GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q8N8Y2 ATP6V0D2 part_of GO:0016471 vacuolar proton-transporting V-type ATPase complex cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000111953|SGD:S000004439|UniProtKB:P61420|UniProtKB:P61421|UniProtKB:Q8N8Y2 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 2 20250902 UniProtKB Q8N8Y2 ATP6V0D2 contributes_to GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1201778|PANTHER:PTN000111953|SGD:S000004439 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 2 20250731 UniProtKB Q8N8Y2 ATP6V0D2 is_active_in GO:0005769 early endosome cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1201778|MGI:MGI:1924415|PANTHER:PTN000867164 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 2 20170228 UniProtKB Q8N8Y2 ATP6V0D2 involved_in GO:0007034 vacuolar transport biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000111953|SGD:S000004439 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 2 20170228 UniProtKB Q8N8Y2 ATP6V0D2 involved_in GO:0007035 vacuolar acidification biological_process ECO:0000318 IBA GO_REF:0000033 FB:FBgn0285910|PANTHER:PTN000111953 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 2 20170228 UniProtKB Q8N8Y2 ATP6V0D2 part_of GO:0033181 plasma membrane proton-transporting V-type ATPase complex cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0285910|PANTHER:PTN000867164 9606 Homo sapiens GO_Central V-type proton ATPase subunit d 2 20170228 UniProtKB Q8N8Y2 ATP6V0D2 involved_in GO:0006811 monoatomic ion transport biological_process ECO:0007322 IEA GO_REF:0000043 UniProtKB-KW:KW-0406 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20260105 UniProtKB Q8N8Y2 ATP6V0D2 part_of GO:0016471 vacuolar proton-transporting V-type ATPase complex cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00088504 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20260105 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0030670 phagocytic vesicle membrane cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00026470 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20260105 UniProtKB Q8N8Y2 ATP6V0D2 part_of GO:0033179 proton-transporting V-type ATPase, V0 domain cellular_component ECO:0000256 IEA GO_REF:0000002 InterPro:IPR016727 9606 Homo sapiens InterPro V-type proton ATPase subunit d 2 20260105 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR002843|InterPro:IPR016727 9606 Homo sapiens InterPro V-type proton ATPase subunit d 2 20260105 UniProtKB Q8N8Y2 ATP6V0D2 involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000501 IEA GO_REF:0000120 InterPro:IPR016727|UniProtKB-KW:KW-0375 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20260105 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:O43186 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:P01189 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:P26367 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q03989 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q04864-2 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q0VD86 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q15019-3 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q6FHY5 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q6IPU0 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q6S9Z5 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q8N443 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q96QT6-2 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9BSH3 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9BVN2 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9UKT9 9606 Homo sapiens IntAct V-type proton ATPase subunit d 2 20260103 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005768 endosome cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00028568|UniProtKB:Q5FVL0|ensembl:ENSRNOP00000009334 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20251226 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005769 early endosome cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q80SY3|ensembl:ENSMUSP00000029900 9606 Homo sapiens Ensembl V-type proton ATPase subunit d 2 20251226 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0016324 apical plasma membrane cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:Q5FVL0|ensembl:ENSRNOP00000009334 9606 Homo sapiens Ensembl V-type proton ATPase subunit d 2 20251226 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9639286 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640167 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640168 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640175 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9640195 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9645598 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9645608 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9646468 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20190323 UniProtKB Q8N8Y2 ATP6V0D2 involved_in GO:0016241 regulation of macroautophagy biological_process ECO:0000303 NAS PMID:22982048 9606 Homo sapiens ParkinsonsUK-UCL V-type proton ATPase subunit d 2 20160215 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0016324 apical plasma membrane cellular_component ECO:0000314 IDA PMID:15800125 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20141023 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19056867 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20131024 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0030670 phagocytic vesicle membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-1222516 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20110228 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5252133 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20100712 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-74723 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20100712 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0010008 endosome membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-917841 9606 Homo sapiens Reactome V-type proton ATPase subunit d 2 20100712 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0016324 apical plasma membrane cellular_component ECO:0000314 IDA PMID:15800125 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20090605 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:18752060 UniProtKB:Q16864 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20090424 UniProtKB Q8N8Y2 ATP6V0D2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:18752060 UniProtKB:Q9Y5K8 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20090424 UniProtKB Q8N8Y2 ATP6V0D2 located_in GO:0016020 membrane cellular_component ECO:0000314 IDA PMID:18752060 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20090424 UniProtKB Q8N8Y2 ATP6V0D2 part_of GO:0016471 vacuolar proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:18752060 9606 Homo sapiens UniProt V-type proton ATPase subunit d 2 20090424