GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB P61421 ATP6V0D1 part_of GO:0016471 vacuolar proton-transporting V-type ATPase complex cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000111953|SGD:S000004439|UniProtKB:P61420|UniProtKB:P61421|UniProtKB:Q8N8Y2 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 1 20250902 UniProtKB P61421 ATP6V0D1 contributes_to GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1201778|PANTHER:PTN000111953|SGD:S000004439 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 1 20250731 UniProtKB P61421 ATP6V0D1 is_active_in GO:0005769 early endosome cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1201778|MGI:MGI:1924415|PANTHER:PTN000867164 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 1 20170228 UniProtKB P61421 ATP6V0D1 involved_in GO:0007034 vacuolar transport biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000111953|SGD:S000004439 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 1 20170228 UniProtKB P61421 ATP6V0D1 involved_in GO:0007035 vacuolar acidification biological_process ECO:0000318 IBA GO_REF:0000033 FB:FBgn0285910|PANTHER:PTN000111953 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 1 20170228 UniProtKB P61421 ATP6V0D1 part_of GO:0033181 plasma membrane proton-transporting V-type ATPase complex cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0285910|PANTHER:PTN000867164 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 1 20170228 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0157 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 located_in GO:0016020 membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0162 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 part_of GO:0016471 vacuolar proton-transporting V-type ATPase complex cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00088504 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 located_in GO:0030665 clathrin-coated vesicle membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0071 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 located_in GO:0030670 phagocytic vesicle membrane cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026470 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 part_of GO:0033179 proton-transporting V-type ATPase, V0 domain cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:P51863|ensembl:ENSMUSP00000013304|InterPro:IPR016727 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 involved_in GO:0042592 homeostatic process biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00027526 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000501 IEA GO_REF:0000120 UniProtKB:P51863|ensembl:ENSMUSP00000013304|InterPro:IPR002843|InterPro:IPR016727 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 located_in GO:0098793 presynapse cellular_component ECO:0000366 IEA GO_REF:0000108 GO:0097401 9606 Homo sapiens GOC V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR016727 9606 Homo sapiens InterPro V-type proton ATPase subunit d 1 20260428 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16713569 UniProtKB:P54253 9606 Homo sapiens IntAct V-type proton ATPase subunit d 1 20260425 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:O43711 9606 Homo sapiens IntAct V-type proton ATPase subunit d 1 20260425 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9NQL9 9606 Homo sapiens IntAct V-type proton ATPase subunit d 1 20260425 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P42858 9606 Homo sapiens IntAct V-type proton ATPase subunit d 1 20260425 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P54253 9606 Homo sapiens IntAct V-type proton ATPase subunit d 1 20260425 UniProtKB P61421 ATP6V0D1 located_in GO:0005769 early endosome cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P51863|ensembl:ENSMUSP00000013304 9606 Homo sapiens Ensembl V-type proton ATPase subunit d 1 20260422 UniProtKB P61421 ATP6V0D1 contributes_to GO:0015078 proton transmembrane transporter activity molecular_function ECO:0000265 IEA GO_REF:0000107 UniProtKB:P51863|ensembl:ENSMUSP00000013304 9606 Homo sapiens Ensembl V-type proton ATPase subunit d 1 20260422 UniProtKB P61421 ATP6V0D1 part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P51863|ensembl:ENSMUSP00000013304 9606 Homo sapiens Ensembl V-type proton ATPase subunit d 1 20260422 UniProtKB P61421 ATP6V0D1 involved_in GO:0097401 synaptic vesicle lumen acidification biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:P51863|ensembl:ENSMUSP00000013304 9606 Homo sapiens Ensembl V-type proton ATPase subunit d 1 20260422 UniProtKB P61421 ATP6V0D1 involved_in GO:0071230 cellular response to amino acid stimulus biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260217 UniProtKB P61421 ATP6V0D1 contributes_to GO:0160124 guanyl nucleotide exchange factor activator activity molecular_function ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260217 UniProtKB P61421 ATP6V0D1 is_active_in GO:0005765 lysosomal membrane cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260213 UniProtKB P61421 ATP6V0D1 part_of GO:0046611 lysosomal proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260213 UniProtKB P61421 ATP6V0D1 contributes_to GO:0160124 guanyl nucleotide exchange factor activator activity molecular_function ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260213 UniProtKB P61421 ATP6V0D1 involved_in GO:1904263 positive regulation of TORC1 signaling biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20260213 UniProtKB P61421 ATP6V0D1 part_of GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P61420 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20210916 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:30374053 UniProtKB:O75787 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20200625 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:30374053 UniProtKB:Q9P0T7 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20200625 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:29644770 UniProtKB:Q86T03 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20190408 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9639286 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640167 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640168 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640175 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640195 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9645598 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9645608 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9646468 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9858932 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20190323 UniProtKB P61421 ATP6V0D1 involved_in GO:0006879 intracellular iron ion homeostasis biological_process ECO:0000315 IMP PMID:28296633 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20170626 UniProtKB P61421 ATP6V0D1 involved_in GO:0036295 cellular response to increased oxygen levels biological_process ECO:0000315 IMP PMID:28296633 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20170626 UniProtKB P61421 ATP6V0D1 involved_in GO:0016241 regulation of macroautophagy biological_process ECO:0000303 NAS PMID:22982048 9606 Homo sapiens ParkinsonsUK-UCL V-type proton ATPase subunit d 1 20160215 UniProtKB P61421 ATP6V0D1 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:23533145 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20140714 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:20093472 UniProtKB:O75787 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20140528 UniProtKB P61421 ATP6V0D1 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19199708 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20131029 UniProtKB P61421 ATP6V0D1 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19056867 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20131024 UniProtKB P61421 ATP6V0D1 located_in GO:0005765 lysosomal membrane cellular_component ECO:0007005 HDA PMID:17897319 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20130924 UniProtKB P61421 ATP6V0D1 involved_in GO:0060271 cilium assembly biological_process ECO:0000250 ISS GO_REF:0000024 UniProtKB:Q6PGV1 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20130529 UniProtKB P61421 ATP6V0D1 colocalizes_with GO:0005813 centrosome cellular_component ECO:0000314 IDA PMID:21844891 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20130528 UniProtKB P61421 ATP6V0D1 located_in GO:0030670 phagocytic vesicle membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-1222516 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20110228 UniProtKB P61421 ATP6V0D1 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-1791184 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20100712 UniProtKB P61421 ATP6V0D1 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5252133 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20100712 UniProtKB P61421 ATP6V0D1 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-74723 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20100712 UniProtKB P61421 ATP6V0D1 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-917841 9606 Homo sapiens Reactome V-type proton ATPase subunit d 1 20100712 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:18752060 UniProtKB:Q16864 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20090424 UniProtKB P61421 ATP6V0D1 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:18752060 UniProtKB:Q9Y5K8 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20090424 UniProtKB P61421 ATP6V0D1 located_in GO:0016020 membrane cellular_component ECO:0000314 IDA PMID:18752060 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20090424 UniProtKB P61421 ATP6V0D1 part_of GO:0016471 vacuolar proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:18752060 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20090424 UniProtKB P61421 ATP6V0D1 part_of GO:0016471 vacuolar proton-transporting V-type ATPase complex cellular_component ECO:0000303 NAS PMID:11118322 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20041202 UniProtKB P61421 ATP6V0D1 involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000303 NAS PMID:11118322 9606 Homo sapiens UniProt V-type proton ATPase subunit d 1 20041202