# AKIRIN1 notes

Human AKIRIN1 encodes a small, conserved nuclear Akirin-family protein. The strongest direct evidence in the local cache is for nuclear localization and a role as a transcriptional cofactor in NF-kappaB-dependent gene expression [PMID:18066067, "strict nuclear localization"; PMID:18066067, "novel important nuclear cofactors regulating the transcriptional activities of main transactivators"].

The 2008 mouse paper also makes the paralog split explicit: Akirin2, not Akirin1, is the paralog required for the IL-1/TLR cytokine-response phenotype, while Akirin1 knockout mice were viable and showed no gross developmental abnormalities [PMID:18066067, "MmAkirin1-/- mice were born in a Mendelian ratio, grew healthily and did not show gross developmental abnormalities"; PMID:18066067, "the functional role of MmAkirin1, attested by its sequence conservation, is unknown thus far"].

The Proteostasis PN projection for AKIRIN1 points to `GO:0070628 proteasome binding` in the adaptor/shuttle bucket [file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_annotations.tsv]. In the local literature cache I do not see direct AKIRIN1-specific proteasome-binding evidence, so that projection should be treated conservatively rather than promoted automatically.