ARIH1

UniProt ID: Q9Y4X5
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for ARIH1

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031624 ubiquitin conjugating enzyme binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000151 ubiquitin ligase complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008270 zinc ion binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0015030 Cajal body
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0046872 metal ion binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
IEA
GO_REF:0000003 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21145461
Dynamics of cullin-RING ubiquitin ligase network revealed by... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21532592
UBCH7 reactivity profile reveals parkin and HHARI to be RING... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23707686
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:28514442
Architecture of the human interactome defines protein commun... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0039585 PKR/eIFalpha signaling
TAS
Reactome:R-HSA-9833482 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061662 ISG15 ligase activity
TAS
Reactome:R-HSA-1169394 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061662 ISG15 ligase activity
TAS
Reactome:R-HSA-1169395 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061662 ISG15 ligase activity
TAS
Reactome:R-HSA-1169398 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061662 ISG15 ligase activity
TAS
Reactome:R-HSA-1169402 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061662 ISG15 ligase activity
TAS
Reactome:R-HSA-1169405 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061662 ISG15 ligase activity
TAS
Reactome:R-HSA-1169406 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061662 ISG15 ligase activity
TAS
Reactome:R-HSA-9833973 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:23707686
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:27565346
Two Distinct Types of E3 Ligases Work in Unison to Regulate ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:23059369
Human Homolog of Drosophila Ariadne (HHARI) is a marker of c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008270 zinc ion binding
IDA
PMID:23707686
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:23707686
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:27565346
Two Distinct Types of E3 Ligases Work in Unison to Regulate ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016604 nuclear body
IDA
PMID:23059369
Human Homolog of Drosophila Ariadne (HHARI) is a marker of c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019005 SCF ubiquitin ligase complex
IDA
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019005 SCF ubiquitin ligase complex
IDA
PMID:27565346
Two Distinct Types of E3 Ligases Work in Unison to Regulate ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031462 Cul2-RING ubiquitin ligase complex
IDA NOT
PMID:27565346
Two Distinct Types of E3 Ligases Work in Unison to Regulate ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031462 Cul2-RING ubiquitin ligase complex
IDA
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:27565346
Two Distinct Types of E3 Ligases Work in Unison to Regulate ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
IDA
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031624 ubiquitin conjugating enzyme binding
IPI
PMID:23707686
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031624 ubiquitin conjugating enzyme binding
IPI
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddy... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031624 ubiquitin conjugating enzyme binding
IPI
PMID:27565346
Two Distinct Types of E3 Ligases Work in Unison to Regulate ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097413 Lewy body
IDA
PMID:21590270
The parkin-like human homolog of Drosophila ariadne-1 (HHARI... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1169394 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1169395 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1169398 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1169402 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1169403 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1169405 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1169406 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1678843 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9833973 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9837231 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9927247 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:14623119
Human homologue of ariadne promotes the ubiquitylation of tr... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:15236971
Structure of the C-terminal RING finger from a RING-IBR-RING... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:21532592
UBCH7 reactivity profile reveals parkin and HHARI to be RING... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:14623119
Human homologue of ariadne promotes the ubiquitylation of tr... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:11278816
Features of the parkin/ariadne-like ubiquitin ligase, HHARI,... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008270 zinc ion binding
IDA
PMID:15236971
Structure of the C-terminal RING finger from a RING-IBR-RING... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:14623119
Human homologue of ariadne promotes the ubiquitylation of tr... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:15236971
Structure of the C-terminal RING finger from a RING-IBR-RING... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:21532592
UBCH7 reactivity profile reveals parkin and HHARI to be RING... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding
IPI
PMID:11278816
Features of the parkin/ariadne-like ubiquitin ligase, HHARI,... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding
IPI
PMID:21532592
UBCH7 reactivity profile reveals parkin and HHARI to be RING... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:10521492
The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact w... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000151 ubiquitin ligase complex
TAS
PMID:10521492
The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact w... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
TAS
PMID:10521492
The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact w... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0019787 ubiquitin-like protein transferase activity
TAS
PMID:10521492
The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact w... 		PENDING
Summary: TODO: Review this GOA annotation

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000003
Gene Ontology annotation based on Enzyme Commission mapping
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10521492
The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.
PMID:11278816
Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.
PMID:14623119
Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP.
PMID:15236971
Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING.
PMID:21145461
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
PMID:21532592
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
PMID:21590270
The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies.
PMID:23059369
Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation associated with nuclear bodies.
PMID:23707686
Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism.
PMID:24076655
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
PMID:27565346
Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Reactome:R-HSA-1169394
ISGylation of IRF3
Reactome:R-HSA-1169395
ISGylation of viral protein NS1
Reactome:R-HSA-1169398
ISGylation of host protein filamin B
Reactome:R-HSA-1169402
ISGylation of E2 conjugating enzymes
Reactome:R-HSA-1169403
Interaction of E3 ligase with ISG15:E2 complex
Reactome:R-HSA-1169405
ISGylation of protein phosphatase 1 beta (PP2CB)
Reactome:R-HSA-1169406
ISGylation of host proteins
Reactome:R-HSA-1678843
ISGylation of protein translation regulator 4EHP
Reactome:R-HSA-9833482
PKR-mediated signaling
Reactome:R-HSA-9833973
ISGylation of PKR
Reactome:R-HSA-9837231
ISGylation of BECN1
Reactome:R-HSA-9927247
ISGylation of DDX58 (RIG-I)

📄 View Raw YAML

 
id: Q9Y4X5
gene_symbol: ARIH1
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for ARIH1'
existing_annotations:
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031624
    label: ubiquitin conjugating enzyme binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006511
    label: ubiquitin-dependent protein catabolic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061630
    label: ubiquitin protein ligase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000151
    label: ubiquitin ligase complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0015030
    label: Cajal body
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0046872
    label: metal ion binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061630
    label: ubiquitin protein ligase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000003
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21145461
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21532592
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23707686
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28514442
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0039585
    label: PKR/eIFalpha signaling
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9833482
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061662
    label: ISG15 ligase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169394
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061662
    label: ISG15 ligase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169395
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061662
    label: ISG15 ligase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169398
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061662
    label: ISG15 ligase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169402
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061662
    label: ISG15 ligase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169405
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061662
    label: ISG15 ligase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169406
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061662
    label: ISG15 ligase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9833973
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:23707686
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:27565346
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:23059369
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: IDA
  original_reference_id: PMID:23707686
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:23707686
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:27565346
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016604
    label: nuclear body
  evidence_type: IDA
  original_reference_id: PMID:23059369
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019005
    label: SCF ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019005
    label: SCF ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:27565346
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031462
    label: Cul2-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:27565346
  negated: true
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031462
    label: Cul2-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:27565346
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031464
    label: Cul4A-RING E3 ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031624
    label: ubiquitin conjugating enzyme binding
  evidence_type: IPI
  original_reference_id: PMID:23707686
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031624
    label: ubiquitin conjugating enzyme binding
  evidence_type: IPI
  original_reference_id: PMID:24076655
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031624
    label: ubiquitin conjugating enzyme binding
  evidence_type: IPI
  original_reference_id: PMID:27565346
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097413
    label: Lewy body
  evidence_type: IDA
  original_reference_id: PMID:21590270
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169394
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169395
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169398
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169402
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169403
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169405
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1169406
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1678843
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9833973
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9837231
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9927247
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:14623119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:15236971
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:21532592
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14623119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:11278816
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008270
    label: zinc ion binding
  evidence_type: IDA
  original_reference_id: PMID:15236971
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:14623119
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:15236971
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:21532592
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IPI
  original_reference_id: PMID:11278816
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IPI
  original_reference_id: PMID:21532592
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10521492
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000151
    label: ubiquitin ligase complex
  evidence_type: TAS
  original_reference_id: PMID:10521492
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006511
    label: ubiquitin-dependent protein catabolic process
  evidence_type: TAS
  original_reference_id: PMID:10521492
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0019787
    label: ubiquitin-like protein transferase activity
  evidence_type: TAS
  original_reference_id: PMID:10521492
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000003
  title: Gene Ontology annotation based on Enzyme Commission mapping
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10521492
  title: The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR
    motif-containing domains of HHARI and H7-AP1.
  findings: []
- id: PMID:11278816
  title: Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate
    its interaction with the ubiquitin-conjugating enzyme, Ubch7.
  findings: []
- id: PMID:14623119
  title: Human homologue of ariadne promotes the ubiquitylation of translation initiation
    factor 4E homologous protein, 4EHP.
  findings: []
- id: PMID:15236971
  title: Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif
    reveals a novel zinc-binding domain distinct from a RING.
  findings: []
- id: PMID:21145461
  title: Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative
    proteomics.
  findings: []
- id: PMID:21532592
  title: UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
  findings: []
- id: PMID:21590270
  title: The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce
    aggresome formation in mammalian cells and is immunologically detectable in Lewy
    bodies.
  findings: []
- id: PMID:23059369
  title: Human Homolog of Drosophila Ariadne (HHARI) is a marker of cellular proliferation
    associated with nuclear bodies.
  findings: []
- id: PMID:23707686
  title: 'Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of
    an Ariadne-family E3 and insights into ligation mechanism.'
  findings: []
- id: PMID:24076655
  title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING
    ligase complexes.
  findings: []
- id: PMID:27565346
  title: Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.
  findings: []
- id: PMID:28514442
  title: Architecture of the human interactome defines protein communities and disease
    networks.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human
    interactome.
  findings: []
- id: Reactome:R-HSA-1169394
  title: ISGylation of IRF3
  findings: []
- id: Reactome:R-HSA-1169395
  title: ISGylation of viral protein NS1
  findings: []
- id: Reactome:R-HSA-1169398
  title: ISGylation of host protein filamin B
  findings: []
- id: Reactome:R-HSA-1169402
  title: ISGylation of E2 conjugating enzymes
  findings: []
- id: Reactome:R-HSA-1169403
  title: Interaction of E3 ligase with ISG15:E2 complex
  findings: []
- id: Reactome:R-HSA-1169405
  title: ISGylation of protein phosphatase 1 beta (PP2CB)
  findings: []
- id: Reactome:R-HSA-1169406
  title: ISGylation of host proteins
  findings: []
- id: Reactome:R-HSA-1678843
  title: ISGylation of protein translation regulator 4EHP
  findings: []
- id: Reactome:R-HSA-9833482
  title: PKR-mediated signaling
  findings: []
- id: Reactome:R-HSA-9833973
  title: ISGylation of PKR
  findings: []
- id: Reactome:R-HSA-9837231
  title: ISGylation of BECN1
  findings: []
- id: Reactome:R-HSA-9927247
  title: ISGylation of DDX58 (RIG-I)
  findings: []