GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q15904 ATP6AP1 part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0051030|FB:FBgn0262515|PANTHER:PTN007576952 9606 Homo sapiens GO_Central V-type proton ATPase subunit S1 20220414 UniProtKB Q15904 ATP6AP1 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0097 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260428 UniProtKB Q15904 ATP6AP1 located_in GO:0012505 endomembrane system cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00028953 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260428 UniProtKB Q15904 ATP6AP1 located_in GO:0030659 cytoplasmic vesicle membrane cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026540 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260428 UniProtKB Q15904 ATP6AP1 located_in GO:0030665 clathrin-coated vesicle membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0071 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260428 UniProtKB Q15904 ATP6AP1 located_in GO:0030672 synaptic vesicle membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0260 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260428 UniProtKB Q15904 ATP6AP1 located_in GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0099 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260428 UniProtKB Q15904 ATP6AP1 located_in GO:0098588 bounding membrane of organelle cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00027281 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260428 UniProtKB Q15904 ATP6AP1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32353859 UniProtKB:P0DTD1-PRO_0000449624 9606 Homo sapiens IntAct V-type proton ATPase subunit S1 20260425 UniProtKB Q15904 ATP6AP1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P42858 9606 Homo sapiens IntAct V-type proton ATPase subunit S1 20260425 UniProtKB Q15904 ATP6AP1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33060197 UniProtKB:P0DTD1-PRO_0000449624 9606 Homo sapiens IntAct V-type proton ATPase subunit S1 20260425 UniProtKB Q15904 ATP6AP1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33845483 UniProtKB:P0DTD1-PRO_0000449624 9606 Homo sapiens IntAct V-type proton ATPase subunit S1 20260425 UniProtKB Q15904 ATP6AP1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:34232536 UniProtKB:P0DTD1-PRO_0000449624 9606 Homo sapiens IntAct V-type proton ATPase subunit S1 20260425 UniProtKB Q15904 ATP6AP1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:34997207 UniProtKB:P0DTD1-PRO_0000449624 9606 Homo sapiens IntAct V-type proton ATPase subunit S1 20260425 UniProtKB Q15904 ATP6AP1 is_active_in GO:0010008 endosome membrane cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 enables GO:0031267 small GTPase binding molecular_function ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 involved_in GO:0036035 osteoclast development biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 part_of GO:0046611 lysosomal proton-transporting V-type ATPase complex cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 involved_in GO:0097401 synaptic vesicle lumen acidification biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 involved_in GO:0099638 endosome to plasma membrane protein transport biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 enables GO:0140677 molecular function activator activity molecular_function ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 involved_in GO:1904263 positive regulation of TORC1 signaling biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q9R1Q9|ensembl:ENSMUSP00000019231 9606 Homo sapiens Ensembl V-type proton ATPase subunit S1 20260422 UniProtKB Q15904 ATP6AP1 is_active_in GO:0005765 lysosomal membrane cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260213 UniProtKB Q15904 ATP6AP1 part_of GO:0046611 lysosomal proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260213 UniProtKB Q15904 ATP6AP1 involved_in GO:0071230 cellular response to amino acid stimulus biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260213 UniProtKB Q15904 ATP6AP1 contributes_to GO:0160124 guanyl nucleotide exchange factor activator activity molecular_function ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260213 UniProtKB Q15904 ATP6AP1 involved_in GO:1904263 positive regulation of TORC1 signaling biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9R1Q9 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260213 UniProtKB Q15904 ATP6AP1 involved_in GO:1904263 positive regulation of TORC1 signaling biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20260213 UniProtKB Q15904 ATP6AP1 located_in GO:0000139 Golgi membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 located_in GO:0005886 plasma membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 involved_in GO:0007035 vacuolar acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 involved_in GO:0007042 lysosomal lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 involved_in GO:0007042 lysosomal lumen acidification biological_process ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 located_in GO:0010008 endosome membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 located_in GO:0016020 membrane cellular_component ECO:0000314 IDA PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 involved_in GO:0048388 endosomal lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 involved_in GO:0051452 intracellular pH reduction biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 involved_in GO:0061795 Golgi lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 involved_in GO:1902600 proton transmembrane transport biological_process ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit S1 20240902 UniProtKB Q15904 ATP6AP1 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000269 EXP PMID:27231034 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20240313 UniProtKB Q15904 ATP6AP1 located_in GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane cellular_component ECO:0000269 EXP PMID:27231034 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20240313 UniProtKB Q15904 ATP6AP1 involved_in GO:0036035 osteoclast development biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9R1Q9 9606 Homo sapiens CAFA V-type proton ATPase subunit S1 20210824 UniProtKB Q15904 ATP6AP1 involved_in GO:0099638 endosome to plasma membrane protein transport biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9R1Q9 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20210824 UniProtKB Q15904 ATP6AP1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:29127204 UniProtKB:O75787 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20190606 UniProtKB Q15904 ATP6AP1 involved_in GO:0006879 intracellular iron ion homeostasis biological_process ECO:0000315 IMP PMID:28296633 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20170626 UniProtKB Q15904 ATP6AP1 involved_in GO:0036295 cellular response to increased oxygen levels biological_process ECO:0000315 IMP PMID:28296633 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20170626 UniProtKB Q15904 ATP6AP1 enables GO:0031267 small GTPase binding molecular_function ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q9R1Q9 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20140529 UniProtKB Q15904 ATP6AP1 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5252133 9606 Homo sapiens Reactome V-type proton ATPase subunit S1 20140205 UniProtKB Q15904 ATP6AP1 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-74723 9606 Homo sapiens Reactome V-type proton ATPase subunit S1 20140205 UniProtKB Q15904 ATP6AP1 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-917841 9606 Homo sapiens Reactome V-type proton ATPase subunit S1 20140205 UniProtKB Q15904 ATP6AP1 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19056867 9606 Homo sapiens UniProt V-type proton ATPase subunit S1 20131024 UniProtKB Q15904 ATP6AP1 part_of GO:0016469 proton-transporting two-sector ATPase complex cellular_component ECO:0000304 TAS PMID:8733135 9606 Homo sapiens PINC V-type proton ATPase subunit S1 20030904