GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB P21281 ATP6V1B2 involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000318 IBA GO_REF:0000033 FB:FBgn0005671|MGI:MGI:103285|MGI:MGI:109618|PANTHER:PTN000389697|SGD:S000000331|UniProtKB:P15313 9606 Homo sapiens GO_Central V-type proton ATPase subunit B, brain isoform 20250904 UniProtKB P21281 ATP6V1B2 part_of GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000389697|RGD:620284|SGD:S000000331|UniProtKB:P15313|UniProtKB:P21281|UniProtKB:P31408 9606 Homo sapiens GO_Central V-type proton ATPase subunit B, brain isoform 20250624 UniProtKB P21281 ATP6V1B2 is_active_in GO:0005886 plasma membrane cellular_component ECO:0000318 IBA GO_REF:0000033 CGD:CAL0000199755|FB:FBgn0005671|MGI:MGI:103285|MGI:MGI:109618|PANTHER:PTN000389697|RGD:1310619|UniProtKB:P15313|UniProtKB:P21281 9606 Homo sapiens GO_Central V-type proton ATPase subunit B, brain isoform 20250624 UniProtKB P21281 ATP6V1B2 is_active_in GO:0016324 apical plasma membrane cellular_component ECO:0000318 IBA GO_REF:0000033 MGI:MGI:103285|MGI:MGI:109618|PANTHER:PTN000389708|RGD:1310619|UniProtKB:P15313|UniProtKB:P21281 9606 Homo sapiens GO_Central V-type proton ATPase subunit B, brain isoform 20250624 UniProtKB P21281 ATP6V1B2 involved_in GO:0007035 vacuolar acidification biological_process ECO:0000318 IBA GO_REF:0000033 CGD:CAL0000199755|FB:FBgn0005671|PANTHER:PTN000389698|SGD:S000000331 9606 Homo sapiens GO_Central V-type proton ATPase subunit B, brain isoform 20220223 UniProtKB P21281 ATP6V1B2 enables GO:0005524 ATP binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR000194|InterPro:IPR020003 9606 Homo sapiens InterPro V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 located_in GO:0005737 cytoplasm cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:P62814|ensembl:ENSMUSP00000006435|UniProtKB:P62815|ensembl:ENSRNOP00000015931|UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 located_in GO:0016324 apical plasma membrane cellular_component ECO:0000501 IEA GO_REF:0000120 UniProtKB:P62814|ensembl:ENSMUSP00000006435|UniProtKB:P62815|ensembl:ENSRNOP00000015931|UniProtKB-SubCell:SL-0015 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 located_in GO:0030665 clathrin-coated vesicle membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0071 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 located_in GO:0030672 synaptic vesicle membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0260 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 part_of GO:0033180 proton-transporting V-type ATPase, V1 domain cellular_component ECO:0000256 IEA GO_REF:0000002 InterPro:IPR005723 9606 Homo sapiens InterPro V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 located_in GO:0042470 melanosome cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0161 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 involved_in GO:0046034 ATP metabolic process biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR004100 9606 Homo sapiens InterPro V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR005723 9606 Homo sapiens InterPro V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00027610|InterPro:IPR004100|InterPro:IPR005723 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20260601 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P15884 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:O76024 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P07196 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P14136 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P42858 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q8WXH2 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:Q9Y3C5 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:34159380 UniProtKB:P0DTD1-PRO_0000449620 9606 Homo sapiens IntAct V-type proton ATPase subunit B, brain isoform 20260530 UniProtKB P21281 ATP6V1B2 part_of GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00090169|UniProtKB:P62815|ensembl:ENSRNOP00000015931 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20260529 UniProtKB P21281 ATP6V1B2 located_in GO:0001726 ruffle cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P62814|ensembl:ENSMUSP00000006435 9606 Homo sapiens Ensembl V-type proton ATPase subunit B, brain isoform 20260529 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P62814|ensembl:ENSMUSP00000006435 9606 Homo sapiens Ensembl V-type proton ATPase subunit B, brain isoform 20260529 UniProtKB P21281 ATP6V1B2 located_in GO:0005886 plasma membrane cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P62814|ensembl:ENSMUSP00000006435 9606 Homo sapiens Ensembl V-type proton ATPase subunit B, brain isoform 20260529 UniProtKB P21281 ATP6V1B2 located_in GO:0005902 microvillus cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P62814|ensembl:ENSMUSP00000006435 9606 Homo sapiens Ensembl V-type proton ATPase subunit B, brain isoform 20260529 UniProtKB P21281 ATP6V1B2 involved_in GO:0097401 synaptic vesicle lumen acidification biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:P62814|ensembl:ENSMUSP00000006435 9606 Homo sapiens Ensembl V-type proton ATPase subunit B, brain isoform 20260529 UniProtKB P21281 ATP6V1B2 is_active_in GO:0098850 extrinsic component of synaptic vesicle membrane cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:P62815|ensembl:ENSRNOP00000015931 9606 Homo sapiens Ensembl V-type proton ATPase subunit B, brain isoform 20260529 UniProtKB P21281 ATP6V1B2 located_in GO:0005737 cytoplasm cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P62814 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20211209 UniProtKB P21281 ATP6V1B2 located_in GO:0042470 melanosome cellular_component ECO:0000269 EXP PMID:12643545 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20211209 UniProtKB P21281 ATP6V1B2 part_of GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain cellular_component ECO:0000314 IDA PMID:33065002 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20210318 UniProtKB P21281 ATP6V1B2 located_in GO:0016324 apical plasma membrane cellular_component ECO:0000314 IDA PMID:29993276 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20210318 UniProtKB P21281 ATP6V1B2 involved_in GO:0016241 regulation of macroautophagy biological_process ECO:0000303 NAS PMID:22982048 9606 Homo sapiens ParkinsonsUK-UCL V-type proton ATPase subunit B, brain isoform 20160215 UniProtKB P21281 ATP6V1B2 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:23533145 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20140714 UniProtKB P21281 ATP6V1B2 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19199708 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20131029 UniProtKB P21281 ATP6V1B2 located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19056867 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20131024 UniProtKB P21281 ATP6V1B2 located_in GO:0005765 lysosomal membrane cellular_component ECO:0007005 HDA PMID:17897319 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20130924 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1222516 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5252133 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-74723 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-917841 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9639286 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640167 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640168 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640175 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640195 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9645598 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9645608 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9646468 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9858918 9606 Homo sapiens Reactome V-type proton ATPase subunit B, brain isoform 20100712 UniProtKB P21281 ATP6V1B2 located_in GO:0005829 cytosol cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P62814 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20090804 UniProtKB P21281 ATP6V1B2 located_in GO:0005886 plasma membrane cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P62814 9606 Homo sapiens UniProt V-type proton ATPase subunit B, brain isoform 20090804 UniProtKB P21281 ATP6V1B2 enables GO:0015078 proton transmembrane transporter activity molecular_function ECO:0000304 TAS PMID:2145275 9606 Homo sapiens PINC V-type proton ATPase subunit B, brain isoform 20030904 UniProtKB P21281 ATP6V1B2 enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000304 TAS PMID:2145275 9606 Homo sapiens PINC V-type proton ATPase subunit B, brain isoform 20030904 UniProtKB P21281 ATP6V1B2 involved_in GO:1902600 proton transmembrane transport biological_process ECO:0000304 TAS PMID:2145275 9606 Homo sapiens PINC V-type proton ATPase subunit B, brain isoform 20030904