BCOR is a predominantly nuclear transcriptional corepressor recruited by DNA-binding regulators such as BCL6. It forms a variant Polycomb repressive complex, PRC1.1, with PCGF1, RING proteins and associated chromatin regulators, linking promoter recruitment to histone modification and transcriptional repression. BCOR also associates with selected histone deacetylases in repression assays. Its regulatory effects depend on cell type and partner composition, including germinal-center B-cell programs and osteo/dentinogenic differentiation of mesenchymal stem cells. Alternative isoforms differ in interaction capacity and localization. Pathogenic loss-of-function variants cause oculofaciocardiodental syndrome.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000122 negative regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | ACCEPT | Summary: BCOR represses RNA polymerase II transcription as a recruited corepressor. Reason: The PAINT assertion is consistent with human reporter repression and the TFAP2A perturbation/rescue experiments. Target experimental evidence in WITH/FROM is expected in an IBA and is not circular; no contrary phylogenetic placement or loss is established. |
| GO:0000122 negative regulation of transcription by RNA polymerase II | IMP PMID:19578371 BCOR regulates mesenchymal stem cell function by epigenetic ... | ACCEPT | Summary: BCOR suppresses TFAP2A expression in human mesenchymal stem cells. Reason: PMID:19578371 reports reduced AP-2alpha expression after wild-type BCOR restoration and increased expression after BCOR knockdown. This is a direct example of the transcriptional repression that defines its corepressor role. |
| GO:0000785 chromatin | NAS PMID:22325352 PCGF homologs, CBX proteins, and RYBP define functionally di... | ACCEPT | Summary: BCOR-containing PRC1.1 complexes act on chromatin. Reason: The cited PRC1 family study places BCOR within a chromatin-regulatory assembly. BCOR occupancy at endogenous promoters is directly demonstrated in PMID:19578371 and PMID:16943429, supporting the broad chromatin location without implying intrinsic DNA recognition. |
| GO:0000976 transcription cis-regulatory region binding | IMP PMID:19578371 BCOR regulates mesenchymal stem cell function by epigenetic ... | UNDECIDED | Summary: BCOR occupies a regulatory region of the TFAP2A promoter, but the molecular DNA-contact claim remains unresolved. Reason: PMID:19578371 Figure 5 and ChIP methods show occupancy at a BCL6 motif using protein crosslinking and immunoprecipitation. GO:0000976 concerns regulatory-region DNA binding; its comment also permits nonspecific binding. These assays do not distinguish BCOR DNA contact from recruitment through BCL6 or other proteins. The antibody does not recognize mutant BCOR, so the mutant ChIP absence is not proof of lost occupancy. Retain the source assertion pending resolution of the binding mechanism. Supporting Evidence: PMID:19578371 BCOR was present at the BCL6-binding site of AP-2Ξ± in MSC-WT cells |
| GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding | IEA GO_REF:0000107 | UNDECIDED | Summary: Sequence-specific DNA recognition by BCOR is unresolved. Reason: This Ensembl transfer names mouse Q8CGN4/ENSMUSP00000111175. GO:0000977 requires sequence-specific regulatory-region DNA binding. Human promoter occupancy and corepressor recruitment do not by themselves establish that activity. The official MGI Bcor record does contain an IDA annotation to this term from J:218799. Its underlying assay and PMID were not resolved from the accessible citation pages. This is an unresolved experimental-donor interpretation, not evidence that the transfer lacks experimental grounding; no loss or wrong-donor diagnosis is asserted. |
| GO:0003714 transcription corepressor activity | IBA GO_REF:0000033 | ACCEPT | Summary: Transcription corepression is the principal molecular function of BCOR. Reason: The phylogenetically inferred activity agrees with direct human BCL6-dependent and tethered-reporter repression. The PAINT node is retained without inventing a family or challenging the donor count. |
| GO:0003714 transcription corepressor activity | IDA PMID:10898795 BCoR, a novel corepressor involved in BCL-6 repression. | ACCEPT | Summary: BCOR potentiates BCL6-dependent repression. Reason: Human-cell reporter experiments show repression by tethered BCOR and enhancement of BCL6 repression, with weaker behavior of the truncated short form. This directly supports corepressor activity; it does not require BCOR to recognize DNA independently. Supporting Evidence: PMID:10898795 can repress transcription when physically tethered to a promoter |
| GO:0003714 transcription corepressor activity | IEA GO_REF:0000107 | ACCEPT | Summary: The ortholog-transferred corepressor activity is directly supported in human BCOR. Reason: Human BCL6 reporter and interaction experiments independently substantiate the transferred function. Accept the activity without needing to infer a new species-specific mechanism. |
| GO:0003714 transcription corepressor activity | IMP PMID:15878880 Transcriptional activity of Sp1 is regulated by molecular in... | ACCEPT | Summary: BCOR contributes to repression of Sp1-dependent transcription. Reason: The available abstract reports Sp1-domain association with BCoR and increased Sp1-driven transcription after corepressor knockdown. This agrees with the established corepressor mechanism. Detailed constructs and individual experimental panels were not available in this normal abstract-only cache. |
| GO:0004842 ubiquitin-protein transferase activity | IDA PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | ACCEPT | Summary: BCOR contributes to the ubiquitin-transferase activity of its PRC1.1 complex. Reason: The source qualifier is contributes_to. The original primary Results assay purified BCOR complex with ubiquitination components and nucleosomes; RNF2 provides the catalytic activity. Retain the complex-subunit contribution, without assigning an autonomous ubiquitin-transferase active site to BCOR. Supporting Evidence: PMID:16943429 BCOR complex has E3 ligase activity for histone H2A |
| GO:0005515 protein binding | IPI PMID:16713569 A protein-protein interaction network for human inherited at... | KEEP AS NON CORE | Summary: The BCORβUSP7 association is supported and retained as non-core. Reason: IntAct IM-11827-464 (EBI-953656) links human USP7 Q93009 and BCOR Q6W2J9 to PMID:16713569 using two-hybrid detection (MI:0018), with Figure 1/Table S3 provenance. This checks the exact curated pair, source and method; the full article, original supplementary table and assay controls were not newly inspected. Retain the supported low-resolution interaction as non-core under the explicit ClinGen project instruction. The record does not establish a BCOR deubiquitinase activity or a physiological regulatory mechanism. |
| GO:0005515 protein binding | IPI PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | KEEP AS NON CORE | Summary: The BCORβSKP1 association is supported and retained as non-core. Reason: The source identifies SKP1 among proteins copurifying with tagged BCOR and supports its association within the complex. This does not establish an isolated direct BCORβSKP1 interface. Retain the supported association as non-core under the explicit ClinGen project instruction; the corepressor and complex annotations describe the mechanism without supplying a narrower partner-specific molecular activity. |
| GO:0005515 protein binding | IPI PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | KEEP AS NON CORE | Summary: The BCORβRING1 association is supported and retained as non-core. Reason: The source recovers RING1 with BCOR while reporting no detected direct BCOR interaction with RING1 or RNF2; PCGF1 bridges the association. The direct-contact limitation does not contradict recovery in the same complex. Retain this supported low-resolution association as non-core under the explicit ClinGen project instruction, without assigning BCOR the catalytic activity of its partner. |
| GO:0005515 protein binding | IPI PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | KEEP AS NON CORE | Summary: The BCORβKDM2B association is supported and retained as non-core. Reason: The source identifies KDM2B/FBXL10 in the BCOR assembly and demonstrates coimmunoprecipitation with BCOR, while leaving the direct interface unresolved. Retain the supported association as non-core under the explicit ClinGen project instruction. Neither copurification nor the partner's identity establishes a demethylase activity of BCOR. |
| GO:0005515 protein binding | IPI PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | KEEP AS NON CORE | Summary: The BCORβRNF2 association is supported and retained as non-core. Reason: The source recovers RNF2 with BCOR while reporting no detected direct BCOR interaction with RING1 or RNF2; PCGF1 bridges the association. The direct-contact limitation does not contradict recovery in the same complex. Retain this supported low-resolution association as non-core under the explicit ClinGen project instruction, without assigning BCOR the catalytic activity of its partner. |
| GO:0005515 protein binding | IPI PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | KEEP AS NON CORE | Summary: The BCORβPCGF1 association is supported and retained as non-core. Reason: The source demonstrates a BCOR C-terminal interaction with PCGF1 in pull-down and cellular assays. Retain the supported binding assertion as non-core under the explicit ClinGen project instruction. This binding helps organize the BCOR complex, but the inspected assay does not establish a separate, narrower molecular activity for this row. |
| GO:0005515 protein binding | IPI PMID:24981860 Human-chromatin-related protein interactions identify a deme... | KEEP AS NON CORE | Summary: The BCORβKDM2B association is supported and retained as non-core. Reason: BioGRID interaction 2942056 directly links human KDM2B bait and BCOR prey to PMID:24981860 with affinity capture-MS evidence. This verifies the source-specific curated interaction record; it does not claim a new audit of the original supplementary measurements or a direct binary interface. The association is also consistent with the independent BCOR-complex experiments in PMID:16943429. Retain the supported low-resolution association as non-core under the explicit ClinGen project instruction, without assigning BCOR demethylase activity. |
| GO:0005515 protein binding | IPI Q6W2J9-4 PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The isoform-specific BCORβNAA10 binary-map interaction remains unresolved. Reason: The original IPI assertion and normal UniProt interaction entry specify this same isoform and partner. The source is a proteome-scale binary interaction map; its individual supplementary pair was not re-audited. Preserve Q6W2J9-4 exactly; the tested isoform does not prove exclusivity to that isoform. Leave this source-specific assertion UNDECIDED until the pair-level evidence can be checked. |
| GO:0005515 protein binding | IPI Q6W2J9-4 PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The isoform-specific BCORβPCGF3 binary-map interaction remains unresolved. Reason: The original IPI assertion and normal UniProt interaction entry specify this same isoform and partner. The source is a proteome-scale binary interaction map; its individual supplementary pair was not re-audited. Preserve Q6W2J9-4 exactly; the tested isoform does not prove exclusivity to that isoform. Leave this source-specific assertion UNDECIDED until the pair-level evidence can be checked. |
| GO:0005515 protein binding | IPI Q6W2J9-4 PMID:25416956 A proteome-scale map of the human interactome network. | UNDECIDED | Summary: The isoform-specific BCORβPCGF5 binary-map interaction remains unresolved. Reason: The original IPI assertion and normal UniProt interaction entry specify this same isoform and partner. The source is a proteome-scale binary interaction map; its individual supplementary pair was not re-audited. Preserve Q6W2J9-4 exactly; the tested isoform does not prove exclusivity to that isoform. Leave this source-specific assertion UNDECIDED until the pair-level evidence can be checked. |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | UNDECIDED | Summary: The BCORβKDM2B quantitative-proteomics interaction remains unresolved. Reason: The cited study uses quantitative affinity proteomics in HeLa cells. The GOA IPI partner is consistent with normal UniProt and the BCOR complex described in PMID:16943429. The exact supplementary measurement was not re-audited, and no isolated binary contact or new biochemical activity is inferred. Use UNDECIDED until the pair-level supplementary evidence can be checked. |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | UNDECIDED | Summary: The BCORβUSP7 quantitative-proteomics interaction remains unresolved. Reason: The cited study uses quantitative affinity proteomics in HeLa cells. The GOA IPI partner is consistent with normal UniProt and the BCOR complex described in PMID:26687479. The exact supplementary measurement was not re-audited, and no isolated binary contact or new biochemical activity is inferred. Use UNDECIDED until the pair-level supplementary evidence can be checked. |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | UNDECIDED | Summary: The BCORβPCGF1 quantitative-proteomics interaction remains unresolved. Reason: The cited study uses quantitative affinity proteomics in HeLa cells. The GOA IPI partner is consistent with normal UniProt and the BCOR complex described in PMID:26687479. The exact supplementary measurement was not re-audited, and no isolated binary contact or new biochemical activity is inferred. Use UNDECIDED until the pair-level supplementary evidence can be checked. |
| GO:0005515 protein binding | IPI PMID:26687479 The variant Polycomb Repressor Complex 1 component PCGF1 int... | KEEP AS NON CORE | Summary: The BCORβPCGF1 association is supported and retained as non-core. Reason: The source recovers BCOR in endogenous PCGF1 immunoprecipitates and confirms association by coimmunoprecipitation in NT2 cells. Retain protein binding as non-core under the explicit ClinGen project instruction. The existing quotation supports this association; it does not transfer the entire PCGF1 pluripotency interaction network to BCOR. Supporting Evidence: PMID:26687479 our experiments confirmed that PCGF1 interacts with the variant PRC1 complex component BCOR |
| GO:0005515 protein binding | IPI PMID:27505670 EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Rep... | KEEP AS NON CORE | Summary: The BCORβKDM2B association is supported and retained as non-core. Reason: The source's BCOR tandem-affinity purification is represented in IntAct IM-25601-45 (EBI-12553433), Table S2, with KDM2B as a recovered partner. This source-specific record supports complex association beyond promoter co-occupancy; a direct BCORβKDM2B interface is not established. Retain the supported low-resolution association as non-core under the explicit ClinGen project instruction, without assigning BCOR its partner's demethylase activity. |
| GO:0005515 protein binding | IPI PMID:27505670 EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Rep... | KEEP AS NON CORE | Summary: The BCORβPCGF1 association is supported and retained as non-core. Reason: The source includes PCGF1 in the BCOR tandem-affinity purification recorded as IntAct IM-25601-45 (EBI-12553433), Table S2, and tests association in reconstituted complexes. Retain the supported association as non-core under the explicit ClinGen project instruction. Recovery in this assembly does not by itself resolve a new partner-specific molecular activity or universal complex stoichiometry. |
| GO:0005515 protein binding | IPI PMID:27505670 EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Rep... | KEEP AS NON CORE | Summary: The BCORβCBX8 association is supported and retained as non-core. Reason: The source confirms endogenous BCORβCBX8 coimmunoprecipitation in human germinal-center B cells and DLBCL cells. Reconstitution shows that CBX8 incorporation depends on its RING1B contact, so the association is not an established direct BCORβCBX8 interface. Retain the supported association as non-core under the explicit ClinGen project instruction; the existing quotation records the observed association. Supporting Evidence: PMID:27505670 endogenous CBX8 association with BCOR in purified GC B cells from human tonsils |
| GO:0005515 protein binding | IPI PMID:27705803 A High-Density Map for Navigating the Human Polycomb Complex... | UNDECIDED | Summary: The BCORβPCGF1 complexome interaction remains unresolved. Reason: The cited Polycomb complexome uses affinity purification/MS. The individual supplementary entry was not re-audited, but the curated partner is directly corroborated in PMID:26687479. This low-resolution association adds no separate core molecular function. Use UNDECIDED until the pair-level supplementary evidence can be checked. |
| GO:0005515 protein binding | IPI PMID:27705803 A High-Density Map for Navigating the Human Polycomb Complex... | UNDECIDED | Summary: The BCORβCBX8 complexome interaction remains unresolved. Reason: The cited Polycomb complexome uses affinity purification/MS. The individual supplementary entry was not re-audited, but the curated partner is directly corroborated in PMID:27505670. This low-resolution association adds no separate core molecular function. Use UNDECIDED until the pair-level supplementary evidence can be checked. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | UNDECIDED | Summary: The BCORβPCGF1 BioPlex interaction remains unresolved. Reason: BioPlex surveys affinity-purified complexes in distinct human cell backgrounds. The source-specific supplementary record and cell assignment were not re-audited; the pair is supported independently by endogenous NT2-cell experiments. That independent experiment does not identify the exact BioPlex observation or establish universal stoichiometry. Leave this source-specific assertion UNDECIDED until its pair-level evidence and context can be checked. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | UNDECIDED | Summary: The BCORβUSP7 OpenCell interaction remains unresolved. Reason: OpenCell uses endogenous tagging, imaging and interaction proteomics. The source-specific USP7 pair was not re-audited in the supplementary dataset, but the curated IPI assertion is consistent with normal UniProt and USP7 recovery in BCOR-associated assemblies. No core deubiquitinase or signaling activity is assigned to BCOR. Use UNDECIDED until the pair-level supplementary evidence can be checked. |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | UNDECIDED | Summary: The allele context of the BCORβAKT1 interaction needs resolution. Reason: The source studies mutation-directed interactions and explicitly reports allele-selective partners of AKT1 E17K. GOA and UniProt identify a BCORβAKT1 pair, but the BCOR-specific wild-type versus mutant comparison was not recovered. Retain uncertainty rather than generalizing this to constitutive binding or rejecting it from the paper title. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: BCOR acts in the nucleus. Reason: The PAINT location agrees with human nuclear immunofluorescence and promoter-associated corepression. Its target-containing donor list is not circular. |
| GO:0005634 nucleus | IDA PMID:10898795 BCoR, a novel corepressor involved in BCL-6 repression. | ACCEPT | Summary: The tested long BCOR construct localizes to the nucleus. Reason: The source observes nuclear myc-tagged BCoR in HeLa cells. Its truncated BCoR-S construct also appears in cytoplasmic puncta, so this positive nuclear location must not be read as excluding all cytoplasmic localization of all isoforms. |
| GO:0005634 nucleus | IDA PMID:25331958 Interferon regulatory factor 8 (IRF8) interacts with the B c... | ACCEPT | Summary: Endogenous BCOR staining is nuclear in the tested human-cell experiment. Reason: The paper contains mouse B-cell experiments and also HEK293-cell immunostaining for endogenous BCOR alongside transfected GFP-IRF8. The human-cell localization supports this annotation; it is not rejected merely because other assays use mouse proteins. Supporting Evidence: PMID:25331958 The pattern for BCOR staining also overlapped with that of GFP-IRF8 |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: The electronic nuclear localization agrees with direct human observations. Reason: Nuclear localization is supported by independent human-cell imaging and promoter experiments. Retain the composite electronic source fields unchanged. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: Nucleoplasmic localization is compatible with BCOR corepression. Reason: The immunofluorescence-derived annotation agrees with diffuse and punctate intranuclear BCOR staining. It does not assert a particular punctum subtype or that every isoform is exclusively nuclear. |
| GO:0006338 chromatin remodeling | IDA PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | ACCEPT | Summary: BCOR contributes to chromatin reorganization through its recruited modifying complex. Reason: The official chromatin-remodeling definition is broader than ATP-driven nucleosome movement and includes histone-modifying activities. The source supports BCOR-complex H2A ubiquitination and promoter recruitment; the human TFAP2A study also connects BCOR to altered promoter histone marks. Retain the process without inventing a BCOR ATPase. Supporting Evidence: PMID:16943429 addition of Flag-tagged ubiquitin onto H2A |
| GO:0007507 heart development | IMP PMID:17517692 Left-sided embryonic expression of the BCL-6 corepressor, BC... | KEEP AS NON CORE | Summary: BCOR has a developmental role affecting the heart. Reason: The source combines human OFCD cardiac phenotypes with Xenopus knockdown and cardiac laterality experiments. Retain this tissue-level consequence as non-core, while keeping the animal assay context separate from human clinical observations. |
| GO:0030502 negative regulation of bone mineralization | IMP PMID:19578371 BCOR regulates mesenchymal stem cell function by epigenetic ... | KEEP AS NON CORE | Summary: BCOR restrains osteogenic mineralization in the studied mesenchymal stem cells. Reason: Human OFCD-cell comparisons and wild-type BCOR restoration support a negative effect on mineralization. This is a contextual downstream output of transcriptional corepression, not the defining molecular function. Supporting Evidence: PMID:19578371 mineralization was potently inhibited in MSC-O/BCOR cells |
| GO:0031072 heat shock protein binding | IDA PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | KEEP AS NON CORE | Summary: A heat-shock protein associates with the purified BCOR complex. Reason: The original Results identify HSP70 among proteins copurifying with tagged BCOR and report recovery of the same associated bands with tagged NSPC1. GO:0031072 describes binding to a heat-shock protein; it does not assert that BCOR has chaperone activity or mediates heat responses. The paper separates HSP70 from the Polycomb and SCF protein categories, without demonstrating that the observed association is artifactual. Retain the curated association as non-core. The purification does not establish an isolated binary interface or a stable physiological HSP70-containing repression complex. Supporting Evidence: PMID:16943429 identified HSP70 |
| GO:0031507 heterochromatin formation | NAS PMID:22325352 PCGF homologs, CBX proteins, and RYBP define functionally di... | MARK AS OVER ANNOTATED | Summary: The source supports PRC1-family repression more directly than BCOR-specific heterochromatin formation. Reason: GO:0031507 describes establishment of compact, transcription-refractory heterochromatin through nucleation, spreading and boundary formation. The cited study distinguishes PRC1 assemblies, but its reconstituted compaction comparison focuses on PRC1.4 rather than BCOR-containing PRC1.1. Extending that mechanism to BCOR is broader than the inspected evidence. BCOR chromatin-associated repression is retained separately. |
| GO:0035102 PRC1 complex | NAS PMID:22325352 PCGF homologs, CBX proteins, and RYBP define functionally di... | ACCEPT | Summary: BCOR belongs to the noncanonical PRC1.1 branch of PRC1 assemblies. Reason: The official PRC1 definition includes a family of mammalian complexes with distinct subunit compositions. The cited proteomic classification and the original BCOR-complex work support this membership. Do not interpret the broad term as universal membership in canonical CBX/PHC-containing PRC1. |
| GO:0042476 odontogenesis | IMP PMID:17517692 Left-sided embryonic expression of the BCL-6 corepressor, BC... | KEEP AS NON CORE | Summary: BCOR contributes to tooth development in the OFCD context. Reason: The source describes human dental abnormalities and developmental pleiotropy. This supported tissue-level role is non-core; the later human mesenchymal-cell study provides mechanistic support for altered osteo/dentinogenic regulation without replacing the original source. |
| GO:0042826 histone deacetylase binding | IPI PMID:10898795 BCoR, a novel corepressor involved in BCL-6 repression. | ACCEPT | Summary: BCOR associates with HDAC3 in a repression-related context. Reason: PMID:10898795 tests the indicated HDAC in transfected human 293 cells and reports coimmunoprecipitation with BCOR. This specific partner-class activity is consistent with transcriptional corepression. Association does not establish that BCOR itself catalyzes histone deacetylation. |
| GO:0042826 histone deacetylase binding | IPI PMID:10898795 BCoR, a novel corepressor involved in BCL-6 repression. | ACCEPT | Summary: BCOR associates with HDAC1 in a repression-related context. Reason: PMID:10898795 tests the indicated HDAC in transfected human 293 cells and reports coimmunoprecipitation with BCOR. This specific partner-class activity is consistent with transcriptional corepression. Association does not establish that BCOR itself catalyzes histone deacetylation. |
| GO:0042826 histone deacetylase binding | IPI PMID:10898795 BCoR, a novel corepressor involved in BCL-6 repression. | ACCEPT | Summary: BCOR associates with HDAC5 in a repression-related context. Reason: PMID:10898795 tests the indicated HDAC in transfected human 293 cells and reports coimmunoprecipitation with BCOR. This specific partner-class activity is consistent with transcriptional corepression. Association does not establish that BCOR itself catalyzes histone deacetylation. |
| GO:0045892 negative regulation of DNA-templated transcription | IDA PMID:10898795 BCoR, a novel corepressor involved in BCL-6 repression. | ACCEPT | Summary: BCOR represses transcription when recruited to a promoter. Reason: The original tethered and BCL6-responsive reporter experiments directly support the broad negative transcriptional process. Retain this valid broader source term alongside the RNA polymerase II-specific evidence. |
| GO:0045892 negative regulation of DNA-templated transcription | IMP PMID:15878880 Transcriptional activity of Sp1 is regulated by molecular in... | ACCEPT | Summary: BCOR is implicated in repression of Sp1-driven transcription. Reason: The source abstract reports Sp1-corepressor interactions and increased transcription after corepressor depletion. This agrees with the broader negative transcriptional role, while detailed construct-level interpretation remains limited by the normal abstract-only cache. |
| GO:0045892 negative regulation of DNA-templated transcription | NAS PMID:22325352 PCGF homologs, CBX proteins, and RYBP define functionally di... | ACCEPT | Summary: BCOR contributes to repressive PRC1-family transcriptional regulation. Reason: The cited study classifies BCOR-containing PRC1.1 among distinct chromatin-regulatory assemblies. Direct human BCOR repression and TFAP2A experiments independently support the stated broad process. |
| GO:0060021 roof of mouth development | IMP PMID:17517692 Left-sided embryonic expression of the BCL-6 corepressor, BC... | KEEP AS NON CORE | Summary: Palatal development is part of the pleiotropic OFCD phenotype. Reason: The inspected primary discussion explicitly includes cleft or high-arched palate among affected human cases. Retain the developmental annotation as non-core; the paper does not establish a BCOR-specific palate-cell mechanism. |
| GO:0065001 specification of axis polarity | IMP PMID:17517692 Left-sided embryonic expression of the BCL-6 corepressor, BC... | KEEP AS NON CORE | Summary: BCOR affects vertebrate leftβright axis specification. Reason: The source describes sided Xenopus knockdown, abnormal cardiac/gut orientation and reduced Pitx2c expression, together with human laterality phenotypes. Retain the developmental role as non-core; direct activation of PITX2 by BCOR is not established. Supporting Evidence: PMID:17517692 Reversed cardiac orientation and disorganized gut patterning were seen |
| GO:0070171 negative regulation of tooth mineralization | IMP PMID:19578371 BCOR regulates mesenchymal stem cell function by epigenetic ... | KEEP AS NON CORE | Summary: BCOR restrains dentinogenic mineralization in the studied human stem-cell system. Reason: Patient-derived mesenchymal cells show enhanced differentiation and mineralization, and restoring wild-type BCOR suppresses these effects. Retain this contextual negative-regulatory role as non-core, distinct from the corepressor molecular activity. |
| GO:0140261 BCOR complex | IDA PMID:16943429 Polycomb group and SCF ubiquitin ligases are found in a nove... | ACCEPT | Summary: BCOR is a defining component of the BCOR/PRC1.1 complex. Reason: The source purification identifies the BCOR-containing repressive assembly. The official GO:0140261 definition names BCOR or BCORL1 and the associated Polycomb machinery. This is the appropriate specific complex assignment. Supporting Evidence: PMID:16943429 BCOR and NSPC1 are requisite partners |
| GO:0140297 DNA-binding transcription factor binding | IPI PMID:10898795 BCoR, a novel corepressor involved in BCL-6 repression. | ACCEPT | Summary: BCOR binds the DNA-binding transcription factor BCL6. Reason: The source directly tests the BCL6βBCOR interaction in vitro and in human cells, mapping recruitment to the BCL6 POZ/BTB domain. This partner-recognition activity supports BCOR corepression; it does not imply that BCOR itself is a sequence-specific DNA-binding factor. Supporting Evidence: PMID:10898795 BCoR interacts specifically with BCL-6 |
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Q: Does the BCORβAKT1 interaction in PMID:35512704 occur with wild-type AKT1, E17K, or both, and under which cellular conditions?
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