GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB P38606 ATP6V1A is_active_in GO:0005774 vacuolar membrane cellular_component ECO:0000318 IBA GO_REF:0000033 CGD:CAL0000187512|PANTHER:PTN000389801|SGD:S000002344|UniProtKB:P31404|UniProtKB:P31405|UniProtKB:P38606 9606 Homo sapiens GO_Central V-type proton ATPase catalytic subunit A 20251110 UniProtKB P38606 ATP6V1A involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1201780|PANTHER:PTN000389800|SGD:S000002344|ZFIN:ZDB-GENE-040426-1143 9606 Homo sapiens GO_Central V-type proton ATPase catalytic subunit A 20250904 UniProtKB P38606 ATP6V1A enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000318 IBA GO_REF:0000033 MGI:MGI:1201780|PANTHER:PTN000389800|SGD:S000002344 9606 Homo sapiens GO_Central V-type proton ATPase catalytic subunit A 20210531 UniProtKB P38606 ATP6V1A enables GO:0005524 ATP binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000194|InterPro:IPR020003 9606 Homo sapiens InterPro V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A located_in GO:0005737 cytoplasm cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00026971|UniProtKB:P50516|ensembl:ENSMUSP00000110314|UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A located_in GO:0005765 lysosomal membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0157 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:P50516|ensembl:ENSMUSP00000110314|UniProtKB-SubCell:SL-0091 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A enables GO:0016887 ATP hydrolysis activity molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR005725 9606 Homo sapiens InterPro V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A located_in GO:0030133 transport vesicle cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0244 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A located_in GO:0030665 clathrin-coated vesicle membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0071 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A part_of GO:0033180 proton-transporting V-type ATPase, V1 domain cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00092827|UniProtKB:P50516|ensembl:ENSMUSP00000110314|InterPro:IPR005725 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A involved_in GO:0042592 homeostatic process biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00027526 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A involved_in GO:0046034 ATP metabolic process biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR004100|InterPro:IPR022878|InterPro:IPR036121 9606 Homo sapiens InterPro V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000501 IEA GO_REF:0000120 UniProtKB:P50516|ensembl:ENSMUSP00000110314|InterPro:IPR005725|InterPro:IPR022878 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A located_in GO:0098793 presynapse cellular_component ECO:0000366 IEA GO_REF:0000108 GO:0097401 9606 Homo sapiens GOC V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR004100|InterPro:IPR005725|InterPro:IPR036121 9606 Homo sapiens InterPro V-type proton ATPase catalytic subunit A 20260601 UniProtKB P38606 ATP6V1A enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33208464 UniProtKB:P0DOF2 9606 Homo sapiens IntAct V-type proton ATPase catalytic subunit A 20260530 UniProtKB P38606 ATP6V1A located_in GO:0005886 plasma membrane cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P50516|ensembl:ENSMUSP00000110314 9606 Homo sapiens Ensembl V-type proton ATPase catalytic subunit A 20260529 UniProtKB P38606 ATP6V1A located_in GO:0005902 microvillus cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P50516|ensembl:ENSMUSP00000110314 9606 Homo sapiens Ensembl V-type proton ATPase catalytic subunit A 20260529 UniProtKB P38606 ATP6V1A contributes_to GO:0015078 proton transmembrane transporter activity molecular_function ECO:0000265 IEA GO_REF:0000107 UniProtKB:P50516|ensembl:ENSMUSP00000110314 9606 Homo sapiens Ensembl V-type proton ATPase catalytic subunit A 20260529 UniProtKB P38606 ATP6V1A located_in GO:0016324 apical plasma membrane cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P50516|ensembl:ENSMUSP00000110314 9606 Homo sapiens Ensembl V-type proton ATPase catalytic subunit A 20260529 UniProtKB P38606 ATP6V1A part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P50516|ensembl:ENSMUSP00000110314 9606 Homo sapiens Ensembl V-type proton ATPase catalytic subunit A 20260529 UniProtKB P38606 ATP6V1A involved_in GO:0097401 synaptic vesicle lumen acidification biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:P50516|ensembl:ENSMUSP00000110314 9606 Homo sapiens Ensembl V-type proton ATPase catalytic subunit A 20260529 UniProtKB P38606 ATP6V1A involved_in GO:0071230 cellular response to amino acid stimulus biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260217 UniProtKB P38606 ATP6V1A contributes_to GO:0160124 guanyl nucleotide exchange factor activator activity molecular_function ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260217 UniProtKB P38606 ATP6V1A is_active_in GO:0005765 lysosomal membrane cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260213 UniProtKB P38606 ATP6V1A part_of GO:0046611 lysosomal proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260213 UniProtKB P38606 ATP6V1A contributes_to GO:0160124 guanyl nucleotide exchange factor activator activity molecular_function ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260213 UniProtKB P38606 ATP6V1A involved_in GO:1904263 positive regulation of TORC1 signaling biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260213 UniProtKB P38606 ATP6V1A part_of GO:0046611 lysosomal proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:33065002 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260212 UniProtKB P38606 ATP6V1A enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000250 ISS GO_REF:0000024 MGI:MGI:1201780 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20260212 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA V-type proton ATPase catalytic subunit A 20251115 UniProtKB P38606 ATP6V1A located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:29668857 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20250130 UniProtKB P38606 ATP6V1A located_in GO:0005737 cytoplasm cellular_component ECO:0000269 EXP PMID:33208464 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20250130 UniProtKB P38606 ATP6V1A located_in GO:0005764 lysosome cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P50516 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20250130 UniProtKB P38606 ATP6V1A located_in GO:0000139 Golgi membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A located_in GO:0005765 lysosomal membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A located_in GO:0005886 plasma membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A involved_in GO:0007035 vacuolar acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A involved_in GO:0007042 lysosomal lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A involved_in GO:0007042 lysosomal lumen acidification biological_process ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A located_in GO:0010008 endosome membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A located_in GO:0016020 membrane cellular_component ECO:0000314 IDA PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A involved_in GO:0048388 endosomal lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A involved_in GO:0051452 intracellular pH reduction biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A involved_in GO:0061795 Golgi lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A involved_in GO:1902600 proton transmembrane transport biological_process ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase catalytic subunit A 20240902 UniProtKB P38606 ATP6V1A part_of GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain cellular_component ECO:0000314 IDA PMID:33065002 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20210318 UniProtKB P38606 ATP6V1A enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23035048 UniProtKB:O76024 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20210318 UniProtKB P38606 ATP6V1A located_in GO:0030141 secretory granule cellular_component ECO:0000314 IDA PMID:23035048 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20210318 UniProtKB P38606 ATP6V1A located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS PMID:8463241 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20180503 UniProtKB P38606 ATP6V1A involved_in GO:0006879 intracellular iron ion homeostasis biological_process ECO:0000315 IMP PMID:28296633 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20170626 UniProtKB P38606 ATP6V1A involved_in GO:0036295 cellular response to increased oxygen levels biological_process ECO:0000315 IMP PMID:28296633 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20170626 UniProtKB P38606 ATP6V1A involved_in GO:0016241 regulation of macroautophagy biological_process ECO:0000303 NAS PMID:22982048 9606 Homo sapiens ParkinsonsUK-UCL V-type proton ATPase catalytic subunit A 20160215 UniProtKB P38606 ATP6V1A located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:23533145 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20140714 UniProtKB P38606 ATP6V1A located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19199708 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20131029 UniProtKB P38606 ATP6V1A located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19056867 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20131024 UniProtKB P38606 ATP6V1A located_in GO:0005765 lysosomal membrane cellular_component ECO:0007005 HDA PMID:17897319 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20130924 UniProtKB P38606 ATP6V1A located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:20458337 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20130829 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1222516 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5252133 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-74723 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-917841 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9639286 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640167 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640168 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640175 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640195 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9645598 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9645608 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9646468 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9858928 9606 Homo sapiens Reactome V-type proton ATPase catalytic subunit A 20100712 UniProtKB P38606 ATP6V1A located_in GO:0005829 cytosol cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P50516 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20090608 UniProtKB P38606 ATP6V1A located_in GO:0005886 plasma membrane cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P50516 9606 Homo sapiens UniProt V-type proton ATPase catalytic subunit A 20090608 UniProtKB P38606 ATP6V1A part_of GO:0016469 proton-transporting two-sector ATPase complex cellular_component ECO:0000304 TAS PMID:8463241 9606 Homo sapiens PINC V-type proton ATPase catalytic subunit A 20030904