GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB Q9Y5K8 ATP6V1D part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0022097|MGI:MGI:1921084|PANTHER:PTN002268884|SGD:S000000777|UniProtKB:O59941|UniProtKB:P39942|UniProtKB:Q9Y5K8 9606 Homo sapiens GO_Central V-type proton ATPase subunit D 20250902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0007035 vacuolar acidification biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000186829|SGD:S000000777|UniProtKB:O59941 9606 Homo sapiens GO_Central V-type proton ATPase subunit D 20250731 UniProtKB Q9Y5K8 ATP6V1D contributes_to GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN002268884|SGD:S000000777|UniProtKB:O59941 9606 Homo sapiens GO_Central V-type proton ATPase subunit D 20250731 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005765 lysosomal membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0157 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260601 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005813 centrosome cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0048 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260601 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005929 cilium cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0066 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260601 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0016020 membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0162 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260601 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0030665 clathrin-coated vesicle membrane cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0071 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260601 UniProtKB Q9Y5K8 ATP6V1D enables GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR002699 9606 Homo sapiens InterPro V-type proton ATPase subunit D 20260601 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8N1B4 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:O14777 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q16864 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q7Z3Y8 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q8N1B4 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q96CS2 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32296183 UniProtKB:Q9BUW7 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q16864 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q9BUW7 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:35271311 UniProtKB:Q16864 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:35271311 UniProtKB:Q9BUW7 9606 Homo sapiens IntAct V-type proton ATPase subunit D 20260530 UniProtKB Q9Y5K8 ATP6V1D contributes_to GO:0015078 proton transmembrane transporter activity molecular_function ECO:0000265 IEA GO_REF:0000107 UniProtKB:P57746|ensembl:ENSMUSP00000021536 9606 Homo sapiens Ensembl V-type proton ATPase subunit D 20260529 UniProtKB Q9Y5K8 ATP6V1D part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00092829|UniProtKB:P57746|ensembl:ENSMUSP00000021536 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260529 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0097401 synaptic vesicle lumen acidification biological_process ECO:0000265 IEA GO_REF:0000107 UniProtKB:P57746|ensembl:ENSMUSP00000021536 9606 Homo sapiens Ensembl V-type proton ATPase subunit D 20260529 UniProtKB Q9Y5K8 ATP6V1D is_active_in GO:0098850 extrinsic component of synaptic vesicle membrane cellular_component ECO:0000265 IEA GO_REF:0000107 UniProtKB:F7EUL0|ensembl:ENSRNOP00000012101 9606 Homo sapiens Ensembl V-type proton ATPase subunit D 20260529 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0071230 cellular response to amino acid stimulus biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260217 UniProtKB Q9Y5K8 ATP6V1D contributes_to GO:0160124 guanyl nucleotide exchange factor activator activity molecular_function ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260217 UniProtKB Q9Y5K8 ATP6V1D is_active_in GO:0005765 lysosomal membrane cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260213 UniProtKB Q9Y5K8 ATP6V1D part_of GO:0046611 lysosomal proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260213 UniProtKB Q9Y5K8 ATP6V1D contributes_to GO:0160124 guanyl nucleotide exchange factor activator activity molecular_function ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260213 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:1904263 positive regulation of TORC1 signaling biological_process ECO:0000314 IDA PMID:22053050 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20260213 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005886 plasma membrane cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA V-type proton ATPase subunit D 20251115 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0000139 Golgi membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005765 lysosomal membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005886 plasma membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0007035 vacuolar acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0007042 lysosomal lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0007042 lysosomal lumen acidification biological_process ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0010008 endosome membrane cellular_component ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0016020 membrane cellular_component ECO:0000314 IDA PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0048388 endosomal lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0051452 intracellular pH reduction biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0061795 Golgi lumen acidification biological_process ECO:0005547 NAS PMID:32001091 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:1902600 proton transmembrane transport biological_process ECO:0005547 NAS PMID:33065002 9606 Homo sapiens ComplexPortal V-type proton ATPase subunit D 20240902 UniProtKB Q9Y5K8 ATP6V1D part_of GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain cellular_component ECO:0000250 ISS GO_REF:0000024 UniProtKB:P39942 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20210916 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-6799350 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20160716 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0035579 specific granule membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-6799350 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20160716 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0016241 regulation of macroautophagy biological_process ECO:0000303 NAS PMID:22982048 9606 Homo sapiens ParkinsonsUK-UCL V-type proton ATPase subunit D 20160215 UniProtKB Q9Y5K8 ATP6V1D part_of GO:0033176 proton-transporting V-type ATPase complex cellular_component ECO:0000314 IDA PMID:18752060 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20141003 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19199708 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20131029 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0070062 extracellular exosome cellular_component ECO:0007005 HDA PMID:19056867 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20131024 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005765 lysosomal membrane cellular_component ECO:0007005 HDA PMID:17897319 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20130924 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0061512 protein localization to cilium biological_process ECO:0000315 IMP PMID:21844891 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20130529 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21844891 UniProtKB:Q9Y5X0 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20130528 UniProtKB Q9Y5K8 ATP6V1D colocalizes_with GO:0005813 centrosome cellular_component ECO:0000314 IDA PMID:21844891 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20130528 UniProtKB Q9Y5K8 ATP6V1D colocalizes_with GO:0005929 cilium cellular_component ECO:0000314 IDA PMID:21844891 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20130528 UniProtKB Q9Y5K8 ATP6V1D involved_in GO:0060271 cilium assembly biological_process ECO:0000315 IMP PMID:21844891 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20130528 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1222516 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-5252133 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-74723 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-917841 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9639286 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640167 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640168 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640175 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9640195 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9645598 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9645608 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-9646468 9606 Homo sapiens Reactome V-type proton ATPase subunit D 20100712 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:18752060 UniProtKB:P61421 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20090424 UniProtKB Q9Y5K8 ATP6V1D enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:18752060 UniProtKB:Q8N8Y2 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20090424 UniProtKB Q9Y5K8 ATP6V1D located_in GO:0016020 membrane cellular_component ECO:0000314 IDA PMID:18752060 9606 Homo sapiens UniProt V-type proton ATPase subunit D 20090424