. AIRIM's second, genuinely distinct role: 55LCC-mediated replisome proteostasis at the fork. Reason: Core, and not a duplicate of the ribosome function. The 55LCC complex acts on replisome substrates [PMID:38554706 "55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage."], its loss produces replication-specific phenotypes [PMID:38554706 "Deficiency in the 55LCC complex elicited ubiquitin-independent proteotoxicity, replication stress, and severe chromosome instability."], and the authors frame the role in exactly these terms [PMID:38554706 "These findings define 55LCC-mediated proteostasis as critical for replication fork progression and genome stability"]. A more specific child term covering replisome protein turnover at the fork would be preferable to the bare parent, but none exists that fits; noted under suggested_questions rather than forced. Supporting Evidence: PMID:38554706 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. PMID:38554706 Deficiency in the 55LCC complex elicited ubiquitin-independent proteotoxicity, replication stress, and severe chromosome instability. PMID:38554706 These findings define 55LCC-mediated proteostasis as critical for replication fork progression and genome stability |
| GO:0042273 ribosomal large subunit biogenesis | IDA PMID:35354024 Labeling of heterochronic ribosomes reveals C1ORF109 and SPA... | ACCEPT | Summary: Ribosomal large subunit biogenesis. Directly demonstrated: AIRIM controls a late cytoplasmic step of pre-60S maturation. Reason: Core. AIRIM was found in an unbiased genome-wide screen for ribosome biogenesis factors [PMID:35354024 "These efforts identify two functionally uncharacterized genes, C1orf109 and SPATA5."], and the step it acts at is specified [PMID:35354024 "We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm."]. The downstream consequence is measured [PMID:35354024 "Loss of either C1orf109 or SPATA5 impairs global protein synthesis."]. Note the term names the large subunit specifically, which matches pre-60S and is the right level of granularity. Supporting Evidence: PMID:35354024 We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm. PMID:35354024 Loss of either C1orf109 or SPATA5 impairs global protein synthesis. PMID:35354024 These efforts identify two functionally uncharacterized genes, C1orf109 and SPATA5. |
| GO:0090069 regulation of ribosome biogenesis | IDA PMID:38554706 The SPATA5-SPATA5L1 ATPase complex directs replisome proteos... | ACCEPT | Summary: Regulation of ribosome biogenesis. Correct but broader than the specific pre-60S maturation role already annotated. Reason: Defensible and consistent with the specific term. AIRIM acts within ribosome production rather than only on its rate [PMID:35354024 "We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm."], so GO:0042273 is the more precise statement and this row is the broader companion. Accepted rather than modified because a general and a specific term can legitimately coexist, and this one is anchored to a different study. Supporting Evidence: PMID:35354024 We provide evidence that these factors, together with CINP and SPATA5L1, control a late step of human pre-60S maturation in the cytoplasm. PMID:35354024 Loss of either C1orf109 or SPATA5 impairs global protein synthesis. |
| GO:1904949 ATPase complex | IPI PMID:38554706 The SPATA5-SPATA5L1 ATPase complex directs replisome proteos... | ACCEPT | Summary: ATPase complex. This is AIRIM's defining annotation: it is a constituent subunit of the 55LCC ATPase assembly, resolved structurally at 4:2:2:2 stoichiometry. Reason: Core, and the term the 174 protein-binding rows should have been pointing at. AIRIM is one of four subunits of 55LCC [PMID:38554706 "Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC)."], and its position within the assembly is resolved [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."]. The complex has measurable ATPase activity [PMID:38554706 "55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage."], contributed by the AAA+ subunits rather than by AIRIM itself, which is why AIRIM's own molecular function is recorded in this review as a structural one with the ATPase activity placed under contributes_to. Supporting Evidence: PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. PMID:38554706 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. |
| GO:0005198 structural molecule activity | IDA PMID:38554706 The SPATA5-SPATA5L1 ATPase complex directs replisome proteos... | NEW | Summary: AIRIM has no molecular function annotation at all beyond generic protein binding. Its demonstrated contribution to the 55LCC complex is structural, and GO:0005198 states that directly. Reason: After removing 166 uninformative protein-binding rows this gene would carry zero molecular function annotations, which misrepresents a protein whose role is well defined. GO:0005198 is 'the action of a molecule that contributes to the structural integrity of a complex', which is precisely what the structural work shows [PMID:38554706 "An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor."], and what the higher-resolution follow-up confirms [PMID:40268917 "This complex features an N-terminal ring made of C1orf109, CINP and NTDs of SPATA5/SPATA5L1, and two hexameric AAA+ ATPase rings."]. AIRIM is not the ATPase - that activity belongs to the AFG2A/AFG2B motor subunits and is recorded in this review under contributes_to_molecular_function, following the schema's guidance for complex subunits that do not independently possess the complex-level activity. The complementary claim - that AIRIM also brings the substrate RLP24 to that motor - is captured separately by GO:0060090 molecular adaptor activity, proposed as its own NEW row. The two are separable: this one is about holding the ring together, that one about delivering the substrate, and either could hold without the other. Supporting Evidence: PMID:38554706 An integrative structural biology approach revealed a molecular architecture of SPATA5-SPATA5L1 N-terminal domains interacting with C1orf109-CINP to form a funnel-like structure above a cylindrically shaped ATPase motor. PMID:38554706 Here, we identify replisome factor interactions with a protein complex composed of AAA+ ATPases SPATA5-SPATA5L1 together with heterodimeric partners C1orf109-CINP (55LCC). PMID:38554706 55LCC showed ATPase activity that was specifically enhanced by replication fork DNA and was coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. file:genes/human/AIRIM/AIRIM-deep-research-affinage.md AIRIM (C1orf109) is a structural subunit of the eumetazoan-specific 55LCC complex |
| GO:0060090 molecular adaptor activity | IPI PMID:40268917 Cryo-EM structure of the AAA+ SPATA5 complex and its role in... | NEW | Summary: AIRIM binds the AAA+ substrate RLP24 inside the funnel and brings it to the motor - the paper's own conclusion is that C1orf109 is an adapter protein. This is the most informative molecular function available for this gene. Reason: The structural study states the conclusion directly: [PMID:40268917 "these data collectively support that CINP and C1orf109 are adapter proteins to mediate the interaction between the SPATA5 complex and its substrate RLP24"]. It is not a structural inference alone - a fragment of the substrate pulls AIRIM down [PMID:40268917 "our immunoprecipitation experiments show that a fragment (residues 85–163) of RLP24 was indeed able to immunoprecipitate both CINP and C1orf109"], and the structure shows which part binds [PMID:40268917 "the last two helices (residues 80–163) of RLP24 are able to bind to both CINP and C1orf109"]. GO:0060090 is defined as bringing two or more molecules together through a selective non-covalent interaction so they can function in a coordinated way, which is exactly this. Evidence code IPI rather than IDA: the load-bearing experiment is a physical interaction, the RLP24 fragment pulling down C1orf109. It is proposed alongside GO:0005198 rather than instead of it - both are proposed, though only this one occupies the single-valued molecular_function slot in core_functions - because the two claims are separable: AIRIM holds the NTD ring together [PMID:40268917 "the helical bundles of CINP and C1orf109 constitute the inner wall of the funnel"] and it delivers the substrate, and either could be true without the other. Note the scope: AIRIM binds RLP24, not the pre-60S particle itself [PMID:40268917 "CINP contributes to both the interfaces between the SPATA5 complex and the pre-60S particle, while C1orf109 does not interact with the pre-60S particle directly"], which is CINP's contribution. Supporting Evidence: PMID:40268917 these data collectively support that CINP and C1orf109 are adapter proteins to mediate the interaction between the SPATA5 complex and its substrate RLP24 PMID:40268917 our immunoprecipitation experiments show that a fragment (residues 85–163) of RLP24 was indeed able to immunoprecipitate both CINP and C1orf109 PMID:40268917 the last two helices (residues 80–163) of RLP24 are able to bind to both CINP and C1orf109 PMID:40268917 the helical bundles of CINP and C1orf109 constitute the inner wall of the funnel |
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Download this section (compressed HTML)Q: Should GO have a term for replisome protein turnover at the replication fork? GO:0006260 DNA replication is the only available home for the 55LCC role and it is far too broad for a mechanism the authors define as ubiquitin-independent replisome proteostasis, distinct from the VCP/p97 route that unloads CMG.
Q: AIRIM had no molecular function annotation other than protein binding. This review proposes both molecular adaptor activity and structural molecule activity, which are separable claims - one about bringing RLP24 to the motor, one about holding the NTD ring together. Should GOA carry both, or is the adaptor term alone the more useful single statement?
Q: Is the nucleolar localisation a genuine site of AIRIM action? The demonstrated ribosome step is late and cytoplasmic and the replisome role is nucleoplasmic, so neither characterised activity happens in the nucleolus.
Q: C1ORF109 is a CK2 substrate, and that phosphorylation is captured by no GO annotation. Does CK2 phosphorylation switch AIRIM between the ribosomal and replisome pools?
Q: Do the two activities compete? Both draw on the same four-subunit complex, so replication stress might sequester 55LCC away from ribosome maturation, which would matter for interpreting the neurodevelopmental phenotypes of AIRIM and SPATA5 variants.
Experiment: Separation-of-function mutagenesis at the AIRIM-CINP funnel interface, testing whether pre-60S maturation and replisome clearance can be uncoupled. If one survives and the other does not, the two processes use the complex differently and warrant separate annotation.
Experiment: Quantify the 55LCC pool partitioning between cytoplasm and chromatin before and after fork damage, to test whether the complex is redistributed rather than separately assembled.
Experiment: Test whether CK2 phosphorylation of AIRIM alters complex assembly or localisation, which would connect the 2012 characterisation to the current mechanism.
Experiment: Re-derive AIRIM's interactome by affinity purification from human cells rather than by Y2H, and check how many of the 148 binary partners reproduce. This would say whether the 174 protein-binding rows removed here conceal any real complex besides 55LCC.
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